Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness

Project Information

FAMILY

Grant agreement ID: 101057529

DOI

10.3030/101057529

EC signature date 24 May 2022

Start date 1 October 2022

End date 30 September 2027

Funded under

• Health

Total cost

€ 10 906 409,75

EU contribution

€ 10 906 409,75

Coordinated by

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (7)

1st version of data management, harmonisation, and open science plan
Report on the software pipelines based on simulation studies
Training plan
Marketing materials
1st report and plan for gender balance
Dissemination and Communication plan
Report on relevant outside initiatives and activities in the field and plan for collaboration

Other (2)

Registration numbers of the clinical studies (WHO Registry criteria)
Ethics institutional approvals

Websites, patent fillings, videos etc. (1)

Go-online of the public project website

Publications

Peer reviewed articles (72)

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Author(s): Charlotte A. M. Cecil, Alexander Neumann, Esther Walto
Published in: JCPP Advances, Issue 3, 1, 2023, ISSN 2692-9384
Publisher: CPP Advances Volume 3, Issue 1
DOI: 10.1186/s13073-023-01233-z

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Author(s): Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Published in: Brain, Behavior, and Immunity, Issue 118, 2025, ISSN 0889-1591
Publisher: Elsevier BV
DOI: 10.1016/J.BBI.2024.02.024

Understanding and predicting the intergenerational transmission of mental illness

Author(s): Nina Karguth, Lisanne A.E.M. van Houtum, Jörg M Fegert, Karen Schlaegel, Andrea Raballo, John Saunders, André Decraene, Neeltje E.M. van Haren
Published in: Open Access Government, Issue 44, 2024, ISSN 2516-3817
Publisher: Adjacent Digital Politics Ltd
DOI: 10.56367/OAG-044-11713

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Author(s): Hughes DE, Kunitoki K, Elyounssi S, Luo M, Bazer OM, Hopkinson CE, Dowling KF, Doyle AE, Dunn EC, Eryilmaz H, Gilman JM, Holt DJ, Valera EM, Smoller JW, Cecil CAM, Tiemeier H, Lee PH, Roffman JL.
Published in: Nature Neuroscience, Issue 26, 2023, ISSN 1546-1726
Publisher: Nature Neuroscience
DOI: 10.1038/s41593-023-01321-8

Plasma circulating microRNAs and symptoms of depression: Results from a population‐based study

Author(s): Midas M. Kuilman, Tim Finke, M. Arfan Ikram, Annemarie I. Luik, Alexander Neumann, Charlotte A.M. Cecil, Mohsen Ghanbari
Published in: Psychiatry and Clinical Neurosciences, Issue 79, 2025, ISSN 1323-1316
Publisher: Wiley
DOI: 10.1111/PCN.13869

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Author(s): Mulder RH, Kraaij R, Schuurmans IK, Frances-Cuesta C, Sanz Y, Medina-Gomez C, Duijts L, Rivadeneira F, Tiemeier H, Jaddoe VWV, Felix JF, Cecil CAM.
Published in: Brain, Behavior, and Immunity, 2024, ISSN 0889-1591
Publisher: Brain, Behavior, and Immunity
DOI: 10.1016/j.bbi.2024.02.024

Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness

Author(s): Lisanne A. E. M. van Houtum, William F. C. Baaré, Christian F. Beckmann, Josefina Castro-Fornieles, Charlotte A. M. Cecil, Juliane Dittrich, Bjørn H. Ebdrup, Jörg M. Fegert, Alexandra Havdahl, Manon H. J. Hillegers, Raffael Kalisch, Steven A. Kushner, Isabelle M. Mansuy, Signe Mežinska, Carmen Moreno, Ryan L. Muetzel, Alexander Neumann, Merete Nordentoft, Jean-Baptiste Pingault, Martin Preisig, Andrea Raballo, John Saunders, Emma Sprooten, Gisela Sugranyes, Henning Tiemeier, Geeske M. van Woerden, Caroline L. Vandeleur, Neeltje E. M. van Haren
Published in: European Child & Adolescent Psychiatry, Issue 33, 2024, ISSN 1018-8827
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00787-024-02423-9

Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis

Author(s): Ivars Neiders, Signe Mežinska, Neeltje E. M. van Haren
Published in: BMC Psychiatry, Issue 25, 2025, ISSN 1471-244X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12888-025-06949-3

Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls

Author(s): Kit Melissa Larsen, Júlia Díaz-i-Calvete, Anna Hester Ver Loren van Themaat, Anne Amalie Elgaard Thorup, Kerstin Jessica Plessen, Merete Nordentoft, Hartwig Roman Siebner
Published in: NeuroImage: Clinical, Issue 48, 2025, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/J.NICL.2025.103841

Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

Author(s): Xiaolong Guo, Mahnoor Sulaiman, Alexander Neumann, Shijie C. Zheng, Charlotte A.M. Cecil, Andrew E. Teschendorff, Bastiaan T. Heijmans
Published in: Genome Medicine, Issue 17, 2025, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01489-7

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Author(s): Irina Lazar-Contes, Rodrigo G Arzate-Mejia, Deepak K Tanwar, Leonard C Steg, Kerem Uzel, Olivier Ulrich Feudjio, Marion Crespo, Pierre-Luc Germain, Isabelle M Mansuy
Published in: eLife, Issue 12, 2025, ISSN 2050-084X
Publisher: eLife Sciences Publications, Ltd
DOI: 10.7554/ELIFE.91528.3

Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia

Author(s): Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse, Hugo G. Schnack, Manon H.J. Hillegers, Neeltje E.M. van Haren
Published in: European Neuropsychopharmacology, Issue 87, 2024, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/J.EURONEURO.2024.06.011

Inflammatory markers in pregnancy – identifying drivers in four large cohorts

Author(s): Frederieke A. J. Gigase, Anna Suleri, Elena Isaevska, Anna-Sophie Rommel, Myrthe G. B. M. Boekhorst, Olga Dmitrichenko, Hanan El Marroun, Eric A. P. Steegers, Manon H. J. Hillegers, Ryan L. Muetzel, Whitney Lieb, Charlotte A. M. Cecil, Victor J. M. Pop, Michael Breen, Veerle Bergink, Lot D. de Witte
Published in: Frontiers in Immunology, Issue 16, 2025, ISSN 1664-3224
Publisher: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1561798

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Author(s): Walton E, Baltramonaityte V, Calhoun V, Heijmans BT, Thompson PM, Cecil CAM.
Published in: Molecular Psychiatry, Issue 28, 2023, ISSN 1476-5578
Publisher: Molecular Psychiatry
DOI: 10.1038/s41380-023-02067-2

Exposure to prenatal infection and the developmentof internalizing and externalizing problems inchildren: a longitudinal population-based study

Author(s): Suleri A, Rommel AS, Neumann A, Luo M, Hillegers M, de Witte L, Bergink V, Cecil CAM.
Published in: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Publisher: Journal of Child Psychology and Psychiatry
DOI: 10.1111/jcpp.13923

Principal and independent genomic components of brain structure and function

Author(s): Oblong LM,Soheili-Nezhad S, Trevisan N, Shi Y, Beckmann CF, Sprooten E
Published in: Genes, Brain and Behavior, 2024, ISSN 1601-183X
Publisher: Genes, Brain and Behavior
DOI: 10.1111/gbb.12876

Participant engagement and involvement in longitudinal cohort studies: qualitative insights from a selection of pregnancy and birth, twin, and family-based population cohort studies

Author(s): Isabelle Budin-Ljøsne, Nanna A. G. Fredheim, Charlotte Alison Jevne, Bojana Milanovic Kleven, Marie Aline Charles, Janine F. Felix, Robin Flaig, María Paz García, Alexandra Havdahl, Shahid Islam, Shona M. Kerr, Inger Kristine Meder, Lynn Molloy, Susan M. B. Morton, Costanza Pizzi, Aamnah Rahman, Gonneke Willemsen, Diane Wood, Jennifer R. Harris
Published in: BMC Medical Research Methodology, Issue 24, 2024, ISSN 1471-2288
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12874-024-02419-8

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Author(s): Alexander Neumann, Sara Sammallahti, Marta Cosin-Tomas, Sarah E. Reese, Matthew Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrusaityte, Syed H. Arshad, Marian J. Bakermans-Kranenburg, Lawrence Beilin, Carrie Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, Celeste Eng, Brenda Eskenazi, Bernard F. Fuemmeler, Frank D. Gilliland, Regina Grazuleviciene, Siri E. Håberg, Gunda Herberth, Nina Holland, Amy Hough, Donglei Hu, Karen Huen, Anke Hüls, Marjo-Riitta Jarvelin, Jianping Jin, Jordi Julvez, Berthold V. Koletzko, Gerard H. Koppelman, Inger Kull, Xueling Lu, Léa Maitre, Dan Mason, Erik Melén, Simon K. Merid, Peter L. Molloy, Trevor A. Mori, Rosa H. Mulder, Christian M. Page, Rebecca C. Richmond, Stefan Röder, Jason P. Ross, Laura Schellhas, Sylvain Sebert, Dean Sheppard, Harold Snieder, Anne P. Starling, Dan J. Stein, Gwen Tindula, Marinus H. van IJzendoorn, Judith Vonk, Esther Walton, Jonathan Witonsky, Cheng-Jian Xu, Ivana V. Yang, Paul D. Yousefi, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Henning Tiemeier, Stephanie J. London, Janine F. Felix, Charlotte Cecil
Published in: Genome Medicine, Issue 17, 2025, ISSN 1756-994X
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01451-7

Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis

Author(s): Isabel K. Schuurmans, Dinka Smajlagic, Vilte Baltramonaityte, Anni L.K. Malmberg, Alexander Neumann, Nicole Creasey, Janine F. Felix, Henning Tiemeier, Jean-Baptiste Pingault, Darina Czamara, Katri Raïkkönen, Christian Magnus Page, Robert Lyle, Alexandra Havdahl, Jari Lahti, Esther Walton, Mona Bekkhus, Charlotte A.M. Cecil
Published in: Biological Psychiatry, 2025, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPSYCH.2025.09.005

Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring

Author(s): Dogukan Koc, Adriana P. C. Hermans, Bing Xu, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier
Published in: JAMA Network Open, Issue 8, 2025, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.23978

Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study

Author(s): Anna Suleri, Kristina Salontaji, Mannan Luo, Alexander Neumann, Rosa H. Mulder, Henning Tiemeier, Janine F. Felix, Riccardo E. Marioni, Veerle Bergink, Charlotte A.M. Cecil
Published in: Brain, Behavior, and Immunity, Issue 121, 2024, ISSN 0889-1591
Publisher: Elsevier BV
DOI: 10.1016/J.BBI.2024.07.046

Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches

Author(s): Ingunn Olea Lund, Laurie J. Hannigan, Helga Ask, Adrian D. Askelund, Laura Hegemann, Elizabeth C. Corfield, Robyn E. Wootton, Yasmin I. Ahmadzadeh, George Davey Smith, Tom A. McAdams, Eivind Ystrom, Alexandra Havdahl
Published in: BMC Medicine, Issue 23, 2025, ISSN 1741-7015
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03834-W

Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population‐based cohorts

Author(s): Marie‐Pier Larose, Isabel Schuurmans, Edward D. Barker, Liliana Garcia Mondragon, Henning Tiemeier, Irwin Waldman, Charlotte Cecil
Published in: Journal of Child Psychology and Psychiatry, 2025, ISSN 0021-9630
Publisher: Wiley
DOI: 10.1111/JCPP.70043

Risk factors for mood disorders among offspring of parents with bipolar disorder: Findings from a discordant-sibling study

Author(s): Giacomo FD, Strippoli MF, Castelao E, Amoussou JR, Gholam M, Ranjbar S, Glaus J, Marquet P, Preisig M, Plessen KJ, Vandeleur CL.
Published in: Psychiatry Research, 2023, ISSN 0165-1781
Publisher: Psychiatry Research
DOI: 10.1016/j.psychres.2023.115615

Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study

Author(s): Nicole Creasey, Isabel Schuurmans, Stella Tsotsi, Serena Defina, Vilte Baltramonaityte, Janine F. Felix, Alexander Neumann, Christian M. Page, Marieke Tollenaar, Mona Bekkhus, Esther Walton, Charlotte Cecil
Published in: Psychoneuroendocrinology, Issue 175, 2025, ISSN 0306-4530
Publisher: Elsevier BV
DOI: 10.1016/J.PSYNEUEN.2025.107388

Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders

Author(s): Nora R. Bakken, Nadine Parker, Laurie J. Hannigan, Espen Hagen, Pravesh Parekh, Alexey Shadrin, Piotr Jaholkowski, Evgeniia Frei, Viktoria Birkenæs, Guy Hindley, Laura Hegemann, Elizabeth C. Corfield, Martin Tesli, Alexandra Havdahl, Ole A. Andreassen
Published in: Journal of Child Psychology and Psychiatry, Issue 66, 2025, ISSN 0021-9630
Publisher: Wiley
DOI: 10.1111/JCPP.14063

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023).

Author(s): Cecil CAM, Schuurmans IK. 
Published in: Research on Child and Adolescent Psychopathology, 2023, ISSN 2730-7174
Publisher: Research on Child and Adolescent Psychopathology
DOI: 10.1007/S10802-023-01103-7

Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study

Author(s): Annalisa Lella, Linda A. Antonucci, Roberta Passiatore, Loredana Bellantuono, Pierluigi Selvaggi, Teresa Popolizio, Guido Di Sciascio, Alessandro Saponaro, Patrizia Ricci, Mario Altamura, Giuseppe Blasi, Antonio Rampino, Chris Vriend, Vince D. Calhoun, Kelly Rootes-Murdy, Aaron L. Goldman, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes, Elena De la Serna, Edith Pomarol-Clotet, Mar Fatjó-Vilas, Raymond Salvador, Andriana Karuk, Paola Fuentes-Claramonte, David C. Glahn, Amanda L. Rodrigue, John Blangero, Lei Wang, Taeyoung Lee, Karolin E. Einenkel, Saskia Hamers, Oliver Gruber, Adrian Preda, Young-Chul Chung, Soyolsaikhan Odkhuu, Corentin Vallée, Paola Dazzan, Machteld Marcelis, Stijn Michielse, Katharina Brosch, Frederike Stein, Igor Nenadić, Benjamin Straube, Florian Thomas-Odenthal, Tilo Kircher, Sean Carruthers, Susan L. Rossell, Phillip J. Sumner, Tamsyn E. Van Rheenen, Caroline Demro, Ian S. Ramsay, Scott R. Sponheim, Rebekka Lencer, Susanne Meinert, Tim Hahn, Udo Dannlowski, Dominik Grotegerd, Mariateresa Ciccarelli, Felice Iasevoli, Giuseppe Pontillo, Godfrey D. Pearlson, Derin Cobia, Fabrizio Piras, Nerisa Banaj, Daniela Vecchio, Marjolein E.A. Barendse, Neeltje E.M. van Haren, Hang Joon Jo, Kang Sim, Yann Quidé, Melissa J. Green, Rachael Slate, Giacomo Cecere, Wolfgang Omlor, Stephanie Homan, Philipp Homan, Sophia I. Thomopoulos, Anna Manzari, Antonello Bellomo, Jessica A. Turner, Theo G.M. van Erp, Paul M. Thompson, Alessandro Bertolino, Giulio Pergola
Published in: Biological Psychiatry, Issue 98, 2025, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPSYCH.2025.03.027

Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium

Author(s): Isabel K. Schuurmans, Rosa H. Mulder, Vilte Baltramonaityte, Alexandra Lahtinen, Fan Qiuyu, Leonardo Melo Rothmann, Marlene Staginnus, Jetro J. Tuulari, S. Alexandra Burt, Claudia Buss, Jeffrey M. Craig, Kirsten A. Donald, Johan G. Eriksson, Janine F. Felix, Tom P. Freeman, Rodrigo Grassi-Oliveira, Anke Huels, Luke W. Hyde, Scott A. Jones, Hasse Karlsson, Linnea Karlsson, Nastassja Koen, Will Lawn, Colter Mitchell, Christopher S. Monk, Michael A. Mooney, Ryan Muetzel, Joel T. Nigg, Síntia Iole Nogueira Belangero, Daniel Notterman, Yi Ying Ong, Tom O’Connor, Kieran J. O’Donnell, Pedro Mario Pan, Tiina Paunio, Peter Ryabinin, Richard Saffery, Giovanni A. Salum, Marc Seal, Tim J. Silk, Dan J. Stein, Ai Peng Tan, Ai Ling Teh, Dennis Wang, Heather Zar, Esther Walton, Charlotte A. M. Cecil
Published in: Molecular Psychiatry, 2025, ISSN 1359-4184
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41380-025-03203-W

Principal and independent genomic components of brain structure and function

Author(s): Lennart M. Oblong, Sourena Soheili‐Nezhad, Nicolò Trevisan, Yingjie Shi, Christian F. Beckmann, Emma Sprooten
Published in: Genes, Brain and Behavior, Issue 23, 2024, ISSN 1601-1848
Publisher: Wiley
DOI: 10.1111/GBB.12876

Examining longitudinal associations between prenatal exposure to infections and child brain morphology

Author(s): Anna Suleri, Carolin Gaiser, Charlotte A.M. Cecil, Annet Dijkzeul, Alexander Neumann, Jeremy A. Labrecque, Tonya White, Veerle Bergink, Ryan L. Muetzel
Published in: Brain, Behavior, and Immunity, Issue 119, 2024, ISSN 0889-1591
Publisher: Elsevier BV
DOI: 10.1016/J.BBI.2024.05.014

DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.

Author(s): Luo M, Walton E, Neumann A, Thio CHL, Felix JF, van IJzendoorn MH, Pappa I, Cecil CAM. 
Published in: Journal of Child Psychology and Psychiatry, 2024, ISSN 0021-9630
Publisher: Journal of Child Psychology and Psychiatry
DOI: 10.1111/JCPP.13866

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Author(s): Defina S, Woofenden T, Baltramonaityte V, Tiemeier H, Fairchild G, Felix JF, Cecil CAM, Walton E.
Published in: Preventive Medicine, 2024, ISSN 0091-7435
Publisher: Preventive Medicine
DOI: 10.1016/j.ypmed.2024.107926

The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank

Author(s): María Rodriguez-Ayllon, Alexander Neumann, Amy Hofman, Meike W. Vernooij, Julia Neitzel
Published in: Neurobiology of Aging, Issue 138, 2025, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/J.NEUROBIOLAGING.2024.03.001

Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology

Author(s): Kathryn Freeman, Alyson Zwicker, Janice M. Fullerton, Danella M. Hafeman, Neeltje E. M. van Haren, John Merranko, Benjamin I. Goldstein, Emma K. Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergi Mas, Gloria Roberts, Claudio Toma, Peter R. Schofield, Howard J. Edenberg, Holly C. Wilcox, Melvin G. McInnis, Lukas Propper, Barbara Pavlova, Samuel A. Stewart, Eileen M. Denovan-Wright, Guy A. Rouleau, Josefina Castro-Fornieles, Manon H. J. Hillegers, Boris Birmaher, Philip B. Mitchell, Martin Alda, John I. Nurnberger, Rudolf Uher
Published in: JAMA Network Open, Issue 8, 2025, ISSN 2574-3805
Publisher: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.5331

Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

Author(s): Siwen Wang, Emma Casey, Joanne Sordillo, Sofía Aguilar-Lacasaña, Fernanda Morales Berstein, Richard J. Biedrzycki, Sonia Brescianini, Su Chen, Amy Hough, Elena Isaevska, Woo Jin Kim, Marion Lecorguillé, Sebastian Shaobo Li, Christian M. Page, Jaehyun Park, Stefan Röder, Kristina Salontaji, Gillian Santorelli, Yidan Sun, Sungho Won, Eric Zillich, Lea Zillich, Isabella Annesi-Maesano, S. Hasan Arshad, Mariona Bustamante, Charlotte A. M. Cecil, Hannah R. Elliott, Susan Ewart, Janine F. Felix, Luigi Gagliardi, Siri E. Håberg, Gunda Herberth, Barbara Heude, John W. Holloway, Anke Huels, Wilfried Karmaus, Gerard H. Koppelman, Stephanie J. London, Sunni L. Mumford, Lorenza Nisticò, Maja Popovic, Franca Rusconi, Enrique F. Schisterman, Dan J. Stein, Tabea Send, Henning Tiemeier, Judith M. Vonk, Martine Vrijheid, Joseph Leo Wiemels, Stephanie H. Witt, John Wright, Edwina H. Yeung, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Jorge E. Chavarro, Marie-France Hivert
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR2084

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Author(s): Lazar-Contes I, Tanwar DK, Arzate-Meija RG, Steg LC, Feudijo OU, Crespo M, Germain PL, Mansuy IM
Published in: Genetics and Genomics, 2023, ISSN 2050-084X
Publisher: eLife
DOI: 10.7554/eLife.91528.1

A father’s legacy: the sperm epigenome, preimplantation development, and paternal environment

Author(s): Leonard C. Steg, Isabelle M. Mansuy
Published in: Epigenomics, 2025, ISSN 1750-1911
Publisher: Informa UK Limited
DOI: 10.1080/17501911.2025.2569301

Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation – A longitudinal population-based study

Author(s): Anna Suleri, Nicole Creasey, Esther Walton, Ryan Muetzel, Janine F. Felix, Liesbeth Duijts, Veerle Bergink, Charlotte A.M. Cecil
Published in: Brain, Behavior, and Immunity, Issue 122, 2025, ISSN 0889-1591
Publisher: Elsevier BV
DOI: 10.1016/J.BBI.2024.08.053

Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia

Author(s): Simon R. Poortman, Jakub Jamarík, Louise ten Harmsen van der Beek, Nikita Setiaman, Manon H.J. Hillegers, Marjolein E.A. Barendse, Neeltje E.M. van Haren
Published in: Developmental Cognitive Neuroscience, Issue 72, 2025, ISSN 1878-9293
Publisher: Elsevier BV
DOI: 10.1016/J.DCN.2025.101536

Long-term physical health conditions and youth anxiety and depression: Is there a causal link?

Author(s): Amy Shakeshaft, Jessica R. Mundy, Emil M. Pedersen, Charlotte A. Dennison, Lucy Riglin, Daniela Bragantini, Elizabeth C. Corfield, Ajay K. Thapar, Ole A. Andreassen, Evie Stergiakouli, George Davey Smith, Laurie Hannigan, Katherine L. Musliner, Alexandra Havdahl, Anita Thapar
Published in: Psychological Medicine, Issue 55, 2025, ISSN 0033-2917
Publisher: Cambridge University Press (CUP)
DOI: 10.1017/S0033291724003271

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Author(s): Kaupper CS, Blaauwendraad SM, Cecil CAM, Mulder RH, Gaillard R, Goncalves R, Borggraefe I, Koletzko B, Jaddoe VWV.
Published in: Metabolites, 2023, ISSN 2218-1989
Publisher: Metabolites
DOI: 10.3390/metabo13111140

Comparing cognition in parents with schizophrenia or bipolar disorder and their 7-year-old offspring

Author(s): Aja Neergaard Greve, Nicoline Hemager, Erik Lykke Mortensen, Ditte Lou Gantriis, Birgitte Klee Burton, Ditte Ellersgaard, Kerstin J. Plessen, Anne A.E. Thorup, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Ole Mors, Arndis Simonsen
Published in: Psychiatry Research, Issue 340, 2024, ISSN 0165-1781
Publisher: Elsevier BV
DOI: 10.1016/J.PSYCHRES.2024.116112

Debate: Child and adolescent mental health services: time to take the lead in prevention of psychosis in youth

Author(s): Inmaculada Baeza, Gisela Sugranyes
Published in: Child and Adolescent Mental Health, Issue 28, 2025, ISSN 1475-357X
Publisher: Wiley
DOI: 10.1111/CAMH.12679

Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study

Author(s): E. De la Serna, D. Moreno, G. Sugranyes, P. Camprodon-Boadas, D. Ilzarbe, A. Bigorra, B. Mora-Maltas, I. Baeza, I. Flamarique, S. Parrilla, C. M. Díaz-Caneja, C. Moreno, R. Borras, C. Torrent, C. Garcia-Rizo, J. Castro-Fornieles
Published in: European Child & Adolescent Psychiatry, Issue 34, 2025, ISSN 1018-8827
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00787-025-02719-4

Fetal Head Growth and Head Circumference at Birth in Children of Women with Psychotic Disorders and Population-Based Controls

Author(s): Lisanne A E M van Houtum, Dogukan Koc, Sterna A Grundeman, Hans J Duvekot, Hanan El Marroun, Neeltje E M van Haren, Hilmar H Bijma
Published in: Schizophrenia Bulletin, 2025, ISSN 0586-7614
Publisher: Oxford University Press (OUP)
DOI: 10.1093/SCHBUL/SBAF171

The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life

Author(s): Adrian Dahl Askelund, Laura Hegemann, Andrea G. Allegrini, Elizabeth C. Corfield, Helga Ask, Neil M. Davies, Ole A. Andreassen, Alexandra Havdahl, Laurie J. Hannigan
Published in: Biological Psychiatry, Issue 97, 2025, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/J.BIOPSYCH.2024.12.021

Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia

Author(s): Simon R. Poortman, Marjolein E.A. Barendse, Nikita Setiaman, Martijn P. van den Heuvel, Siemon C. de Lange, Manon H.J. Hillegers, Neeltje E.M. van Haren
Published in: Biological Psychiatry Global Open Science, Issue 4, 2024, ISSN 2667-1743
Publisher: Elsevier BV
DOI: 10.1016/J.BPSGOS.2024.100336

Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study

Author(s): Kristina Salontaji, Kristine L. Haftorn, Faye Sanders, Christian M. Page, Esther Walton, Janine F. Felix, Mona Bekkhus, Jon Bohlin, Henning Tiemeier, Charlotte A. M. Cecil
Published in: Molecular Psychiatry, Issue 29, 2024, ISSN 1359-4184
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02544-2

Transgenerational effects of early life stress on the fecal microbiota in mice

Author(s): Nize Otaru, Lola Kourouma, Benoit Pugin, Florentin Constancias, Christian Braegger, Isabelle M. Mansuy, Christophe Lacroix
Published in: Communications Biology, Issue 7, 2024, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S42003-024-06279-2

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

Author(s): A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-57694-W

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain. 

Author(s): Arzate-Mejia RG, Carullo NVN, Mansuy IM.
Published in: Current Opinion in Neurobiology, 2023, ISSN 0959-4388
Publisher: Current Opinion in Neurobiology
DOI: 10.1016/J.CONB.2023.102832

Neurobiology and systems biology of stress resilience

Author(s): Raffael Kalisch, Scott J. Russo, Marianne B. Müller
Published in: Physiological Reviews, Issue 104, 2024, ISSN 0031-9333
Publisher: American Physiological Society
DOI: 10.1152/PHYSREV.00042.2023

Early detection and intervention through the lens of the neurodevelopmental framework: the salience of developmental years and related services

Author(s): Andrea Raballo, Michele Poletti, Antonio Preti
Published in: The British Journal of Psychiatry, Issue 225, 2024, ISSN 0007-1250
Publisher: Royal College of Psychiatrists
DOI: 10.1192/BJP.2024.146

Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior

Author(s): Marta Schiavon, Birgitte K. Burton, Nicoline Hemager, Aja N. Greve, Katrine S. Spang, Ditte Ellersgaard, Kerstin Jessica Plessen, Jens Richardt M. Jepsen, Anne A. E. Thorup, Thomas Werge, Merete Nordentoft, Ron Nudel
Published in: European Journal of Neuroscience, Issue 61, 2025, ISSN 0953-816X
Publisher: Wiley
DOI: 10.1111/EJN.70163

Evocative effects of children's education‐associated genetics on maternal parenting: results from the Norwegian mother, father and child cohort study

Author(s): Chloe Austerberry, Tetyana Zayats, Angelica Ronald, Elizabeth Corfield, Dinka Smajlagic, Alexandra Havdahl, Ole A. Andreassen, Per Magnus, Pål R. Njølstad, Mona Bekkhus, Pasco Fearon
Published in: Journal of Child Psychology and Psychiatry, 2025, ISSN 0021-9630
Publisher: Wiley
DOI: 10.1111/JCPP.70025

The effect of age and sex on brain metabolites: from childhood to adulthood

Author(s): María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes
Published in: NeuroImage, Issue 317, 2025, ISSN 1053-8119
Publisher: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2025.121353

Assessing risk for bipolar disorder. Comments on ``Young people at risk for developing bipolar disorder: Two-year findings from the multicenter prospective, naturalistic Early-BipoLife study'' (Martini et al., 2023)

Author(s): Mireia Solerdelcoll, Inmaculada Baeza, Gisela Sugranyes
Published in: European Neuropsychopharmacology, Issue 81, 2025, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/J.EURONEURO.2024.01.001

The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank

Author(s): Rodriguez-Ayllon M, Neumann A, Hofman A, Vernooij MW, Neitzel J.
Published in: Neurobiology of Aging, 2024, ISSN 0197-4580
Publisher: Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2024.03.001

Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study

Author(s): Robyn E. Wootton, Kyle Dack, Hannah J. Jones, Lucy Riglin, Paul Madley-Dowd, Carolina Borges, Panagiota Pagoni, Christine Roth, Anne Lise Brantsæter, Elizabeth C. Corfield, Camilla Stoltenberg, Anne-Siri Øyen, George Davey Smith, Helga Ask, Anita Thapar, Evie Stergiakouli, Alexandra Havdahl
Published in: Psychological Medicine, Issue 54, 2025, ISSN 0033-2917
Publisher: Cambridge University Press (CUP)
DOI: 10.1017/S0033291724001466

Prenatal exposure to adverse life events and autism and autistic‐like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)

Author(s): Aleksandra Kanina, Arvid Sjölander, Miriam I. Martini, Agnieszka Butwicka, Henrik Larsson, Amanda M. Hughes, Márta K. Radó, Mark J. Taylor, Alexandra Havdahl, Helga Ask, Mina A. Rosenqvist
Published in: JCPP Advances, 2025, ISSN 2692-9384
Publisher: Wiley
DOI: 10.1002/JCV2.70002

Biological pathways underlying the relationship between childhood maltreatment and Multimorbidity: A two-step, multivariable Mendelian randomisation study

Author(s): Vilte Baltramonaityte, Ville Karhunen, Janine F. Felix, Brenda W.J.H. Penninx, Charlotte A.M. Cecil, Graeme Fairchild, Yuri Milaneschi, Esther Walton
Published in: Brain, Behavior, and Immunity, Issue 126, 2025, ISSN 0889-1591
Publisher: Elsevier BV
DOI: 10.1016/J.BBI.2025.01.024

Neurobiology and systems biology of stress resilience. 

Author(s): Kalisch R, Russo SJ, Müller MB.
Published in: Physiological Reviews, 2023, ISSN 0031-9333
Publisher: Physiological Reviews
DOI: 10.1152/PHYSREV.00042.2023

Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.

Author(s): Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, Blin O, Richardson JC, Bordet R, Lleó A, Alcolea D, Popp J, Marsh TW, Gorijala
Published in: Genome Medicine volume, 2023, ISSN 1756-994X
Publisher: Genome Medicine volume
DOI: 10.1186/s13073-023-01233-z

Are different types of childhood adversities correlated within and across time? A comparison of data on adversity co-occurrence from three longitudinal birth cohort studies

Author(s): Madison E. Bigler, Isabel K. Schuurmans, Yiwen Zhu, Nitasha Siddique, Nadia Hoffman, Nastassja Koen, Heather J. Zar, Dan J. Stein, Charlotte A.M. Cecil, Erin C. Dunn
Published in: Child Abuse & Neglect, Issue 168, 2025, ISSN 0145-2134
Publisher: Elsevier BV
DOI: 10.1016/J.CHIABU.2025.107315

Youth psychotic experiences: psychometric evaluation and diagnostic associations of the <scp>CAPE</scp> ‐16 in adolescents from the Norwegian Mother, Father and Child Cohort

Author(s): Viktoria Birkenæs, Pravesh Parekh, Laura Hegemann, Nora R. Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B. Smeland, Ezra Susser, Katrina M. Rodriguez, Markos Tesfaye, Ole A. Andreassen, Alexandra Havdahl, Ida E. Sønderby
Published in: Journal of Child Psychology and Psychiatry, 2025, ISSN 0021-9630
Publisher: Wiley
DOI: 10.1111/JCPP.70007

Parental education and children’s depression, anxiety, and ADHD traits, a within-family study in MoBa

Author(s): Amanda M. Hughes, Fartein Ask Torvik, Elsje van Bergen, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Eivind Ystrom, Helga Ask, George Davey Smith, Neil M. Davies, Alexandra Havdahl
Published in: npj Science of Learning, Issue 9, 2024, ISSN 2056-7936
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41539-024-00260-8

Characterising developmental dynamics of adult epigenetic clock sites

Author(s): Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil
Published in: eBioMedicine, Issue 109, 2024, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/J.EBIOM.2024.105425

Remembering through the genome: the role of chromatin states in brain functions and diseases

Author(s): Arzate-Mejia RG, Mansuy IM.
Published in: Translational Psychiatry, Issue 122, 2023, ISSN 2158-3188
Publisher: Translational Psychiatry
DOI: 10.1038/s41398-023-02415-4

Dynastic social processes and the transgenerational transmission of risk and resilience to mental illness: implications for prevention

Author(s): Andrea Raballo, Michele Poletti, Antonio Preti
Published in: European Child &amp; Adolescent Psychiatry, Issue 34, 2025, ISSN 1018-8827
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00787-024-02551-2

Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults

Author(s): Yingjie Shi, Nina Roth Mota, Barbara Franke, Emma Sprooten
Published in: Translational Psychiatry, Issue 15, 2025, ISSN 2158-3188
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41398-025-03443-Y

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Author(s): Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Published in: Preventive Medicine, Issue 182, 2025, ISSN 0091-7435
Publisher: Elsevier BV
DOI: 10.1016/J.YPMED.2024.107926