BUILDING A SUSTAINABLE EUROPEAN INNOVATION PLATFORM TO ENHANCE THE REPURPOSING OF MEDICINES FOR ALL

Informazioni relative al progetto

REMEDi4ALL

ID dell’accordo di sovvenzione: 101057442

DOI

10.3030/101057442

Data della firma CE 19 Maggio 2022

Data di avvio 1 Settembre 2022

Data di completamento 31 Agosto 2027

Finanziato da

• Health

Costo totale

€ 22 561 532,00

Contributo UE

€ 22 561 532,00

Coordinato da

EATRIS ERIC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Report on AI tools and data resource

Report on existing AI tools and data resources carefully tested, ranked and classified for various repurposing applications.

Training landscape map

Report summarising existing information training and support in DR with publicfacing signposting to existing repurposing resources and trainings

Report on establishment of the Funders network

Documentation of commitment of funders that are motivated to join the Repurposing Funders Network, including Charter.

Report on the strategy and roadmap for collaboration with other synergies

This report will provide a guide of synergies with other projects and networks to be implemented during the project the methodological framework process and sources for the identification of projects with which to build synergies

Report on the 1st Annual Conference

Report on the 1st Annual Conference describing program highlights, attendees, interactions with key stakeholders and suggestions for agenda and organisation of next conference.

Report on services, expertise, barriers in the clinical development

Report describing the mapping of the clinical drug repruposing landscape identification of barriers gap analysis and blueprint report focusing on the clinical development

Pubblicazioni

Peer reviewed articles (16)

Integrated drug profiling and CRISPR screening identify BCR::ABL1-independent vulnerabilities in chronic myeloid leukemia

Autori: Adnan Awad, Shady; Dufva, Olli; Klievink, Jay; Karjalainen, Ella; Ianevski, Aleksandr; Pietarinen, Paavo; Kim, Daehong; Potdar, Swapnil; Wolf, Maija; Lotfi, Kourosh; Aittokallio, Tero; Wennerberg, Krister; Porkka, Kimmo; Mustjoki, Satu
Pubblicato in: Cell Reports Medicine, 2024, ISSN 2666-3791
Editore: Elsevier
DOI: 10.1016/J.XCRM.2024.101521

Medical Management for Fracture Prevention in Children with Osteogenesis Imperfecta

Autori: Paul Arundel; Nick Bishop
Pubblicato in: Calcified Tissue International, 2024, ISSN 1432-0827
Editore: Springer Nature
DOI: 10.1007/S00223-024-01202-7

Robust scoring of selective drug responses for patient-tailored therapy selection

Autori: Yingjia Chen; Liye He; Aleksandr Ianevski; Pilar Ayuda-Durán; Swapnil Potdar; Jani Saarela; Juho J. Miettinen; Sari Kytölä; Susanna Miettinen; Mikko Manninen; Caroline A. Heckman; Jorrit M. Enserink; Krister Wennerberg; Tero Aittokallio
Pubblicato in: Nature Protocols, 2023, ISSN 1750-2799
Editore: Nature Portfolio
DOI: 10.1038/S41596-023-00903-X

Randomized phase 2 study of valproic acid combined with simvastatin and gemcitabine/nab-paclitaxel-based regimens in untreated metastatic pancreatic adenocarcinoma patients: the VESPA trial study protocol

Autori: Alfredo Budillon, Alessandra Leone, Eugenia Passaro, Lucrezia Silvestro, Francesca Foschini, Federica Iannelli, Maria Serena Roca, Marina Macchini, Francesca Bruzzese, Maria Laura Garcia Bermejo, Mercedes Rodriguez Garrote, Giampaolo Tortora, Michele Mile
Pubblicato in: BMC Cancer, 2024, ISSN 1471-2407
Editore: BioMed Central
DOI: 10.1186/S12885-024-12936-W

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted<i>in vivo</i>and<i>in vitro</i>Data

Autori: Srijit Seal; Dominic P. Williams; Layla Hosseini-Gerami; Manas Mahale; Anne E. Carpenter; Ola Spjuth; Andreas Bender
Pubblicato in: Chemical Research in Toxicology, 2024, ISSN 1520-5010
Editore: American Chemical Society
DOI: 10.1021/ACS.CHEMRESTOX.4C00015

Nature Communications

Autori: Aleksandr Ianevski; Kristen Nader; Kyriaki Driva; Wojciech Senkowski; Daria Bulanova; Lidia Moyano-Galceran; Tanja Ruokoranta; Heikki Kuusanmäki; Nemo Ikonen; Philipp Sergeev; Markus Vähä-Koskela; Anil K. Giri; Anna Vähärautio; Mika Kontro; Kimmo Porkka; Esa Pitkänen; Caroline A. Heckman; Krister Wennerberg; Tero Aittokallio
Pubblicato in: Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones, 2024, ISSN 2041-1723
Editore: Springer Nature
DOI: 10.1038/S41467-024-52980-5

RepurposeDrugs: an interactive web-portal and predictive platform for repurposing mono- and combination therapies

Autori: Aleksandr Ianevski; Aleksandr Kushnir; Kristen Nader; Mitro Miihkinen; Henri Xhaard; Tero Aittokallio; Ziaurrehman Tanoli
Pubblicato in: Briefings in Bioinformatics, 2024, ISSN 1477-4054
Editore: Oxford University Press
DOI: 10.1093/BIB/BBAE328

Cell Painting: a decade of discovery and innovation in cellular imaging

Autori: Seal, Srijit; Trapotsi, Maria-Anna; Spjuth, Ola; Singh, Shantanu; Carreras-Puigvert, Jordi; Greene, Nigel; Bender, Andreas; Carpenter, Anne E
Pubblicato in: Nature Methods, 2024, ISSN 1548-7105
Editore: Nature Portfolio
DOI: 10.17863/CAM.112378

Artificial intelligence for high content imaging in drug discovery

Autori: Jordi Carreras-Puigvert; Ola Spjuth
Pubblicato in: Current Opinion in Structural Biology, 2024, ISSN 1879-033X
Editore: Elsevier
DOI: 10.1016/J.SBI.2024.102842

HPR155 Drug Repurposing: Policy Barriers to Using Existing Pharmaceuticals in New Indications: Results of a Systematic Literature Review

Autori: Z Petykó, D Hosszú, M Csanádi, GD Obeng, D Ameyaw, K Gyöngyösi, HG van der Meer, P Pantziarka, Z Kalo, A Inotai
Pubblicato in: Value in Health, Numero 27, 2024, ISSN 1098-3015
Editore: Elsevier BV
DOI: 10.1016/J.JVAL.2024.10.1581

From pixels to phenotypes: Integrating image-based profiling with cell health data as BioMorph features improves interpretability

Autori: Srijit Seal; Jordi Carreras-Puigvert; Shantanu Singh; Anne E. Carpenter; Ola Spjuth; Andreas Bender
Pubblicato in: Molecular Biology of the Cell, 2024, ISSN 1939-4586
Editore: American Society for Cell Biology
DOI: 10.1091/MBC.E23-08-0298

Attention-based approach to predict drug-target interactions across seven target superfamilies

Autori: Aron Schulman; Juho Rousu; Tero Aittokallio; Ziaurrehman Tanoli
Pubblicato in: Bioinformatics, 2024, ISSN 1367-4811
Editore: Oxford University Press
DOI: 10.1093/BIOINFORMATICS/BTAE496

Drug repurposing in Rett and Rett-like syndromes: a promising yet underrated opportunity?

Autori: Claudia Fuchs; Peter A. C. ‘t Hoen; Annelieke R. Müller; Annelieke R. Müller; Annelieke R. Müller; Friederike Ehrhart; Clara D. M. Van Karnebeek; Clara D. M. Van Karnebeek; Clara D. M. Van Karnebeek
Pubblicato in: Frontiers in Medicine, 2024, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/FMED.2024.1425038

Exploring SureChEMBL from a drug discovery perspective

Autori: Yojana Gadiya; Simran Shetty; Martin Hofmann-Apitius; Philip Gribbon; Andrea Zaliani
Pubblicato in: Nature Scientific Data, 2024, ISSN 2052-4463
Editore: Nature Portfolio
DOI: 10.1038/S41597-024-03371-4

Drug repurposing for rare: progress and opportunities for the rare disease community

Autori: Anneliene Hechtelt Jonker; Anneliene Hechtelt Jonker; Daniel O’Connor; Daniel O’Connor; Maria Cavaller-Bellaubi; Maria Cavaller-Bellaubi; Christine Fetro; Christine Fetro; Maria Gogou; Maria Gogou; Peter A. C. ’T Hoen; Peter A. C. ’T Hoen; Martin de Kort; Martin de Kort; Heather Stone; Heather Stone; Nivedita Valentine; Nivedita Valentine; Anna Maria Gerdina Pasmooij; Anna Maria Gerdina Pasmooij
Pubblicato in: Frontiers in Medicine, 2024, ISSN 2296-858X
Editore: Frontiers Media
DOI: 10.3389/FMED.2024.1352803

Insights into Drug Cardiotoxicity from Biological and Chemical Data: The First Public Classifiers for FDA Drug-Induced Cardiotoxicity Rank

Autori: Srijit Seal; Ola Spjuth; Layla Hosseini-Gerami; Miguel García-Ortegón; Shantanu Singh; Andreas Bender; Anne E. Carpenter
Pubblicato in: Journal of Chemical Information and Modeling, 2024, ISSN 1520-5142
Editore: American Chemical Society
DOI: 10.1021/ACS.JCIM.3C01834

Other (1)

REMEDi4ALL - Standard Operating Guideline - Fair Data Assessment

Autori: Gadiya, Yojana; Zaliani, Andrea
Pubblicato in: Zenodo, 2025
Editore: Zenodo
DOI: 10.5281/ZENODO.14605175