Bacteriocins from interbacterial warfare as antibiotic alternative

Informations projet

BACtheWINNER

N° de convention de subvention: 101054719

DOI

10.3030/101054719

Date de signature de la CE 1 Decembre 2022

Date de début 1 Avril 2023

Date de fin 31 Mars 2028

Financé au titre de

• European Research Council (ERC)

Coût total

€ 2 500 000,00

Contribution de l’UE

€ 2 500 000,00

Coordonné par

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland

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Publications

Peer reviewed articles (23)

Anionic liposome formulation for oral delivery of thuricin CD, a potential antimicrobial peptide therapeutic.

Auteurs: Viera Herrera C, O'Connor PM, Ratrey P, Paul Ross R, Hill C, Hudson SP.
Publié dans: International Journal of Pharmaceutics, 2024, ISSN 1873-3476
Éditeur: Elsevier
DOI: 10.1016/j.ijpharm.2024.123918

Promiscuous, persistent and problematic: insights into current enterococcal genomics to guide therapeutic strategy

Auteurs: Hourigan D, Stefanovic E, Hill C, Ross RP.
Publié dans: BMC Microbiology, 2024, ISSN 1471-2180
Éditeur: Springer Nature
DOI: 10.1186/s12866-024-03243-2

The Marine Fish Gut Microbiome as a Source of Novel Bacteriocins

Auteurs: Uniacke-Lowe S, Stanton C, Hill C, Ross RP.
Publié dans: Microorganisms, 2024, ISSN 2076-2607
Éditeur: MDPI
DOI: 10.3390/microorganisms12071346

Bacteriocin diversity, function, discovery and application as antimicrobials.

Auteurs: Sugrue I, Ross RP, Hill C.
Publié dans: Nature Reviews Microbiology, 2024, ISSN 1740-1534
Éditeur: Springer Nature
DOI: 10.1038/s41579-024-01045-x

Interplay between inflammatory bowel disease therapeutics and the gut microbiome reveals opportunities for novel treatment approaches

Auteurs: O’ Reilly C, Mills S, Rea MC, Lavelle A, Ghosh S, Hill C, Ross RP
Publié dans: Microbiome Research Reports, 2023, ISSN 2771-5965
Éditeur: OAE Publishing
DOI: 10.20517/mrr.2023.41

Raffinocyclicin is a novel plasmid-encoded circular bacteriocin produced by Lactococcus raffinolactis with broad-spectrum activity against many gram-positive food pathogens

Auteurs: Miceli de Farias F, O’ Connor PM, Buttimer C, Kamilari E, Soria MC, Johnson CN, Deliephan A, Hill D, Fursenko O, Wiese J, Draper LA, Stanton C, Hill C, Ross RP
Publié dans: Applied and Environmental Microbiology, 2024, ISSN 1098-5336
Éditeur: American Society for Microbiology
DOI: 10.1128/aem.00809-24

Scientific Reports

Auteurs: Felipe Miceli de Farias; Maria Cecilia Soria; Paula M. O’Connor; Xiaohui Huang; Colin Buttimer; Eleni Kamilari; Aiswariya Deliephan; Daragh Hill; Oxana Fursenko; Jonathan Wiese; Lorraine Draper; Catherine Stanton; Colin Hill; R. Paul Ross
Publié dans: Scientific Reports, 2025, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/S41598-025-89450-X

Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome

Auteurs: Walsh L, Hill C, Ross RP.
Publié dans: Gut Microbes, 2023, ISSN 1949-0984
Éditeur: Taylor and Francis Online
DOI: 10.1080/19490976.2023.2263935

Comparison of fidaxomicin, thuricin CD, vancomycin and nisin highlights the narrow spectrum nature of thuricin CD

Auteurs: Walsh L, Lavelle A, O'Connor PM, Hill C, Ross RP.
Publié dans: Gut Microbes, 2024, ISSN 1949-0984
Éditeur: Taylor and Francis Group
DOI: 10.1080/19490976.2024.2342583

Production, composition and nutritional properties of organic milk: A critical review.

Auteurs: Linehan K, Patangia DV, Ross RP, Stanton C.
Publié dans: Foods, 2024, ISSN 2304-8158
Éditeur: MDPI
DOI: 10.3390/foods13040550

Impact of bacteriocin-producing strains on bacterial community composition in a simplified human intestinal microbiota

Auteurs: Ríos Colombo NS, Perez-Ibarreche M, Draper LA, O’Connor PM, Field D, Ross RP and Hill C.
Publié dans: Frontiers in Microbiology, 2023, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2023.1290697

Winogradskyella bathintestinalis sp. nov., isolated from the intestine of the deep-sea loosejaw dragonfish, Malacosteus niger.

Auteurs: Uniacke-Lowe S, Johnson CN, Stanton C, Hill C, Ross P.
Publié dans: International Journal of Systematic and Evolutionary Microbiology, Numéro VOL 73 (10), 2023, ISSN 1466-5034
Éditeur: Microbiology Society
DOI: 10.1099/ijsem.0.006135

Bioactivity screening and genomic analysis reveals deep-sea fish microbiome isolates as sources of novel antimicrobials.

Auteurs: Uniacke-Lowe S, Collins FWJ, Hill C, Ross RP.
Publié dans: Marine Drugs, 2023, ISSN 1660-3397
Éditeur: MDPI
DOI: 10.3390/md21080444

Somatic cell count as an indicator of subclinical mastitis and increased inflammatory response in asymptomatic lactating women

Auteurs: Angelopoulou A, Harris HMB, Warda AK, O’ Shea C-A, Lavelle A, Ryan A, Dempsey E, Stanton C, Ross RP.
Publié dans: Microbiology Spectrum, 2024, ISSN 2165-0497
Éditeur: American Society for Microbiology
DOI: 10.1128/spectrum.04051-23

Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for <i>Clostridioides difficile</i> infection control

Auteurs: Natalia S. Ríos Colombo; R. Paul Ross; Colin Hill
Publié dans: Gut Microbes, 2025, ISSN 2162-402X
Éditeur: Taylor & Francis Online
DOI: 10.1080/19490976.2025.2451081

<i>Bacillus safensis</i> APC 4099 has broad-spectrum antimicrobial activity against both bacteria and fungi and produces several antimicrobial peptides, including the novel circular bacteriocin safencin E

Auteurs: E. Kamilari, P. M. O'Connor, F. Miceli de Farias, C. N. Johnson, C. Buttimer, A. Deliephan, D. Hill, O. Fursenko, J. Wiese, C. Stanton, C. Hill, R. P. Ross
Publié dans: Applied and Environmental Microbiology, 2024, ISSN 0099-2240
Éditeur: American Society for Microbiology
DOI: 10.1128/aem.01942-24

Early life exposure of infants to benzylpenicillin and gentamicin is associated with a persistent amplification of the gut resistome

Auteurs: Patangia DV, Grimaud G, O’ Shea C-A, Ryan CA, Dempsey E, Stanton C, Ross RP.
Publié dans: Microbiome, 2024, ISSN 2049-2618
Éditeur: BMC Part of Springer Nature
DOI: 10.1186/s40168-023-01732-6

Screening canine sources for novel antimicrobials reveals the circular broad-spectrum bacteriocin, caledonicin, produced by Staphylococcus caledonicus.

Auteurs: O’Connor M, O’Connor PM, Hourigan D, Murray E, de Farias FM, Field D, Hill C, Ross RP.
Publié dans: Frontiers in Microbiology, 2024, ISSN 1664-302X
Éditeur: Frontiers Media
DOI: 10.3389/fmicb.2024.1470988

Planococcus notacanthi sp. nov., isolated from the skin of a deep-sea snub-nosed spiny eel.

Auteurs: Uniacke-Lowe S, Stanton C, Hill C, Ross P
Publié dans: International Journal of Systemic and Evolutionary Microbiology, 2024, ISSN 1466-5026
Éditeur: Microbiology Society
DOI: 10.1099/ijsem.0.006298

Discovery and synthesis of leaderless bacteriocins from the Actinomycetota

Auteurs: David Hourigan, Felipe Miceli de Farias, Paula M. O’Connor, Colin Hill, R. Paul Ross
Publié dans: Journal of Bacteriology, 2024, ISSN 0021-9193
Éditeur: American Society for Microbiology
DOI: 10.1128/jb.00298-24

Microbiota and Resistome Analysis of Colostrum and Milk from Dairy Cows Treated with and without Dry Cow Therapies

Auteurs: Patangia DV, Grimaud G, Linehan K, Ross RP, Stanton C.
Publié dans: Antibiotics, 2023, ISSN 2079-6382
Éditeur: MDPI
DOI: 10.3390/antibiotics12081315

Genome plasticity shapes the ecology and evolution of Phocaeicola dorei and Phocaeicola vulgatus.

Auteurs: Da Silva Morais E, Grimaud GM, Warda A, Stanton C, Ross P.
Publié dans: Scientific Reports, 2024, ISSN 2045-2322
Éditeur: Nature Portfolio
DOI: 10.1038/s41598-024-59148-7

Influence of age, socioeconomic status, and location on the infant gut resistome across populations

Auteurs: Patangia DV, Grimaud G, Wang S, Ross RP, Stanton C.
Publié dans: Gut Microbes, 2023, ISSN 1949-0984
Éditeur: Taylor and Francis Group
DOI: 10.1080/19490976.2023.2297837