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Understanding, predicting, and treating depression in pregnancy to improve mothers and offspring mental health outcomes

Projektbeschreibung

Biologische Ursachen von Depressionen bei Müttern beleuchten

Die psychische Gesundheit und das Wohlbefinden der Mutter können sich auf die Entwicklung des Kindes auswirken. Stress, Depressionen und Ängste während und nach der Schwangerschaft werden mit Störungen der Entwicklung im Kindesalter in Verbindung gebracht. In diesem Zusammenhang wird das EU-finanzierte Projekt HappyMums die physiologischen Mechanismen dieses Phänomens erforschen, um wirksame wissenschaftlich fundierte klinische Interventionen zur Unterstützung gefährdeter Mütter und zur Verbesserung der Umgebung und Entwicklung des Fötus zu ermöglichen. Forschungsmodelle aus dem Labor werden einzigartigen menschlichen Proben der Plazenta, der Chorionzotten und des Fruchtwassers gegenübergestellt, um die grundlegenden biologischen Ursachen der mütterlichen Depression ans Licht zu bringen. Eine digitale Plattform wird umfangreiche medizinische Daten und eine Mobiltelefon-App zur Unterstützung von Müttern und ihren Kindern zur Verfügung stellen.

Ziel

HappyMums is designed to improve our understanding on the biological mechanisms underlying the development of depressive symptoms in pregnancy, and the efficacy of interventions. It will interrogate a large collection of cohorts with multiple biological, medical, clinical, socio-demographic and environmental and lifestyle data to identify the most robust risk factors triggering depressive symptoms, but also moderators of the risk.
By putting together unique human samples of placenta, chorionic villi and amniotic fluid, and animal models, HappyMums will improve the understanding of the neurobiological mechanisms affected by depressive symptoms in pregnancy that lead to alterations in the foetal environment, shaping offspring risk for developing negative mental outcomes. The use of three complimentary rodent models will allow to achieve a proof of causality, and the presence of an innovative fish model will elucidate the mechanisms specific to placenta by which adverse maternal conditions are transmitted to the offspring without the potentially confounding mitigating effects of compensatory postnatal maternal care. This knowledge will allow the identification of new targets for the development of novel medications, for the repurposing of existing medications or for the development of non-pharmacological interventions. HappyMums will also develop a digital platform where AI tools-based data can be collected, together with biological, clinical, medical, environmental and lifestyle data, through a mobile phone App that will be at the interface with clinicians via a dedicated dashboard. This will allow early screening of depressive symptoms, prompt diagnoses, personalized treatments, and the promotion of protective lifestyle attitudes. Overall, HappyMums will not only increase the knowledge in the field of mental disorders in pregnancy, but also improve the wellbeing of these women, providing unprecedented benefits also to the offspring and thus to society at large.

Koordinator

UNIVERSITA DEGLI STUDI DI MILANO
Netto-EU-Beitrag
€ 1 620 416,00
Adresse
Via Festa Del Perdono 7
20122 Milano
Italien

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Region
Nord-Ovest Lombardia Milano
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 1 620 416,25

Beteiligte (13)

Partner (3)