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Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness

Objective

Mental illness runs in families. The FAMILY consortium aims to improve the life of mentally-ill persons with novel prediction models that are based on better understanding the mechanisms of intergenerational transmission of mental illness. The objectives are to improve causal understanding and gain prediction power from the family context by the innovative combination of statistical modelling of genetically informed designs, causal inference, multimodal and multilevel normative prediction, and molecular mapping, brought by world-leading neuroscientific expertise of the consortium, and address key bioethical and social issues raised by the concept of intergenerational risk transmission and risk prediction. FAMILY will bring together the largest existing human (epi)genetic and neuroimaging datasets from both within-family population cohorts and familial high-risk offspring studies, as well as utilise innovative animal models to shed light on pathways underlying intergenerational risk transmission. FAMILY will focus specifically on risk for mood and psychosis symptoms and diagnoses. In-depth causal analyses of how and when risk for mental illness occurs will help identify early risk and resilience factors and predict who is likely to be diagnosed or develop symptoms of mental illness. Advanced insights can uncover new targets for the development of preventive strategies to break the intergenerational cycle of mental illness and to support strengths and resource building. An immediate benefit will be to open direct translational perspectives to mental health care professionals by providing new (family-based) risk prediction tools for the early identification of adults and children at risk and to deliver ethical guidelines to guide its implementation. This will accelerate preventive and treatment intervention in vulnerable families and help target resilience strategies to prevent the transition from health to disease despite high familial risk.

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Net EU contribution
€ 3 953 833,75
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands

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Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (13)

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netherlands
Net EU contribution
€ 2 720 437,00
Address
Geert Grooteplein 10 Zuid
6525 GA Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LEIBNIZ-INSTITUT FUR RESILIENZFORSCHUNG (LIR) GGMBH
Germany
Net EU contribution
€ 588 125,00
Address
Wallstrasse 7
55122 Mainz

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
LATVIJAS UNIVERSITATE
Latvia
Net EU contribution
€ 483 781,00
Address
Rainis Boulevard 19
1586 Riga

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Region
Latvija Latvija Rīga
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI PERUGIA
Italy
Net EU contribution
€ 67 500,00
Address
Piazza Dell Universita 1
06123 Perugia

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Region
Centro (IT) Umbria Perugia
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FOLKEHELSEINSTITUTTET
Norway
Net EU contribution
€ 361 777,00
Address
Lovisenberggata 8
0456 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
Net EU contribution
€ 571 622,00
Address
Carrer Rossello 149
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 121 093,00
Address
Calle Villarroel 170
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
HARVARD GLOBAL RESEARCH AND SUPPORT SERVICES INC.
United States
Net EU contribution
€ 456 348,00
Address
Office Of The General Counsel, Holyoke Center, Suite 980, Massachusetts Avenue 1350
02138 Cambridge

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Activity type
Research Organisations
Non-EU contribution
€ 0,00
CONCENTRIS RESEARCH MANAGEMENT GMBH
Germany
Net EU contribution
€ 651 625,00
Address
Ludwigstr. 4
82256 Furstenfeldbruck

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON
Spain
Net EU contribution
€ 263 313,00
Address
Calle Doctor Esquerdo 46
28007 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Other
Non-EU contribution
€ 0,00
REGION HOVEDSTADEN
Denmark
Net EU contribution
€ 611 705,00
Address
Kongens Vaenge 2
3400 Hillerod

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Region
Danmark Hovedstaden Nordsjælland
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
EUROPEAN SOCIETY FOR CHILD AND ADOLESCENT PSYCHIATRY
Belgium
Net EU contribution
€ 60 250,00
Address
Avenue De La Couronne 20
1050 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00
EUROPESE FEDERATIE VAN FAMILIEVERENIGINGEN VAN PSYCHIATRISCH ZIEKE PERSONEN IVZW
Belgium
Net EU contribution
€ 62 500,00
Address
Diestsevest 100
3000 Leuven

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven
Activity type
Other
Non-EU contribution
€ 0,00