Partnership for the Assessment of Risks from Chemicals

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

1st Report on national needs

The reports will describe the results of the first round of surveys launched among the NHs to identify the existing knowledge gaps, requests, suggestions and expertise. The reports will describe the suggestions formed and actions taken to promote the sustainable development of NHs.

1st PARC Extit Strategy Plan and sustainability report

1st PARC sustainability report - leader : INSERM (AE of ANSES)The sustainability report will describe the achievements of PARC and its legacy. It will describe strategic action plan for what will be done in the following period in addition to reporting on results of the different options for exit strategy and the initiatives that are taken to develop these options and eventually to implement them.

Report on the conceptual design and development guidelines of the PARC EWS

Report on the conceptual design and development guidelines of the PARC EWS - leader: SLU (AE of SEPA)This report will describe the conceptual design configuration of the early warning system envisaged in PARC coupling computational with analytical approaches to allow for integrative early warning regarding signals of the emergence of chemicals of concern in the environment and consumer and food products. The report will serve as the blueprint for the development of the system providing operational guidelines and user requirements translated into system requirements.

Report on the establishment of the interactions with SF and IB

The report will include the selection criteria and members of the SF and IB

PARC governance process timeline

Timeline providing the important input collection, meetings, reporting requirements

Report on the conceptual design of the integrative tools

Report on the conceptual design of the integrative toolsThis report will provide the description of the conceptual design configuration of the integrative modelling platform network to be developed by PARC in order to meet the research and regulatory questions expected in PARC linking to the data infrastructure developed in WP7 its software architecture, and a blueprint for software implementation.

2nd Annual CL/ML reports' coordination and submission

Second annual report on the activities developed by the CL/ML within PARC.

1st Mapping of Needs report

This deliverables will describe the first exercise that will be perform to identify priorities for PARC from partners but also from third parties (as users of PARC results). These priorities will reflect the information needs of policy makers at both EU and national levels with regards to human and environmental exposure to chemicals and resulting health impacts. This will be done by engaging with the scientific community, regulatory entities and key stakeholders and harvesting their needs through surveys, workshops and documents that will specify regulatory needs and what activities and processes are necessary to achieve these objectives.

Report on the conceptual design of the SSbD toolbox

Report on the conceptual design of the SSbD toolbox This report will describe the conceptual design configuration of the SSbD toolbox, covering all aspects of the SSbD process and criteria for SSbD chemicals and materials. This document will be the blueprint for the further development of the SSbD toolbox. It will result from extended consultation with the relevant stakeholders and will ensure the full compliance with the SSbD criteria developed by the European Commission. The SSbD toolbox design will ensure that tools developed outside of PARC can be readily integrated into the toolbox.

Data Management Plan (DMP)

Data Management Plan (DMP) - Leader: TNO (AE of RIVM)

1st Progress report on the general survey

1st Progress report on the general surveyAn HBM survey in the general population will generate baseline internal chemical exposure data for European citizens. This will be complemented with implementation of innovative sampling tools, untargeted screening methods, linkage to exposure sources and routes, and measurement of effect biomarkers. The design, planning, and implementation of the general survey will be prepared in year 1, fieldwork will start in year 2, and statistics commence in year 5. This deliverable will summarise the progress of this survey.

1st new AOPs report

1st new AOPs report - leader: INSERM (AE of ANSES)This report will summarize results from 5.3 on the AOPs. The report will give details on the developed AOPs and on the follow-up action to be taken to make the AOPs robust enough that regulators accept it. Additionally scientific achievements (publications, oral presentations etc.), presentations and discussion of the AOPs to 6.1 and to regulators (e.g. OECD).

1st Generic guidance documents for QA/QC on sampling; chemical analysis; toxicity, EDA, & toxicokinetics studies

1st Generic guidance documents for QA/QC on sampling; chemical analysis; toxicity, EDA, & toxicokinetics studies - Leader: WR (AE of RIVM)Generic QA/QC guidance documents will be prepared based on the inventory of existing protocols and guidance documents, by taking into account the leading principles of metrology and standardisation organisations on one hand and the particular aspects of the various dedicated chemical/matrix/technique domains and their varying degrees of maturity on the other. The documents will be periodically updated.This deliverable initially due M24 is postponed to M36. The explanation for this delay is that QA/QC is an integral part in many WP4/WP5 projects, and alignment of scope of activities done within T9.3 and WP4/WP5 projects took time and effort as projects were largely under construction in Y1-Y2. This resulted in re-defining of scope and activities in T9.3, and also slowed down the progress of the work. While the scheduled inventory of existing QA/QC was largely done, digesting this information and identifying gaps and needs was delayed. This resulted in a delay of the establishment of generic QA/QC guidance documents.

1st Report on aggregate exposure for general population and workers, and source to dose models applied to case studies

1st Report on aggregate exposure for general population and workers, and source to dose models applied to case studiesThis deliverable describes aggregate exposure combining various exposure environments including occupational and general life exposure scenarios. In first instance, this deliverable will present a review of available models, tools, data and the proposed strategy to aggregate exposures from multiple sources and routes. It will address exposure in the general population and occupational exposures. In a follow-up stage, the deliverable will also summarize the applications of the developed methods in case studies selected from PARC priorities. In a third phase, aggregated models will be improved and higher tier approaches will refine the accuracy of aggregated risk assessment. It will provide a better understanding of the sources and routes of exposure to support effective risk mitigation measures.

1st report on Data infrastructure, tools and services for FAIRification and reuse of chemical RA data

1st report on Data infrastructure, tools and services for FAIRification and reuse of chemical RA dataThis report will describe the architecture and implementation of the PARC FAIR data hub, as well as concrete solutions that have been elaborated for FAIR and sustainable storage of data generated in PARC, reuse of external data, intra- and cross-domain linking of data, and interoperability with applications for selected use cases.

Review of Communication and Dissemination Strategy

The Communication and Dissemination Strategy will be reviewed and updated to reflect the activities and outputs foreseen for the remaining period of the Partnership.

Communication and Dissemination Strategy

Description of the Communication and Dissemination Strategy will be developed identifying target audiences and including a roadmap for the production of relevant communication materials and tools. 

1st Annual CL/ML reports' coordination and submission

First annual report on the activities developed by the CL/ML within PARC.

1st Report on citizen's perception and concern: results of the surveys and focus groups

1st Report on surveys and focus groups conducted to evaluate European citizens' perception and concerns on chemical exposure and risk assessment will be produced.

1st Report on health impact indicators and their policy implications

1st Report on health impact indicators and their policy implicationsHealth impact assessments and (social) cost benefit analyses inform stakeholders and policymakers on the impact of current chemical exposure on health in EU populations, which supports prioritization of preventive or mitigatory actions to be taken and estimation of the environmental burden of disease and costs avoided as a result of EU policies and regulations. This deliverable summarizes the progress and main results of the development of indicators related to health impact of PARC priority substances, based on data and methodologies resulting from various PARC tasks.

Rapid Response Report

In order to respond to new and urgent needs for information in the EU policy community and at national level, a rapid response mechanism will allow policy makers to submit requests for specific information. This deliverable will describe the process put in place in PARC to answer to these urgent needs and illustrate with first request if there is already one. These information requests may require new surveys on particular chemicals or in particular geographical regions (respecting the scope of countries included in PARC consortium).

Optimised list of indicators

Optimised list of indicators - leader: DOMG (AE of VITO)A monitoring and evaluation framework was already prepared, previous to PARC submission, including a long list of key performance indicators. It was used as basis for the PSIPS and KPI table (see First Biennial Monitoring Report for European Partnerships). This initial set of indicators will be further developed and optimised to prepare an optimised list of indicators for upcoming years. This will be done in collaboration with the MB, GSB and the GB, NHs and stakeholders, to ensure its relevance for evaluating the progress of the Partnership’s key, useful and impactful results. The list will include baselines and clear targets and will feed into the annual ASR reporting. A revised list will be produced on month 40 to be used within the mid-term review.

AWP Y3 including PARC Project Portfolio

Description of the activities to be implemented during year 3, including the updated PARC Project Portfolio with projects that are in the planning/executive phase

Ethics & Data Protection Policy

The PARC ethics and data protection framework will set out the collaborative processes to be implemented to ensure the monitoring of PARC’s actions concerning ethical considerations. It will provide the PARC ethical principles and procedures and will be developed in parallel and in coordination with the Data Management Plan under WP7.

1st Report on the testing and uptake of the SSbD toolbox through use cases

1st Report on the testing and uptake of the SSbD toolbox through use casesThe SSbD toolbox will be tested and validated in selected use cases that will be determined during year 1 of the project. This first report will give an account on the outcome of this selection process.

Description of a mechanism for selection of chemicals / matrices / endpoints for projects

Description of a mechanism for selection of chemicals / matrices / endpoints for projects - Leader: INERIS (AE of ANSES)Mechanism for identification of knowledge gaps concerning the presence of chemical contaminants in environmental matrices, food and consumer products, and identification of priority (groups of) substances deserving further monitoring actions. The process will build on existing successful frameworks and existing monitoring databases. The process will be aimed to provide monitoring project proposals.

PARC SRIA Y3

SRIA is an overarching document presenting PARC at a strategic level with PARC vision, objectives, exit strategy, a description of what has been achieved and what will be done in the next year(s) organised by specific topics related to risk assessment (monitoring, hazard, environment, mixtures…). The strategy and reasons for the selection of new projects will be included.SRIA will be an deliverable to be validated by GB and submitted to HaDEA at M33 and M80.

PARC FAIR Data Policy (PFDP)

PARC FAIR Data Policy (PFDP) - Leader: TNO (AE of RIVM)This report will describe the PARC FAIR Data Policy, defining the (guiding) principles and conditions for management of data produced and/or used in PARC, in adherence with FAIR data principles and GDPR requirements, and specifying practices to take into account privacy, informed consent, security, transparency, sustainability and scalability, quality and reliability.

ASR Y3

Summary of the action, implemented activities and achievements during Y3

AWP Y4 including PARC Project Portfolio

Description of the activities to be implemented during year 4, including the updated PARC Project Portfolio with projects that are in the planning/executive phase

PARCopedia Scoping study

Report with the results from the scoping study for the implementation of a pilot of the Content Management System (CMS) for PARC (PARCopedia)

1st Report on innovative approaches for real-life mixture RA

1st Report on innovative approaches for real-life mixture RAThis deliverable reports on results and progress on mixture risk assessment of priority mixtures identified in EFSA opinions or identified from the PARC prioritisation process. Co-occurrence probabilities of chemicals observed in HBM studies across Europe will be analysed using new developed statistical tools aiming to better identify real-life co-exposure frequencies. Chemicals will be grouped based the use of in silico approaches and their adverse outcome pathways. PBPK models will be developed and applied to better understand the internal and external exposure doses. This deliverable will bring together advances made for mixture risk assessment in regulatory risk assessment and in the field of epidemiological research. Training materials will be developed and training will be provided in close cooperation with WP9.

AWP Y2 including rolling SRIA

Description of the activities to be implemented during year 2, including the updated rolling SRIA with projects that are in the planning/executive phase

Report on Training events Y1
1st closing data gaps report

1st closing data gaps reportThis report will summarize results from 5.1 on data gaps. The report will give details on the results obtained to close the prioritized data gaps (human health or environment health). Additionally scientific achievements (publications, oral presentations etc.), presentations and discussion of the results with appropriate regulators (e.g. EU Agencies).

Report on Training events Y2

The training events will be reported on an annual basis to allow tracking of the activities related to the dissemination of knowledge among PARC partners and other potentially interested stakeholders and effective and timely planning of further training events.This deliverable initially due M24 is postponed to M30.The explanation for this delay is that the first PARC training courses were not scheduled until May/June 2024 (as outlined in AD9.1 of the PARC Training Plan). By delaying the deliverable until M30, authors will be able to include valuable insights from both the May and June training courses, as well as the progress made on developing online resources, allowing for a more comprehensive and informative report.

1st Report on the development and validation of the integrative models

1st Report on the development and validation of the integrative models - Leader: WR (AE of RIVM)The integrative models encompassing the PARC integrative risk modelling platform network envisaged in task 8.3 will be checked in a series of use cases that will be developed in conjunction with other WPs of PARC in order to ensure their effectiveness and transparency. This deliverable will report on the development, update and validation of these integrative exposure and risk modelling tools in order to make them readily available by the relevant stakeholders.

AWP Y1 including rolling SRIA

Description of the activities to be implemented during year 1 , including the updated rolling SRIA with projects that are in the planning/executive phase

Revised list of indicators

leader: DOMG (AE of VITO)A monitoring and evaluation framework was already prepared, previous to PARC submission, including a long list of key performance indicators. It was used as basis for the PSIPS and KPI table (see First Biennial Monitoring Report for European Partnerships). This initial set of indicators will be further developed and optimised to prepare an optimised list of indicators for upcoming years. This will be done in collaboration with the MB, GSB and the GB, NHs and stakeholders, to ensure its relevance for evaluating the progress of the Partnership’s key, useful and impactful results. The list will include baselines and clear targets and will feed into the annual ASR reporting. A revised list will be produced on month 40 to be used within the mid-term review.

Prioritisation criteria report

This deliverable will describe the criteria that will be used to rank the priorities (either for substances or groups of substances and methods) identified following the mapping of needs together with the targeted activities under the WPs. It will also document the process that has been used to agree on these criteria among PARC partners. The criteria might be related to hazardous properties of the substance/group and/or exposure and /or risk, either for human health or for the environment. For methods, the deliverable will develop criteria to identify the areas for which new methods and other innovative tools should be developed or standardised or pre-validated.

1st Evaluation of innovative analytical approaches and uncertainty approaches for introduction in chemical RA

1st Evaluation of innovative analytical approaches and uncertainty approaches for introduction in chemical RA - Leader: IISPV (AE of ISCIII)Further to the reduction of contribution of the affiliated entity UU-IRAS due to difficulties to bring co-funding in PARC (cf. previous amendment of the PARC GA), IISPV replaces UU-IRAS as leader for this deliverable.This report will describe innovative analytical approaches and uncertainty approaches that have been identified and evaluated in specific use cases, and will provide recommendations for their use in chemical RA. It will contain novel methods for combined analyses of FAIR (heterogeneous) data, computational methods for integrating and extracting knowledge from non-structured data, and approaches from network biology and machine learning to predict chemicals exposure or adverse effects at the level of the biological system.

1st New approach methodologies report

1st New approach methodologies reportThis report will summarize results from 5.2 on the endpoints ED, (D)NT, NGtx-carc, immunotox, metabolic disruption. The report will give details on the developed NAMs and on the follow-up action to be taken to make the methods robust enough that regulators accept the results. Additionally scientific achievements (publications, oral presentations etc.), presentations of the NAMs to regulators.

ASR Y1

Summary of the action, implemented activities and achievements during Y1

1st Report on innovative methods based on PBK models

1st Report on innovative methods based on PBK modelsThis deliverable describes the development of PBPK models including the absorption, the distribution, the metabolism, and the elimination processes of hazardous chemicals in the human body. This deliverable will present the refinement and application of PBPK models for PARC prioritized compounds, and case studies to perform exposure assessment through life including physiological and behavioural changes. Internal and external exposures will be calculated and results from in vitro studies will be transferred into in vivo doses. The application of different exposure scenarios will support risk assessors and managers in evaluating the human internal exposure.

PARCroute roadmap1

"Interim report on the work on the roadmap for the transition of the major European chemical regulation programs towards NGRA (""NGRAroute"")"

Database and roadmap for SYNnet

A database with partnerships, programmes, infrastructures, projects and other activities with which PARC can establish potential synergies and collaborations will be established and a roadmap developed for the establishment of these synergies.

1st new PBK models report

1st new PBK models report - leader: Fraunhofer ITEM (AE of BfR)This report will summarize results from 5.3 on the PBPKs. The report will give details on the developed PBPKs and the associated sensitivity analyses. Additionally scientific achievements (publications, oral presentations etc.), presentations and discussion of the PBPKs with 6.2 and to regulators (e.g. EU Agencies).This deliverable initially due M24 is postponed to M36 due to delays in the calendar of the related project.

Catalogues on environmental and biomonitoring networks Y3

The catalogues will gather under a common umbrella information on (bio)monitoring networks existing in the various risk assessment domains at national and European levels, related (meta)data, and sample collections. The previously built “living” catalogues will be updated and new catalogues will be built for domains not yet covered.

Catalogues on environmental and biomonitoring networks Y1

The catalogues will gather under a common umbrella information on (bio)monitoring networks existing in the various risk assessment domains at national and European levels, related (meta)data, and sample collections. Catalogues on air monitoring networks, HBM, and articles will be built first and it is expected that pilot catalogues on air monitoring networks and HBM will be available within the first year of PARC. The catalogues will be regularly updated, initially assumed on an annual basis.

Laboratory catalogue and network platform (dashboard) Y1

The catalogue and network platform will gather and provide information and contacts on the existing laboratory capacities and networks within HBM and environmental monitoring under a common architecture. They will serve as a roadmap for users and stakeholders searching resources and capacities needed for next generation risk assessment. The catalogues and information provided there will be gradually built to finally encompass all the relevant risk assessment domains and updated (initially assuming) on an biannual basis.

Laboratory catalogue and network platform (dashboard) Y3

PARCopedia

PARC’s knowledge management platform to facilitate the (co-)creation, organisation, contextualisation, and sharing/dissemination of the knowledge acquired by the Partnership in the form of a Content Management System (CMS) and discussion forum to connect the data landscape created by the data-generating WPs 4-6 and 8-9 (overseen by WP7) with one or more portals, embedded in the PARC website (overseen by WP3).

PARC website

PARC's website will support the dissemination of the partnership and contribute to increase PARC's visibility. A landing page with general information will be launched early in the project.

Pubblicazioni

Combined RP-HILIC for suspect screening of persistent, mobile, and toxic substances in surface water: A case study

Autori: Javad Mottaghipisheh, Rajneesh Gautam, Lutz Ahrens
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-29664-1

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autori: Ilinca Suciu, Johannes Delp, Simon Gutbier, Anna-Katharina Ückert, Anna-Sophie Spreng, Philipp Eberhard, Christiaan Karreman, Falk Schreiber, Katrin Madjar, Jörg Rahnenführer, Ivana Celardo, Ivano Amelio, Marcel Leist
Pubblicato in: Antioxidants, Numero 12, 2025, ISSN 2076-3921
Editore: MDPI AG
DOI: 10.3390/ANTIOX12010164

Chemical respiratory sensitization—Current status of mechanistic understanding, knowledge gaps and possible identification methods of sensitizers

Autori: Rita Hargitai, Lucia Parráková, Tünde Szatmári, Pablo Monfort-Lanzas, Valentina Galbiati, Karine Audouze, Florence Jornod, Yvonne C. M. Staal, Sabina Burla, Aline Chary, Arno C. Gutleb, Katalin Lumniczky, Rob J. Vandebriel, Johanna M. Gostner
Pubblicato in: Frontiers in Toxicology, Numero 6, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2024.1331803

Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health

Autori: Anne-Cathrin Behr, Christiane Kruse Fæste, Amaya Azqueta, Ana M. Tavares, Anastasia Spyropoulou, Anita Solhaug, Ann-Karin Olsen, Ariane Vettorazzi, Birgit Mertens, Bojana Zegura, Camille Streel, Dieynaba Ndiaye, Eliana Spilioti, Estelle Dubreil, Franca Maria Buratti, Francesco Crudo, Gunnar Sundstøl Eriksen, Igor Snapkow, João Paulo Teixeira, Josef D. Rasinger, Julie Sanders, Kyriaki Machera, Lada Ivanova, Laurent Gaté, Ludovic Le Hegarat, Matjaz Novak, Nicola M. Smith, Sabrina Tait, Sónia Fraga, Sonja Hager, Doris Marko, Albert Braeuning, Henriqueta Louro, Maria João Silva, Hubert Dirven, Jessica Dietrich
Pubblicato in: Archives of Toxicology, Numero 99, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-03988-3

New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project

Autori: Louise Ramhøj, Marta Axelstad, Yoni Baert, Ana I. Cañas-Portilla, Frédéric Chalmel, Lars Dahmen, Antonio De La Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, Kim Heikamp, Henrik Holbech, Patricia Iglesias-Hernandez, Dries Knapen, Lorna Marchandise, Jane E. Morthorst, Nikolai Georgiev Nikolov, Ana C. V. E. Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schüürmann, Evelyn Stinckens, Mette H. Stub, Monica Torres-Ruiz, Majorie Van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen
Pubblicato in: Frontiers in Toxicology, Numero 5, 2023, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2023.1189303

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

Autori: Marc Audebert 1, Ann-Sophie Assmann 2, Amaya Azqueta 3, Pavel Babica 4, Emilio Benfenati 5, Sylvie Bortoli 6, Peter Bouwman 7, Albert Braeuning 2, Tanja Burgdorf 2, Xavier Coumoul 6, Kloé Debizet 6, Maria Dusinska 8, Norman Ertych 2, Jörg Fahrer 9, Verena Fetz 2, Ludovic Le Hégarat 10, Adela López de Cerain 3, Harm J Heusinkveld 11, Kevin Hogeveen 10, Miriam N Jacobs 12, Mirjam Luijten 11, Giuseppa Raitano 5, Cynthia Recoules 1, Elise Rundén-Pran 8, Mariam Saleh 10, Iva Sovadinová 4, Martina Stampar 13, Lea Thibol 9, Céline Tomkiewicz 6, Ariane Vettorazzi 3, Bob Van de Water 7, Naouale El Yamani 8, Bojana Zegura 13, Michael Oelgeschläger 2
Pubblicato in: 2023
Editore: MDPI
DOI: 10.3389/FTOX.2023.1220998

Insights into Drug Cardiotoxicity from Biological and Chemical Data: The First Public Classifiers for FDA Drug-Induced Cardiotoxicity Rank

Autori: Srijit Seal, Ola Spjuth, Layla Hosseini-Gerami, Miguel García-Ortegón, Shantanu Singh, Andreas Bender, Anne E. Carpenter
Pubblicato in: Journal of Chemical Information and Modeling, Numero 64, 2024, ISSN 1549-9596
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.JCIM.3C01834

A benchmark dataset for machine learning in ecotoxicology

Autori: Christoph Schür, Lilian Gasser, Fernando Perez-Cruz, Kristin Schirmer, Marco Baity-Jesi
Pubblicato in: Scientific Data, Numero 10, 2023, ISSN 2052-4463
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41597-023-02612-2

Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020–2030

Autori: Marissa B. Kosnik a, Stylianos Kephalopoulos b, Amalia Muñoz c, Nicolò Aurisano a, Alberto Cusinato b, Sani Dimitroulopoulou d, Jaroslav Slobodnik e, Jonathas De Mello f, Maryam Zare Jeddi g, Claudia Cascio h, Andreas Ahrens i, Yuri Bruinen de Bruin j, Lothar Lieck j, Peter Fantke
Pubblicato in: Environment International, Numero 170, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107610

Conceptual framework for identifying polymers of concern

Autori: Sangwon Suh, Anne-Marie Boulay, Peter Fantke, Dingsheng Li, Dilip Menon, Raoul Meys, Llorenç Milà i Canals
Pubblicato in: Frontiers in Sustainability, Numero 5, 2024, ISSN 2673-4524
Editore: Frontiers Media SA
DOI: 10.3389/FRSUS.2024.1399431

Next Generation Risk Assessment of Acute Neurotoxicity from Organophosphate Exposures Using the In Vitro–In Silico Derived Dietary Comparator Ratio

Autori: Jiaqi Chen, Thijs M. J. A. Moerenhout, Nynke I. Kramer, Ivonne M. C. M. Rietjens
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C00220

From principles to reality. FAIR implementation in the nanosafety community

Autori: Verónica I. Dumit, Ammar Ammar, Martine I. Bakker, Miguel A. Bañares, Cecilia Bossa, Anna Costa, Hilary Cowie, Damjana Drobne, Thomas E. Exner, Lucian Farcal, Steffi Friedrichs, Irini Furxhi, Roland Grafström, Andrea Haase, Martin Himly, Nina Jeliazkova, Iseult Lynch, Dieter Maier, Cornelle W. Noorlander, Hyun Kil Shin, Penny Nymark
Pubblicato in: NANOTODAY, 2023
Editore: ELSEVIER
DOI: 10.1016/J.NANTOD.2023.101923

The Role of "Physiologically Based Pharmacokinetic Model (PBPK)" New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

Autori: Deepika Deepika, Vikas Kumar
Pubblicato in: Int J Environ Res Public Health, 2023
Editore: MDPI
DOI: 10.3390/IJERPH20043473

Comparison of different techniques for γH2AX/pH3 biomarkers quantification for chemical genotoxicity assessment

Autori: Cynthia Recoules, Chloé Huertas, Julien Vignard, Marc Audebert
Pubblicato in: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Numero 906, 2026, ISSN 1383-5718
Editore: Elsevier BV
DOI: 10.1016/J.MRGENTOX.2025.503878

Towards prospective identification of respiratory sensitizers: effects of piperazine, chloramine-T, and toluene-diisocyanate in an air–liquid interface model comprising human bronchial epithelial cells

Autori: Evert Duistermaat, Véronique M. P. de Bruijn, Jolanda P. Vermeulen, Eric R. Gremmer, Rob J. Vandebriel
Pubblicato in: Archives of Toxicology, Numero 99, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04029-9

Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae

Autori: Marina Ricarte, Eva Prats, Nicola Montemurro, Juliette Bedrossiantz, Marina Bellot, Cristian Gómez-Canela, Demetrio Raldúa
Pubblicato in: Science of The Total Environment, Numero 896, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2023.165240

Combined chronic dietary exposure to four nephrotoxic metals exceeds tolerable intake levels in the adult population of 10 European countries

Autori: R. Corinne Sprong,Annick D. van den BrandORCID Icon,Gerda van Donkersgoed,Urska Blaznik,Despo Christodoulou,Amélie Crépet,Maria da Graça Dias,Bodil Hamborg Jensen,Angelo Morretto,Elke Rauscher-Gabernig, Darja Sokolić, Jacob D. van Klaveren,Mirjam Luijten ANDMarcel J. B. Mengelers
Pubblicato in: Food Additives AND Contaminants: Part A, Numero 40, 2023
Editore: TAYLOR AND FRANCIS
DOI: 10.1080/19440049.2023.2272716

Temporal patterns of bisphenol exposure in the Czech population within the framework of regulatory measures

Autori: Daria Sapunova, Klára Komprdová, Jiří Kohoutek, Vladimíra Puklová, Andrea Krsková, Milena Černá, Martin Zvonař, Zdenko Reguli, Lenka Andrýsková, Pavel Piler, Petra Přibylová, Jana Klánová, Jiří Kalina
Pubblicato in: Environmental Sciences Europe, Numero 37, 2025, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-025-01244-0

Metabolic and molecular Characterization, following dietary exposure to DINCH, Reveals new Implications for its role as a Metabolism-Disrupting chemical

Autori: Sontje Krupka, Alix Sarah Aldehoff, Cornelius Goerdeler, Beatrice Engelmann, Ulrike Rolle-Kampczyk, Kristin Schubert, Nora Klöting, Martin von Bergen, Matthias Blüher
Pubblicato in: Environment International, Numero 196, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109306

"""Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks"""

Autori: """Libor ˇSulc a,1, Tom´aˇs Janoˇs a,1, Daniel Figueiredo b, Ilse Ottenbros b,c, Petr ˇSenk a, Ondˇrej Mikeˇs a, Anke Huss b, Pavel ˇCupr a,*"""
Pubblicato in: Environmental Research, Numero 214 (2022) 114002, 2022, ISSN 0013-9351
Editore: Elsevier
DOI: 10.1016/j.envres.2022.114002

AOP-helpFinder 2.0: Integration of an event-event searches module

Autori: Thomas Jaylet, Thibaut Coustillet, Florence Jornod, Patricia Margaritte-Jeannin, Karine Audouze
Pubblicato in: Environment International, Numero 177, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108017

The European exposure science strategy 2020–2030

Autori: """Peter Fantke a,*, Yuri Bruinen de Bruin b,f, Urs Schlüter c, Alison Connolly d, Jos Bessems e, Stylianos Kephalopoulos f, Maryam Zare Jeddi g, An van Nieuwenhuyse h,i, Tatsiana Dudzina j, Paul T.J. Scheepers k, Natalie von Goetz l,m,*"""
Pubblicato in: Environment International, Numero 170 (2022) 107555, 2022, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107555

Development and validation of an LC-HRMS method for the screening and the quantification of 45 biocidal active substances in fortified chicken muscle and their monitoring in commercial samples

Autori: Gaël Touchais, Clara Le Tennier, Dominique Hurtaud-Pessel, Michel Laurentie, Sophie Mompelat
Pubblicato in: Food Additives & Contaminants: Part A, Numero 43, 2026, ISSN 1944-0049
Editore: Informa UK Limited
DOI: 10.1080/19440049.2025.2565697

Pharmacophore Modeling Using Machine Learning for Screening the Blood–Brain Barrier Permeation of Xenobiotics

Autori: Saurav Kumar, Deepika Deepika, Vikas Kumar
Pubblicato in: International Journal of Environmental Research and Public Health, Numero 19, 2025, ISSN 1660-4601
Editore: MDPI AG
DOI: 10.3390/IJERPH192013471

Near-field exposures and human health impacts for organic chemicals in interior paints: A high-throughput screening

Autori: Lei Huang, Nicolò Aurisano, Peter Fantke, Amal Dissanayake, L.G.L.M. Edirisinghe, Olivier Jolliet
Pubblicato in: Journal of Hazardous Materials, Numero 465, 2025, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2023.133145

Advancing exposure knowledge and its uptake into policy: The European exposure science strategy 2020–2030 (Special Issue)

Autori: Peter Fantke, Natalie von Goetz, Matti Jantunen
Pubblicato in: Environment International, Numero 172, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2022.107692

Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women

Autori: Lucie Bláhová, Tomáš Janoš, Vicente Mustieles, Andrea Rodríguez-Carrillo, Mariana F. Fernández, Luděk Bláha
Pubblicato in: International Journal of Hygiene and Environmental Health, Numero 250, 2023
Editore: elsevier
DOI: 10.1016/J.IJHEH.2023.114175

Is the potential for bioaccumulation of cannabinoids underestimated? Insights from biomimetic chromatography in cannabinoid exposure evaluation

Autori: Krzesimir Ciura, Kamila Jarzyńska, Katarzyna Ewa Greber, Wiesław Sawicki, Karolina Jagiello, Bartosz Wielgomas, Magdalena Kierkowicz
Pubblicato in: Food and Chemical Toxicology, Numero 197, 2026, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/J.FCT.2025.115252

OS02-07 The PARC Real-life Mixtures Project: Mixture Risk Assessment Results of the Case Studies on Pesticides, PFAS and Heavy Metals

Autori: H. McKeon, M. Carsique, P. Palmont, K. Machera, W. Bil, B. Bokkers, M. Mengelers, N. Vrijenhoek, E. McVey, A. Hernandez Jerez, E. Govarts, B. Cox, J. Engel, A. Ratier, J. van Klaveren, A. Crépet
Pubblicato in: Toxicology Letters, Numero 411, 2025, ISSN 0378-4274
Editore: Elsevier BV
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Current-use pesticide exposure pathways in Czech adults and children from the CELSPAC-SPECIMEn cohort

Autori: Libor Šulc, Daniel Figueiredo, Anke Huss, Jiří Kalina, Petr Gregor, Tomáš Janoš, Petr Šenk, Andrea Dalecká, Lenka Andrýsková, Vít Kodeš, Pavel Čupr
Pubblicato in: Environment International, Numero 181, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108297

Daphnids can safeguard the use of alternative bioassays to the acute fish toxicity test: a focus on neurotoxicity

Autori: Christoph Schür, Martin Paparella, Christopher Faßbender, Gilly Stoddart, Marco Baity Jesi, Kristin Schirmer
Pubblicato in: Environmental Toxicology and Chemistry, Numero 44, 2025, ISSN 0730-7268
Editore: Oxford University Press (OUP)
DOI: 10.1093/ETOJNL/VGAF014

Prediction of relevant exposure sources to aggregate chemical exposures from general and occupational environments: exploration of a decision tree approach

Autori: Hasnaa Chettou, Natalie Von Goetz, Katleen De Brouwere, Ilse Bente Ottenbros, Clément Blassiau, Amélie Crépet, David Vernez
Pubblicato in: Annals of Work Exposures and Health, Numero 70, 2026, ISSN 2398-7308
Editore: Oxford University Press (OUP)
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Developmental neurotoxicity as a case example for a six-step framework for the sustainable regulatory implementation of NAMs

Autori: Jonathan Blum, Kristina Bartmann, Joyce de Paula Souza, Ellen Fritsche
Pubblicato in: Current Opinion in Toxicology, Numero 42, 2025, ISSN 2468-2020
Editore: Elsevier BV
DOI: 10.1016/J.COTOX.2025.100528

Chemical and Microbiological Hazards Arising from New Plant-Based Foods, Including Precision Fermentation–Produced Food Ingredients

Autori: Jing Jin, Heidy M.W. den Besten, Ivonne M.C.M. Rietjens, Frances Widjaja-van den Ende
Pubblicato in: Annual Review of Food Science and Technology, Numero 16, 2026, ISSN 1941-1413
Editore: Annual Reviews
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Human biomonitoring and toxicokinetics as key building blocks for next generation risk assessment

Autori: Elena Reale, Maryam Zare Jeddi, Alicia Paini, Alison Connolly, Radu Duca, Francesco Cubadda, Emilio Benfenati, Jos Bessems, Karen S. Galea, Hubert Dirven, Tiina Santonen, Holger M. Koch, Kate Jones, Craig Sams, Susana Viegas, Machera Kyriaki, Luca Campisi, Arthur David, Jean-Philippe Antignac, Nancy B Hopf
Pubblicato in: Environment International, Numero 184, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108474

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Autori: Tamara Tal, Oddvar Myhre, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Müller, John K. Colbourne, Winfried Neuhaus, Giorgia Pallocca, Bettina Seeger, Ilka Scharkin, Stefan Scholz, Ola Spjuth, Monica Torres-Ruiz, Kristina Bartmann
Pubblicato in: Frontiers in Toxicology, Numero 6, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2024.1359507

Revealing the cascade of pesticide effects from gene to community

Autori: Ayesha Siddique, Naeem Shahid, Matthias Liess
Pubblicato in: Science of The Total Environment, Numero 917, 2026, ISSN 0048-9697
Editore: Elsevier BV
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A benchmark dataset for machine learning in ecotoxicology

Autori: Christoph Schür, Lilian Gasser, Fernando Perez-Cruz, Kristin Schirmer and Marco Baity-Jesi
Pubblicato in: Numero 10, 718, 2023
Editore: NATURE
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A tiered next-generation risk assessment framework integrating toxicokinetics and NAM-based toxicodynamics: “proof of concept” case study using pyrethroids

Autori: Ana Fernandez-Agudo, Jose V. Tarazona
Pubblicato in: Archives of Toxicology, Numero 99, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
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A systems toxicology approach for identification of disruptions in cholesterol homeostasis after aggregated exposure to mixtures of perfluorinated compounds in humans

Autori: Joost Westerhout, Annemiek den Heijer-Jordaan, Hans M G Princen, Rob Stierum
Pubblicato in: Toxicological Sciences, Numero 198, 2024, ISSN 1096-6080
Editore: Oxford University Press (OUP)
DOI: 10.1093/TOXSCI/KFAE006

Determination of glyphosate and its derivative, aminomethylphosphonic acid, in human urine by gas chromatography coupled to tandem mass spectrometry and isotope pattern deconvolution

Autori: Eva Junqué a, Pilar Fernández a, Iohanna Filippi b, Joan O. Grimalt
Pubblicato in: Journal of Chromatography Open, Numero 4, 2023
Editore: ELSEVIER
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AOP-helpFinder 3.0: from text mining to network visualization of key event relationships, and knowledge integration from multiple sources

Autori: Thomas Jaylet, Florence Jornod, Quentin Capdet, Olivier Armant, Karine Audouze
Pubblicato in: Bioinformatics, Numero 41, 2025, ISSN 1367-4811
Editore: Oxford University Press (OUP)
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Combined western diet and bisphenol A exposure induces an oxidative stress-based paraoxonase 1 response in larval zebrafish

Autori: Rik van den Boom, Lucia Vergauwen, Noortje Koedijk, Katyeny Manuela da Silva, Adrian Covaci, Dries Knapen
Pubblicato in: 2023
Editore: ELSEVIER
DOI: 10.1016/J.CBPC.2023.109758

Unveiling the dynamics of acetylation and phosphorylation in SGBS and 3T3-L1 adipogenesis

Autori: Alix Sarah Aldehoff, Isabel Karkossa, Cornelius Goerdeler, Laura Krieg, Jana Schor, Beatrice Engelmann, Martin Wabitsch, Kathrin Landgraf, Jörg Hackermüller, Antje Körner, Ulrike Rolle-Kampczyk, Kristin Schubert, Martin von Bergen
Pubblicato in: iScience, Numero 27, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2024.109711

Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare

Autori: Marx, U.; Beken, S.; Chen, Z.; Dehne, E.-M.; Doherty, A.; Ewart, L.; Fitzpatrick, S.; Griffith, L.G.; Gu, Z.; Hartung, T.; Hickman, J.; Ingber, D.E.; Ishida, S.; Jeong, J.; Leist, M.; Levin, L.; Mendrick, D.L.; Pallocca, G.; Platz, S.; Raschke, M.; Smirno
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2410112

Association between PFAS exposure and metabolic-related biomarkers in Spanish adolescents

Autori: Andrea Rodriguez-Carrillo, Fernando Vela-Soria, Fatima Smagulova, Mariana F. Fernández, Carmen Freire
Pubblicato in: Environmental Research, Numero 273, 2025, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121171

An automated high-throughput platform reveals chromatic phototactic disruption in Daphnia magna exposed to the UV filters benzophenone-3 and octocrylene

Autori: Juliette Bedrossiantz, Sergi Pujol, Josep M. Porta, Juan C. Carrizo, M. Silvia Diaz-Cruz, Carlos Barata
Pubblicato in: Chemosphere, Numero 392, 2026, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2025.144748

Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants

Autori: Viktoria Magel, Jonathan Blum, Xenia Dolde, Heidrun Leisner, Karin Grillberger, Hiba Khalidi, Iain Gardner, Gerhard F. Ecker, Giorgia Pallocca, Nadine Dreser, Marcel Leist
Pubblicato in: Cells, Numero 13, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS13242057

Application of Biomimetic Chromatography and QSRR Approach for Characterizing Organophosphate Pesticides

Autori: Katarzyna Ewa Greber, Karol Topka Kłończyński, Julia Nicman, Beata Judzińska, Kamila Jarzyńska, Yash Raj Singh, Wiesław Sawicki, Tomasz Puzyn, Karolina Jagiello, Krzesimir Ciura
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS26051855

Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae

Autori: Marina Ricarte, Eva Prats, Nicola Montemurro, Juliette Bedrossiantz, Marina Bellot, Cristian Gómez-Canela, Demetrio Raldúa
Pubblicato in: Science of The Total Environment, Numero 896, 2023
Editore: ELSEVIER
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Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women

Zebra_K, a kinematic analysis automated platform for assessing sensitivity, habituation and prepulse inhibition of the acoustic startle response in adult zebrafish

Autori: Marija Stevanović, Niki Tagkalidou, Cristiana Roberta Multisanti, Sergi Pujol, Ouwais Aljabasini, Eva Prats, Caterina Faggio, Josep Maria Porta, Carlos Barata, Demetrio Raldúa
Pubblicato in: Science of The Total Environment, Numero 958, 2025, ISSN 0048-9697
Editore: Elsevier BV
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Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Autori: Karin Slater, Paul N. Schofield, James Wright, Paul Clift, Anushka Irani, William Bradlow, Furqan Aziz, Georgios V. Gkoutos
Pubblicato in: npj Digital Medicine, Numero 7, 2024, ISSN 2398-6352
Editore: Springer Science and Business Media LLC
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Exploring BPA alternatives – Environmental levels and toxicity review

Autori: Ondrej Adamovsky, Ksenia J. Groh, Anna Białk-Bielińska, Beate I. Escher, R. Beaudouin, Liadys Mora Lagares, Knut Erik Tollefsen, Martina Fenske, Ewa Mulkiewicz, Nicolas Creusot, Anita Sosnowska, Susana Loureiro, Jonny Beyer, Guillermo Repetto, Alja Štern, Isabel Lopes, Marta Monteiro, Andrea Zikova-Kloas, Tina Eleršek, Marjan Vračko, Szymon Zdybel, Tomasz Puzyn, Weronika Koczur, Jane Ebsen Morthorst, Henrik Holbech, Gunnar Carlsson, Stefan Örn, Óscar Herrero, Ayesha Siddique, Matthias Liess, Georg Braun, Vanessa Srebny, Bojana Žegura, Nathalie Hinfray, François Brion, Dries Knapen, Ellen Vandeputte, Evelyn Stinckens, Lucia Vergauwen, Lars Behrendt, Maria João Silva, Ludek Blaha, Katerina Kyriakopoulou
Pubblicato in: Environment International, Numero 189, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108728

Temperature and salinity affect growth and toxin content of cyanobacterium Microcystis aeruginosa (PCC 7806) in estuarine environments

Autori: Wenxin Liu, Ilias Semmouri, Suzanne Bulckaert, Colin R. Janssen, Jana Asselman
Pubblicato in: Harmful Algae, Numero 146, 2025, ISSN 1568-9883
Editore: Elsevier BV
DOI: 10.1016/J.HAL.2025.102871

Comparison of Three DNA Isolation Methods and Two Sequencing Techniques for the Study of the Human Microbiota

Autori: Julio Plaza-Díaz, Mariana F. Fernández, Federico García, Natalia Chueca, Luis Fontana, Ana I. Álvarez-Mercado
Pubblicato in: Life, Numero 15, 2025, ISSN 2075-1729
Editore: MDPI AG
DOI: 10.3390/LIFE15040599

Probabilistic Reference and 10% Effect Concentrations for Characterizing Inhalation Non-cancer and Developmental/Reproductive Effects for 2,160 Substances

Autori: Nicolò Aurisano, Peter Fantke, Weihsueh A. Chiu, Richard Judson, Suji Jang, Aswani Unnikrishnan, Olivier Jolliet
Pubblicato in: Environmental Science & Technology, Numero 58, 2024, ISSN 0013-936X
Editore: American Chemical Society (ACS)
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Perfluorooctanesulfonic acid (PFOS) antagonizes gamma-aminobutyric acid (GABA) receptors in larval zebrafish and mammalian models

Autori: Renee Owen, Gabriel de Macedo, Jana Nerlich, Ilka Scharkin, Kristina Bartmann, Jonas Döbler, Beatrice Engelmann, Ulrike E Rolle-Kampczyk, David Leuthold, Sebastian Gutsfeld, Nicole Schweiger, Tamara Tal
Pubblicato in: Toxicological Sciences, Numero 207, 2025, ISSN 1096-6080
Editore: Oxford University Press (OUP)
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Toxicological effects of selenium nanoparticles in laboratory animals: A review

Autori: Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Pubblicato in: Journal of Applied Toxicology, Numero 44, 2025, ISSN 0260-437X
Editore: Wiley
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PBTK-TD model of the phagocytosis activity in three-spined stickleback exposed to BPA

Autori: Corentin Mit, Anne Bado-Nilles, Cyril Turiès, Gaëlle Daniele, Barbara Giroud, Rémy Beaudouin
Pubblicato in: Aquatic Toxicology, Numero 261, 2025, ISSN 0166-445X
Editore: Elsevier BV
DOI: 10.1016/J.AQUATOX.2023.106608

Embryotoxicity and mixture effects of legacy PFAS in a human iPSC-based 3D model

Autori: Andreas Frederik Treschow, Elisa Martiny, Claudia Torero Gutierrez, Agnieszka Anna Niklas, Martin Scholze, Anne Marie Vinggaard, Maria João Valente
Pubblicato in: Cell Biology and Toxicology, Numero 42, 2026, ISSN 1573-6822
Editore: Springer Science and Business Media LLC
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Insights from an invited expert panel using a World Café: Developing a national policy for a human biomonitoring programme

Autori: Richa Singh, Sewon Lee, Darragh Doherty, Conor Buggy, Holger Martin Koch, Marike Kolossa-Gehring, Alison Connolly
Pubblicato in: Environment International, Numero 207, 2026, ISSN 0160-4120
Editore: Elsevier BV
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Framework for defining pesticide maximum residue levels in feed: applications to cattle and sheep

Autori: Zijian Li, Peter Fantke
Pubblicato in: PEST MANAGEMENT SCIENCE, Numero 79, 2, 2022
Editore: WILEY
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New approach methods to improve human health risk assessment of thyroid hormone system disruption-a PARC project

Autori: Louise Ramhøj, Marta Axelstad, Yoni Baert, Ana I Cañas-Portilla, Frédéric Chalmel, Lars Dahmen, Antonio De La Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, Kim Heikamp, Henrik Holbech, Patricia Iglesias-Hernandez, Dries Knapen, Lorna Marchandis, Jane E Morthorst, Nikolai Georgiev Nikolov, Ana C V E Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schüürmann, Evelyn Stinckens, Mette H Stub, Monica Torres-Ruiz, Majorie Van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen
Pubblicato in: Numero 17,5, 2023
Editore: PUBMED
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Associations between exposure to metals, chlorinated pesticides, and PCBs and differential leukocyte profiles in Flemish adolescents

Autori: Fen Zhang, Lützen Portengen, Hamid Y. Hassen, Laura Rodriguez Martin, Madeline Carsique, Amélie Crépet, Jasper Engel, Jacob Van Klaveren, Nicolas Van Larebeke, Willy Baeyens, Stefaan De Henauw, Tim S. Nawrot, Adrian Covaci, Elly Den Hond, Greet Schoeters, Veerle J. Verheyen, Eva Govarts, Bianca Cox
Pubblicato in: Environmental Research, Numero 288, 2026, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.123188

The long way from raw data to NAM-based information: overview on data layers and processing steps

Autori: Blum, J.; Brüll, M.; Hengstler, J.G.; Dietrich, D.R.; Gruber, A.J.; Dipalo, M.; Kraushaar, U.; Mangas, I.; Terron, A.; Fritsche, E.; Marx-Stoelting, P.; Hardy, B.; Schepky, A.; Escher, S.E.; Hartung, T.; Landsiedel, R.; Odermatt, A.; Sachana, M.; Koch, K.
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
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Bioassay predictive values for chemical health risks in drinking water

Autori: Tessa E. Pronk, Renske P.J. Hoondert, Stefan A.E. Kools, Vikas Kumar, Milo L. de Baat
Pubblicato in: Environment International, Numero 188, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108733

Fulfilling the criteria for CLP classification: the implications for substances under the EU chemicals legislation

Autori: Diana Kättström, Anna Beronius, Urban Boije af Gennäs, Christina Rudén, Marlene Ågerstrand
Pubblicato in: Frontiers in Toxicology, Numero 6, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2024.1452065

Induction of drug metabolizing enzyme and drug transporter expression by antifungal triazole pesticides in human HepaSH hepatocytes

Autori: Anna Zerdoug, Marc Le Vée, Hélène Le Mentec, Jennifer Carteret, Elodie Jouan, Agnès Jamin, Béatrice Lopez, Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Christophe Chesné, Hiroshi Suemizu, Olivier Fardel
Pubblicato in: Chemosphere, Numero 366, 2024, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2024.143474

Comparative toxicity of plant protection products, their active substances and mixtures in zebrafish embryos and HepaRG cells

Autori: Bente Nissen, Alkiviadis Stagkos-Georgiadis, Martin Krauss, Denise Bloch, Wibke Busch
Pubblicato in: Archives of Toxicology, Numero 100, 2026, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04290-Y

From principles to reality. FAIR implementation in the nanosafety community

Autori: Verónica I. Dumit, Ammar Ammar, Martine I. Bakker, Miguel A. Bañares, Cecilia Bossa, Anna Costa, Hilary Cowie, Damjana Drobne, Thomas E. Exner, Lucian Farcal, Steffi Friedrichs, Irini Furxhi, Roland Grafström, Andrea Haase, Martin Himly, Nina Jeliazkova, Iseult Lynch, Dieter Maier, Cornelle W. Noorlander, Hyun Kil Shin, Galo J.A.A. Soler-Illia, Blanca Suarez-Merino, Egon Willighagen, Penny Nymark
Pubblicato in: Nano Today, Numero 51, 2025, ISSN 1748-0132
Editore: Elsevier BV
DOI: 10.1016/J.NANTOD.2023.101923

Plasticizer sources and concentrations in indoor environments in Europe: A systematic review of existing data

Autori: Wenjuan Wei, Aya Mansouri, Sebastiaan L. Zoutendijk, Sarka Langer, Ioannis Liagkouridis, Nancy B. Hopf, Radu Corneliu Duca
Pubblicato in: Science of The Total Environment, Numero 972, 2026, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2025.179080

Chronic exposure to tebuconazole impairs offspring growth and survival in farmland birds: An experiment in captive house sparrows

Autori: Pauline Bellot, François Brischoux, Clémentine Fritsch, Loula Lièvre, Cécile Ribout, Frédéric Angelier
Pubblicato in: Environmental Research, Numero 275, 2025, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121321

Pharmacophore Modeling Using Machine Learning for Screening the Blood–Brain Barrier Permeation of Xenobiotics

Autori: Saurav Kumar, Deepika Deepika and Vikas Kumar
Pubblicato in: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Numero 19 (20), 2022
Editore: MDPI
DOI: 10.3390/IJERPH192013471

Confronting pesticide exposure predictions from different models to observations from a monitoring study in small freshwater streams in Germany

Autori: Paula Scharlach, Gustaf Boström, Jörg Klasmeier, Amelie Leonardi, Andreas Focks
Pubblicato in: Environment International, Numero 208, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110057

Identification of contaminants of emerging concern through temporal trend analysis of suspended particulate matter in the Rhine River catchments (2005–2022): A case study using LC-HRMS to support early-warning systems

Autori: Javad Mottaghipisheh, Erica Selin, Anna Kärrman, Maria Larsson, Fredric Södergren-Seilitz, Jan Koschorreck, Bernd Göckener, Lutz Ahrens
Pubblicato in: Journal of Hazardous Materials, Numero 503, 2026, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.140993

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification

Autori: Kristin Fritsche, Andrea Ziková-Kloas, Philip Marx-Stoelting, Albert Braeuning
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS24032686

Pioneering an effect-based early warning system for hazardous chemicals in the environment

Autori: Georgios Niarchos, Nikiforos Alygizakis, Mario Carere, Valeria Dulio, Magnus Engwall, Tuulia Hyötyläinen, Roland Kallenborn, Spyros Karakitsios, Achilleas Karakoltzidis, Anna Kärrman, Marja Lamoree, Maria Larsson, Johan Lundqvist, Laura Mancini, Javad Mottaghipisheh, Pawel Rostkowski, Dimosthenis Sarigiannis, Katrin Vorkamp, Lutz Ahrens
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Innovative analytical methodologies for characterizing chemical exposure with a view to next-generation risk assessment

Autori: Žiga Tkalec, Jean-Philippe Antignac, Nicole Bandow, Frederic M. Béen, Lidia Belova, Jos Bessems, Bruno Le Bizec, Werner Brack, German Cano-Sancho, Jade Chaker, Adrian Covaci, Nicolas Creusot, Arthur David, Laurent Debrauwer, Gaud Dervilly, Radu Corneliu Duca, Valérie Fessard, Joan O. Grimalt, Thierry Guerin, Baninia Habchi, Helge Hecht, Juliane Hollender, Emilien L. Jamin, Jana Klánová, Tina Kosjek, Martin Krauss, Marja Lamoree, Gwenaelle Lavison-Bompard, Jeroen Meijer, Ruth Moeller, Hans Mol, Sophie Mompelat, An Van Nieuwenhuyse, Herbert Oberacher, Julien Parinet, Christof Van Poucke, Robert Roškar, Anne Togola, Jurij Trontelj, Elliott J. Price
Pubblicato in: Environment International, Numero 186, 2024, ISSN 0160-4120
Editore: Elsevier BV
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Identifying Novel DNA Adducts in Amphipods and Developing Sample Preparation for Adductomics Using Dispersive Solid-Phase Extraction

Autori: Zareen Khan, Elena Gorokhova, Giulia Martella, Nisha H. Motwani, Natalia Tretyakova, Pedro F. M. Sousa, Hitesh V. Motwani
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
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Meta-analysis on the effects of chemical stressors on freshwater ecosystem functions

Autori: Alexander Feckler, Ralf Schulz, Ralf B. Schäfer
Pubblicato in: Environmental Sciences Europe, Numero 37, 2025, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
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In vitro endocrine-disrupting effects of the natural toxins Enniatins and Beauvericin on steroidogenesis

Autori: Gabriele Lori, Lucia Coppola, Daniele Sadutto, Elena Bossù, Livia Manna, Sabrina Tait
Pubblicato in: Emerging Contaminants, Numero 12, 2026, ISSN 2405-6650
Editore: Elsevier BV
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Counting cells can accurately predict small-molecule bioactivity benchmarks

Autori: Srijit Seal, William Dee, Adit Shah, Natacha Cerisier, Andrew Zhang, Esteban Miglietta, Katherine Titterton, Ángel Alexander Cabrera, Daniil Boiko, Alex Beatson, Gregory Slabaugh, Olivier Taboureau, Jordi Carreras Puigvert, Shantanu Singh, Ola Spjuth, Andreas Bender, Anne E. Carpenter
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
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Pesticide contamination is associated with invertebrate community change in non-agricultural streams

Autori: Leonie Schweiger, Marco Foit, Philipp Vormeier, Ralf Schäfer, Matthias Liess
Pubblicato in: Water Research, Numero 282, 2025, ISSN 0043-1354
Editore: Elsevier BV
DOI: 10.1016/J.WATRES.2025.123903

Modeling zebrafish escape swim reveals maximum neuromuscular power output and efficient body movement adaptation to increased water viscosity

Autori: Guillaume Ravel, Théo Mercé, Michel Bergmann, Anja Knoll-Gellida, Afaf Bouharguane, Sara Al Kassir, Angelo Iollo, Patrick J. Babin
Pubblicato in: iScience, Numero 28, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2025.112056

"""Generating environmental sampling and testing data for micro- and nanoplastics for use in life cycle impact assessment"""

Autori: """Cecilia Askhama,⁎, Valentina H. Pauna a,b, Anne-Marie Boulay c, Peter Fantke d, Olivier Jolliet d, Jérôme Lavoie e, Andy M. Booth f, Claire Coutris g, Francesca Verones h, MiriamWeber i, Martina G. Vijver j, Amy Lusher k,l, Carla Hajjar c"""
Pubblicato in: Science of the Total Environment, Numero 859 (2023) 160038, 2023, ISSN 0048-9697
Editore: Elsevier
DOI: 10.1016/j.scitotenv.2022.160038

Species composition and ecological structure of ground beetles (Coleoptera, Carabidae) communities as biological indicators of the agro-environmental sustainability

Autori: K. Yu Maksimovich, R. Yu Dudko, E.I. Shatalova, A.K. Tsakalof, A.M. Tsatsakis, K.S. Golokhvast, E.A. Novikov
Pubblicato in: Environmental Research, Numero 234, 2026, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2023.116030

Wastewater as a dual indicator of human and environmental exposure to synthetic antioxidants: Occurrence and fate in biological and advanced wastewater treatment

Autori: Corina Meyer, Mara L. Bär, Juliane Hollender
Pubblicato in: Environment International, Numero 203, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109709

Spatio-temporal transcriptomic analysis reveals distinct nephrotoxicity, DNA damage, and regeneration response after cisplatin

Autori: Lukas S. Wijaya, Steven J. Kunnen, Panuwat Trairatphisan, Ciarán P. Fisher, Meredith E. Crosby, Kai Schaefer, Karen Bodié, Erin E. Vaughan, Laura Breidenbach, Thomas Reich, Diana Clausznitzer, Sylvestre Bonnet, Sipeng Zheng, Chantal Pont, James L. Stevens, Sylvia E. Le Dévédec, Bob van de Water
Pubblicato in: Cell Biology and Toxicology, Numero 41, 2025, ISSN 1573-6822
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10565-025-10003-Z

ODE-based models of signaling networks in autophagy

Autori: Markus Galhuber, Kathrin Thedieck
Pubblicato in: Current Opinion in Systems Biology, Numero 39, 2026, ISSN 2452-3100
Editore: Elsevier BV
DOI: 10.1016/J.COISB.2024.100519

Decoding the genetic program of micronucleus formation: linking chromosomal instability to human disease

Autori: Jörg Fahrer
Pubblicato in: Signal Transduction and Targeted Therapy, Numero 9, 2024, ISSN 2059-3635
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41392-024-01869-2

Cortico-Muscular Phase Connectivity During an Isometric Knee Extension Task in People With Early Parkinson’s Disease

Autori: Nina Omejc, Tomislav Stankovski, Manca Peskar, Miloš Kalc, Paolo Manganotti, Klaus Gramann, Sašo Džeroski, Uros Marusic
Pubblicato in: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Numero 33, 2025, ISSN 1534-4320
Editore: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TNSRE.2025.3527578

FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation

Autori: Maryam Zare Jeddi1, Karen S. GaleaKaren S. Galea, Susana Viegas, Susana Viegas, Peter Fantke, Peter Fantke, Henriqueta Louro, Henriqueta Louro, Jan Theunis, Jan Theunis, Eva Govarts, Eva GovartS, Sébastien Denys, Fillo Clémence Fillol, Loïc RambaudLoïc Rambaud, Marike Kolossa-GehringMarike Kolossa-Gehring, Tiina Santonen, Tiina Santonen, Hilko van der Voet, Hilko van der Voet, Manosij Ghosh, Manosij Ghosh, Carla Costa, Carla Costa, Joo Paulo Teixeira, João Paulo Teixeira, Hans Verhagen,Hans Verhagen, Radu-Corneliu Duca, Radu-Corneliu Duca, An Van Nieuwenhuyse, An Van Nieuwenhuyse, Kate Jones, Kate Jones, Craig Sams, Craig Sams, Ovnair Sepai, Ovnair Sepai, Giovanna Tranfo, Giovanna Tranfo, Martine Bakker, Martine Bakker, Nicole Palmen, Jacob van Klaveren, Jacob van Klaveren, Paul T. J. Scheepers, Paul T. J. Scheepers, Alicia Paini, Alicia Paini, Cristina Canova, Cristina Canova, Natalie von Goetz, Natalie von Goetz, Andromachi Katsonouri, Andromachi Katsonouri, Spyros Karakitsios, Spyros Karakitsios, Dimosthenis A. Sarigiannis, Dimosthenis A. Sarigiannis, Jos Bessems, Jos Bessems, Kyriaki Machera, Kyriaki Machera, Stuart Harrad, Stuart Harrad, Nancy B. Hopf, Nancy B. Hopf
Pubblicato in: FRONTIERS IN TECHNOLOGY, Numero 5, 2023
Editore: FRONTIERS
DOI: 10.3389/FTOX.2023.1116707

Comparison of aggregated exposure to perfluorooctanoic acid (PFOA) from diet and personal care products with concentrations in blood using a PBPK model – Results from the Norwegian biomonitoring study in EuroMix

Autori: T. Husøy, I.H. Caspersen, E. Thépaut, H. Knutsen, L.S. Haug, M. Andreassen, A. Gkrillas, B. Lindeman, C. Thomsen, D. Herzke, H. Dirven, M.W. Wojewodzic
Pubblicato in: Environmental Research, Numero 239, 2026, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2023.117341

A strategy for the investigation of toxic mechanisms and protection by efflux pumps using Schizosaccharomyces pombe strains: Application to rotenone

Autori: Consuelo Álvarez-Herrera, Sara Maisanaba, María Llana Ruíz-Cabello, Raquel Rojas, Guillermo Repetto
Pubblicato in: Science of The Total Environment, Numero 922, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.171253

"""Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations"""

Autori: """Lola Bajard a, Ondrej Adamovsky a, Karine Audouze b, Kirsten Baken c, Robert Barouki b, Joost B. Beltman d, Anna Beronius e, Eva Cecilie Bonefeld-Jørgensen f,g, German Cano-Sancho h, Milo L. de Baat i, Filippo Di Tillio d, Mariana F. Fern´andez j,k,l, Re"
Pubblicato in: Environmental Research, Numero 217 (2023) 114650, 2023, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2022.114650

Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet

Autori: Aude Ratier, Maribel Casas, Regina Grazuleviciene, Remy Slama, Line Småstuen Haug, Cathrine Thomsen, Marina Vafeiadi, John Wright, Florence A. Zeman, Martine Vrijheid, Céline Brochot
Pubblicato in: Environment International, Numero 186, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108621

Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union

Autori: Axel Mie and Christina Rudén
Pubblicato in: Numero 22,44, 2023
Editore: Biomed Central
DOI: 10.1186/S12940-023-00994-9

How Wastewater Reflects Human Metabolism─Suspect Screening of Pharmaceutical Metabolites in Wastewater Influent

Autori: Corina Meyer, Michael A. Stravs, Juliane Hollender
Pubblicato in: Environmental Science & Technology, Numero 58, 2024, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.4C00968

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

Autori: Kristina Bartmann , Farina Bendt, Arif Dönmez, Daniel Haag, H. Eike Keßel, Stefan Masjosthusmann, Christopher Noel, Ji Wu, Peng Zhou, Ellen Fritsche
Pubblicato in: 2023
Editore: ALTEX
DOI: 10.14573/ALTEX.2206031

Framework for defining pesticide maximum residue levels in feed: applications to cattle and sheep

Autori: Zijian Li, Peter Fantke
Pubblicato in: Pest Management Science, Numero 79, 2025, ISSN 1526-498X
Editore: Wiley
DOI: 10.1002/PS.7241

The European Commission’s safe and sustainable by design framework: bridging innovation and legislation

Autori: Kathrin Schwirn, Doris Völker, Magnus Løfstedt, Peter Fantke, Cecilia Bossa, Anežka Sharma, Leo Posthuma, Achilleas Karakoltzidis, Fotini Nikiforou, Alicja Mikołajczyk, Jaco Westra, Spyros Karakitsios, Dimosthenis Sarigiannis, Irantzu Garmendia Aguirre
Pubblicato in: Environmental Sciences Europe, Numero 37, 2025, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-025-01246-Y

Making food systems more resilient to food safety risks by including artificial intelligence, big data, and internet of things into food safety early warning and emerging risk identification tools

Autori: Wenjuan Mu, Gijs A. Kleter, Yamine Bouzembrak, Eleonora Dupouy, Lynn J. Frewer, Fadi Naser Radwan Al Natour, H. J. P. Marvin
Pubblicato in: Comprehensive Reviews in Food Science and Food Safety, Numero 23, 2025, ISSN 1541-4337
Editore: Wiley
DOI: 10.1111/1541-4337.13296

A regulatory perspective on the applicability of NAMs in genotoxicity and carcinogenicity assessment in EU: current practices and future directions

Autori: Cecilia Bossa, Silvia Alivernini, Cristina Andreoli, Gabriele Aquilina, Leonello Attias, Emilio Benfenati, Maria Dusinska, Naouale El Yamani, Henriqueta Louro, Francesca Marcon, Giuseppa Raitano, Elise Rundén-Pran, Maria Teresa Russo, Maria João Silva, Chiara Laura Battistelli
Pubblicato in: Environment International, Numero 207, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109948

Hazard characterization of Alternaria toxins to identify data gaps and improve risk assessment for human health

Autori: Henriqueta Louro, Ariane Vettorazzi, Adela López de Cerain, Anastasia Spyropoulou, Anita Solhaug, Anne Straumfors, Anne-Cathrin Behr, Birgit Mertens, Bojana Žegura, Christiane Kruse Fæste, Dieynaba Ndiaye, Eliana Spilioti, Elisabeth Varga, Estelle Dubreil, Eszter Borsos, Francesco Crudo, Gunnar Sundstøl Eriksen, Igor Snapkow, Jérôme Henri, Julie Sanders, Kyriaki Machera, Laurent Gaté, Ludovic Le Hegarat, Matjaž Novak, Nicola M. Smith, Solveig Krapf, Sonja Hager, Valérie Fessard, Yvonne Kohl, Maria João Silva, Hubert Dirven, Jessica Dietrich, Doris Marko
Pubblicato in: Archives of Toxicology, Numero 98, 2024, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-023-03636-8

Exposure and hazard of bisphenol A, S and F: a multi-biomarker approach in three-spined stickleback

Autori: Corentin Mit, Rémy Beaudouin, Olivier Palluel, Cyril Turiès, Gaëlle Daniele, Barbara Giroud, Anne Bado-Nilles
Pubblicato in: Environmental Science and Pollution Research, Numero 32, 2025
Editore: SPRINGER NATURE
DOI: 10.1007/S11356-023-28462-4

Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays

Autori: Julia Hartmann, Noah Henschel, Kristina Bartmann, Arif Dönmez, Gabriele Brockerhoff, Katharina Koch and Ellen Fritsche
Pubblicato in: CELLS, Numero 12, 2023
Editore: MDPI
DOI: 10.3390/CELLS12091270

A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health

Autori: Albano Pinto, Inês P.E. Macário, Sérgio M. Marques, Joana Lourenço, Inês Domingues, Maria João Botelho, Jana Asselman, Patrícia Pereira, Joana L. Pereira
Pubblicato in: Science of The Total Environment, Numero 951, 2026, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.175431

Advancing exposure knowledge and its uptake into policy: The European exposure science strategy 2020-2030 (Special Issue)

Autori: Peter Fantke, Natalie von Goetz, Matti Jantune
Pubblicato in: ENVIRONMENT INTERNATIONAL, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107692

From toxicogenomics data to cumulative assessment groups: a framework for chemical grouping

Autori: Sebastian Canzler, Julienne Lehmann, Jana Schor, Wibke Busch, Giovanni Iacono, Jörg Hackermüller
Pubblicato in: Archives of Toxicology, Numero 100, 2026, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-025-04133-W

Motor and Non-Motor Effects of Acute MPTP in Adult Zebrafish: Insights into Parkinson’s Disease

Autori: Niki Tagkalidou, Marija Stevanović, Irene Romero-Alfano, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Eva Prats, Cristian Gómez-Canela, Leobardo Manuel Gómez-Oliván, Demetrio Raldúa
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS26041674

Internal Flames: Metal(loid) Exposure Linked to Alteration of the Lipid Profile in Czech Male Firefighters (CELSPAC-FIREexpo Study)

Autori: Nina Pálešová, Katarína Řiháčková, Jan Kuta, Aleš Pindur, Ludmila Šebejová, Pavel Čupr
Pubblicato in: Environmental Science & Technology Letters, Numero 11, 2024, ISSN 2328-8930
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.ESTLETT.4C00272

Link prediction in complex network using information flow

Autori: Furqan Aziz, Luke T. Slater, Laura Bravo-Merodio, Animesh Acharjee and Georgios V. Gkoutos
Pubblicato in: Scientific Reports, Numero 13, 2023
Editore: NATURE
DOI: 10.1038/S41598-023-41476-9

Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations

Autori: Lola Bajard, Ondrej Adamovsky, Karine Audouze, Kirsten Baken, Robert Barouki, Joost B. Beltman, Anna Beronius, Eva Cecilie Bonefeld-Jørgensen, German Cano-Sancho, Milo L. de Baat, Filippo Di Tillio, Mariana F. Fernández, Rex E. FitzGerald, Claudia Gundacker, Antonio F. Hernández, Klara Hilscherova, Spyros Karakitsios, Eliska Kuchovska, Manhai Long, Mirjam Luijten, Sanah Majid, Philip Marx-Stoelting, Vicente Mustieles, Chander K. Negi, Dimosthenis Sarigiannis, Stefan Scholz, Iva Sovadinova, Rob Stierum, Shihori Tanabe, Knut Erik Tollefsen, Annick D. van den Brand, Carolina Vogs, Maria Wielsøe, Clemens Wittwehr, Ludek Blaha
Pubblicato in: Environmental Research, Numero 217, 2026, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2022.114650

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

Autori: Mawien Karaca, Kristin Fritsche, Dajana Lichtenstein, Özlem Vural, Katrin Kreuzer, Jimmy Alarcan, Albert Braeuning, Philip Marx-Stoelting, Tewes Tralau
Pubblicato in: STAR Protocols, Numero 4, 2025, ISSN 2666-1667
Editore: Elsevier BV
DOI: 10.1016/J.XPRO.2023.102500

Occupational exposure limits for reproductive toxicants – A comparative analysis

Autori: Linda Schenk, Meng-Rung Ho, Piia Taxell, Pasi Huuskonen, Mimmi Leite, Inese Martinsone, Karl-Christian Nordby, Linda Paegle, Loreta Strumylaite
Pubblicato in: Reproductive Toxicology, Numero 128, 2024, ISSN 0890-6238
Editore: Elsevier BV
DOI: 10.1016/J.REPROTOX.2024.108649

Pesticide effect on earthworm lethality via interpretable machine learning

Autori: Mihkel Kotli, Geven Piir, Uko Maran
Pubblicato in: Journal of Hazardous Materials, Numero 461, 2025, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2023.132577

Predictive Modeling of Pesticides Reproductive Toxicity in Earthworms Using Interpretable Machine-Learning Techniques on Imbalanced Data

Autori: Mihkel Kotli, Geven Piir, Uko Maran
Pubblicato in: ACS Omega, Numero 10, 2025, ISSN 2470-1343
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSOMEGA.4C09719

Development of a highly sensitive reporter gene cell line for detecting estrogenic activity (the ER Isjaki assay)

Autori: Aline Colonnello Montero, Geeta Mandava, Agneta Oskarsson, Johan Lundqvist
Pubblicato in: Environment International, Numero 202, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109635

"""The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study"""

Autori: """Katarína Řiháčková a, Aleš Pindur a,b,c, Klára Komprdová a, Nina Pálešová a, Jiří Kohoutek a, Petr Šenk a, Jana Navrátilová a, Lenka Andrýsková a, Ludmila Šebejová a, Richard Hůlek a, Mazen Ismael a, Pavel Čupr a,⁎"""
Pubblicato in: Science of the Total Environment, Numero 881 (2023) 163298, 2023, ISSN 0048-9697
Editore: Elsevier
DOI: 10.1016/j.scitotenv.2023.163298

"""Occupational and residential exposures to organophosphate and pyrethroid pesticides in a rural setting"""

Autori: Natalia Bravo, Merc`e Garí *, Joan O. Grimalt
Pubblicato in: Environmental Research, Numero 214 (2022) 114186, 2022, ISSN 0013-9351
Editore: Elsevier
DOI: 10.1016/j.envres.2022.114186

Next generation risk assessment of hair dye HC yellow no. 13: Ensuring protection from liver steatogenic effects

Autori: Sara Sepehri, Dinja De Win, Anja Heymans, Freddy Van Goethem, Robim M. Rodrigues, Vera Rogiers, Tamara Vanhaecke
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 159, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105794

Report of the European Commission workshop on “The roadmap towards phasing out animal testing for chemical safety assessments”, Brussels, 11–12 December 2023

Autori: Mark T.D. Cronin, Elisabet Berggren, Sofia Camorani, Christian Desaintes, Marco Fabbri, Julia Fabrega, Matthias Herzler, Jay D.E. Ingram, Katia Lacasse, Susanna Louhimies, Gavin Maxwell, Katrin Schutte, Tomasz Sobanski, Georg Streck, Andrea Terron, Andrew P. Worth
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 161, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105818

Moving towards making (quantitative) structure-activity relationships ((Q)SARs) for toxicity-related endpoints findable, accessible, interoperable and reusable (FAIR)

Autori: Belfield, S.J.; Basiri, H.; Chavan, S.; Chrysochoou, G.; Enoch, S.J.; Firman, J.W.; Gomatam, A.; Hardy, B.; Helmke, P.S.; Madden, J.C.; Maran, U.; March-Vila, E.; Nikolov, N.G.; Pastor, M.; Piir, G.; Sild, S.; Smaji?, A.; Spinu, N.; Wedebye, E.B.; Cronin,
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2411161

Deoxynivalenol increases pro-inflammatory cytokine secretion and reduces primary bile acid transport in an inflamed intestinal in vitro co-culture model

Autori: Jingxuan Wang, Wouter Bakker, Laura de Haan, Hans Bouwmeester
Pubblicato in: Food Research International, Numero 173, 2025, ISSN 0963-9969
Editore: Elsevier BV
DOI: 10.1016/J.FOODRES.2023.113323

Towards a unified framework for biodiversity action in the Triple Planetary Crisis

Autori: Jiarui Zhou, Jacopo Cricchio, Francisco Sylvester, Leo Posthuma, Martin A. Wilkes, Alberto Di Minin, Henner Hollert, Werner Brack, Luisa Orsini
Pubblicato in: Environment International, Numero 210, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110205

Transcriptomic characterization of 2D and 3D human induced pluripotent stem cell-based in vitro models as New Approach Methodologies for developmental neurotoxicity testing

Autori: Malene Lislien, Eliska Kuchovska, Julia Kapr, Nur Duale, Jill Mari Andersen, Hubert Dirven, Oddvar Myhre, Ellen Fritsche, Katharina Koch, Marcin W. Wojewodzic
Pubblicato in: Toxicology, Numero 510, 2024, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/J.TOX.2024.154000

Nontarget and Suspect Screening of Fluorinated Ionic Liquids and PFAS in European Wastewaters Using Supercritical Fluid Chromatography

Autori: Selina Tisler, Jonathan Zweigle, Maria Kregler Gotil, Saskia Finckh, Werner Brack, Eva-Maria Braxmaier, Corina Meyer, Juliane Hollender, Tina Kosjek, Emma L. Schymanski, Pontus Larsson, Anna Kärrman, Erica Selin, Dalia Elabbadi, Harry Elliss, Barbara Kasprzyk-Hordern, Tim Boogaerts, Adrian Covaci, Herbert Oberacher, Harold Flores Quintana, Foon Yin Lai, Lutz Ahrens, Azziz Assoumani, Frederic Béen, Jan H. Christensen
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C06876

REACH out-numbered! The future of REACH and animal numbers

Autori: Costanza Rovida, Francois Busquet, Marcel Leist, Thomas Hartung
Pubblicato in: 2023
Editore: ALTEX
DOI: 10.14573/ALTEX.2307121

Learning from Safe-by-Design for Safe-and-Sustainable-by-Design: Mapping the current landscape of Safe-by-Design reviews, case studies, and frameworks

Autori: Akshat Sudheshwar, Christina Apel, Klaus Kümmerer, Zhanyun Wang, Lya G Soeteman-Hernández, Eugenia Valsami-Jones, Claudia Som, Bernd Nowack
Pubblicato in: ENVIRON INT, Numero 183, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108305

CLUSplus: A decision tree-based framework for predicting structured outputs

Autori: Matej Petković, Jurica Levatić, Dragi Kocev, Martin Breskva, Sašo Džeroski
Pubblicato in: SoftwareX, Numero 24, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SOFTX.2023.101526

Federated learning for predicting compound mechanism of action based on image-data from cell painting

Autori: Li Ju, Andreas Hellander, Ola Spjuth
Pubblicato in: Artificial Intelligence in the Life Sciences, Numero 5, 2026, ISSN 2667-3185
Editore: Elsevier BV
DOI: 10.1016/J.AILSCI.2024.100098

Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro

Autori: Francesco Crudo, Vanessa Partsch, Dennis Braga, Ruzica Blažević, Judith M. Rollinger, Elisabeth Varga, Doris Marko
Pubblicato in: Archives of Toxicology, Numero 99, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-024-03877-1

Pressures of the urban environment on the endocrine system: Adverse effects and adaptation

Autori: Patricia Rannaud-Bartaire, Barbara A. Demeneix, Jean-Baptiste Fini
Pubblicato in: Molecular and Cellular Endocrinology, Numero 583, 2025, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/J.MCE.2023.112125

Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu

Autori: Erica Buoso, Mirco Masi, Roberta Valeria Limosani, Chiara Oliviero, Sabrina Saeed, Martina Iulini, Francesca Carlotta Passoni, Marco Racchi, Emanuela Corsini
Pubblicato in: Journal of Xenobiotics, Numero 15, 2025, ISSN 2039-4713
Editore: MDPI AG
DOI: 10.3390/JOX15010013

Further development of CometChip technology to measure DNA damage in vitro and in vivo: Comparison with the 2 gels/slide format of the standard and enzyme-modified comet assay

Autori: Miguel Collia, Peter Møller, Sabine A.S. Langie, Ariane Vettorazzi, Amaya Azqueta
Pubblicato in: TOXICOLOGY, Numero 501, 2023
Editore: ELSEVIER
DOI: 10.1016/J.TOX.2023.153690

Linking chemicals, genes and morphological perturbations to diseases

Autori: Natacha Cerisier, Bryan Dafniet, Anne Badel, Olivier Taboureau
Pubblicato in: Toxicol Appl Pharmacol, Numero 15, 2023
Editore: ELSEVIER
DOI: 10.1016/J.TAAP.2023.116407

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Autori: Marta Sendra, Martina Štampar, Katarina Fras, Beatriz Novoa, Antonio Figueras, Bojana Žegura
Pubblicato in: Environment International, Numero 171, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2022.107721

Adverse outcomes of the newly emerging bisphenol A substitutes

Autori: Nina Franko, Anja Kodila, Marija Sollner Dolenc
Pubblicato in: Chemosphere, Numero 364, 2025, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2024.143147

AI for predicting chemical-effect associations at the chemical universe level— <tt>deepFPlearn</tt>

Autori: Jana Schor, Patrick Scheibe, Matthias Bernt, Wibke Busch, Chih Lai, Jörg Hackermüller
Pubblicato in: Briefings in Bioinformatics, Numero 23, 2023, ISSN 1467-5463
Editore: Oxford University Press (OUP)
DOI: 10.1093/BIB/BBAC257

Development of a rat physiologically based kinetic model (PBK) for three organophosphate flame retardants (TDCIPP, TCIPP, TCEP)

Autori: Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar
Pubblicato in: Toxicology Letters, Numero 383, 2023
Editore: ELSEVIER
DOI: 10.1016/J.TOXLET.2023.06.006

In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids

Autori: Yasser Alhejji, Frances Widjaja, Shenghan Tian, Thomas Hoekstra, Sebastiaan Wesseling, Ivonne M.C.M. Rietjens
Pubblicato in: Current Research in Toxicology, Numero 6, 2024, ISSN 2666-027X
Editore: Elsevier BV
DOI: 10.1016/J.CRTOX.2024.100160

Ultra-low esfenvalerate exposure may disrupt interspecific competition

Autori: Florian Schunck, Matthias Liess
Pubblicato in: Science of The Total Environment, Numero 906, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2023.167455

A simplified landscape-based approach for including agronomical and ecological characteristic in pesticide risk assessments for terrestrial vertebrates

Autori: Awot George Ukbamichael, Thomas Sagredo, Erik Urionabarrenetxea, Manu Soto, Jose V. Tarazona
Pubblicato in: Environmental Pollution, Numero 385, 2026, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2025.127142

Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

Autori: Nina Pálešová, Léa Maitre, Nikos Stratakis, Katarína Řiháčková, Aleš Pindur, Jiří Kohoutek, Petr Šenk, Anna Bartošková Polcrová, Petr Gregor, Martine Vrijheid, Pavel Čupr
Pubblicato in: International Journal of Hygiene and Environmental Health, Numero 252, 2025, ISSN 1438-4639
Editore: Elsevier BV
DOI: 10.1016/J.IJHEH.2023.114215

Out of REACH: environmental hazards of cosmetic preservatives

Autori: Diana Kättström, Anna Beronius, Urban Boije af Gennäs, Christina Rudén, Marlene Ågerstrand
Pubblicato in: Human and Ecological Risk Assessment: An International Journal, Numero 30, 2024, ISSN 1080-7039
Editore: Informa UK Limited
DOI: 10.1080/10807039.2023.2301073

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods

Autori: Beate I. Escher, Rolf Altenburger, Matthias Blüher, John K. Colbourne, Ralf Ebinghaus, Peter Fantke, Michaela Hein, Wolfgang Köck, Klaus Kümmerer, Sina Leipold, Xiaojing Li, Martin Scheringer, Stefan Scholz, Michael Schloter, Pia-Johanna Schweizer, Tamara Tal, Igor Tetko, Claudia Traidl-Hoffmann, Lukas Y. Wick, Kathrin Fenner
Pubblicato in: Archives of Toxicology, Numero 97, 2023, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-023-03485-5

A 2024 inventory of test methods relevant to thyroid hormone system disruption for human health and environmental regulatory hazard assessment

Autori: Lucia Vergauwen, Lola Bajard, Sabrina Tait, Ingrid Langezaal, Anita Sosnowska, Alessandra Roncaglioni, Ellen Hessel, Annick D van den Brand, Ann-Cathrin Haigis, Jiří Novák, Klára Hilscherová, Natalia Buławska, Nafsika Papaioannou, Elisavet Renieri, Eliana Spilioti, Anastasia Spyropoulou, Arno C Gutleb, Henrik Holbech, Dimitra Nikolopoulou, Miriam N Jacobs, Dries Knapen
Pubblicato in: Open Research Europe, Numero 4, 2024, ISSN 2732-5121
Editore: F1000 Research Ltd
DOI: 10.12688/OPENRESEUROPE.18739.1

"""Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure"""

Autori: Yourdasmine Ali Daoud, Cleo Tebby, Remy Beaudouin, Celine Brochot
Pubblicato in: Toxicology and Applied Pharmacology, Numero 476 (2023) 116651, 2023, ISSN 0041-008X
Editore: Elsevier
DOI: 10.1016/j.taap.2023.116651

The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study

Autori: Katarína Řiháčková, Aleš Pindur, Klára Komprdová, Nina Pálešová, Jiří Kohoutek, Petr Šenk, Jana Navrátilová, Lenka Andrýsková, Ludmila Šebejová, Richard Hůlek, Mazen Ismael, Pavel Čupr
Pubblicato in: Science of The Total Environment, Numero 881, 2026, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2023.163298

Risk ranking of biocidal active substances in the food chain: a case study on food of animal origin

Autori: Gaël Touchais, Marion Rey, Opaline A. Journeau, Dominique Hurtaud-Pessel, Michel Laurentie, Sophie Mompelat
Pubblicato in: Food Control, Numero 179, 2025, ISSN 0956-7135
Editore: Elsevier BV
DOI: 10.1016/J.FOODCONT.2025.111542

Interplay between aryl hydrocarbon and estrogen receptor signaling- A possible explanation of endocrine- disrupting and immunomodulatory effects of mycotoxins

Autori: Karolina Kowalska, Ibrahim Fouad Ibrahim Elesh, Doris Marko
Pubblicato in: Journal of Hazardous Materials, Numero 501, 2026, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.140838

A comprehensive library of lifetime physiological equations for PBK models: Enhancing dietary exposure modeling with mercury as a case study

Autori: Thomas Gastellu, Achilleas Karakoltzidis, Aude Ratier, Marie Bellouard, Jean-Claude Alvarez, Bruno Le Bizec, Gilles Rivière, Spyros Karakitsios, Dimosthenis A. Sarigiannis, Carolina Vogs
Pubblicato in: Environmental Research, Numero 265, 2024, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2024.120393

The environmental occurrence, fate, and risks of 25 endocrine disruptors in Slovenian waters

Autori: Andrej Grobin, Robert Roškar, Jurij Trontelj
Pubblicato in: Science of The Total Environment, Numero 906, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.167245

The zebrafish visual and acoustic motor response (VAMR) assay has the potential to add value to the developmental neurotoxicity in Vitro battery (DNT IVB)

Autori: Julia Spath, Jana Raab, Jana Schor, Stefan Scholz, Sebastian Gutsfeld, Tamara Tal
Pubblicato in: NeuroToxicology, Numero 114, 2026, ISSN 0161-813X
Editore: Elsevier BV
DOI: 10.1016/J.NEURO.2026.103414

Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies

Autori: Camilla Svendsen, Paul Whaley, Gunn E. Vist, Trine Husøy, Anna Beronius, Emma Di Consiglio, Ingrid Druwe, Thomas Hartung, Vasiliki I. Hatzi, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Gro H. Mathisen
Pubblicato in: Evidence-Based Toxicology, Numero 1, 2024, ISSN 2833-373X
Editore: Informa UK Limited
DOI: 10.1080/2833373X.2023.2232415

A Computational Framework to Evaluate Interactions of BPA and Its Analogs with Human Liver X Receptor-Beta for Health Risk Assessment

Autori: Rajesh Kumar Pathak, Saurav Kumar, Vikas Kumar
Pubblicato in: Chemical Research in Toxicology, Numero 39, 2026, ISSN 0893-228X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00460

Ozonation of Pharmaceuticals and Their Human Metabolites in Wastewater─Insights from Laboratory Experiments and Field Data

Autori: Corina Meyer, Pia M. Kronsbein, Valentin Rougé, Urs von Gunten, Christa S. McArdell, Juliane Hollender
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C08128

Mixtures of per- and poly-fluoroalkyl substances (PFAS) reduce the in vitro activation of human T cells and basophils

Autori: Ambra Maddalon, Arkadiusz Pierzchalski, Tobias Kretschmer, Mario Bauer, Ana C. Zenclussen, Marina Marinovich, Emanuela Corsini, Gunda Herberth
Pubblicato in: Chemosphere, Numero 336, 2025, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2023.139204

Repression of bile salt efflux pump expression by tri-ortho-cresyl phosphate in cultured human hepatic cells

Autori: Valentin Tastet, Marc Le Vée, Jennifer Carteret, David Malnoë, Arnaud Bruyère, Olivier Fardel
Pubblicato in: Toxicology in Vitro, Numero 105, 2025, ISSN 0887-2333
Editore: Elsevier BV
DOI: 10.1016/J.TIV.2025.106021

Assessment of endocrine disruptors in the European Union: Current regulatory framework, use of new approach methodologies (NAMs) and recommendations for improvements

Autori: Marie Louise Holmer, Rikke Donchil Holmberg, Caroline Despicht, Nora Bouftas, Marta Axelstad, Anna Beronius, Johanna Zilliacus, Majorie Van Duursen, Terje Svingen
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 162, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105883

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification

Autori: Kristin Fritsche, Andrea Ziková-Kloas, Philip Marx-Stoelting, Philip Marx-Stoelting and Albert Braeuning
Pubblicato in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Numero 24 (3), 2023
Editore: MDPI
DOI: 10.3390/IJMS24032686

Mapping chemical footprints of organic micropollutants in European streams

Autori: Saskia Finckh, Eric Carmona, Dietrich Borchardt, Olaf Büttner, Martin Krauss, Tobias Schulze, Soohyun Yang, Werner Brack
Pubblicato in: Environment International, Numero 183, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108371

Everyday exposures: feasibility of community-based trace metal monitoring using non-invasive bio-sampling in children’s environments, a pilot study

Autori: Laura-Jayne A Ellis (Bradford), Andrew J Chetwynd, Sophie Hadfield-Hill, Alice Menzel, Ruth Till, Iseult Lynch, Peter Kraftl
Pubblicato in: Environmental Research: Health, Numero 4, 2026, ISSN 2752-5309
Editore: IOP Publishing
DOI: 10.1088/2752-5309/AE4260

Exposure and hazard of bisphenol A, S and F: a multi-biomarker approach in three-spined stickleback

Autori: Corentin Mit, Rémy Beaudouin, Olivier Palluel, Cyril Turiès, Gaëlle Daniele, Barbara Giroud, Anne Bado-Nilles
Pubblicato in: Environmental Science and Pollution Research, Numero 32, 2025, ISSN 1614-7499
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S11356-023-28462-4

Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays

Autori: Julia Hartmann, Noah Henschel, Kristina Bartmann, Arif Dönmez, Gabriele Brockerhoff, Katharina Koch, Ellen Fritsche
Pubblicato in: Cells, Numero 12, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS12091270

Associations between Urinary Phthalate Metabolites with BDNF and Behavioral Function among European Children from Five HBM4EU Aligned Studies

Autori: Elena Salamanca-Fernández, Lydia Espín-Moreno, Alicia Olivas-Martínez, Ainhoa Pérez-Cantero, José L. Martín-Rodríguez, Rafael M. Poyatos, Fabio Barbone, Valentina Rosolen, Marika Mariuz, Luca Ronfani, Ľubica Palkovičová Murínová, Lucia Fábelová, Tamás Szigeti, Réka Kakucs, Amrit K. Sakhi, Line S. Haug, Birgitte Lindeman, Janja Snoj Tratnik, Tina Kosjek, Griet Jacobs, Stefan Voorspoels, Helena Jurdáková, Renáta Górová, Ida Petrovičová, Branislav Kolena, Marta Esteban, Susana Pedraza-Díaz, Marike Kolossa-Gehring, Sylvie Remy, Eva Govarts, Greet Schoeters, Mariana F. Fernández, Vicente Mustieles
Pubblicato in: Toxics, Numero 12, 2025, ISSN 2305-6304
Editore: MDPI AG
DOI: 10.3390/TOXICS12090642

Method optimization for a simultaneous determination of neonicotinoid, carbamate/thiocarbamate, triazole, organophosphate and pyrethroid pesticides and their metabolites in urine using UPLC-MS/MS

Autori: Carolina M. Bustamante, Natalia Bravo, Paula Ruiz, Joan O. Grimalt, Mercè Garí
Pubblicato in: Journal of Chromatography A, Numero 1730, 2024, ISSN 0021-9673
Editore: Elsevier BV
DOI: 10.1016/J.CHROMA.2024.465054

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

Autori: Thalia De Castelbajac, Kiara Aiello, Celia Garcia Arenas, Terje Svingen, Louise Ramhøj, Daniel Zalko, Robert Barouki, Tamara Vanhaecke, Vera Rogiers, Marc Audebert, Michael Oelgeschlaeger, Albert Braeuning, Etienne Blanc, Tamara Tal, Joëlle Rüegg, Ellen Fritsche, Philip Marx-Stoelting, Gilles Rivière
Pubblicato in: Frontiers in Toxicology, Numero 5, 2023, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2023.1216369

Probabilistic grammars for modeling dynamical systems from coarse, noisy, and partial data

Autori: Nina Omejc, Boštjan Gec, Jure Brence, Ljupčo Todorovski, Sašo Džeroski
Pubblicato in: Machine Learning, Numero 113, 2024, ISSN 0885-6125
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10994-024-06522-1

Estimated exposure of flame-retardants in Spanish toddlers: a modelling approach

Autori: Roser Esplugas, Joaquim Rovira, Helena García-Cortés, Vikas Kumar, Montse Mari, Antonio F. Hernández, Marina Lacasaña-Navarro, José L. Domingo, Marta Schuhmacher
Pubblicato in: Environmental Pollution, Numero 383, 2026, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2025.126873

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

Autori: Deepika Deepika, Vikas Kumar
Pubblicato in: International Journal of Environmental Research and Public Health, Numero 20, 2025, ISSN 1660-4601
Editore: MDPI AG
DOI: 10.3390/IJERPH20043473

A new alternative method using cyp3a65 expression in transgenic zebrafish embryos to assess metabolic endocrine-disrupting chemicals in the intestine

Autori: Chedi Erradhouani, Florian Geffroy, Benjamin Piccini, Nathalie Hinfray, Edith Chadili, Patrick Balaguer, Frédéric Sohm, Selim Aït-Aïssa, Xavier Coumoul, François Brion
Pubblicato in: Environment International, Numero 205, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109872

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Autori: Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Pubblicato in: JOURNAL OF APPLIED TOXICOLOGY, Numero 44, 2023
Editore: WILEY
DOI: 10.1002/JAT.4499

Physiologically based kinetic (PBK) modeling as a new approach methodology (NAM) for predicting systemic levels of gut microbial metabolites

Autori: Maja Stevanoska, Jacob Folz, Karsten Beekmann, Georg Aichinger
Pubblicato in: Toxicology Letters, Numero 396, 2024, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/J.TOXLET.2024.04.013

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

Autori: Albert Braeuning, Albert Braeuning, Patrick Balaguer, Patrick Balaguer, William Bourguet, William Bourguet, Jordi Carreras-Puigvert, Jordi Carreras-Puigvert, Katreece Feiertag, Katreece Feiertag, Jorke H. Kamstra, Jorke H. Kamstra, Dries Knapen, Dries Knapen, Dajana Lichtenstein, Dajana Lichtenstein, Philip Marx-Stoelting, Philip Marx-Stoelting, Jonne Rietdijk, Jonne Rietdijk, Kristin Schubert, Kristin Schubert, Ola Spjuth, Ola Spjuth, Evelyn Stinckens, Evelyn Stinckens, Kathrin Thedieck, Kathrin Thedieck, Rik van den Boom, Rik van den Boom, Lucia Vergauwen, Lucia Vergauwen, Martin von Bergen, Martin von Bergen, Neele Wewer, Neele Wewer, Daniel ZalkoDaniel Zalko
Pubblicato in: FRONTIERS IN TOXICOLOGY, Numero 5, 2023
Editore: FRONTIERS
DOI: 10.3389/FTOX.2023.1212509

Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020–2030

Autori: Marissa B. Kosnik, Stylianos Kephalopoulos, Amalia Muñoz, Nicolò Aurisano, Alberto Cusinato, Sani Dimitroulopoulou, Jaroslav Slobodnik, Jonathas De Mello, Maryam Zare Jeddi, Claudia Cascio, Andreas Ahrens, Yuri Bruinen de Bruin, Lothar Lieck, Peter Fantke
Pubblicato in: Environment International, Numero 170, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2022.107610

Differential Responses of Human iPSC-Derived Microglia to Stimulation with Diverse Inflammogens

Autori: Chiara Wolfbeisz, Julian Suess, Nadine Dreser, Heidrun Leisner, Markus Brüll, Madeleine Fandrich, Nicole Schneiderhan-Marra, Oliver Poetz, Thomas Hartung, Marcel Leist
Pubblicato in: Cells, Numero 14, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS14211687

"""PBTK-TD model of the phagocytosis activity in three-spined stickleback exposed to BPA"""

Autori: """Corentin Mit a,b, Anne Bado-Nilles b, Cyril Turi`es b, Ga¨elle Daniele c, Barbara Giroud c, R´emy Beaudouin a,*"""
Pubblicato in: Aquatic Toxicology, Numero 261 (2023) 106608, 2023, ISSN 0166-445X
Editore: Elsevier
DOI: 10.1016/j.aquatox.2023.106608

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Autori: Markus Brüll, Nils Geese, Ivana Celardo, Michael Laumann, Marcel Leist
Pubblicato in: Cells, Numero 13, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS13030242

Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater

Autori: Saskia Finckh, Sebastian Buchinger, Beate I. Escher, Henner Hollert, Maria König, Martin Krauss, Warich Leekitratanapisan, Sabrina Schiwy, Rita Schlichting, Aliaksandra Shuliakevich, Werner Brack
Pubblicato in: Environment International, Numero 170, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2022.107608

Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca2+ Oscillations Across Human Neuronal Spheroids and Extended 2D Cultures

Autori: Jasmin Kormann, Eike Cöllen, Ayla Aksoy-Aksel, Jana Schneider, Yaroslav Tanaskov, Kevin Wulkesch, Marcel Leist, Udo Kraushaar
Pubblicato in: Cells, Numero 14, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS14211744

Advanced Proteomics Approaches Hold Potential for the Risk Assessment of Metabolism-Disrupting Chemicals as Omics-Based NAM: A Case Study Using the Phthalate Substitute DINCH

Autori: Alix Sarah Aldehoff, Isabel Karkossa, Helen Broghammer, Sontje Krupka, Juliane Weiner, Cornelius Goerdeler, Rima Nuwayhid, Stefan Langer, Martin Wabitsch, Ulrike Rolle-Kampczyk, Nora Klöting, Matthias Blüher, John T. Heiker, Martin von Bergen, Kristin Schubert
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C01206

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

Autori: Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, Sylvie Bortoli, Peter Bouwman, Albert Braeuning, Tanja Burgdorf, Xavier Coumoul, Kloé Debizet, Maria Dusinska, Norman Ertych, Jörg Fahrer, Verena Fetz, Ludovic Le Hégarat, Adela López de Cerain, Harm J. Heusinkveld, Kevin Hogeveen, Miriam N. Jacobs, Mirjam Luijten, Giuseppa Raitano, Cynthia Recoules, Elise Rundén-Pran, Mariam Saleh, Iva Sovadinová, Martina Stampar, Lea Thibol, Céline Tomkiewicz, Ariane Vettorazzi, Bob Van de Water, Naouale El Yamani, Bojana Zegura, Michael Oelgeschläger
Pubblicato in: Frontiers in Toxicology, Numero 5, 2023, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2023.1220998

Applicability of Food Monitoring Data for Assessing Relative Exposure Contributions of Pyrethroids in Retrospective Human Biomonitoring Risk Estimations

Autori: Mercedes de Alba-Gonzalez, Maria González-Caballero, Jose Tarazona
Pubblicato in: Toxics, Numero 12, 2025, ISSN 2305-6304
Editore: MDPI AG
DOI: 10.3390/TOXICS12010024

Considering degradation kinetics of pesticides in plant uptake models: proof of concept for potato

Autori: Zijian Li, Peter Fantke
Pubblicato in: PEST MANAGEMENT SCIENCE, Numero 79, 2023
Editore: WILEY
DOI: 10.1002/PS.7288

Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment

Autori: Patricia Iglesias-Hernandez, Jose Vicente Tarazona, Juliana Manosalva, Diego Megias, Felix Docando, Ana I. Cañas-Portilla, Monica Torres-Ruiz, Antonio De la Vieja
Pubblicato in: Journal of Hazardous Materials, Numero 498, 2026, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.139890

Leveraging biomarkers and translational medicine for preclinical safety - Lessons for advancing the validation of alternatives to animal testing

Autori: Hartung, Thomas; King, Nicolas M.P.; Kleinstreuer, Nicole; Leist, Marcel; Tagle, Danilo A.
Pubblicato in: ALTEX, 2024, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2410011

AOP-networkFinder—a versatile tool for the reconstruction and visualization of Adverse Outcome Pathway networks from AOP-Wiki

Autori: Nurettin Yarar, Marvin Martens, Torbjørn Rognes, Jan Lavender, Hubert Dirven, Karine Audouze, Marcin W Wojewodzic
Pubblicato in: Bioinformatics Advances, Numero 5, 2025, ISSN 2635-0041
Editore: Oxford University Press (OUP)
DOI: 10.1093/BIOADV/VBAF007

Computational Tools to Facilitate Early Warning of New Emerging Risk Chemicals

Autori: Farina Tariq, Lutz Ahrens, Nikiforos A. Alygizakis, Karine Audouze, Emilio Benfenati, Pedro N. Carvalho, Ioana Chelcea, Spyros Karakitsios, Achilleas Karakoltzidis, Vikas Kumar, Liadys Mora Lagares, Dimosthenis Sarigiannis, Gianluca Selvestrel, Olivier Taboureau, Katrin Vorkamp, Patrik L. Andersson
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Editore: MDPI AG
DOI: 10.3390/TOXICS12100736

The integrated stress response‐related expression of CHOP due to mitochondrial toxicity is a warning sign for <scp>DILI</scp> liability

Autori: Matthijs Vlasveld, Giulia Callegaro, Ciarán Fisher, Julie Eakins, Paul Walker, Samantha Lok, Siddh van Oost, Brechtje de Jong, Damiano Pellegrino‐Coppola, Gerhard Burger, Steven Wink, Bob van de Water
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Editore: Wiley
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Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

Autori: Albert Braeuning, Patrick Balaguer, William Bourguet, Jordi Carreras-Puigvert, Katreece Feiertag, Jorke H. Kamstra, Dries Knapen, Dajana Lichtenstein, Philip Marx-Stoelting, Jonne Rietdijk, Kristin Schubert, Ola Spjuth, Evelyn Stinckens, Kathrin Thedieck, Rik van den Boom, Lucia Vergauwen, Martin von Bergen, Neele Wewer, Daniel Zalko
Pubblicato in: Frontiers in Toxicology, Numero 5, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2023.1212509

How does habitat use influence PFAS contamination in wildlife? Combining stable isotopes and GPS tracking in three gull species

Autori: David Rozen-Rechels, Prescillia Lemesle, William Jouanneau, Manrico Sebastiano, Stephanie M. Harris, Pierre Blévin, Frédéric Angelier, Julien Gernigon, Jean-Christophe Lemesle, Frédéric Robin, Hélène Budzinski, Pierre Labadie, Paco Bustamante, Olivier Chastel
Pubblicato in: Environmental Pollution, Numero 391, 2026, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2025.127556

A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human biomonitoring

Autori: Anthony Purece, Sofie Theresa Thomsen, Dietrich Plass, Anastasia Spyropoulou, Kyriaki Machera, Philippe Palmont, Amélie Crépet, Rafiqa Benchrih, Brecht Devleesschauwer, Nina Wieland, Paul Scheepers, Deepika Deepika, Vikas Kumar, Gerardo Sanchez, Jos Bessems, Dario Piselli, Jurgen Buekers
Pubblicato in: Environmental Health, Numero 23, 2024, ISSN 1476-069X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12940-024-01131-W

BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality

Autori: Anna Khalizieva, Sarah C. Moser, Peter Bouwman, Jos Jonkers
Pubblicato in: Genes & Development, 2024, ISSN 0890-9369
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/GAD.352083.124

Advancing environmental risk assessment (ERA) of plant protection products through a systems-based approach to strengthen biodiversity protection

Autori: Sabine Duquesne, Annette Aldrich, Johan Axelman, Yann Devos, Vanessa Mazerolles, Gustaf Boström, Romana Hornek-Gausterer, Matthias Liess, Ralf B Schäfer, Ralf Schulz, José V Tarazona, Lina Wendt-Rasch
Pubblicato in: Environment International, Numero 207, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109974

Double trouble: The synergistic threat of environmental stressors and pesticide mixtures

Autori: Naeem Shahid, Ayesha Siddique, Martin Krauss, Alexander Böhme, Werner Brack, Annika Jahnke, Matthias Liess
Pubblicato in: Journal of Hazardous Materials, Numero 500, 2026, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.140293

Evaluating the performance of multi-omics integration: a thyroid toxicity case study

Autori: Sebastian Canzler, Kristin Schubert, Ulrike E. Rolle-Kampczyk, Zhipeng Wang, Stephan Schreiber, Hervé Seitz, Sophie Mockly, Hennicke Kamp, Volker Haake, Maike Huisinga, Martin von Bergen, Roland Buesen, Jörg Hackermüller
Pubblicato in: Archives of Toxicology, Numero 99, 2025, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-024-03876-2

The European Partnership PARC’s role in actively promoting the uptake of new approach methodologies and next-generation risk assessment into regulatory risk assessment practice

Autori: Matthias Herzler, Mirjam Luijten, Philip Marx-Stoelting, Gilles Rivière
Pubblicato in: Current Opinion in Toxicology, Numero 42, 2025, ISSN 2468-2020
Editore: Elsevier BV
DOI: 10.1016/J.COTOX.2025.100517

Legislation and Current Practices Concerning Risk Assessment of Skin Sensitizers in the European Union: A Comparative and Survey Study

Autori: Mathias Krogh Pedersen, Jakob Ferløv Baselius Schwensen, Jose Hernán Alfonso, Steen Mollerup, Gianluca Selvestrel, Christina Rudén, Martin F. Wilks, Jeanne Duus Johansen
Pubblicato in: Contact Dermatitis, Numero 92, 2025, ISSN 0105-1873
Editore: Wiley
DOI: 10.1111/COD.14754

Tailored iron oxide nanoparticles for biomedical applications: Hydroxyethyl starch coating enhances endothelial biocompatibility

Autori: Lydia-Nefeli Thrapsanioti, Andrey N. Kuskov, Aikaterini Berdiaki, Anna L. Luss, Elizaveta R. Vlaskina, Anna V. Ivanova, Maxim A. Abakumov, Maria Marmara, Kalliope Plexousaki, Aristides Tsatsakis, Dragana Nikitovic
Pubblicato in: Nanomedicine: Nanotechnology, Biology and Medicine, Numero 71, 2026, ISSN 1549-9634
Editore: Elsevier BV
DOI: 10.1016/J.NANO.2025.102880

Water Quality Monitoring with the Multiplexed Assay MitoOxTox for Mitochondrial Toxicity, Oxidative Stress Response, and Cytotoxicity in AREc32 Cells

Autori: Jungeun Lee, Maria König, Georg Braun, Beate I. Escher
Pubblicato in: Environmental Science & Technology, Numero 58, 2024, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.3C09844

Inconsistencies in the EU regulatory risk assessment of PFAS call for readjustment

Autori: Jussi Reinikainen, Elodie Bouhoulle, Jaana Sorvari
Pubblicato in: Environment International, Numero 186, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108614

Two decades of spatial and temporal pesticide risk to non-target invertebrates in England farmlands

Autori: Melanie Gibbs, Francesca Mancini, Claire Carvell, Gary Powney, Colin A. Harrower, Grace Skinner, Ellie Dearlove, Alexander Robinson, Carolin L. Schultz, Susan Jarvis, Richard Pywell, Ben A. Woodcock, David Spurgeon
Pubblicato in: Environment International, Numero 204, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109856

Adverse outcome pathway networks of microplastic ecotoxicity to aquatic organisms: A critical review

Autori: Nik Nurhidayu Nik Mut, Zhihan Cao, Joorim Na, Ali Yuzir, Knut Erik Tollefsen, Jinho Jung
Pubblicato in: Aquatic Toxicology, Numero 289, 2026, ISSN 0166-445X
Editore: Elsevier BV
DOI: 10.1016/J.AQUATOX.2025.107594

"""Mixtures of per- and poly-fluoroalkyl substances (PFAS) reduce the in vitro activation of human T cells and basophils"""

Autori: """Ambra Maddalon a,1, Arkadiusz Pierzchalski b,1, Tobias Kretschmer b, Mario Bauer b, Ana C. Zenclussen b,c, Marina Marinovich a, Emanuela Corsini a, Gunda Herberth b,*"""
Pubblicato in: Chemosphere, Numero 336 (2023) 139204, 2023, ISSN 0045-6535
Editore: Elsevier
DOI: 10.1016/j.chemosphere.2023.139204

Testing Strategies for Metabolite-Mediated Neurotoxicity

Autori: Julian Suess, Moritz Reinmoeller, Viktoria Magel, Baiba Gukalova, Edgars Liepinsh, Iain Gardner, Nadine Dreser, Anna-Katharina Holzer, Marcel Leist
Pubblicato in: International Journal of Molecular Sciences, Numero 26, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS26178338

Interactions of organophosphate flame retardants with human drug transporters

Autori: Valentin Tastet, Marc Le Vée, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyère, Olivier Fardel
Pubblicato in: Ecotoxicology and Environmental Safety, Numero 263, 2025, ISSN 0147-6513
Editore: Elsevier BV
DOI: 10.1016/J.ECOENV.2023.115348

Exploring the mixture assessment or allocation factor (MAF): A brief overview of the current discourse

Autori: Thomas Backhaus
Pubblicato in: Current Opinion in Toxicology, Numero 37, 2025, ISSN 2468-2020
Editore: Elsevier BV
DOI: 10.1016/J.COTOX.2024.100460

Chemical Mixture Exposures and Their Effects on Sensitisation and Elicitation Responses: A Systematic Review

Autori: Mikkel Bak Jensen, Jose Hernán Alfonso, Alexandra Teresa Seibel, Steen Mollerup, Martin F. Wilks, Gianluca Selvestrel, Christina Rudén, Mayes Alswady‐Hoff, Jakob Ferløv Baselius Schwensen, Charlotte Menne Bonefeld, Jeanne Duus Johansen
Pubblicato in: Contact Dermatitis, Numero 94, 2026, ISSN 0105-1873
Editore: Wiley
DOI: 10.1111/COD.70069

Development of historic monthly land use regression models of SO2, NOx and suspended particulate matter for birth cohort ELSPAC

Autori: Ondřej Mikeš, Ondřej Sáňka, Aneta Rafajová, Jelle Vlaanderen, Jie Chen, Gerard Hoek, Jana Klánová, Pavel Čupr
Pubblicato in: Atmospheric Environment, Numero 301, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ATMOSENV.2023.119688

Wild fish and seafood species in the western Mediterranean Sea with low safe mercury concentrations

Autori: Marco Capodiferro, Esther Marco, Joan O. Grimalt
Pubblicato in: Environmental Pollution, Numero 314, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVPOL.2022.120274

Exploring Domestic Discharge Patterns in Wastewater through LC-HRMS Screening and Temporal Clustering

Autori: Inga Haalck, Martin Krauss, Werner Brack, Carolin Huber
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C02486

The mixture assessment or allocation factor: conceptual background, estimation algorithms and a case study example

Autori: Thomas Backhaus
Pubblicato in: Environmental Sciences Europe, Numero 35, 2023
Editore: SPRINGER
DOI: 10.1186/S12302-023-00757-W

Antimicrobials Shape the Gut Microbiome Structure and Digestive Profile of Invertebrates

Autori: Alexander Feckler, Eric Bollinger, Sven Katzenmeier, Ondrej Adamovsky, Hana Vespalcova, Eva Budinska, Thorsten Stoeck, Mirco Bundschuh
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C04159

Microplastics and PFAS as ubiquitous pollutants affect potencies of highly toxic chemicals in mixtures

Autori: Sam van Loon, Ge Xie, Claus Svendsen, Michiel H.S. Kraak, Lotte de Jeu, Nienke C. Schut, Eva Sprokkereef, Rachel Hurley, Annemarie P. van Wezel, Cornelis A.M. van Gestel
Pubblicato in: Journal of Hazardous Materials, Numero 500, 2026, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.140493

Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study

Autori: Mirjam Luijten, R. Corinne Sprong, Emiel Rorije, Leo T. M. van der Ven
Pubblicato in: Frontiers in Toxicology, Numero 4, 2022, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2022.933197

IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by Bisphenol A

Autori: Mengmei Ni, Deepika Deepika, Xiaomeng Li, Wei Xiong, Lishi Zhang, Jinyao Chen, Vikas Kumar
Pubblicato in: Environmental Research, Numero 240, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVRES.2023.117343

A population physiologically based kinetic and toxicodynamic model for acute diazinon exposure

Autori: Jiaqi Chen, Bingxu Chen, Sebastiaan Wesseling, Hans Bouwmeester, Ivonne M.C.M. Rietjens, Nynke I. Kramer
Pubblicato in: Ecotoxicology and Environmental Safety, Numero 294, 2026, ISSN 0147-6513
Editore: Elsevier BV
DOI: 10.1016/J.ECOENV.2025.118083

Easy-MODA: Simplifying standardised registration of scientific simulation workflows through MODA template guidelines powered by the Enalos Cloud Platform

Autori: Panagiotis D. Kolokathis, Nikolaos K. Sidiropoulos, Dimitrios Zouraris, Dimitra-Danai Varsou, Dimitris G. Mintis, Andreas Tsoumanis, Francesco Dondero, Thomas E. Exner, Haralambos Sarimveis, Evgenia Chaideftou, Martin Paparella, Fotini Nikiforou, Achilleas Karakoltzidis, Spyros Karakitsios, Dimosthenis Sarigiannis, Jesper Friis, Gerhard Goldbeck, David A. Winkler, Willie Peijnenburg, Angela Serra, Dario Greco, Georgia Melagraki, Iseult Lynch, Antreas Afantitis
Pubblicato in: Computational and Structural Biotechnology Journal, Numero 25, 2026, ISSN 2001-0370
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1016/J.CSBJ.2024.10.018

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Autori: Marta Sendra, Martina Štampar, Katarina Fras, Beatriz Novoa, Antonio Figueras, Bojana Žegura
Pubblicato in: Environment International, Numero 171, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107721

G × E interactions as a basis for toxicological uncertainty

Autori: Ilinca Suciu, David Pamies, Roberta Peruzzo, Petra H. Wirtz, Lena Smirnova, Giorgia Pallocca, Christof Hauck, Mark T. D. Cronin, Jan G. Hengstler, Thomas Brunner, Thomas Hartung, Ivano Amelio, Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 97, 2023, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-023-03500-9

Shinyscreen: mass spectrometry data inspection and quality checking utility

Autori: Todor Kondić, Anjana Elapavalore, Jessy Krier, Adelene Lai, Hiba Mohammed Taha, Mira Narayanan, Emma L. Schymanski
Pubblicato in: Journal of Cheminformatics, Numero 17, 2025, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-025-01044-X

Linking chemicals, genes and morphological perturbations to diseases

Autori: Natacha Cerisier, Bryan Dafniet, Anne Badel, Olivier Taboureau
Pubblicato in: Toxicology and Applied Pharmacology, Numero 461, 2025, ISSN 0041-008X
Editore: Elsevier BV
DOI: 10.1016/J.TAAP.2023.116407

Adolescent exposure to benzophenone ultraviolet filters: cross-sectional associations with obesity, cardiometabolic biomarkers, and asthma/allergy in six European biomonitoring studies

Autori: Francisco M. Peinado, Ainhoa Pérez-Cantero, Alicia Olivas-Martínez, Lydia Espín-Moreno, Tomás de Haro, Luis D. Boada, Andrea Rodríguez-Carrillo, Eva Govarts, Susana Pedraza-Díaz, Marta Esteban-López, Ludek Blaha, Lucie Blahova, Beata Janasik, Wojciech Wasowicz, Sanna Lignell, Loïc Rambaud, Margaux Riou, Clémence Fillol, Sébastien Denys, Aline Murawski, Anne Lise Brantsæter, Amrit Kaur Sakhi, Nina Iszatt, Greet Schoeters, Marike Kolossa-Gehring, Mariana F. Fernández, Vicente Mustieles
Pubblicato in: Environmental Research, Numero 280, 2025, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2025.121912

Proteome Coverage after Simultaneous Proteo-Metabolome Liquid–Liquid Extraction

Autori: Alienke van Pijkeren, Anna-Sophia Egger, Madlen Hotze, Elisabeth Zimmermann, Tobias Kipura, Julia Grander, André Gollowitzer, Andreas Koeberle, Rainer Bischoff, Kathrin Thedieck, Marcel Kwiatkowski
Pubblicato in: Journal of Proteome Research, Numero 22, 2023, ISSN 1535-3893
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPROTEOME.2C00758

Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation

Autori: Betul Danisman, Betul Cicek, Serkan Yildirim, Ismail Bolat, Deniz Kantar, Kirill S. Golokhvast, Dragana Nikitovic,Aristidis Tsatsakis and Ali Taghizadehghalehjoughi
Pubblicato in: BIOMEDICINES, Numero 11, 2023
Editore: MDPI
DOI: 10.3390/BIOMEDICINES11030829

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

Autori: Deepika Deepika, andVikas Kumar
Pubblicato in: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2023
Editore: MDPI
DOI: 10.3390/IJERPH20043473

Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees

Autori: Humblenoble Stembridge Ayuk, Arkadiusz Pierzchalski, Tamara Tal, Oddvar Myhre, Birgitte Lindeman, Nicola Margareta Smith, Violeta Stojanovska, Ana Claudia Zenclussen
Pubblicato in: Environment International, Numero 198, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109409

Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies

Autori: Camilla Svendsen, Paul Whaley, Gunn E. Vist, Trine Husøy, Anna Beronius, Emma Di Consiglio, Ingrid Druwe, Thomas Hartung, Vasiliki I. Hatzi, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Joshua F. Robinson,Erwin Roggen,Andrew A. Rooneyq, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken and Gro H. Mathisen
Pubblicato in: Evidence-Based Toxicology, Numero 1, 2023
Editore: TAYLOR AND FRANCIS
DOI: 10.1080/2833373X.2023.2232415

Next generation risk assessment and new approach methodologies for safe and sustainable by design chemicals and materials: Perspectives and challenges for occupational health

Autori: Veruscka Leso, Bernd Nowack, Achilleas Karakoltzidis, Fotini Nikiforou, Spyros Karakitsios, Denis Sarigiannis, Ivo Iavicoli
Pubblicato in: Toxicology, Numero 517, 2025, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/J.TOX.2025.154211

SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex

Autori: Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Jules Imler, Céline Tomkiewicz-Raulet, Etienne B Blanc, Robert Barouki, Xavier Coumoul, Sylvie Bortol
Pubblicato in: 2023
Editore: PUBMED
DOI: 10.1016/J.ENVINT.2023.108219

Regulatory and practical considerations on the implementation of a mixture allocation factor in REACH

Autori: Gabriele Treu, Jona Schulze, Wiebke Galert, Enken Hassold
Pubblicato in: Environmental Sciences Europe, Numero 36, 2024, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-024-00910-Z

S2CIE: semantic, syntactic, and context-based information extraction for AOP development

Autori: Saurav Kumar, Shubh Sharma, Deepika Deepika, Judit Biosca-Brull, Antonio Moreno, Vikas Kumar
Pubblicato in: Environment International, Numero 207, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109986

nanoPharos: A case study on FAIR (Nano)material (Meta)data management

Autori: Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Iseult Lynch, Antreas Afantitis
Pubblicato in: NanoImpact, Numero 41, 2026, ISSN 2452-0748
Editore: Elsevier BV
DOI: 10.1016/J.IMPACT.2025.100602

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autori: Ilinca Suciu, Johannes Delp, Simon Gutbier, Anna-Katharina Ückert, Anna-Sophie Spreng, Philipp Eberhard, Christiaan Karreman, Falk Schreiber, Katrin Madjar, Jörg Rahnenführer, Ivana Celardo, Ivano Amelio and Marcel Leist
Pubblicato in: antioxidants, Numero 12, 2022
Editore: MDPI
DOI: 10.3390/ANTIOX12010164

EU roadmap for phasing out animal testing for chemical safety assessments: Recommendations from a multi-stakeholder roundtable

Autori: Laurence Walder*, Giorgia Pallocca, Luisa F. Bastos, Manon Beekhuijzen, François Busquet, Helder Constantino, Marco Corvaro, Lilas Courtot, Beate Escher, Rebeca Fernandez, Emeline Gougeon, Love Hansell, Matthias Herzler, Laura Holden, Romana Hornek-Gauste
Pubblicato in: ALTEX, 2024, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2503241

Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

Autori: David Pamies, Jason Ekert, Marie-Gabrielle Zurich, Olivier Frey, Sophie Werner, Monica Piergiovanni, Benjamin S. Freedman, Adrian Kee Keong Teo, Hendrik Erfurth, Darwin R. Reyes, Peter Loskill, Pelin Candarlioglu, Laura Suter-Dick, Shan Wang, Thomas Hartung, Sandra Coecke, Glyn N. Stacey, Beren Atac Wagegg, Eva-Maria Dehne, Francesca Pistollato, Marcel Leist
Pubblicato in: Stem Cell Reports, Numero 19, 2024, ISSN 2213-6711
Editore: Elsevier BV
DOI: 10.1016/J.STEMCR.2024.03.009

Ecotoxicological Evaluation of Bisphenol A and Alternatives: A Comprehensive In Silico Modelling Approach

Autori: Liadys Mora Lagares, Marjan Vračko
Pubblicato in: Journal of Xenobiotics, Numero 13, 2025, ISSN 2039-4713
Editore: MDPI AG
DOI: 10.3390/JOX13040046

A review on aquatic toxins - Do we really know it all regarding the environmental risk posed by phytoplankton neurotoxins?

Autori: Albano Pinto, Maria João Botelho, Catarina Churro, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira
Pubblicato in: Journal of Environmental Management, Numero 345, 2025, ISSN 0301-4797
Editore: Elsevier BV
DOI: 10.1016/J.JENVMAN.2023.118769

Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study

Autori: Mirjam Luijten, R Corinne Sprong, Emiel Rorije, Leo T M van der Ven
Pubblicato in: Numero 19, 2022
Editore: FRONTIERS
DOI: 10.3389/FTOX.2022.933197

Unveiling Landscape‐Level Drivers of Freshwater Biodiversity Dynamics

Autori: Niamh Eastwood, Arron Watson, Jiarui Zhou, Luisa Orsini
Pubblicato in: Environmental DNA, Numero 7, 2025, ISSN 2637-4943
Editore: Wiley
DOI: 10.1002/EDN3.70058

Advancing transcriptomics-based mechanistic assessment of nephrotoxicity in vitro using the human RPTEC/TERT1 TXG-MAPr gene co-expression network

Autori: Hugo W van Kessel, Steven J Kunnen, Giulia Callegaro, Bob van de Water
Pubblicato in: Toxicological Sciences, Numero 209, 2026, ISSN 1096-6080
Editore: Oxford University Press (OUP)
DOI: 10.1093/TOXSCI/KFAF159

IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by Bisphenol A

Autori: Mengmei Ni, Deepika Deepika, Xiaomeng Li, Wei Xiong, Lishi Zhang, Jinyao Chen, Vikas Kumar
Pubblicato in: Environmental Research, Numero 240, 2025, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2023.117343

Ultra-low esfenvalerate exposure may disrupt interspecific competition

Autori: Florian Schunck, Matthias Liess
Pubblicato in: Science of The Total Environment, Numero 906, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.167455

A rapid, simple and high-throughput LC-HRMS workflow for contaminants analysis in distilled alcoholic beverages and associated consumers risk assessment

Autori: Alessandro Rozzoni, Deborah E. Martin, Jean-Charles Leblanc, Yassine Makni, Julien Parinet
Pubblicato in: Food Control, Numero 187, 2026, ISSN 0956-7135
Editore: Elsevier BV
DOI: 10.1016/J.FOODCONT.2026.112178

Modeling ferroptosis in human dopaminergic neurons: Pitfalls and opportunities for neurodegeneration research

Autori: Nadine Renner, Franziska Schöb, Regina Pape, Ilinca Suciu, Anna-Sophie Spreng, Anna-Katharina Ückert, Eike Cöllen, Federica Bovio, Bruno Chilian, Johannes Bauer, Stefan Röpcke, Jörg Bergemann, Marcel Leist, Stefan Schildknecht
Pubblicato in: Redox Biology, Numero 73, 2024, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/J.REDOX.2024.103165

A cognitive and sensory approach based on workshops using the zebrafish model promotes the discovery of life sciences in the classroom

Autori: Laure M Bourcier, Patrick J Babin
Pubblicato in: Biology Methods and Protocols, Numero 9, 2024, ISSN 2396-8923
Editore: Oxford University Press (OUP)
DOI: 10.1093/BIOMETHODS/BPAE092

Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans

Autori: Raju Prasad Sharma, Elsje J. Burgers, Joost B. Beltman
Pubblicato in: Pharmaceutics, Numero 15, 2025, ISSN 1999-4923
Editore: MDPI AG
DOI: 10.3390/PHARMACEUTICS15092199

Controversy on health-based guidance values for bisphenol A—the need of criteria for studies that serve as a basis for risk assessment

Autori: Marcel Leist, Andrea Buettner, Patrick Diel, Gerhard Eisenbrand, Bernd Epe, Petra Först, Tilman Grune, Dirk Haller, Volker Heinz, Michael Hellwig, Hans-Ulrich Humpf, Henry Jäger, Sabine E. Kulling, Angela Mally, Doris Marko, Ute Nöthlings, Elke Röhrdanz, Joachim Spranger, Stefan Vieths, Wim Wätjen, Jan G. Hengstler
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Editore: Springer Science and Business Media LLC
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Early-stage quality—late-stage confidence: Neural induction quality control as a key to reproducible MEA-based neurotoxicity assays

Autori: Ilka Scharkin, Jochen Dobner, Nadine Pierchala, Kristina Bartmann, Ulrike Hübenthal, Farina Bendt, Gabriele Brockerhoff, Andrea Rossi, Ellen Fritsche, Julia Tigges, Katharina Koch
Pubblicato in: NeuroToxicology, Numero 114, 2026, ISSN 0161-813X
Editore: Elsevier BV
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A Systematic Workflow for Compliance Testing of Emerging International Classwide Restrictions on PFAS

Autori: Robin Vestergren, Anders Appelblom, Simona A. Bălan, Sicco H. Brandsma, Thomas A. Bruton, Ian T. Cousins, Jeremy R. Gauthier, Audun Heggelund, Jenny Ivarsson, Anna Kärrman, Lisa Melymuk, Chijioke Olisah, Amanda Rosen, Eleni K. Savvidou, Steffen Schellenberger, Lisa Skedung, Petteri Talasniemi, Tonie Wickman, Jonathan Zweigle, Christian Zwiener, Jonathan P. Benskin
Pubblicato in: Environmental Science & Technology, 2024, ISSN 0013-936X
Editore: American Chemical Society (ACS)
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Human and zebrafish mineralocorticoid receptors reporter cell assays to assess the activity of chemicals

Autori: Anna Toso, Abdelhay Boulahtouf, Marina Grimaldi, Audrey Sansaloni, Yoshinao Katsu, Michael E. Baker, Aurélie Escande, Clémentine Garoche, Selim Aït-Aïssa, Patrick Balaguer
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Latent pesticide effects and their mechanisms

Autori: Matthias Liess, Jonas Gröning
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Editore: ELSEVIER
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Enhancing data interoperability in human biomonitoring studies: the HBM data toolkit

Autori: Ruben Peeters, Laura Rodriguez Martin, Fen Zhang, Hanny Willems, Liese Gilles, Jan Theunis, Jos Bessems, Caio Mescouto Terra de Souza, Stijn Baken, Dirk Devriendt, Eva Govarts
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Mechanistic Insights of BPA Alternatives on PPARγ Binding and the Consequence on Adipocyte Differentiation

Autori: Daniela Flores Gomez, Nikita Korpel, Marina Grimaldi, Coralie Carivenc, Patrick Balaguer, William Bourguet, Jorke H. Kamstra
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Editore: American Chemical Society (ACS)
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Assessing the impact of waste co-incineration at the Anhovo cement plant (Slovenia) on the regional cancer burden

Autori: Vesna Zadnik, Mojca Birk, Teja Oblak, Maja Jurtela, Sonja Tomsic, Katarina Lokar, Ana Mihor, Nika Bric, Miran Mlakar, Amela Duratovic Konjevic, Tina Zagar
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Zebra_K+ : High-throughput analysis of acoustic startle response plasticity in zebrafish embryos and larvae in neurotoxicity testing

Autori: Niki Tagkalidou, Ouwais Aljabasini, Sergi Pujol, Eva Prats, Josep Maria Porta, Carlos Barata, Demetrio Raldúa
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Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of In Vitro Studies

Autori: Gro H. Mathisen, Gunn E. Vist, Paul Whaley, Richard A. White, Trine Husøy, Heather M. Ames, Anna Beronius, Emma Di Consiglio, Ingrid Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Camilla Svendsen
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Editore: Informa UK Limited
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Cell Painting: a decade of discovery and innovation in cellular imaging

Autori: Srijit Seal, Maria-Anna Trapotsi, Ola Spjuth, Shantanu Singh, Jordi Carreras-Puigvert, Nigel Greene, Andreas Bender, Anne E. Carpenter
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Curated mode-of-action data and effect concentrations for chemicals relevant for the aquatic environment

Autori: Lena Kramer, Tobias Schulze, Nils Klüver, Rolf Altenburger, Jörg Hackermüller, Martin Krauss, Wibke Busch
Pubblicato in: Scientific Data, Numero 11, 2024, ISSN 2052-4463
Editore: Springer Science and Business Media LLC
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Further development of CometChip technology to measure DNA damage in vitro and in vivo: Comparison with the 2 gels/slide format of the standard and enzyme-modified comet assay

Autori: Miguel Collia, Peter Møller, Sabine A.S. Langie, Ariane Vettorazzi, Amaya Azqueta
Pubblicato in: Toxicology, Numero 501, 2025, ISSN 0300-483X
Editore: Elsevier BV
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A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment

Autori: Liza-Marie Beckers, Rolf Altenburger, Werner Brack, Beate I. Escher, Jörg Hackermüller, Enken Hassold, Gianina Illing, Martin Krauss, Janet Krüger, Paul Michaelis, Andreas Schüttler, Sarah Stevens, Wibke Busch
Pubblicato in: Environment International, Numero 179, 2023
Editore: ELSEVIER
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A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

Autori: P. Marx-Stoelting, G. Rivière, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Cañas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. Norager, A. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle and P. Sanders
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Editore: springer
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Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation

Autori: Jiaqi Chen, Shensheng Zhao, Sebastiaan Wesseling, Nynke I. Kramer, Ivonne M.C.M. Rietjens, Hans Bouwmeester
Pubblicato in: Environmental Science & Technology, Numero 57, 2023, ISSN 0013-936X
Editore: American Chemical Society (ACS)
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Quantifying the effect of human interindividual kinetic differences on the relative potency value for riddelliine N-oxide at low dose levels by a new approach methodology

Autori: F. Widjaja-van den Ende, M.A.J.S. van Boekel, C. Davis, S. Wesseling, I.M.C.M. Rietjens
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 156, 2025, ISSN 0273-2300
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CLUSplus: A decision tree-based framework for predicting structured outputs

Autori: Matej Petković, Jurica Levatić, Dragi Kocev, Martin Breskvar, Sašo Džeroski
Pubblicato in: SoftwareX, Numero 24, 2025, ISSN 2352-7110
Editore: Elsevier BV
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Use of Physiologically Based Kinetic Modeling to Predict Deoxynivalenol Metabolism and Its Role in Intestinal Inflammation and Bile Acid Kinetics in Humans

Autori: Jingxuan Wang, Veronique de Bruijn, Ivonne M.C.M. Rietjens, Nynke I. Kramer, Hans Bouwmeester
Pubblicato in: Journal of Agricultural and Food Chemistry, Numero 72, 2024, ISSN 0021-8561
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.JAFC.3C07137

Impact of chemical mixtures from wastewater treatment plant effluents on human immune cell activation: An effect-based analysis

Autori: Ambra Maddalon, Arkadiusz Pierzchalski, Jannike Lea Krause, Mario Bauer, Saskia Finckh, Werner Brack, Ana C. Zenclussen, Marina Marinovich, Emanuela Corsini, Martin Krauss, Gunda Herberth
Pubblicato in: Science of The Total Environment, Numero 906, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.167495

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Autori: Ilinca Suciu, Johannes Delp, Simon Gutbier, Julian Suess, Lars Henschke, Ivana Celardo, Thomas U. Mayer, Ivano Amelio, Marcel Leist
Pubblicato in: Antioxidants, Numero 13, 2025, ISSN 2076-3921
Editore: MDPI AG
DOI: 10.3390/ANTIOX13010049

Considering degradation kinetics of pesticides in plant uptake models: proof of concept for potato

Autori: Zijian Li, Peter Fantke
Pubblicato in: Pest Management Science, Numero 79, 2025, ISSN 1526-498X
Editore: Wiley
DOI: 10.1002/PS.7288

A conceptual framework for landscape-based environmental risk assessment (ERA) of pesticides

Autori: Jose V. Tarazona, Mercedes de Alba-Gonzalez, Carole Bedos, Pierre Benoit, Colette Bertrand, Olivier Crouzet, Cécile Dagès, Jean-Lou CM Dorne, Ana Fernandez-Agudo, Andreas Focks, Maria del Carmen Gonzalez-Caballero, Alexandra Kroll, Matthias Liess, Susana Loureiro, Manuel E. Ortiz-Santaliestra, Jes J. Rasmussen, Raphaël Royauté, Maj Rundlöf, Ralf B. Schäfer, Stephen Short, Ayesha Siddique, José Paulo Sousa, Dave Spurgeon, Pierre-François Staub, Chris J. Topping, Marc Voltz, Johan Axelman, Annette Aldrich, Sabine Duquesne, Vanessa Mazerolles, Yann Devos
Pubblicato in: Environment International, Numero 191, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108999

MIND: a proposed strategic and collaborative platform for advancing chemical environmental risk assessment

Autori: Yann Devos, Johan Axelman, Annette Aldrich, Nicole Bandow, Kristina Christensen, Sabine Duquesne, Matthias Herzler, Magnus Løfstedt, Vanessa Mazerolles, Natasha Mølgaard, Luisa Orsini, Silvia Pieper, Christophe Rousselle, Pascal Sanders, Christopher John Topping, Gabriele Treu, Maria Uhl, Nico van den Brink, James Henty Williams, Romana Hornek-Gausterer
Pubblicato in: Environmental Sciences Europe, Numero 38, 2026, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-025-01324-1

Insights from an invited expert panel using a World Café: Establishing a national human biomonitoring programme communication strategy

Autori: Richa Singh, Darragh Doherty, Sewon Lee, Conor Buggy, Holger Martin Koch, Marike Kolossa-Gehring, Alison Connolly
Pubblicato in: Environment International, Numero 208, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.110040

AOP-helpFinder 2.0: Integration of an event-event searches module

Autori: Thomas Jaylet, Thibaut Coustillet, Florence Jornod, Patricia Margaritte-Jeannin, Karine Audouze
Pubblicato in: 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108017

Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure

Autori: Francisco M. Peinado, Alicia Olivas-Martínez, Inmaculada Lendínez, Luz M. Iribarne-Durán, Josefa León, Mariana F. Fernández, Rafael Sotelo, Fernando Vela-Soria, Nicolás Olea, Carmen Freire, Olga Ocón-Hernández, Francisco Artacho-Cordón
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS242316678

An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process

Autori: Leist, Marcel; Tangianu, Silvia; Affourtit, Femke; Braakhuis, Hedwig; Colbourne, John; Cöllen, Eike; Dreser, Nadine; Escher, Sylvia E.; Gardner, Iain; Hahn, Stefan; Hardy, Barry; Herzler, Matthias; Islam, Barira; Kamp, Hennicke; Magel, Viktoria; Marx-Stoe
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2509081

Age-specific DNA methylation alterations in sperm at imprint control regions may contribute to the risk of autism spectrum disorder in offspring

Autori: Eugenia Casella, Jana Depovere, Chantal Delger, Mariia Butynets, Philipp Antczak, Thomas Price, Randy L. Jirtle, Susan K. Murphy, Cathrine Hoyo, Adelheid Soubry
Pubblicato in: Aging, Numero 17, 2026, ISSN 1945-4589
Editore: Impact Journals, LLC
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Combined chronic dietary exposure to four nephrotoxic metals exceeds tolerable intake levels in the adult population of 10 European countries

Autori: R. Corinne Sprong, Annick D. van den Brand, Gerda van Donkersgoed, Urska Blaznik, Despo Christodoulou, Amélie Crépet, Maria da Graça Dias, Bodil Hamborg Jensen, Angelo Morretto, Elke Rauscher-Gabernig, Jiri Ruprich, Darja Sokolić, Jacob D. van Klaveren, Mirjam Luijten, Marcel J. B. Mengelers
Pubblicato in: Food Additives & Contaminants: Part A, Numero 40, 2024, ISSN 1944-0049
Editore: Informa UK Limited
DOI: 10.1080/19440049.2023.2272716

"""Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain)"""

Autori: Eva Junqu´e a,b, Adonina Tard´on c,d,e, Ana Fernandez-Somoano c,d,e, Joan O. Grimalt a,*
Pubblicato in: Environmental Research, Numero 214 (2022) 113862, 2022, ISSN 0013-9351
Editore: Elsevier
DOI: 10.1016/j.envres.2022.113862

A human next generation PBK model for PFOA

Autori: Chrysanthi Pachoulide, Carolina Vogs, Aude Ratier, Jack Koster, Trine Husøy, Martine Vrijheid, Yiyi Xu, Antonios Georgelis, Karl Forsell, Joost Westerhout, Nynke I. Kramer
Pubblicato in: Environment International, Numero 209, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110161

FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation

Autori: Maryam Zare Jeddi, Karen S. Galea, Susana Viegas, Peter Fantke, Henriqueta Louro, Jan Theunis, Eva Govarts, Sébastien Denys, Clémence Fillol, Loïc Rambaud, Marike Kolossa-Gehring, Tiina Santonen, Hilko van der Voet, Manosij Ghosh, Carla Costa, João Paulo Teixeira, Hans Verhagen, Radu-Corneliu Duca, An Van Nieuwenhuyse, Kate Jones, Craig Sams, Ovnair Sepai, Giovanna Tranfo, Martine Bakker, Nicole Palmen, Jacob van Klaveren, Paul T. J. Scheepers, Alicia Paini, Cristina Canova, Natalie von Goetz, Andromachi Katsonouri, Spyros Karakitsios, Dimosthenis A. Sarigiannis, Jos Bessems, Kyriaki Machera, Stuart Harrad, Nancy B. Hopf
Pubblicato in: Frontiers in Toxicology, Numero 5, 2023, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2023.1116707

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Autori: Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Pubblicato in: Cell Stress, Numero 6, 2022, ISSN 2523-0204
Editore: Shared Science Publishers OG
DOI: 10.15698/CST2022.08.270

The European exposure science strategy 2020–2030

Autori: Peter Fantke, Yuri Bruinen de Bruin, Urs Schlüter, Alison Connolly, Jos Bessems, Stylianos Kephalopoulos, Maryam Zare Jeddi, An van Nieuwenhuyse, Tatsiana Dudzina, Paul T.J. Scheepers, Natalie von Goetz
Pubblicato in: Environment International, Numero 170, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2022.107555

Toxicity of true-to-life microplastics to human iPSC-derived intestinal epithelia correlates to their protein corona composition

Autori: Hugo Brouwer, Mathias Busch, Shuo Yang, Tom Venus, Germaine Aalderink, Juan Francisco Ferrer Crespo, Aliro Villacorta, Alba Hernández, Irina Estrela-Lopis, Sjef Boeren, Hans Bouwmeester
Pubblicato in: Journal of Hazardous Materials, Numero 495, 2025, ISSN 0304-3894
Editore: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.138908

Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation

Autori: Betul Danisman, Betul Cicek, Serkan Yildirim, Ismail Bolat, Deniz Kantar, Kirill S. Golokhvast, Dragana Nikitovic, Aristidis Tsatsakis, Ali Taghizadehghalehjoughi
Pubblicato in: Biomedicines, Numero 11, 2025, ISSN 2227-9059
Editore: MDPI AG
DOI: 10.3390/BIOMEDICINES11030829

Multi-behavioral fingerprints can identify potential modes of action for neuroactive environmental chemicals

Autori: Nadia K. Herold, Sebastian Gutsfeld, David Leuthold, Chloe Wray, Julia Spath, Tamara Tal
Pubblicato in: NeuroToxicology, Numero 108, 2026, ISSN 0161-813X
Editore: Elsevier BV
DOI: 10.1016/J.NEURO.2025.05.001

A review on aquatic toxins - Do we really know it all regarding the environmental risk posed by phytoplankton neurotoxins?

Autori: Albano Pinto, Maria João Botelho, Catarina Churro, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira
Pubblicato in: Journal of Environmental Management, Numero 345, 2023
Editore: ELSEVIER
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Elements and development processes for test methods in toxicology and human health-relevant life science research

Autori: Cöllen, Eike; Tanaskov, Yaroslav; Holzer, Anna-Katharina; Dipalo, Michele; Schäfer, Jasmin; Kraushaar, Udo; Leist, Marcel
Pubblicato in: ALTEX, 2024, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2401041

Identifying human toxicodynamic variability: A systematic evidence map of the current knowledge

Autori: Annika Boye Petersen, Lea Bredsdorff, Natasha Tahir, Marije Niemeijer, George E.N. Kass, Aiste Vitkauskaite, Matthijs Moerland, Frederic Y. Bois, Nadia Quignot, Bob van de Water, Susanne Hougaard Bennekou
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 161, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105842

Glyphosate and AMPA in saliva and other traditional human matrices. New findings for less invasive biomonitoring to the exposure to pesticides

Autori: Iohanna Filippi, Pilar Fernández, Joan O. Grimalt, Mariana Butinof, María V. Amé, Sonia E. Muñoz
Pubblicato in: Environmental Advances, Numero 15, 2025, ISSN 2666-7657
Editore: Elsevier BV
DOI: 10.1016/J.ENVADV.2023.100474

Can a tiered next generation risk assessment framework bridge human health and environmental risk assessment? Insights from pyrethroids in wild mammals

Autori: Ana Fernandez-Agudo, Jose V. Tarazona
Pubblicato in: Science of The Total Environment, Numero 1024, 2026, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2026.181631

Benchmarking environmental risks of plant protection products: Toward a comparative and systems-based approach in the EU pesticide regulation

Autori: Paul N. Ozoh, Johan Axelman, Annette Aldrich, Sabine Duquesne, Jonathan Jupke, Matthias Liess, Paula Scharlach, Ayesha Siddique, Susana Loureiro, Ralf B. Schäfer
Pubblicato in: Environment International, Numero 207, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.110013

Safety and sustainability by design: An explorative survey on concepts’ knowledge and application

Autori: Veruscka Leso, Tomas Rydberg, Maja Halling, Spyros Karakitsios, Fotini Nikiforou, Achilleas Karakoltzidis, Denis A. Sarigiannis, Ivo Iavicoli
Pubblicato in: Environmental Science & Policy, Numero 162, 2024, ISSN 1462-9011
Editore: Elsevier BV
DOI: 10.1016/J.ENVSCI.2024.103909

Genetic and epigenetic biomarkers in human biomonitoring: why needed and how can Oxford Nanopore sequencing contribute?

Autori: Mathieu Gand, Adelheid Soubry, Birgit Mertens, Nancy H. C. Roosens, Sigrid C. J. De Keersmaecker
Pubblicato in: Frontiers in Public Health, Numero 13, 2025, ISSN 2296-2565
Editore: Frontiers Media SA
DOI: 10.3389/FPUBH.2025.1610248

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

Autori: P. Marx-Stoelting, G. Rivière, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Cañas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. Norager, A. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle, P. Sanders
Pubblicato in: Archives of Toxicology, Numero 97, 2023, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-022-03435-7

"""Ecotoxicity characterization of chemicals: Global recommendations and implementation in USEtox"""

Autori: """Mikołaj Owsianiak a, Michael Z. Hauschild a,**, Leo Posthuma b,c, Erwan Saouter d,1, Martina G. Vijver e, Thomas Backhaus f, M´elanie Douziech g,h, Tamar Schlekat i, Peter Fantke a,*"""
Pubblicato in: Chemosphere, Numero 310 (2023) 136807, 2023, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.136807

Cross-mapping of terms used in chemical risk assessment with those used in systematic review: research protocol

Autori: Camilla Svendsen, Gro H. Mathisen, Gunn E. Vist, Trine Husøy, Heather M. Ames, Anna Beronius, Emma Di Consiglio, Ingrid Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Paul Whaley
Pubblicato in: Evidence-Based Toxicology, Numero 2, 2025, ISSN 2833-373X
Editore: Informa UK Limited
DOI: 10.1080/2833373X.2024.2371285

Mechanism-based drug safety testing using innovative in vitro liver models: from DILI prediction to idiosyncratic DILI liability assessment

Autori: Sibel Bahtiri, Tessa M. S. Hagens, Bob van de Water, Marije Niemeijer
Pubblicato in: Expert Opinion on Drug Metabolism & Toxicology, Numero 21, 2025, ISSN 1742-5255
Editore: Informa UK Limited
DOI: 10.1080/17425255.2025.2516051

Challenges and Future Directions in Assessing the Quality and Completeness of Advanced Materials Safety Data for Re‐Usability: A Position Paper From the Nanosafety Community

Autori: Verónica I. Dumit, Irini Furxhi, Penny Nymark, Antreas Afantitis, Ammar Ammar, Monica J. B. Amorim, Dalila Antunes, Svetlana Avramova, Chiara L. Battistelli, Gianpietro Basei, Cecilia Bossa, Emil Cimpan, Mihaela Roxana Cimpan, Dmitri Ciornii, Anna Costa, Camilla Delpivo, Maria Dusinska, Ana Sofia Fonseca, Steffi Friedrichs, Vasile‐Dan Hodoroaba, Danail Hristozov, Panagiotis Isigonis, Nina Jeliazkova, Nikolay Kochev, Eva Kranjc, Dieter Maier, Georgia Melagraki, Anastasios G. Papadiamantis, Tomasz Puzyn, Hubert Rauscher, Katie Reilly, Araceli Sánchez Jiménez, Janeck J. Scott‐Fordsmand, Neeraj Shandilya, Hyun Kil Shin, Gergana Tancheva, Jeaphianne P. M. van Rijn, Egon L. Willighagen, Ewelina Wyrzykowska, Martine I. Bakker, Damjana Drobne, Thomas E. Exner, Martin Himly, Iseult Lynch
Pubblicato in: Advanced Sustainable Systems, Numero 10, 2026, ISSN 2366-7486
Editore: Wiley
DOI: 10.1002/ADSU.202500567

Toward Product Safety and Circularity: Understanding the Information Structure of Global Databases on Chemicals in Products and Articles

Autori: Chijioke Olisah, Lisa Melymuk, Robin Vestergren, Karin Rumar, Tonie Wickman, Nina Melander, Petteri Talasniemi, Sicco Brandsma, Urban Boije af Gennäs, Martin Scheringer
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.4C07992

The mixture assessment or allocation factor: conceptual background, estimation algorithms and a case study example

Autori: Thomas Backhaus
Pubblicato in: Environmental Sciences Europe, Numero 35, 2023, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-023-00757-W

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Autori: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Pubblicato in: Environment International, Numero 180, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108229

Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption

Autori: Patricia Rannaud-Bartaire, Anni Herranen, Giovanni Levi, Barbara Demeneix, Jean-Baptiste Fini
Pubblicato in: Current Opinion in Endocrine and Metabolic Research, Numero 42, 2026, ISSN 2451-9650
Editore: Elsevier BV
DOI: 10.1016/J.COEMR.2026.100597

Potential for Machine Learning to Address Data Gaps in Human Toxicity and Ecotoxicity Characterization

Autori: Kerstin von Borries, Hanna Holmquist, Marissa Kosnik, Katie V. Beckwith, Olivier Jolliet, Jonathan M. Goodman, Peter Fantke
Pubblicato in: Environmental Science & Technology, Numero 57, 2023, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.3C05300

Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain)

Autori: Eva Junqué, Adonina Tardón, Ana Fernandez-Somoano, Joan O. Grimalt
Pubblicato in: Environmental Research, Numero 214, 2026, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2022.113862

Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis

Autori: Sarah Lennon, Jade Chaker, Elliott J. Price, Juliane Hollender, Carolin Huber, Tobias Schulze, Lutz Ahrens, Frederic Béen, Nicolas Creusot, Laurent Debrauwer, Gaud Dervilly, Catherine Gabriel, Thierry Guérin, Baninia Habchi, Emilien L. Jamin, Jana Klánová, Tina Kosjek, Bruno Le Bizec, Jeroen Meijer, Hans Mol, Rosalie Nijssen, Herbert Oberacher, Nafsika Papaioannou, Julien Parinet, Dimosthenis Sarigiannis, Michael A. Stravs, Žiga Tkalec, Emma L. Schymanski, Marja Lamoree, Jean-Philippe Antignac, Arthur David
Pubblicato in: TrAC Trends in Analytical Chemistry, Numero 174, 2024, ISSN 0165-9936
Editore: Elsevier BV
DOI: 10.1016/J.TRAC.2024.117674

Quo vadis human biomonitoring?

Autori: Gabriele Sabbioni
Pubblicato in: Chemico-Biological Interactions, Numero 419, 2026, ISSN 0009-2797
Editore: Elsevier BV
DOI: 10.1016/J.CBI.2025.111643

In vitro to in vivo extrapolation modeling to facilitate the integration of transcriptomics data into genotoxicity assessment

Autori: Anouck Thienpont, Eunnara Cho, Andrew Williams, Matthew J. Meier, Carole L. Yauk, Marc A. Beal, Freddy Van Goethem, Vera Rogiers, Tamara Vanhaecke, Birgit Mertens
Pubblicato in: Toxicology, Numero 515, 2026, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/J.TOX.2025.154165

Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation

Autori: André Gollowitzer, Helmut Pein, Zhigang Rao, Lorenz Waltl, Leonhard Bereuter, Konstantin Loeser, Tobias Meyer, Vajiheh Jafari, Finja Witt, René Winkler, Fengting Su, Silke Große, Maria Thürmer, Julia Grander, Madlen Hotze, Sönke Harder, Lilia Espada, Alexander Magnutzki, Ronald Gstir, Christina Weinigel, Silke Rummler, Günther Bonn, Johanna Pachmayr, Maria Ermolaeva, Takeshi Harayama, Hartmut Schlüter, Christian Kosan, Regine Heller, Kathrin Thedieck, Michael Schmitt, Takao Shimizu, Jürgen Popp, Hideo Shindou, Marcel Kwiatkowski, Andreas Koeberle
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-56711-2

Link prediction in complex network using information flow

Autori: Furqan Aziz, Luke T. Slater, Laura Bravo-Merodio, Animesh Acharjee, Georgios V. Gkoutos
Pubblicato in: Scientific Reports, Numero 13, 2023, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-023-41476-9

Determination of glyphosate and its derivative, aminomethylphosphonic acid, in human urine by gas chromatography coupled to tandem mass spectrometry and isotope pattern deconvolution

Autori: Eva Junqué, Pilar Fernández, Iohanna Filippi, Joan O. Grimalt
Pubblicato in: Journal of Chromatography Open, Numero 4, 2024, ISSN 2772-3917
Editore: Elsevier BV
DOI: 10.1016/J.JCOA.2023.100087

Mechanistic toxicity profiling of chemicals: A comparative study in 2D and 3D HepaRG models using high-content analysis

Autori: Mariam Saleh, Kevin Hogeveen, Valérie Fessard, Ludovic Le Hégarat
Pubblicato in: Toxicology, Numero 519, 2026, ISSN 0300-483X
Editore: Elsevier BV
DOI: 10.1016/J.TOX.2025.154280

G × E interactions as a basis for toxicological uncertainty

Autori: Ilinca Suciu, David Pamies, Roberta Peruzzo, Petra H Wirtz, Lena Smirnova, Giorgia Pallocca, Christof Hauck, Mark T D Cronin, Jan G Hengstler, Thomas Brunner, Thomas Hartung, Ivano Amelio, Marcel Leist
Pubblicato in: ARCHIVES OF TOCXICOLOGY, Numero 97, 2023
Editore: SPRINGER
DOI: 10.1007/S00204-023-03500-9

Development of historic monthly land use regression models of SO2, NOx and suspended particulate matter for birth cohort ELSPAC

Autori: Ondřej Mikeš, Ondřej Sáňka, Aneta Rafajová, Jelle Vlaanderen, Jie Chen, Gerard Hoek, Jana Klánová, Pavel Čupr
Pubblicato in: Atmospheric Environment, Numero 301, 2025, ISSN 1352-2310
Editore: Elsevier BV
DOI: 10.1016/J.ATMOSENV.2023.119688

Toxicity of bisphenol A alternatives: A study on bisphenol E in two generations of the freshwater snail Lymnaea stagnalis

Autori: Gaëtan Y. Tucoo, Jane E. Morthorst, Elvis Genbo Xu, Henrik Holbech
Pubblicato in: Aquatic Toxicology, Numero 290, 2025, ISSN 0166-445X
Editore: Elsevier BV
DOI: 10.1016/J.AQUATOX.2025.107641

Introducing artificial intelligence and sperm epigenetics in the fertility clinic: a novel foundation for diagnostics and prediction modelling

Autori: Adelheid Soubry
Pubblicato in: Frontiers in Reproductive Health, Numero 7, 2025, ISSN 2673-3153
Editore: Frontiers Media SA
DOI: 10.3389/FRPH.2025.1506312

Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure

Autori: Yourdasmine Ali Daoud, Cleo Tebby, Rémy Beaudouin, Céline Brochot
Pubblicato in: Toxicology and Applied Pharmacology, Numero 476, 2025, ISSN 0041-008X
Editore: Elsevier BV
DOI: 10.1016/J.TAAP.2023.116651

Clustering of bisphenols based on toxicity predictions for key aquatic species: Daphnia magna, Pimephales promelas, and Oryzias latipes

Autori: Marjan Vračko, Liadys Mora Lagares
Pubblicato in: Ecotoxicology and Environmental Safety, Numero 295, 2025, ISSN 0147-6513
Editore: Elsevier BV
DOI: 10.1016/J.ECOENV.2025.118149

Species composition and ecological structure of ground beetles (Coleoptera, Carabidae) communities as biological indicators of the agro-environmental sustainability

Autori: K. Yu Maksimovich, R. Yu Dudko b, E.I. Shatalova, A.K. Tsakalof, A.M. Tsatsakis, K.S. Golokhvast, E.A. Novikov
Pubblicato in: Environmental Research, Numero 234, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVRES.2023.116030

"""Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals"""

Autori: """Mikołaj Owsianiak a, Michael Z. Hauschild a,**, Leo Posthuma b,c, Erwan Saouter d,1, Martina G. Vijver e, Thomas Backhaus f, M´elanie Douziech g,h, Tamar Schlekat i, Peter Fantke a,*"""
Pubblicato in: Chemosphere, Numero 311 (2023) 137035, 2023, ISSN 0045-6535
Editore: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Nontargeted Urinary Profiling Strategy for Endocrine-Disrupting Chemicals in Women with Ovarian Malignancies

Autori: Helena Plešnik, Žan Rekar, Stefanela Stevanović, Irma Virant-Klun, Senka Imamović Kumalić, Mateja Sladič, Darja Mazej, Janja Snoj Tratnik, Milena Horvat, Tina Kosjek
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.4C13290

Repeated exposure to polyethylene microplastic mixtures containing PFAS and bisphenols activates THP-1 macrophages with inflammatory features

Autori: Lucas Gaillard, Léo Sportes-Milot, Kloé Debizet, Arnaud Tête, Bruno Saubamea, Doumet Georges Helou, Stéphanie Devineau, Xavier Coumoul, Étienne Blanc, Sylvie Bortoli, Karine Andréau
Pubblicato in: Environmental Pollution, Numero 397, 2026, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2026.127906

Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure

Autori: Francisco M Peinado, Alicia Olivas-Martínez, Inmaculada Lendínez, Luz M Iribarne-Durán, Josefa León, Mariana F Fernández, Rafael Sotelo, Fernando Vela-Soria, Nicolás Olea, Carmen Freire, Olga Ocón-Hernández, Francisco Artacho-Cordón
Pubblicato in: Numero 24,23, 2023
Editore: pubmed
DOI: 10.3390/IJMS242316678

From prioritization to implementation: updating the PARC WP5 project portfolio through the second prioritization round

Autori: Celia Garcia Arenas, Kiara Aiello Holden, Terje Svingen, Dries Knapen, Saadia Kerdine-Römer, Birgitte Lindeman, Nicola M. Smith, Ludovic Le Hegarat, Tamara Vanhaecke, Gilles Rivière, Philip Marx-Stoelting
Pubblicato in: Frontiers in Toxicology, Numero 8, 2026, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2026.1746437

Interdisciplinary Assessment of Children’s Lead Exposure in Residential Areas Degraded by Mining (Upper Meža Valley, Slovenia)

Autori: Špela Bavec, Teja Čeru, Stanislava Kirinčič, Matej Ivartnik, Viviana Golja, Janja Turšič, Klemen Teran, Miloš Miler
Pubblicato in: Exposure and Health, Numero 17, 2025, ISSN 2451-9766
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S12403-025-00716-1

Impact of chemical mixtures from wastewater treatment plant effluents on human immune cell activation: An effect-based analysis

Autori: Ambra Maddalon, Arkadiusz Pierzchalski, Jannike Lea Krause, Mario Bauer, Saskia Finckh, Werner Brack, Ana C. Zenclussen, Marina Marinovich, Emanuela Corsini, Martin Krauss, Gunda Herberth
Pubblicato in: Science of The Total Environment, Numero 906, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2023.167495

Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps

Autori: Thomas Jaylet, Thibaut Coustillet, Nicola M. Smith, Barbara Viviani, Birgitte Lindeman, Lucia Vergauwen, Oddvar Myhre, Nurettin Yarar, Johanna M. Gostner, Pablo Monfort-Lanzas, Florence Jornod, Henrik Holbech, Xavier Coumoul, Dimosthenis A. Sarigiannis, Philipp Antczak, Anna Bal-Price, Ellen Fritsche, Eliska Kuchovska, Antonios K. Stratidakis, Robert Barouki, Min Ji Kim, Olivier Taboureau, Marcin W. Wojewodzic, Dries Knapen, Karine Audouze
Pubblicato in: Frontiers in Toxicology, Numero 6, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2024.1285768

Hazard identification and characterization of leachable chemicals from plastic products – a new PARC project

Autori: Hubert Dirven, Aleksandra Bogusz, Hans Bouwmeester, Mathias Busch, Guillaume Duflos, Gunnar S. Eriksen, Margarida Fardilha, Daniela Flores-Gomez, Nina Franko, Laurent Gaté, Yves Guichard, Maria João Silva, Jorke H. Kamstra, Konstantinos M. Kasiotis, Sunmi Kim, Young Jun Kim, Youngsam Kim, Elise van der Koogh, Susana Loureiro, Henriqueta Louro, Kyriaki Machera, Raymond H. H. Pieters, Anastasia Spyropoulou, Evangelia N. Tzanetou, Catarina Malheiro, Tim Ravnjak, Guillermo Repetto, Gilles Rivière, Chang Seon Ryu, Evgenia Anna Papadopoulou, Konstantinos A. Aliferis, Anita Solhaug, Marija Sollner Dolenc, Martina Štampar, Ana M. Tavares, Knut Erik Tollefsen, Célia Ventura, Radoslaw Walkowiak, Walter Zobl, Bojana Žegura, Igor Snapkow, Dorte Herzke
Pubblicato in: Frontiers in Toxicology, Numero 7, 2025, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2025.1719035

A review on immunomodulatory effects of BPA analogues

Autori: Anja Kodila, Nina Franko, Marija Sollner Dolenc
Pubblicato in: Archives of Toxicology, Numero 97, 2023, ISSN 0340-5761
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00204-023-03519-Y

Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Autori: Francisco Manuel Peinado 1, Luz María Iribarne-Durán 1, Francisco Artacho-Cordón
Pubblicato in: Numero 24,8, 2023
Editore: PUBMED
DOI: 10.3390/IJMS24087325

Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women

Autori: Lucie Bláhová, Tomáš Janoš, Vicente Mustieles, Andrea Rodríguez-Carrillo, Mariana F. Fernández, Luděk Bláha
Pubblicato in: International Journal of Hygiene and Environmental Health, Numero 250, 2025, ISSN 1438-4639
Editore: Elsevier BV
DOI: 10.1016/J.IJHEH.2023.114175

Advancing human health risk assessment: the role of new approach methodologies

Autori: Deepika Deepika, Kanchan Bharti, Shubh Sharma, Saurav Kumar, Rajesh Kumar Pathak, Judit Biosca Brull, Oscar Sabuz, Silvia García Vilana, Vikas Kumar
Pubblicato in: Frontiers in Toxicology, Numero 7, 2025, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2025.1632941

The FAIR AOP roadmap for 2025: Advancing findability, accessibility, interoperability, and re-usability of adverse outcome pathways

Autori: Holly M. Mortensen, Maciej Gromelski, Ginnie Hench, Marvin Martens, Clemens Wittwehr, Saurav Kumar, Vikas Kumar, Karine Audouze, Vassilis Virvilis, Penny Nymark, Michelle Angrish, Iseult Lynch, Stephen Edwards, Barbara Magagna, Marcin W. Wojewodzic
Pubblicato in: Computational Toxicology, Numero 35, 2025, ISSN 2468-1113
Editore: Elsevier BV
DOI: 10.1016/J.COMTOX.2025.100368

Per- and polyfluorinated alkyl substances (PFAS) in the Scheldt Estuary: Insights from target, suspect and non-target screening of water, sediment and bivalves

Autori: Musa Bonso, Francesca Cappelli, Fabian Simon, Katrin Vorkamp, Laetitia Six, Georgios Niarchos, Adrian Covaci, Lieven Bervoets, Thimo Groffen
Pubblicato in: Environmental Pollution, Numero 388, 2026, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2025.127349

A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment

Autori: Liza-Marie Beckers, Rolf Altenburger, Werner Brack, Beate I. Escher, Jörg Hackermüller, Enken Hassold, Gianina Illing, Martin Krauss, Janet Krüger, Paul Michaelis, Andreas Schüttler, Sarah Stevens, Wibke Busch
Pubblicato in: Environment International, Numero 179, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108155

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Autori: Chijioke Olisah, Lisa Melymuk, Ondrej Audy, Petr Kukucka, Petra Pribylova, Martin Boudot
Pubblicato in: Environmental Sciences Europe, Numero 36, 2024, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-024-00999-2

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study

Autori: Tuulia Hyötyläinen, Aidan McGlinchey, Samira Salihovic, Antonia Schubert, Alex Douglas, David C Hay, Peter J O'Shaughnessy, John P Iredale, Sophie Shaw, Paul A Fowler, Matej Orešič
Pubblicato in: The Lancet Planetary Health, Numero 8, 2024, ISSN 2542-5196
Editore: Elsevier BV
DOI: 10.1016/S2542-5196(23)00257-7

Effects of Metabolic Disruption on Lipid Metabolism and Yolk Retention in Zebrafish Embryos

Autori: Rik Boom, Lucia Vergauwen, Dries Knapen
Pubblicato in: Environmental Toxicology and Chemistry, Numero 43, 2025, ISSN 0730-7268
Editore: Oxford University Press (OUP)
DOI: 10.1002/ETC.5930

Challenging Evolutionary Paradigms: Daphnia Populations Resurrected From Unpolluted Environments Show Enhanced Detoxification Ability to Aromatic Pollutants

Autori: Florian Gigl, Muhammad Abdullahi, Sam Benkwitz‐Bedford, Niamh Eastwood, Jiarui Zhou, Henner Hollert, Luisa Orsini
Pubblicato in: Molecular Ecology, Numero 35, 2026, ISSN 0962-1083
Editore: Wiley
DOI: 10.1111/MEC.70272

Exploring the genotoxic potential of Bisphenol A and its emerging alternatives in an advanced in vitro 3D zebrafish hepatic cell model

Autori: Alja Štern, Katja Kološa, Špela Rozman, Bojana Žegura
Pubblicato in: Science of The Total Environment, Numero 1001, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2025.180527

Automated Liquid Handling Extraction and Rapid Quantification of Underivatized Amino Acids and Tryptophan Metabolites from Human Serum and Plasma Using Dual-Column U(H)PLC-MRM-MS and Its Application to Prostate Cancer Study

Autori: Tobias Kipura, Madlen Hotze, Alexa Hofer, Anna-Sophia Egger, Lea E. Timpen, Christiane A. Opitz, Paul A. Townsend, Lee A. Gethings, Kathrin Thedieck, Marcel Kwiatkowski
Pubblicato in: Metabolites, Numero 14, 2025, ISSN 2218-1989
Editore: MDPI AG
DOI: 10.3390/METABO14070370

Chemical mixture risk drivers and their heterogeneity in European freshwaters

Autori: Jana Schor, Tobias Schulze, Nadin Ulrich, İlhan Mutlu, Martin Krauss, Werner Brack, Triet Doan, Sven Bingert, Jan Bumberger, Wibke Busch, Jörg Hackermüller
Pubblicato in: Environment International, Numero 205, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109881

Association of environmental pollutants with asthma and allergy, and the mediating role of oxidative stress and immune markers in adolescents

Autori: Hamid Y. Hassen, Eva Govarts, Sylvie Remy, Bianca Cox, Nina Iszatt, Lützen Portengen, Adrian Covaci, Greet Schoeters, Elly Den Hond, Stefaan De Henauw, Liesbeth Bruckers, Gudrun Koppen, Veerle J. Verheyen
Pubblicato in: Environmental Research, Numero 265, 2024, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2024.120445

Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks

Autori: Libor Šulc, Tomáš Janoš, Daniel Figueiredo, Ilse Ottenbros, Petr Šenk, Ondřej Mikeš, Anke Huss, Pavel Čupr
Pubblicato in: Environmental Research, Numero 214, 2025, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2022.114002

Pesticide effect on earthworm lethality via interpretable machine learning

Autori: Mihkel Kotli, Geven Piir, Uko Maran
Pubblicato in: Journal of Hazardous Materials, Numero 461, 2023
Editore: ELSEVIER
DOI: 10.1016/J.JHAZMAT.2023.132577

Inhibition of human organic anion transporter 4 (OAT4) activity by bisphenol analogues

Autori: Hélène Le Mentec, David Malnoë, Marc Le Vée, Olivier Fardel
Pubblicato in: Environmental Pollution, Numero 390, 2026, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2025.127540

Integrating the lifelong exposure dimension of a chemical mixture into the risk assessment process. Application to trace elements

Autori: Thomas Gastellu, Bruno Le Bizec, Gilles Rivière
Pubblicato in: Food and Chemical Toxicology, Numero 195, 2024, ISSN 0278-6915
Editore: Elsevier BV
DOI: 10.1016/J.FCT.2024.115111

Origin, transport and processing of organic aerosols at different altitudes in coastal Mediterranean urban areas

Autori: Clara Jaén, Mireia Udina, Roy Harrison, Joan O. Grimalt, Barend L. Van Drooge
Pubblicato in: Atmospheric Chemistry and Physics, Numero 25, 2025, ISSN 1680-7324
Editore: Copernicus GmbH
DOI: 10.5194/ACP-25-18389-2025

Comparing the abatement of pharmaceuticals and their human metabolites in wastewater treatment plants – Insights from biological and advanced treatment stages

Autori: Corina Meyer, Christa S. McArdell, Kathrin Fenner, Adriano Joss, Juliane Hollender
Pubblicato in: Water Research, Numero 285, 2025, ISSN 0043-1354
Editore: Elsevier BV
DOI: 10.1016/J.WATRES.2025.123983

Exposure to bisphenols, parabens, and benzophenones in colostrum breast milk of Panamanian women: A pilot study from the PA-MAMI cohort

Autori: I. Castillero-Rosales, N.E. Alvarado-González, V. Núñez-Samudio, B. Suárez, N. Olea, L.M. Iribarne-Durán
Pubblicato in: Science of The Total Environment, Numero 954, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.176677

Latent pesticide effects and their mechanisms

Autori: Matthias Liess, Jonas Gröning
Pubblicato in: Science of The Total Environment, Numero 909, 2026, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2023.168368

Brain-derived neurotrophic factor (BDNF): an effect biomarker of neurodevelopment in human biomonitoring programs

Autori: Andrea Rodríguez-Carrillo, Veerle J. Verheyen, Alexander L. N. Van Nuijs, Mariana F. Fernández, Sylvie Remy
Pubblicato in: Frontiers in Toxicology, Numero 5, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2023.1319788

2024 International Academy of Toxicologic Pathology (IATP) Satellite Symposium: New Approach Methodologies (NAMs) for Neurotoxicity Assessment and Regulatory Perspectives

Autori: Helena T. Hogberg, Ellen Fritsche, Sibylle Gröters, Ramesh C. Kovi, Deepa B. Rao, Andrea Terron, Matthew J. Winter
Pubblicato in: Toxicologic Pathology, Numero 53, 2026, ISSN 0192-6233
Editore: SAGE Publications
DOI: 10.1177/01926233251335719

An analytical method to quantify tetrabromobisphenol A (TBBPA) and its conjugated metabolites in rat serum or other biological samples

Autori: Mette Stub, Mikael Pedersen, Louise Ramhøj, Kit Granby, Terje Svingen, Agnieszka Anna Niklas
Pubblicato in: Talanta Open, Numero 12, 2026, ISSN 2666-8319
Editore: Elsevier BV
DOI: 10.1016/J.TALO.2025.100537

A comprehensive battery of flow cytometric immunoassays for the in vitro testing of chemical effects in human blood cells

Autori: Arkadiusz Pierzchalski, Ana C. Zenclussen, Gunda Herberth
Pubblicato in: Frontiers in Immunology, Numero 14, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2023.1327960

A review on immunomodulatory effects of BPA analogues

Autori: Anja Kodila, Nina Franko and Marija Sollner Dolenc
Pubblicato in: ARCHIVES OF TOXICOLOGY, Numero 97, 2023
Editore: SPRINGER
DOI: 10.1007/S00204-023-03519-Y

PKSmart: an open-source computational model to predict intravenous pharmacokinetics of small molecules

Autori: Srijit Seal, Maria-Anna Trapotsi, Manas Mahale, Vigneshwari Subramanian, Nigel Greene, Ola Spjuth, Andreas Bender
Pubblicato in: Journal of Cheminformatics, Numero 17, 2025, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-025-01066-5

SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex

Autori: Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Jules Imler, Céline Tomkiewicz-Raulet, Etienne B. Blanc, Robert Barouki, Xavier Coumoul, Sylvie Bortoli
Pubblicato in: Environment International, Numero 180, 2025, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108219

Developing quantitative Adverse Outcome Pathways: An ordinary differential equation-based computational framework

Autori: Filippo Di Tillio, Joost B. Beltman
Pubblicato in: Computational Toxicology, Numero 32, 2024, ISSN 2468-1113
Editore: Elsevier BV
DOI: 10.1016/J.COMTOX.2024.100330

Interdependency of estradiol-mediated ERα activation and subsequent PR and GREB1 induction to control cell cycle progression

Autori: M.M. Heldring, B. Duijndam, A. Kyriakidou, O.M. van der Meer, M. Tedeschi, J.W. van der Laan, B. van de Water, J.B. Beltman
Pubblicato in: Heliyon, Numero 10, 2026, ISSN 2405-8440
Editore: Elsevier BV
DOI: 10.1016/J.HELIYON.2024.E38406

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals — a PARC (Partnership for the Assessment of Risk from Chemicals) project

Autori: Igor Snapkow, Nicola M. Smith, Emma Arnesdotter, Karsten Beekmann, Etienne B. Blanc, Albert Braeuning, Emanuela Corsini, Marija Sollner Dolenc, Loes P. M. Duivenvoorde, Gunnar Sundstøl Eriksen, Nina Franko, Valentina Galbiati, Johanna M. Gostner, Nathalie Grova, Arno C. Gutleb, Rita Hargitai, Aafke W. F. Janssen, Solveig A. Krapf, Birgitte Lindeman, Katalin Lumniczky, Ambra Maddalon, Steen Mollerup, Lucia Parráková, Arkadiusz Pierzchalski, Raymond H. H. Pieters, Maria J. Silva, Anita Solhaug, Yvonne C. M. Staal, Anne Straumfors, Tünde Szatmári, Jonathan D. Turner, Rob J. Vandebriel, Ana Claudia Zenclussen, Robert Barouki
Pubblicato in: Frontiers in Toxicology, Numero 6, 2024, ISSN 2673-3080
Editore: Frontiers Media SA
DOI: 10.3389/FTOX.2024.1339104

Mapping out strategies to further develop human-relevant new approach methodology (NAM)based developmental neurotoxicity (DNT) testing

Autori: Cöllen, E.; Bartmann, K.; Blum, J.; Carstens, K.; Celardo, I.; Chatterjee, N.; Corvaro, M.; Dreser, N.; Fritsche, E.; Hartung, T.; Högberg, H.T.; Knudsen, T.; Koch, K.; Kreutz, A.; Lislien, M.; Magel, V.; Marty, S.; Pallocca, G.; Bal-Price, A.; Rovida, C.
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2501091

Regulatory practices on the genotoxicity testing of nanomaterials and outlook for the future

Autori: Cristina Andreoli, Maria Dusinska, Cecilia Bossa, Chiara Laura Battistelli, Maria João Silva, Henriqueta Louro
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 162, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105881

A comparison of commercial assays quantifying mature brain-derived neurotrophic factor (mBDNF) and its precursor (pro-BDNF) in human serum

Autori: Alicia Olivas-Martínez, Francisco M. Peinado, Ainhoa Pérez-Cantero, Lydia Espín-Moreno, Andrea Rodríguez-Carrillo, Esther García-Esquinas, Nicolás Olea, Vicente Mustieles, Mariana F. Fernández
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-22278-7

Two-Stage Machine Learning-Based Approach to Predict Points of Departure for Human Noncancer and Developmental/Reproductive Effects

Autori: Jacob Kvasnicka, Nicolò Aurisano, Kerstin von Borries, En-Hsuan Lu, Peter Fantke, Olivier Jolliet, Fred A. Wright, Weihsueh A. Chiu
Pubblicato in: Environmental Science & Technology, Numero 58, 2024, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.4C00172

Temperature dependent sensitivity of the harpacticoid copepod Nitokra spinipes to marine algal toxins

Autori: Wenxin Liu, Ilias Semmouri, Colin R. Janssen, Jana Asselman
Pubblicato in: Chemosphere, Numero 366, 2024, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2024.143420

Annali dell'Istituto Superiore di Sanita

Autori: D'amore, Teresa; Testai, Emanuela; Di Consiglio, Emma
Pubblicato in: Ann Ist Super Sanità, 2025, ISSN 0021-2571
Editore: Istituto Superiore di Sanita
DOI: 10.4415/ANN_26_01_07

A critical review to identify data gaps and improve risk assessment of bisphenol A alternatives for human health

Autori: Sakina Mhaouty-Kodja, Daniel Zalko, Sabrina Tait, Emanuela Testai, Catherine Viguié, Emanuela Corsini, Nathalie Grova, Franca Maria Buratti, Nicolas J. Cabaton, Lucia Coppola, Antonio De la Vieja, Maria Dusinska, Naouale El Yamani, Valentina Galbiati, Patricia Iglesias-Hernández, Yvonne Kohl, Ambra Maddalon, Francesca Marcon, Lydie Naulé, Elise Rundén-Pran, Francesca Salani, Nicoletta Santori, Mónica Torres-Ruiz, Jonathan D. Turner, Ondrej Adamovsky, Kiara Aiello-Holden, Hubert Dirven, Henriqueta Louro, Maria João Silva
Pubblicato in: Critical Reviews in Toxicology, Numero 54, 2024, ISSN 1040-8444
Editore: Informa UK Limited
DOI: 10.1080/10408444.2024.2388712

New approach methodologies in human health risk assessment across European regulatory frameworks: Status quo, barriers and drivers for regulatory acceptance and use

Autori: Angela Bearth, Nicolas Roth, Tom Jansen, Laura Holden, Aleksandra Čavoški, Emma Di Consiglio, Ingrid Hauzenberger, Robert Lee, Enrico Mombelli, Olga Tcheremenskaia, Lina Wendt-Rasch, Martin F. Wilks
Pubblicato in: Environment International, Numero 196, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109279

PubChemLite Plus Collision Cross Section (CCS) Values for Enhanced Interpretation of Nontarget Environmental Data

Autori: Anjana Elapavalore, Dylan H. Ross, Valentin Grouès, Dagny Aurich, Allison M. Krinsky, Sunghwan Kim, Paul A. Thiessen, Jian Zhang, James N. Dodds, Erin S. Baker, Evan E. Bolton, Libin Xu, Emma L. Schymanski
Pubblicato in: Environmental Science & Technology Letters, Numero 12, 2025, ISSN 2328-8930
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.ESTLETT.4C01003

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Autori: Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Pubblicato in: 2022
Editore: HAL
DOI: 10.15698/CST2022.08.270

Ciona spp. and ascidians as bioindicator organisms for evaluating effects of endocrine disrupting chemicals: A discussion paper

Autori: Jonny Beyer, You Song, Adam Lillicrap, Simón Rodríguez-Satizábal, Marios Chatzigeorgiou
Pubblicato in: Marine Environmental Research, Numero 191, 2026, ISSN 0141-1136
Editore: Elsevier BV
DOI: 10.1016/J.MARENVRES.2023.106170

Learning from Safe-by-Design for Safe-and-Sustainable-by-Design: Mapping the current landscape of Safe-by-Design reviews, case studies, and frameworks

Autori: Akshat Sudheshwar, Christina Apel, Klaus Kümmerer, Zhanyun Wang, Lya G. Soeteman-Hernández, Eugenia Valsami-Jones, Claudia Som, Bernd Nowack
Pubblicato in: Environment International, Numero 183, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2023.108305

High precision blood lead radiogenic isotope signatures in a community exposed to Pb contaminated soils and implications for the current Pb exposure of the European population

Autori: Jérôme C.J. Petit, Nadine Mattielli, Jeroen De Jong, Elodie Bouhoulle, Wendy Debouge, Patrick Maggi, Geneviève Hublet, Nathalie Fagel, Catherine Pirard, Corinne Charlier, Remy Suzanne
Pubblicato in: Science of The Total Environment, Numero 950, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.174763

Per- and Polyfluoroalkyl Substances in Urine Samples from Eight-Year-Old Children Living in Northwest Spain

Autori: Arianna Bautista, Guillermo Fernandez-Tardon, Marta M. Rodríguez-Suárez, Adonina Tardon, Natalia Bravo, Mercè Garí, Joan O. Grimalt, Marta Llorca, Marinella Farré
Pubblicato in: Molecules, Numero 31, 2026, ISSN 1420-3049
Editore: MDPI AG
DOI: 10.3390/MOLECULES31050900

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

Autori: Kristina Bartmann
Pubblicato in: ALTEX, 2023, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2206031

Interactive toxicity of two commonly co-occurring metals, zinc and cadmium, to earthworms in a natural soil

Autori: Claus Svendsen, David J Spurgeon, Donna McClennan, Amaia Green Etxabe, Cornelis A M Van Gestel
Pubblicato in: Environmental Toxicology and Chemistry, Numero 45, 2026, ISSN 0730-7268
Editore: Oxford University Press (OUP)
DOI: 10.1093/ETOJNL/VGAF295

Sex and Gender Dimensions in Hazard and Risk Assessment of Engineered Nanomaterials

Autori: Lucija Božičević, Karolina Jagiello, Anita Sosnowska, Maciej Stepnik, Maria Dusinska, Iseult Lynch, Nikolina Peranić, Ivona Capjak, Valérie Fessard, Mihaela R. Cimpan, Arno C. Gutleb, Elise Runden Pran, Tomasz Puzyn, Ivana Vinković Vrček
Pubblicato in: WIREs Nanomedicine and Nanobiotechnology, Numero 17, 2025, ISSN 1939-5116
Editore: Wiley
DOI: 10.1002/WNAN.70034

Chronic exposure to a common azole fungicide is associated with reactivation of chronic Plasmodium infections in farmland birds

Autori: Romain Pigeault, Coraline Bichet, Pauline Bellot, François Brischoux, Clémentine Fritsch, Frédéric Angelier
Pubblicato in: International Journal for Parasitology: Parasites and Wildlife, Numero 29, 2026, ISSN 2213-2244
Editore: Elsevier BV
DOI: 10.1016/J.IJPPAW.2026.101222

Interplay of SLC33A1-dependent and -independent Golgi sialic acid O-acetylation in CASD1 catalysis

Autori: Malena Albers, Lydia Bosse, Larissa Schröter, Anna-Maria T. Junemann, Charlotte Rossdam, Maike Hartmann, Melanie Grove, Thomas Litfin, Anna-Sophia Egger, Marcel Kwiatkowski, Kathrin Thedieck, Georg Zocher, Falk F. R. Buettner, Alpeshkumar K. Malde, Mark von Itzstein, Martina Mühlenhoff
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-026-71333-Y

Effect-Based Assessment of the Quality and Potential Presence of Hazardous Chemical Pollutants in Drinking and Potable Water in Mexico City

Autori: Aline Colonnello Montero, Geeta Mandava, Johan Lundqvist
Pubblicato in: ACS ES&T Water, Numero 6, 2026, ISSN 2690-0637
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSESTWATER.5C01058

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods

Autori: Beate I. Escher, Rolf Altenburger, Matthias Blüher, John K. Colbourne, Ralf Ebinghaus, Peter Fantke, Michaela Hein, Wolfgang Köck, Klaus Kümmerer, Sina Leipold, Xiaojing Li, Martin Scheringer, Stefan Scholz, Michael Schloter, Pia-Johanna Schweizer, Tamara Tal, Igor Tetko, Claudia Traidl-Hoffmann, Lukas Y. Wick and Kathrin Fenner
Pubblicato in: Archives of Toxicology, Numero 97, 2023
Editore: SPRINGER
DOI: 10.1007/S00204-023-03485-5

Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation

Autori: Jiaqi Chen, Shensheng Zhao, Sebastiaan Wesseling, Nynke I. Kramer, Ivonne M.C.M. Rietjens, Hans Bouwmeester
Pubblicato in: Environmental Science and Technology, Numero 57, 49, 2023
Editore: acs
DOI: 10.1021/ACS.EST.3C07077

PeriTox-M, a Cell-Based Assay for Peripheral Neurotoxicity with Improved Sensitivity to Mitochondrial Inhibitors

Autori: Anna-Katharina Holzer, Mira Dürr, Selina Multrus, Laura Dangel, Viktoria Magel, Marcel Leist
Pubblicato in: Cells, Numero 14, 2025, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/CELLS14231929

Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

Autori: Nina Pálešová, Léa Maitre, Nikos Stratakis, Katarína Řiháčková, Aleš Pindur, Jiří Kohoutek, Petr Šenk, Anna Bartošková Polcrová, Petr Gregor, Martine Vrijheid, Pavel Čupr
Pubblicato in: 2023
Editore: ELSEVIER
DOI: 10.1016/J.IJHEH.2023.114215

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

Autori: Mawien Karaca, Kristin Fritsche, Dajana Lichtenstein, Özlem VuraL, Katrin Kreuzer, Jimmy Alarcan, Albert Braeuning, Philip Marx-Stoelting, Tewes Tralau
Pubblicato in: STAR PROTOCOLS, Numero 4,3, 2023
Editore: ELSEVIER
DOI: 10.1016/J.XPRO.2023.102500

Interpretable machine learning for the identification of estrogen receptor agonists, antagonists, and binders

Autori: Geven Piir, Sulev Sild, Uko Maran
Pubblicato in: Chemosphere, Numero 347, 2025, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2023.140671

The need for epigenotoxicity testing

Autori: Hartung, T.; Smirnova, L.; Platz, S.; Amelio, I.; Leist, M.
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2509281

Wild fish and seafood species in the western Mediterranean Sea with low safe mercury concentrations

Autori: Marco Capodiferro, Esther Marco, Joan O. Grimalt
Pubblicato in: Environmental Pollution, Numero 314, 2025, ISSN 0269-7491
Editore: Elsevier BV
DOI: 10.1016/J.ENVPOL.2022.120274

A Social Survey to Capture the Public Awareness and Perception About Chemicals Under Ireland’s Human Biomonitoring Feasibility Study

Autori: Richa Singh, Holger Martin Koch, Marike Kolossa-Gehring, André Conrad, Alison Connolly
Pubblicato in: Environments, Numero 12, 2025, ISSN 2076-3298
Editore: MDPI AG
DOI: 10.3390/ENVIRONMENTS12110410

Data source and utilization of artificial intelligence technologies in vascular surgery—a scoping review

Autori: Katarzyna Powezka, Karin Slater, David Brind, Michael Wall, Georgios Gkoutos, Maciej Juszczak
Pubblicato in: Frontiers in Cardiovascular Medicine, Numero 12, 2025, ISSN 2297-055X
Editore: Frontiers Media SA
DOI: 10.3389/FCVM.2025.1497822

Impact of the new hazard classes in the CLP regulation on EU chemicals legislation

Autori: Diana Kättström, Anna Beronius, Urban Boije af Gennäs, Christina Rudén, Marlene Ågerstrand
Pubblicato in: Environmental Sciences Europe, Numero 37, 2025, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-025-01054-4

Combined western diet and bisphenol A exposure induces an oxidative stress-based paraoxonase 1 response in larval zebrafish

Autori: Rik van den Boom, Lucia Vergauwen, Noortje Koedijk, Katyeny Manuela da Silva, Adrian Covaci, Dries Knapen
Pubblicato in: Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, Numero 274, 2026, ISSN 1532-0456
Editore: Elsevier BV
DOI: 10.1016/J.CBPC.2023.109758

Toxicity of Four Common Environmental Chemicals Across <scp> Caenorhabditis elegans </scp> Life Stages Supporting the One Health Concept

Autori: Fábio Campos, Maria D. Pavlaki, Amadeu M. V. M. Soares, Susana Loureiro
Pubblicato in: Environmental Toxicology, 2025, ISSN 1520-4081
Editore: Wiley
DOI: 10.1002/TOX.70002

Unravelling immunomodulatory effects of bisphenol A substitutes on human macrophages, T and B lymphocytes using in vitro models

Autori: Nina Franko, Tijana Markovič, Pia Žižek, Anja Kodila, Irena Mlinarič Raščan, Marija Sollner Dolenc
Pubblicato in: Ecotoxicology and Environmental Safety, Numero 300, 2025, ISSN 0147-6513
Editore: Elsevier BV
DOI: 10.1016/J.ECOENV.2025.118406

Comparative toxicity of bisphenol A and analogues to the marine polychaete Arenicola marina: Another case of regrettable substitutes?

Autori: Paula Milliken, Anais Ansari, Jon Barry, Ioanna Katsiadaki, Melinda Long, Sara Losada, Christopher Martin, Lara Pearson, Marta Vannoni, Alex R.O. Cousins
Pubblicato in: Marine Pollution Bulletin, Numero 228, 2026, ISSN 0025-326X
Editore: Elsevier BV
DOI: 10.1016/J.MARPOLBUL.2026.119588

Utilizing rat kidney gene co-expression networks to enhance safety assessment biomarker identification and human translation

Autori: Steven J. Kunnen, Giulia Callegaro, Jeffrey J. Sutherland, Panuwat Trairatphisan, Hugo W. van Kessel, Lukas S. Wijaya, Git Chung, Keith Pye, Keith M. Goldstein, Claire R. Teague, Ciaran P. Fisher, Julio Saez-Rodriguez, Colin Brown, Susan A. Elmore, Kathleen M. Heinz-Taheny, James L. Stevens, Bob van de Water
Pubblicato in: iScience, Numero 28, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2025.112978

The SCAHT adverse outcome pathway (AOP)_HUB: a hands-on platform for information exchange, sharing, and developing AOPs

Autori: Coerek, E.; Kuchovska, E.; Gerner, L.; Nilma, L.; Villeneuve, D.; Fritsche, E.
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/altex.2502051

Chemical and Biological Mechanisms Relevant to the Rescue of MG-132-Treated Neurons by Cysteine

Autori: Anna-Katharina Ückert, Ilinca Suciu, Anja Land, Anna-Sophie Spreng, Hannah Welte, Doreen Herzog, Michael Basler, Marcel Leist
Pubblicato in: Antioxidants, Numero 14, 2025, ISSN 2076-3921
Editore: MDPI AG
DOI: 10.3390/ANTIOX14020128

Developmental neurotoxicity (DNT): a call for implementation of new approach methodologies for regulatory purposes: summary of the 5th international conference on DNT testing

Autori: Celardo, I.; Áschner, M.; Ashton, R.S.; Carstens, K.; Cediel-Ulloa, A.; Cöllen, E.; Crofton, K.M.; Debad, S.J.; Dreser, N.; Fitzpatrick, S.; Fritsche, E.; Gutsfeld, S.; Hardy, B.; Hartung, T.; Hessel, E.V.S.; Heusinkveld, H.; Högberg, H.T.; Hsieh, J.-H.;
Pubblicato in: ALTEX, 2025, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2503191

State of the science on assessing developmental neurotoxicity using new approach methods

Autori: Debad, S.J.; Aungst, J.; Carstens, K.; Ferrer, M.; Fitzpatrick, S.; Fritsche, E.; Geng, Y.; Hartung, T.; Högberg, H.T.; Li, R.; Mangas, I.; Marty, S.; Musser, S.; Perron, M.; Rattan, S.; Rüegg, J.; Sachana, M.; Schenke, M.; Shafer, T.J.; Smirnova, L.; Tal
Pubblicato in: ALTEX, 2023, ISSN 1868-596X
Editore: ALTEX
DOI: 10.14573/ALTEX.2410231

The environmental occurrence, fate, and risks of 25 endocrine disruptors in Slovenian waters

Autori: Andrej Grobin, Robert Roškar, Jurij Trontelj
Pubblicato in: Science of The Total Environment, Numero 906, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2023.167245

Cumulative risk assessment methodology applied to non-dietary exposures: developmental alterations in professional agricultural settings

Autori: Luca Tosti, Martina Marazzini, Mohammed Kanadil, Francesca Metruccio
Pubblicato in: Journal of Occupational Medicine and Toxicology, Numero 20, 2025, ISSN 1745-6673
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12995-025-00451-Y

P07-20 Human biomonitoring guidance values derived for nickel and its compounds

Autori: J. Weisell-Laitinen, L. Hegg, N. Hopf, P. Apel, T. Santonen
Pubblicato in: Toxicology Letters, Numero 399, 2024, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/J.TOXLET.2024.07.432

Cross-species transcriptomics identifies obesity associated genes between human and mouse studies

Autori: Animesh Acharjee, Susanne N. Wijesinghe, Dominic Russ, Georgios Gkoutos, Simon W. Jones
Pubblicato in: Journal of Translational Medicine, Numero 22, 2024, ISSN 1479-5876
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12967-024-05414-1

Exposure to benzotriazoles and benzothiazoles in Czech male population and its associations with biomarkers of liver function, serum lipids and oxidative stress

Autori: Nina Pálešová, Lucie Bláhová, Tomáš Janoš, Katarína Řiháčková, Aleš Pindur, Ludmila Šebejová, Pavel Čupr
Pubblicato in: International Archives of Occupational and Environmental Health, Numero 97, 2024, ISSN 0340-0131
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00420-024-02059-X

CPSign: conformal prediction for cheminformatics modeling

Autori: Staffan Arvidsson McShane, Ulf Norinder, Jonathan Alvarsson, Ernst Ahlberg, Lars Carlsson, Ola Spjuth
Pubblicato in: Journal of Cheminformatics, Numero 16, 2024, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-024-00870-9

Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies

Autori: Andrea Rodríguez-Carrillo, Sylvie Remy, Gudrun Koppen, Natasha Wauters, Vicente Mustieles, Anteneh Desalegn, Nina Iszatt, Elly den Hond, Veerle J. Verheyen, Lucia Fábelová, Lubica Palkovicova Murinova, Susana Pedraza-Díaz, Marta Esteban, Rafael M. Poyatos, Eva Govarts, Alexander L.N. van Nuijs, Adrian Covaci, Greet Schoeters, Nicolás Olea, Mariana F. Fernández
Pubblicato in: Science of The Total Environment, Numero 929, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.172426

Machine learning-based prediction of fish acute mortality: implementation, interpretation, and regulatory relevance

Autori: Lilian Gasser, Christoph Schür, Fernando Perez-Cruz, Kristin Schirmer, Marco Baity-Jesi
Pubblicato in: Environmental Science: Advances, Numero 3, 2024, ISSN 2754-7000
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4VA00072B

SSL-MAE: Adaptive Semisupervised Learning Framework for Multilabel Classification of Remote Sensing Images Using Masked Autoencoders

Autori: Marjan Stoimchev, Jurica Levatić, Dragi Kocev, Sašo Džeroski
Pubblicato in: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, Numero 18, 2026, ISSN 1939-1404
Editore: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSTARS.2025.3578196

Development of a rat physiologically based kinetic model (PBK) for three organophosphate flame retardants (TDCIPP, TCIPP, TCEP)

Autori: Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar
Pubblicato in: Toxicology Letters, Numero 383, 2025, ISSN 0378-4274
Editore: Elsevier BV
DOI: 10.1016/J.TOXLET.2023.06.006

Automated curation of spatial metadata in environmental monitoring data

Autori: İlhan Mutlu, Jörg Hackermüller, Jana Schor
Pubblicato in: Ecological Informatics, Numero 86, 2025, ISSN 1574-9541
Editore: Elsevier BV
DOI: 10.1016/J.ECOINF.2025.103038

Models for Calculating Predicted Environmental Concentrations (PEC) of Pesticides in Surface Waters: Review, Selection Criteria, and Recommendations for Regulatory Applications

Autori: Marta Gabryszewska, Barbara Gworek, Beata Kubiak, Radosław Kalinowski, Marta Kijeńska-Markuszewska, Adriana Solecka, Magdalena Graniewska, Izabela Samson-Bręk
Pubblicato in: Environmental Protection and Natural Resources, Numero 36, 2026, ISSN 2353-8589
Editore: Walter de Gruyter GmbH
DOI: 10.2478/OSZN-2025-0020

Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union

Autori: Axel Mie, Christina Rudén
Pubblicato in: Environmental Health, Numero 22, 2023, ISSN 1476-069X
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12940-023-00994-9

Development of a Generic Physiologically Based Kinetic Model for the Prediction of Internal Exposure to Organophosphate Pesticides

Autori: Thijs M. J. A. Moerenhout, Jiaqi Chen, Hans Bouwmeester, Ivonne M. C. M. Rietjens, Nynke I. Kramer
Pubblicato in: Environmental Science & Technology, Numero 58, 2024, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.4C06534

Evaluation of THP-1 and Jurkat Cell Lines Coculture for the In Vitro Assessment of the Effects of Immunosuppressive Substances

Autori: Nina Franko, Marija Sollner Dolenc
Pubblicato in: Toxics, Numero 12, 2025, ISSN 2305-6304
Editore: MDPI AG
DOI: 10.3390/TOXICS12080607

Progress, applications, and challenges in high-throughput effect-directed analysis for toxicity driver identification — is it time for HT-EDA?

Autori: Iker Alvarez-Mora, Katarzyna Arturi, Frederic Béen, Sebastian Buchinger, Abd El Rahman El Mais, Christine Gallampois, Meike Hahn, Juliane Hollender, Corine Houtman, Sarah Johann, Martin Krauss, Marja Lamoree, Maria Margalef, Riccardo Massei, Werner Brack, Melis Muz
Pubblicato in: Analytical and Bioanalytical Chemistry, Numero 417, 2025, ISSN 1618-2642
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00216-024-05424-4

Mapping chemical footprints of organic micropollutants in European streams

Autori: Saskia Finckh, Eric Carmona, Dietrich Borchardt, Olaf Büttner, Martin Krauss, Tobias Schulze, Soohyun Yang, Werner Brack
Pubblicato in: Environment International, Numero 183, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108371

Single and mixture effects of bisphenol A and benzophenone-3 on in vitro T helper cell differentiation

Autori: Florence Fischer, Miriam Rebecca Ermer, Julia Howanski, Ziran Yin, Mario Bauer, Marita Wagner, Beate Fink, Ana C. Zenclussen, Anne Schumacher
Pubblicato in: Chemico-Biological Interactions, Numero 395, 2026, ISSN 0009-2797
Editore: Elsevier BV
DOI: 10.1016/J.CBI.2024.111011

Corrigendum to “tailored iron oxide nanoparticles for biomedical applications: Hydroxyethyl starch coating enhances endothelial biocompatibility” [nanomedicine: Nanotechnology, biology and medicine, volume 71, January 2026, 102880]

REACH out-numbered! The future of REACH and animal numbers

Autori: Costanza Rovida
Pubblicato in: ALTEX, 2023, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2307121

GEMCAT—a new algorithm for gene expression-based prediction of metabolic alterations

Autori: Suraj Sharma, Roland Sauter, Madlen Hotze, Aaron Marcellus Paul Prowatke, Marc Niere, Tobias Kipura, Anna-Sophia Egger, Kathrin Thedieck, Marcel Kwiatkowski, Mathias Ziegler, Ines Heiland
Pubblicato in: NAR Genomics and Bioinformatics, Numero 7, 2025, ISSN 2631-9268
Editore: Oxford University Press (OUP)
DOI: 10.1093/NARGAB/LQAF003

Inhibition of human drug transporter activities by succinate dehydrogenase inhibitors

Autori: Marie Kerhoas, Marc Le Vée, Jennifer Carteret, Elodie Jouan, Valentin Tastet, Arnaud Bruyère, Laurence Huc, Olivier Fardel
Pubblicato in: Chemosphere, Numero 358, 2024, ISSN 0045-6535
Editore: Elsevier BV
DOI: 10.1016/J.CHEMOSPHERE.2024.142122

Occupational and residential exposures to organophosphate and pyrethroid pesticides in a rural setting

Autori: Natalia Bravo, Mercè Garí, Joan O. Grimalt
Pubblicato in: Environmental Research, Numero 214, 2026, ISSN 0013-9351
Editore: Elsevier BV
DOI: 10.1016/J.ENVRES.2022.114186

High-Throughput Effect-Directed Analysis of Androgenic Compounds in Hospital Wastewater: Identifying Effect Drivers through Non-Target Screening Supported by Toxicity Prediction

Autori: Iker Alvarez-Mora, Aset Muratuly, Sarah Johann, Katarzyna Arturi, Florian Jünger, Carolin Huber, Henner Hollert, Martin Krauss, Werner Brack, Melis Muz
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.4C09942

Current-use pesticide exposure pathways in Czech adults and children from the CELSPAC-SPECIMEn cohort

Autori: Libor Šulc, Daniel Figueiredo, Anke Huss, Jiří Kalina, Petr Gregor, Tomáš Janoš, Petr Šenk, Andrea Dalecká, Lenka Andrýsková, Vít Kodeš, Pavel Čupr
Pubblicato in: Environment International, Numero 181, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108297

MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data

Autori: Katarzyna Arturi, Eliza J. Harris, Lilian Gasser, Beate I. Escher, Georg Braun, Robin Bosshard, Juliane Hollender
Pubblicato in: Journal of Cheminformatics, Numero 17, 2025, ISSN 1758-2946
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S13321-025-00950-4

Toward safer and more sustainable by design biocatalytic amide-bond coupling

Autori: Elisabeth Söderberg, Kerstin von Borries, Ulf Norinder, Mark Petchey, Ganapathy Ranjani, Swapnil Chavan, Hanna Holmquist, Magnus Johansson, Ian Cotgreave, Martin A. Hayes, Peter Fantke, Per-Olof Syrén
Pubblicato in: Green Chemistry, Numero 26, 2024, ISSN 1463-9262
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4GC03665D

Combined effects of herbicides and insecticides reduce biomass of sensitive aquatic invertebrates

Autori: Liana Liebmann, Verena C. Schreiner, Philipp Vormeier, Oliver Weisner, Matthias Liess
Pubblicato in: Science of The Total Environment, Numero 946, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.174343

A comprehensive item bank of internal validity issues of relevance to in vitro toxicology studies

Autori: Gunn E. Vist, Heather M. R. Ames, Gro H. Mathisen, Trine Husøy, Camilla Svendsen, Anna Beronius, Emma Di Consiglio, Ingrid L. Druwe, Thomas Hartung, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Pilar Prieto, Joshua F. Robinson, Erwin Roggen, Andrew A. Rooney, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken, Paul Whaley
Pubblicato in: Evidence-Based Toxicology, Numero 2, 2025, ISSN 2833-373X
Editore: Informa UK Limited
DOI: 10.1080/2833373X.2024.2418045

Interpretable machine learning for the identification of estrogen receptor agonists, antagonists, and binders

Autori: Geven Piir, Sulev Sild, Uko Maran
Pubblicato in: CHEMOSPHERE, Numero 347, 2023
Editore: ELSEVIER
DOI: 10.1016/J.CHEMOSPHERE.2023.140671

Acceptance criteria for new approach methods in toxicology and human health-relevant life science research – part I

Autori: Anna-Katharina Holzer
Pubblicato in: ALTEX, 2023, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/ALTEX.2310021

An in vitro model system for testing chemical effects on microbiome-immune interactions – examples with BPX and PFAS mixtures

Autori: Florence Fischer, Arkadiusz Pierzchalski, Sarah Riesbeck, Alix Sarah Aldehoff, Victor Alfonso Castaneda-Monsalve, Sven-Bastiaan Haange, Martin von Bergen, Ulrike Elisabeth Rolle-Kampczyk, Nico Jehmlich, Ana Claudia Zenclussen, Gunda Herberth
Pubblicato in: Frontiers in Immunology, Numero 15, 2024, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1298971

Mapping chemicals across EU’s legal frameworks towards a ‘one substance, one assessment’ approach

Autori: Mathilda Andreassen, Christina Rudén, Marlene Ågerstrand
Pubblicato in: Environment International, Numero 199, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2025.109460

Collecting perspectives on project prioritisation process in the EU co-funded multinational partnership for the assessment of risks from chemicals (PARC) through focus group discussion

Autori: Katya Manuella Permana, Maria Tannous, Hanna Mouaziz, Pascal Sanders, Nathalie Bonvallot, Christophe Rousselle
Pubblicato in: Environmental Sciences Europe, Numero 37, 2025, ISSN 2190-4715
Editore: Springer Science and Business Media LLC
DOI: 10.1186/S12302-024-01041-1

Generating environmental sampling and testing data for micro- and nanoplastics for use in life cycle impact assessment

Autori: Cecilia Askham, Valentina H. Pauna, Anne-Marie Boulay, Peter Fantke, Olivier Jolliet, Jérôme Lavoie, Andy M. Booth, Claire Coutris, Francesca Verones, Miriam Weber, Martina G. Vijver, Amy Lusher, Carla Hajjar
Pubblicato in: Science of The Total Environment, Numero 859, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2022.160038

Use of alternatives to animal testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA partners’ forum

Autori: Jose V. Tarazona, Ana Fernandez-Agudo, Ondrej Adamovsky, Marta Baccaro, Natalie Burden, Bruno Campos, Björn Hidding, Karen Jenner, David John, Katia Lacasse, Adam Lillicrap, Delina Lyon, Samuel K. Maynard, Amelie Ott, Veronique Poulsen, Mike Rasenberg, Katrin Schutte, Marta Sobanska, James R. Wheeler
Pubblicato in: Regulatory Toxicology and Pharmacology, Numero 156, 2025, ISSN 0273-2300
Editore: Elsevier BV
DOI: 10.1016/J.YRTPH.2025.105774

Disrupting Defenses: Effects of Bisphenol A and Its Analogs on Human Antibody Production In Vitro

Autori: Francesca Carlotta Passoni, Martina Iulini, Valentina Galbiati, Marina Marinovich, Emanuela Corsini
Pubblicato in: Life, Numero 15, 2025, ISSN 2075-1729
Editore: MDPI AG
DOI: 10.3390/LIFE15081203

Programmed neurite degeneration in human central nervous system neurons driven by changes in NAD+ metabolism

Autori: Markus Brüll, Selina Multrus, Michael Schäfer, Ivana Celardo, Christiaan Karreman, Marcel Leist
Pubblicato in: Cell Death & Disease, Numero 16, 2025, ISSN 2041-4889
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41419-024-07326-W

Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater

Autori: Saskia Finckh, Sebastian Buchinger, Beate I. Escher, Henner Hollert b, Maria König, Martin Krauss, Warich Leekitratanapisan, Sabrina Schiwy , Rita Schlichting, Aliaksandra Shuliakevich, Werner Brack
Pubblicato in: Environment International, Numero 170, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107608

Sequential pesticide exposure: Concentration addition at high concentrations - Inhibition of hormesis at ultra-low concentrations

Autori: Imrana Mushtaq, Naeem Shahid, Ayesha Siddique, Matthias Liess
Pubblicato in: Science of The Total Environment, Numero 954, 2025, ISSN 0048-9697
Editore: Elsevier BV
DOI: 10.1016/J.SCITOTENV.2024.176493

Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Autori: Francisco Manuel Peinado, Luz María Iribarne-Durán, Francisco Artacho-Cordón
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2025, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/IJMS24087325

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

Autori: Thalia De Castelbajac Thalia De Castelbajac1 Kiara Aiello ;Kiara Aiello Celia Garcia Arenas ;Celia Garcia Arenas Terje Svingen Terje Svingen Louise Ramh jLouise Ramhøj Daniel Zalko Daniel Zalko Robert Barouki Robert Barouki Tamara Vanhaecke Tamara Vanhaecke Vera Rogiers Vera Rogiers Marc Audebert Marc Audebert Michael Oelgeschlaeger Michael Oelgeschlaeger Albert Braeuning Albert Braeuning Etienne Blanc Etienne Blanc Tamara Ta Tamara Tal Joëlle Rüegg Joëlle Rüegg Ellen FritscheEllen Fritsche Philip Marx-Stoelting;Philip Marx-Stoelting Gilles Rivi;Gilles Rivière
Pubblicato in: 2023
Editore: FRONTIERS
DOI: 10.3389/FTOX.2023.1216369

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