Objective
Chemistry is far away from being a mature science: many desirable transformations are still out of scope. One important example is the selective (oxy)functionalisation of non-activated C-H bonds, which still represents a dream reaction of organic chemistry. This is because balancing high reactivity (needed for the activation of inert C-H bonds) with selectivity is difficult to achieve. Enzymes, specifically monooxygenases, are catalysts that principally solve this challenge.
Monooxygenases, however, are not practical catalysts for organic chemistry. This is because they have evolved to enable the survival of their host organisms and not to suit the needs of organic chemists. In particular the complex molecular architecture of monooxygenases (necessitating O2, stoichiometric reductants and additional catalytic components) together with mechanistic challenges arising from their complex molecular architecture impede their chemistry-wide application.
PeroxyZyme aims at solving these issues and establish evolved monooxygenases (peroxyzymes) as practical catalysts for organic chemistry. Peroxyzymes will be able to function with simple hydrogen peroxide rather than via the natural, albeit complex and vulnerable electron transport chains. This fundamental change in the monooxygenases catalytic mechanisms will be achieved by a mechanism-driven and experimentally validated semi-rational engineering approach. Evolved peroxyzymes will be characterised using up-to date (ultra)fast spectroscopy identifying catalytic bottlenecks and possible inactivation mechanisms. This molecular understanding will provide the basis for further improvement of first generation peroxyzymes. The practical usefulness of evolved peroxyzymes will be demonstrated on preparative-scale by using them in non-aqueous reaction media enabling high product concentrations and space-time yields.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2021-ADG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2628 CN Delft
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.