Practical oxyfunctionalisation biocatalysts by engineering monooxygenases into peroxyzymes.

Project Information

PeroxyZyme

Grant agreement ID: 101054658

DOI

10.3030/101054658

EC signature date 1 June 2022

Start date 1 August 2022

End date 31 July 2027

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

TECHNISCHE UNIVERSITEIT DELFT
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

The Data Management Plan describes the data management life cycle for all data sets that will be collected processed or generated by the project It is a document describing what data will be collected processed or generated and following what methodology and standards whether and how this data will be shared andor made open and how it will be curated and preserved

Publications

Peer reviewed articles (18)

A solvent-free synthesis of (thio)ester derivatives using FeCl3 as a heterogeneous catalyst

Author(s): Sabry H.H. Younes, F. Hollmann
Published in: Tetrahedron Letters, Issue 123, 2024, ISSN 0040-4039
Publisher: Elsevier BV
DOI: 10.1016/j.tetlet.2023.154524

Combining biocatalytic oxyfunctionalisation and organocatalytic aldol reaction to access chiral β-hydroxy ketones

Author(s): Yutong Wang, Chiara Domestici, Niklas Teetz, Dirk Holtmann, Miguel Alcalde, Mengfan Wang, Wei Qi, Wuyuan Zhang, Frank Hollmann
Published in: Molecular Catalysis, Issue 569, 2024, ISSN 2468-8231
Publisher: Elsevier BV
DOI: 10.1016/j.mcat.2024.114515

Formate‐Mediated Electroenzymatic Synthesis via Biological Cofactor NADH

Author(s): Chuanjun Wang, Wenjin Dong, Pengye Zhang, Yaya Ma, Zhiwei Han, Yutai Zou, Wenshuo Wang, Hao Li, Frank Hollmann, Jian Liu
Published in: Angewandte Chemie International Edition, 2024, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/anie.202408756

Selective Peroxygenase‐Catalysed Oxidation of Toluene Derivates to Benzaldehydes

Author(s): Yutong Wang, Niklas Teetz, Dirk Holtmann, Miguel Alcalde, Jacob M. A. van Hengst, Xiaoxiao Liu, Mengfan Wang, Wei Qi, Wuyuan Zhang, Frank Hollmann
Published in: ChemCatChem, Issue 15, 2023, ISSN 1867-3880
Publisher: Wiley
DOI: 10.1002/cctc.202300645

Photobiocatalysis: More than just an interesting lab curiosity?

Author(s): Yunjian Ma, Yutong Wang, Bin Wu, Jianle Zhou, Shunong Yang, Fangyu Zhang, Keyu Luo, Yonghua Wang, Frank Hollmann
Published in: Chem Catalysis, 2024, ISSN 2667-1093
Publisher: Elsevier BV
DOI: 10.1016/j.checat.2024.101077

Selective oxyfunctionalisation reactions catalysed by P450 monooxygenases and peroxygenases – A bright future for sustainable chemical synthesis

Author(s): X. Xu, T. Hilberath, F. Hollmann
Published in: Current Opinion in Green and Sustainable Chemistry, Issue 39, 2023, ISSN 2452-2236
Publisher: Elsevier BV
DOI: 10.1016/j.cogsc.2022.100745

Biosynthesis of cyclic ketones by a H2O2 self-sufficient cascade reaction

Author(s): Bin Wu, Xiangyun Wang, Bo Yang, Yunjian Ma, Frank Hollmann, Yonghua Wang
Published in: Molecular Catalysis, Issue 547, 2023, ISSN 2468-8231
Publisher: Elsevier BV
DOI: 10.1016/j.mcat.2023.113396

Peroxygenase‐Catalysed Sulfoxidations in Non‐Aqueous Media

Author(s): Huanhuan Li, Qianqian Shen, Xiaoying Zhou, Peigao Duan, Frank Hollmann, Yawen Huang, Wuyuan Zhang
Published in: ChemSusChem, Issue 17, 2024, ISSN 1864-5631
Publisher: Wiley
DOI: 10.1002/cssc.202301321

Oxidation of Cyclohexane to Cyclohexanol/Cyclohexanone Using Sol‐Gel‐Encapsulated Unspecific Peroxygenase from <i>Agrocybe aegerita</i>

Author(s): Yinqi Wu, Frank Hollmann, Musa M. Musa
Published in: ChemistryOpen, 2024, ISSN 2191-1363
Publisher: Wiley
DOI: 10.1002/open.202400152

Structure-Based Redesign of a Methanol Oxidase into an “Aryl Alcohol Oxidase” for Enzymatic Synthesis of Aromatic Flavor Compounds

Author(s): Bin Wu, Shiyu Wang, Yunjian Ma, Shuguang Yuan, Frank Hollmann, Yonghua Wang
Published in: Journal of Agricultural and Food Chemistry, Issue 71, 2023, ISSN 0021-8561
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acs.jafc.3c01069

Selective Peroxygenase‐Catalysed Oxidation of Phenols to Hydroquinones

Author(s): Hugo Brasselet, Fabian Schmitz, Katja Koschorreck, Vlada B. Urlacher, Frank Hollmann, Thomas Hilberath
Published in: Advanced Synthesis &amp; Catalysis, 2024, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/adsc.202400872

Mirror, mirror on the wall, which is the greenest of them all? A critical comparison of chemo- and biocatalytic oxyfunctionalisation reactions

Author(s): Yinqi Wu, Caroline E. Paul, Frank Hollmann
Published in: Green Carbon, Issue 1, 2024, ISSN 2950-1555
Publisher: Elsevier BV
DOI: 10.1016/j.greenca.2023.10.004

Toward Kilogram-Scale Peroxygenase-Catalyzed Oxyfunctionalization of Cyclohexane

Author(s): Thomas Hilberath, Remco van Oosten, Juliet Victoria, Hugo Brasselet, Miguel Alcalde, John M. Woodley, Frank Hollmann
Published in: Organic Process Research &amp; Development, Issue 27, 2023, ISSN 1083-6160
Publisher: American Chemical Society (ACS)
DOI: 10.1021/acs.oprd.3c00135

Hybrid Organometallic and Enzymatic Tandem Catalysis for Oxyfunctionalisation Reactions

Author(s): Chiara Domestici, Yinqi Wu, Thomas Hilberath, Miguel Alcalde, Frank Hollmann, Alceo Macchioni
Published in: ChemCatChem, Issue 15, 2023, ISSN 1867-3880
Publisher: Wiley
DOI: 10.1002/cctc.202201623

Synthesis of Enantiopure Vicinal Halohydrins Using a Sequence of Haloperoxidase and Lipase

Author(s): Elisa De Marchi, Thomas Hilberath, Claudio Zippilli, Ron Wever, Raffaele Saladino, Frank Hollmann, Lorenzo Botta
Published in: Advanced Synthesis &amp; Catalysis, Issue 366, 2024, ISSN 1615-4150
Publisher: Wiley
DOI: 10.1002/adsc.202400516

Peroxygenase‐Promoted Enzymatic Cascades for the Valorisation of Fatty Acids

Author(s): Yinqi Wu, Caroline E. Paul, Thomas Hilberath, Ewald P. J. Jongkind, Wuyuan Zhang, Miguel Alcalde, Frank Hollmann
Published in: ChemCatChem, Issue 15, 2023, ISSN 1867-3880
Publisher: Wiley
DOI: 10.1002/cctc.202300411

Learning from Protein Engineering by Deconvolution of Multi‐Mutational Variants

Author(s): Frank Hollmann, Joaquin Sanchis, Manfred T. Reetz
Published in: Angewandte Chemie International Edition, Issue 63, 2024, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/anie.202404880

Peroxygenase‐Catalysed Selective Oxidation of Silanes to Silanols

Author(s): Xiaomin Xu, Jacob M. A. van Hengst, Yejia Mao, Mireia Martinez, Sergi Roda, Martin Floor, Victor Guallar, Caroline E. Paul, Miguel Alcalde, Frank Hollmann
Published in: Angewandte Chemie International Edition, Issue 62, 2024, ISSN 1433-7851
Publisher: Wiley
DOI: 10.1002/anie.202302844