Bacteriocins from interbacterial warfare as antibiotic alternative

Información del proyecto

BACtheWINNER

Identificador del acuerdo de subvención: 101054719

DOI

10.3030/101054719

Fecha de la firma de la CE 1 Diciembre 2022

Fecha de inicio 1 Abril 2023

Fecha de finalización 31 Marzo 2028

Financiado con arreglo a

• European Research Council (ERC)

Coste total

€ 2 500 000,00

Aportación de la UE

€ 2 500 000,00

Coordinado por

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

Peer reviewed articles (23)

Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic.

Autores: Viera Herrera C, O'Connor PM, Ratrey P, Paul Ross R, Hill C, Hudson SP.
Publicado en: International Journal of Pharmaceutics, 2024, ISSN 1873-3476
Editor: Elsevier
DOI: 10.1016/j.ijpharm.2024.123918

Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy

Autores: Hourigan D, Stefanovic E, Hill C, Ross RP.
Publicado en: BMC Microbiology, 2024, ISSN 1471-2180
Editor: Springer Nature
DOI: 10.1186/s12866-024-03243-2

The Marine Fish Gut Microbiome as a Source of Novel Bacteriocins

Autores: Uniacke-Lowe S, Stanton C, Hill C, Ross RP.
Publicado en: Microorganisms, 2024, ISSN 2076-2607
Editor: MDPI
DOI: 10.3390/microorganisms12071346

Bacteriocin diversity, function, discovery and application as antimicrobials.

Autores: Sugrue I, Ross RP, Hill C.
Publicado en: Nature Reviews Microbiology, 2024, ISSN 1740-1534
Editor: Springer Nature
DOI: 10.1038/s41579-024-01045-x

Interplay between inflammatory bowel disease therapeutics and the gut microbiome reveals opportunities for novel treatment approaches

Autores: O’ Reilly C, Mills S, Rea MC, Lavelle A, Ghosh S, Hill C, Ross RP
Publicado en: Microbiome Research Reports, 2023, ISSN 2771-5965
Editor: OAE Publishing
DOI: 10.20517/mrr.2023.41

Raffinocyclicin is a novel plasmid-encoded circular bacteriocin produced by Lactococcus raffinolactis with broad-spectrum activity against many gram-positive food pathogens

Autores: Miceli de Farias F, O’ Connor PM, Buttimer C, Kamilari E, Soria MC, Johnson CN, Deliephan A, Hill D, Fursenko O, Wiese J, Draper LA, Stanton C, Hill C, Ross RP
Publicado en: Applied and Environmental Microbiology, 2024, ISSN 1098-5336
Editor: American Society for Microbiology
DOI: 10.1128/aem.00809-24

Scientific Reports

Autores: Felipe Miceli de Farias; Maria Cecilia Soria; Paula M. O’Connor; Xiaohui Huang; Colin Buttimer; Eleni Kamilari; Aiswariya Deliephan; Daragh Hill; Oxana Fursenko; Jonathan Wiese; Lorraine Draper; Catherine Stanton; Colin Hill; R. Paul Ross
Publicado en: Scientific Reports, 2025, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/S41598-025-89450-X

Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome

Autores: Walsh L, Hill C, Ross RP.
Publicado en: Gut Microbes, 2023, ISSN 1949-0984
Editor: Taylor and Francis Online
DOI: 10.1080/19490976.2023.2263935

Comparison of fidaxomicin, thuricin CD, vancomycin and nisin highlights the narrow spectrum nature of thuricin CD

Autores: Walsh L, Lavelle A, O'Connor PM, Hill C, Ross RP.
Publicado en: Gut Microbes, 2024, ISSN 1949-0984
Editor: Taylor and Francis Group
DOI: 10.1080/19490976.2024.2342583

Production, composition and nutritional properties of organic milk: A critical review.

Autores: Linehan K, Patangia DV, Ross RP, Stanton C.
Publicado en: Foods, 2024, ISSN 2304-8158
Editor: MDPI
DOI: 10.3390/foods13040550

Impact of bacteriocin-producing strains on bacterial community composition in a simplified human intestinal microbiota

Autores: Ríos Colombo NS, Perez-Ibarreche M, Draper LA, O’Connor PM, Field D, Ross RP and Hill C.
Publicado en: Frontiers in Microbiology, 2023, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2023.1290697

Winogradskyella bathintestinalis sp. nov., isolated from the intestine of the deep-sea loosejaw dragonfish, Malacosteus niger.

Autores: Uniacke-Lowe S, Johnson CN, Stanton C, Hill C, Ross P.
Publicado en: International Journal of Systematic and Evolutionary Microbiology, Edición VOL 73 (10), 2023, ISSN 1466-5034
Editor: Microbiology Society
DOI: 10.1099/ijsem.0.006135

Bioactivity screening and genomic analysis reveals deep-sea fish microbiome isolates as sources of novel antimicrobials.

Autores: Uniacke-Lowe S, Collins FWJ, Hill C, Ross RP.
Publicado en: Marine Drugs, 2023, ISSN 1660-3397
Editor: MDPI
DOI: 10.3390/md21080444

Somatic cell count as an indicator of subclinical mastitis and increased inflammatory response in asymptomatic lactating women

Autores: Angelopoulou A, Harris HMB, Warda AK, O’ Shea C-A, Lavelle A, Ryan A, Dempsey E, Stanton C, Ross RP.
Publicado en: Microbiology Spectrum, 2024, ISSN 2165-0497
Editor: American Society for Microbiology
DOI: 10.1128/spectrum.04051-23

Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for <i>Clostridioides difficile</i> infection control

Autores: Natalia S. Ríos Colombo; R. Paul Ross; Colin Hill
Publicado en: Gut Microbes, 2025, ISSN 2162-402X
Editor: Taylor & Francis Online
DOI: 10.1080/19490976.2025.2451081

<i>Bacillus safensis</i> APC 4099 has broad-spectrum antimicrobial activity against both bacteria and fungi and produces several antimicrobial peptides, including the novel circular bacteriocin safencin E

Autores: E. Kamilari, P. M. O'Connor, F. Miceli de Farias, C. N. Johnson, C. Buttimer, A. Deliephan, D. Hill, O. Fursenko, J. Wiese, C. Stanton, C. Hill, R. P. Ross
Publicado en: Applied and Environmental Microbiology, 2024, ISSN 0099-2240
Editor: American Society for Microbiology
DOI: 10.1128/aem.01942-24

Early life exposure of infants to benzylpenicillin and gentamicin is associated with a persistent amplification of the gut resistome

Autores: Patangia DV, Grimaud G, O’ Shea C-A, Ryan CA, Dempsey E, Stanton C, Ross RP.
Publicado en: Microbiome, 2024, ISSN 2049-2618
Editor: BMC Part of Springer Nature
DOI: 10.1186/s40168-023-01732-6

Screening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced by Staphylococcus caledonicus.

Autores: O’Connor M, O’Connor PM, Hourigan D, Murray E, de Farias FM, Field D, Hill C, Ross RP.
Publicado en: Frontiers in Microbiology, 2024, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2024.1470988

Planococcus notacanthi sp. nov., isolated from the skin of a deep-sea snub-nosed spiny eel.

Autores: Uniacke-Lowe S, Stanton C, Hill C, Ross P
Publicado en: International Journal of Systemic and Evolutionary Microbiology, 2024, ISSN 1466-5026
Editor: Microbiology Society
DOI: 10.1099/ijsem.0.006298

Discovery and synthesis of leaderless bacteriocins from the Actinomycetota

Autores: David Hourigan, Felipe Miceli de Farias, Paula M. O’Connor, Colin Hill, R. Paul Ross
Publicado en: Journal of Bacteriology, 2024, ISSN 0021-9193
Editor: American Society for Microbiology
DOI: 10.1128/jb.00298-24

Microbiota and Resistome Analysis of Colostrum and Milk from Dairy Cows Treated with and without Dry Cow Therapies

Autores: Patangia DV, Grimaud G, Linehan K, Ross RP, Stanton C.
Publicado en: Antibiotics, 2023, ISSN 2079-6382
Editor: MDPI
DOI: 10.3390/antibiotics12081315

Genome plasticity shapes the ecology and evolution of Phocaeicola dorei and Phocaeicola vulgatus.

Autores: Da Silva Morais E, Grimaud GM, Warda A, Stanton C, Ross P.
Publicado en: Scientific Reports, 2024, ISSN 2045-2322
Editor: Nature Portfolio
DOI: 10.1038/s41598-024-59148-7

Influence of age, socioeconomic status, and location on the infant gut resistome across populations

Autores: Patangia DV, Grimaud G, Wang S, Ross RP, Stanton C.
Publicado en: Gut Microbes, 2023, ISSN 1949-0984
Editor: Taylor and Francis Group
DOI: 10.1080/19490976.2023.2297837