Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness

Informations projet

FAMILY

N° de convention de subvention: 101057529

DOI

10.3030/101057529

Date de signature de la CE 24 Mai 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2027

Financé au titre de

• Health

Coût total

€ 10 906 409,75

Contribution de l’UE

€ 10 906 409,75

Coordonné par

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

1st version of data management, harmonisation, and open science plan
Report on the software pipelines based on simulation studies
Training plan
Marketing materials
1st report and plan for gender balance
Dissemination and Communication plan
Report on relevant outside initiatives and activities in the field and plan for collaboration

Other (2)

Registration numbers of the clinical studies (WHO Registry criteria)
Ethics institutional approvals

Websites, patent fillings, videos etc. (1)

Go-online of the public project website

Publications

Peer reviewed articles (72)

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Auteurs: Charlotte A. M. Cecil, Alexander Neumann, Esther Walto
Publié dans: JCPP Advances, Numéro 3, 1, 2023, ISSN 2692-9384
Éditeur: CPP Advances Volume 3, Issue 1
DOI: 10.1186/s13073-023-01233-z

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Auteurs: Rosa H. Mulder, Robert Kraaij, Isabel K. Schuurmans, Carlos Frances-Cuesta, Yolanda Sanz, Carolina Medina-Gomez, Liesbeth Duijts, Fernando Rivadeneira, Henning Tiemeier, Vincent W.V. Jaddoe, Janine F. Felix, Charlotte A.M. Cecil
Publié dans: Brain, Behavior, and Immunity, Numéro 118, 2025, ISSN 0889-1591
Éditeur: Elsevier BV
DOI: 10.1016/J.BBI.2024.02.024

Understanding and predicting the intergenerational transmission of mental illness

Auteurs: Nina Karguth, Lisanne A.E.M. van Houtum, Jörg M Fegert, Karen Schlaegel, Andrea Raballo, John Saunders, André Decraene, Neeltje E.M. van Haren
Publié dans: Open Access Government, Numéro 44, 2024, ISSN 2516-3817
Éditeur: Adjacent Digital Politics Ltd
DOI: 10.56367/OAG-044-11713

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Auteurs: Hughes DE, Kunitoki K, Elyounssi S, Luo M, Bazer OM, Hopkinson CE, Dowling KF, Doyle AE, Dunn EC, Eryilmaz H, Gilman JM, Holt DJ, Valera EM, Smoller JW, Cecil CAM, Tiemeier H, Lee PH, Roffman JL.
Publié dans: Nature Neuroscience, Numéro 26, 2023, ISSN 1546-1726
Éditeur: Nature Neuroscience
DOI: 10.1038/s41593-023-01321-8

Plasma circulating microRNAs and symptoms of depression: Results from a population‐based study

Auteurs: Midas M. Kuilman, Tim Finke, M. Arfan Ikram, Annemarie I. Luik, Alexander Neumann, Charlotte A.M. Cecil, Mohsen Ghanbari
Publié dans: Psychiatry and Clinical Neurosciences, Numéro 79, 2025, ISSN 1323-1316
Éditeur: Wiley
DOI: 10.1111/PCN.13869

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Auteurs: Mulder RH, Kraaij R, Schuurmans IK, Frances-Cuesta C, Sanz Y, Medina-Gomez C, Duijts L, Rivadeneira F, Tiemeier H, Jaddoe VWV, Felix JF, Cecil CAM.
Publié dans: Brain, Behavior, and Immunity, 2024, ISSN 0889-1591
Éditeur: Brain, Behavior, and Immunity
DOI: 10.1016/j.bbi.2024.02.024

Running in the FAMILY: understanding and predicting the intergenerational transmission of mental illness

Auteurs: Lisanne A. E. M. van Houtum, William F. C. Baaré, Christian F. Beckmann, Josefina Castro-Fornieles, Charlotte A. M. Cecil, Juliane Dittrich, Bjørn H. Ebdrup, Jörg M. Fegert, Alexandra Havdahl, Manon H. J. Hillegers, Raffael Kalisch, Steven A. Kushner, Isabelle M. Mansuy, Signe Mežinska, Carmen Moreno, Ryan L. Muetzel, Alexander Neumann, Merete Nordentoft, Jean-Baptiste Pingault, Martin Preisig, Andrea Raballo, John Saunders, Emma Sprooten, Gisela Sugranyes, Henning Tiemeier, Geeske M. van Woerden, Caroline L. Vandeleur, Neeltje E. M. van Haren
Publié dans: European Child & Adolescent Psychiatry, Numéro 33, 2024, ISSN 1018-8827
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00787-024-02423-9

Ethical and social issues in prediction of risk of severe mental illness: a scoping review and thematic analysis

Auteurs: Ivars Neiders, Signe Mežinska, Neeltje E. M. van Haren
Publié dans: BMC Psychiatry, Numéro 25, 2025, ISSN 1471-244X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12888-025-06949-3

Comparable 40 Hz auditory steady-state responses in children at familial high risk for schizophrenia or bipolar disorder and population-based controls

Auteurs: Kit Melissa Larsen, Júlia Díaz-i-Calvete, Anna Hester Ver Loren van Themaat, Anne Amalie Elgaard Thorup, Kerstin Jessica Plessen, Merete Nordentoft, Hartwig Roman Siebner
Publié dans: NeuroImage: Clinical, Numéro 48, 2025, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/J.NICL.2025.103841

Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

Auteurs: Xiaolong Guo, Mahnoor Sulaiman, Alexander Neumann, Shijie C. Zheng, Charlotte A.M. Cecil, Andrew E. Teschendorff, Bastiaan T. Heijmans
Publié dans: Genome Medicine, Numéro 17, 2025, ISSN 1756-994X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01489-7

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Auteurs: Irina Lazar-Contes, Rodrigo G Arzate-Mejia, Deepak K Tanwar, Leonard C Steg, Kerem Uzel, Olivier Ulrich Feudjio, Marion Crespo, Pierre-Luc Germain, Isabelle M Mansuy
Publié dans: eLife, Numéro 12, 2025, ISSN 2050-084X
Éditeur: eLife Sciences Publications, Ltd
DOI: 10.7554/ELIFE.91528.3

Non-linear development of brain morphometry in child and adolescent offspring of individuals with bipolar disorder or schizophrenia

Auteurs: Simon R. Poortman, Nikita Setiaman, Marjolein E.A. Barendse, Hugo G. Schnack, Manon H.J. Hillegers, Neeltje E.M. van Haren
Publié dans: European Neuropsychopharmacology, Numéro 87, 2024, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/J.EURONEURO.2024.06.011

Inflammatory markers in pregnancy – identifying drivers in four large cohorts

Auteurs: Frederieke A. J. Gigase, Anna Suleri, Elena Isaevska, Anna-Sophie Rommel, Myrthe G. B. M. Boekhorst, Olga Dmitrichenko, Hanan El Marroun, Eric A. P. Steegers, Manon H. J. Hillegers, Ryan L. Muetzel, Whitney Lieb, Charlotte A. M. Cecil, Victor J. M. Pop, Michael Breen, Veerle Bergink, Lot D. de Witte
Publié dans: Frontiers in Immunology, Numéro 16, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2025.1561798

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Auteurs: Walton E, Baltramonaityte V, Calhoun V, Heijmans BT, Thompson PM, Cecil CAM.
Publié dans: Molecular Psychiatry, Numéro 28, 2023, ISSN 1476-5578
Éditeur: Molecular Psychiatry
DOI: 10.1038/s41380-023-02067-2

Exposure to prenatal infection and the developmentof internalizing and externalizing problems inchildren: a longitudinal population-based study

Auteurs: Suleri A, Rommel AS, Neumann A, Luo M, Hillegers M, de Witte L, Bergink V, Cecil CAM.
Publié dans: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Éditeur: Journal of Child Psychology and Psychiatry
DOI: 10.1111/jcpp.13923

Principal and independent genomic components of brain structure and function

Auteurs: Oblong LM,Soheili-Nezhad S, Trevisan N, Shi Y, Beckmann CF, Sprooten E
Publié dans: Genes, Brain and Behavior, 2024, ISSN 1601-183X
Éditeur: Genes, Brain and Behavior
DOI: 10.1111/gbb.12876

Participant engagement and involvement in longitudinal cohort studies: qualitative insights from a selection of pregnancy and birth, twin, and family-based population cohort studies

Auteurs: Isabelle Budin-Ljøsne, Nanna A. G. Fredheim, Charlotte Alison Jevne, Bojana Milanovic Kleven, Marie Aline Charles, Janine F. Felix, Robin Flaig, María Paz García, Alexandra Havdahl, Shahid Islam, Shona M. Kerr, Inger Kristine Meder, Lynn Molloy, Susan M. B. Morton, Costanza Pizzi, Aamnah Rahman, Gonneke Willemsen, Diane Wood, Jennifer R. Harris
Publié dans: BMC Medical Research Methodology, Numéro 24, 2024, ISSN 1471-2288
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12874-024-02419-8

Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium

Auteurs: Alexander Neumann, Sara Sammallahti, Marta Cosin-Tomas, Sarah E. Reese, Matthew Suderman, Silvia Alemany, Catarina Almqvist, Sandra Andrusaityte, Syed H. Arshad, Marian J. Bakermans-Kranenburg, Lawrence Beilin, Carrie Breton, Mariona Bustamante, Darina Czamara, Dana Dabelea, Celeste Eng, Brenda Eskenazi, Bernard F. Fuemmeler, Frank D. Gilliland, Regina Grazuleviciene, Siri E. Håberg, Gunda Herberth, Nina Holland, Amy Hough, Donglei Hu, Karen Huen, Anke Hüls, Marjo-Riitta Jarvelin, Jianping Jin, Jordi Julvez, Berthold V. Koletzko, Gerard H. Koppelman, Inger Kull, Xueling Lu, Léa Maitre, Dan Mason, Erik Melén, Simon K. Merid, Peter L. Molloy, Trevor A. Mori, Rosa H. Mulder, Christian M. Page, Rebecca C. Richmond, Stefan Röder, Jason P. Ross, Laura Schellhas, Sylvain Sebert, Dean Sheppard, Harold Snieder, Anne P. Starling, Dan J. Stein, Gwen Tindula, Marinus H. van IJzendoorn, Judith Vonk, Esther Walton, Jonathan Witonsky, Cheng-Jian Xu, Ivana V. Yang, Paul D. Yousefi, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Henning Tiemeier, Stephanie J. London, Janine F. Felix, Charlotte Cecil
Publié dans: Genome Medicine, Numéro 17, 2025, ISSN 1756-994X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S13073-025-01451-7

Genetic Susceptibility to Neurodevelopmental Conditions Is Associated With Neonatal DNA Methylation Patterns in the General Population: An Individual Participant Data Meta-Analysis

Auteurs: Isabel K. Schuurmans, Dinka Smajlagic, Vilte Baltramonaityte, Anni L.K. Malmberg, Alexander Neumann, Nicole Creasey, Janine F. Felix, Henning Tiemeier, Jean-Baptiste Pingault, Darina Czamara, Katri Raïkkönen, Christian Magnus Page, Robert Lyle, Alexandra Havdahl, Jari Lahti, Esther Walton, Mona Bekkhus, Charlotte A.M. Cecil
Publié dans: Biological Psychiatry, 2025, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOPSYCH.2025.09.005

Perinatal Maternal Depressive Symptoms and Brain Connectivity Among 9- to 15-Year-Old Offspring

Auteurs: Dogukan Koc, Adriana P. C. Hermans, Bing Xu, Ryan L. Muetzel, Hanan El Marroun, Henning Tiemeier
Publié dans: JAMA Network Open, Numéro 8, 2025, ISSN 2574-3805
Éditeur: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.23978

Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study

Auteurs: Anna Suleri, Kristina Salontaji, Mannan Luo, Alexander Neumann, Rosa H. Mulder, Henning Tiemeier, Janine F. Felix, Riccardo E. Marioni, Veerle Bergink, Charlotte A.M. Cecil
Publié dans: Brain, Behavior, and Immunity, Numéro 121, 2024, ISSN 0889-1591
Éditeur: Elsevier BV
DOI: 10.1016/J.BBI.2024.07.046

Prenatal maternal stress: triangulating evidence for intrauterine exposure effects on birth and early childhood outcomes across multiple approaches

Auteurs: Ingunn Olea Lund, Laurie J. Hannigan, Helga Ask, Adrian D. Askelund, Laura Hegemann, Elizabeth C. Corfield, Robyn E. Wootton, Yasmin I. Ahmadzadeh, George Davey Smith, Tom A. McAdams, Eivind Ystrom, Alexandra Havdahl
Publié dans: BMC Medicine, Numéro 23, 2025, ISSN 1741-7015
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/S12916-024-03834-W

Associations between genetic predisposition to mental health problems and academic achievement: a developmental perspective using two population‐based cohorts

Auteurs: Marie‐Pier Larose, Isabel Schuurmans, Edward D. Barker, Liliana Garcia Mondragon, Henning Tiemeier, Irwin Waldman, Charlotte Cecil
Publié dans: Journal of Child Psychology and Psychiatry, 2025, ISSN 0021-9630
Éditeur: Wiley
DOI: 10.1111/JCPP.70043

Risk factors for mood disorders among offspring of parents with bipolar disorder: Findings from a discordant-sibling study

Auteurs: Giacomo FD, Strippoli MF, Castelao E, Amoussou JR, Gholam M, Ranjbar S, Glaus J, Marquet P, Preisig M, Plessen KJ, Vandeleur CL.
Publié dans: Psychiatry Research, 2023, ISSN 0165-1781
Éditeur: Psychiatry Research
DOI: 10.1016/j.psychres.2023.115615

Prenatal stress, epigenetically-assessed glucocorticoid exposure at birth, and child psychiatric symptoms: A prospective, multi-cohort study

Auteurs: Nicole Creasey, Isabel Schuurmans, Stella Tsotsi, Serena Defina, Vilte Baltramonaityte, Janine F. Felix, Alexander Neumann, Christian M. Page, Marieke Tollenaar, Mona Bekkhus, Esther Walton, Charlotte Cecil
Publié dans: Psychoneuroendocrinology, Numéro 175, 2025, ISSN 0306-4530
Éditeur: Elsevier BV
DOI: 10.1016/J.PSYNEUEN.2025.107388

Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders

Auteurs: Nora R. Bakken, Nadine Parker, Laurie J. Hannigan, Espen Hagen, Pravesh Parekh, Alexey Shadrin, Piotr Jaholkowski, Evgeniia Frei, Viktoria Birkenæs, Guy Hindley, Laura Hegemann, Elizabeth C. Corfield, Martin Tesli, Alexandra Havdahl, Ole A. Andreassen
Publié dans: Journal of Child Psychology and Psychiatry, Numéro 66, 2025, ISSN 0021-9630
Éditeur: Wiley
DOI: 10.1111/JCPP.14063

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023).

Auteurs: Cecil CAM, Schuurmans IK. 
Publié dans: Research on Child and Adolescent Psychopathology, 2023, ISSN 2730-7174
Éditeur: Research on Child and Adolescent Psychopathology
DOI: 10.1007/S10802-023-01103-7

Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study

Auteurs: Annalisa Lella, Linda A. Antonucci, Roberta Passiatore, Loredana Bellantuono, Pierluigi Selvaggi, Teresa Popolizio, Guido Di Sciascio, Alessandro Saponaro, Patrizia Ricci, Mario Altamura, Giuseppe Blasi, Antonio Rampino, Chris Vriend, Vince D. Calhoun, Kelly Rootes-Murdy, Aaron L. Goldman, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes, Elena De la Serna, Edith Pomarol-Clotet, Mar Fatjó-Vilas, Raymond Salvador, Andriana Karuk, Paola Fuentes-Claramonte, David C. Glahn, Amanda L. Rodrigue, John Blangero, Lei Wang, Taeyoung Lee, Karolin E. Einenkel, Saskia Hamers, Oliver Gruber, Adrian Preda, Young-Chul Chung, Soyolsaikhan Odkhuu, Corentin Vallée, Paola Dazzan, Machteld Marcelis, Stijn Michielse, Katharina Brosch, Frederike Stein, Igor Nenadić, Benjamin Straube, Florian Thomas-Odenthal, Tilo Kircher, Sean Carruthers, Susan L. Rossell, Phillip J. Sumner, Tamsyn E. Van Rheenen, Caroline Demro, Ian S. Ramsay, Scott R. Sponheim, Rebekka Lencer, Susanne Meinert, Tim Hahn, Udo Dannlowski, Dominik Grotegerd, Mariateresa Ciccarelli, Felice Iasevoli, Giuseppe Pontillo, Godfrey D. Pearlson, Derin Cobia, Fabrizio Piras, Nerisa Banaj, Daniela Vecchio, Marjolein E.A. Barendse, Neeltje E.M. van Haren, Hang Joon Jo, Kang Sim, Yann Quidé, Melissa J. Green, Rachael Slate, Giacomo Cecere, Wolfgang Omlor, Stephanie Homan, Philipp Homan, Sophia I. Thomopoulos, Anna Manzari, Antonello Bellomo, Jessica A. Turner, Theo G.M. van Erp, Paul M. Thompson, Alessandro Bertolino, Giulio Pergola
Publié dans: Biological Psychiatry, Numéro 98, 2025, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOPSYCH.2025.03.027

Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium

Auteurs: Isabel K. Schuurmans, Rosa H. Mulder, Vilte Baltramonaityte, Alexandra Lahtinen, Fan Qiuyu, Leonardo Melo Rothmann, Marlene Staginnus, Jetro J. Tuulari, S. Alexandra Burt, Claudia Buss, Jeffrey M. Craig, Kirsten A. Donald, Johan G. Eriksson, Janine F. Felix, Tom P. Freeman, Rodrigo Grassi-Oliveira, Anke Huels, Luke W. Hyde, Scott A. Jones, Hasse Karlsson, Linnea Karlsson, Nastassja Koen, Will Lawn, Colter Mitchell, Christopher S. Monk, Michael A. Mooney, Ryan Muetzel, Joel T. Nigg, Síntia Iole Nogueira Belangero, Daniel Notterman, Yi Ying Ong, Tom O’Connor, Kieran J. O’Donnell, Pedro Mario Pan, Tiina Paunio, Peter Ryabinin, Richard Saffery, Giovanni A. Salum, Marc Seal, Tim J. Silk, Dan J. Stein, Ai Peng Tan, Ai Ling Teh, Dennis Wang, Heather Zar, Esther Walton, Charlotte A. M. Cecil
Publié dans: Molecular Psychiatry, 2025, ISSN 1359-4184
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41380-025-03203-W

Principal and independent genomic components of brain structure and function

Auteurs: Lennart M. Oblong, Sourena Soheili‐Nezhad, Nicolò Trevisan, Yingjie Shi, Christian F. Beckmann, Emma Sprooten
Publié dans: Genes, Brain and Behavior, Numéro 23, 2024, ISSN 1601-1848
Éditeur: Wiley
DOI: 10.1111/GBB.12876

Examining longitudinal associations between prenatal exposure to infections and child brain morphology

Auteurs: Anna Suleri, Carolin Gaiser, Charlotte A.M. Cecil, Annet Dijkzeul, Alexander Neumann, Jeremy A. Labrecque, Tonya White, Veerle Bergink, Ryan L. Muetzel
Publié dans: Brain, Behavior, and Immunity, Numéro 119, 2024, ISSN 0889-1591
Éditeur: Elsevier BV
DOI: 10.1016/J.BBI.2024.05.014

DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.

Auteurs: Luo M, Walton E, Neumann A, Thio CHL, Felix JF, van IJzendoorn MH, Pappa I, Cecil CAM. 
Publié dans: Journal of Child Psychology and Psychiatry, 2024, ISSN 0021-9630
Éditeur: Journal of Child Psychology and Psychiatry
DOI: 10.1111/JCPP.13866

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Auteurs: Defina S, Woofenden T, Baltramonaityte V, Tiemeier H, Fairchild G, Felix JF, Cecil CAM, Walton E.
Publié dans: Preventive Medicine, 2024, ISSN 0091-7435
Éditeur: Preventive Medicine
DOI: 10.1016/j.ypmed.2024.107926

The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank

Auteurs: María Rodriguez-Ayllon, Alexander Neumann, Amy Hofman, Meike W. Vernooij, Julia Neitzel
Publié dans: Neurobiology of Aging, Numéro 138, 2025, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/J.NEUROBIOLAGING.2024.03.001

Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology

Auteurs: Kathryn Freeman, Alyson Zwicker, Janice M. Fullerton, Danella M. Hafeman, Neeltje E. M. van Haren, John Merranko, Benjamin I. Goldstein, Emma K. Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergi Mas, Gloria Roberts, Claudio Toma, Peter R. Schofield, Howard J. Edenberg, Holly C. Wilcox, Melvin G. McInnis, Lukas Propper, Barbara Pavlova, Samuel A. Stewart, Eileen M. Denovan-Wright, Guy A. Rouleau, Josefina Castro-Fornieles, Manon H. J. Hillegers, Boris Birmaher, Philip B. Mitchell, Martin Alda, John I. Nurnberger, Rudolf Uher
Publié dans: JAMA Network Open, Numéro 8, 2025, ISSN 2574-3805
Éditeur: American Medical Association (AMA)
DOI: 10.1001/JAMANETWORKOPEN.2025.5331

Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

Auteurs: Siwen Wang, Emma Casey, Joanne Sordillo, Sofía Aguilar-Lacasaña, Fernanda Morales Berstein, Richard J. Biedrzycki, Sonia Brescianini, Su Chen, Amy Hough, Elena Isaevska, Woo Jin Kim, Marion Lecorguillé, Sebastian Shaobo Li, Christian M. Page, Jaehyun Park, Stefan Röder, Kristina Salontaji, Gillian Santorelli, Yidan Sun, Sungho Won, Eric Zillich, Lea Zillich, Isabella Annesi-Maesano, S. Hasan Arshad, Mariona Bustamante, Charlotte A. M. Cecil, Hannah R. Elliott, Susan Ewart, Janine F. Felix, Luigi Gagliardi, Siri E. Håberg, Gunda Herberth, Barbara Heude, John W. Holloway, Anke Huels, Wilfried Karmaus, Gerard H. Koppelman, Stephanie J. London, Sunni L. Mumford, Lorenza Nisticò, Maja Popovic, Franca Rusconi, Enrique F. Schisterman, Dan J. Stein, Tabea Send, Henning Tiemeier, Judith M. Vonk, Martine Vrijheid, Joseph Leo Wiemels, Stephanie H. Witt, John Wright, Edwina H. Yeung, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Jorge E. Chavarro, Marie-France Hivert
Publié dans: Science Advances, Numéro 10, 2024, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR2084

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Auteurs: Lazar-Contes I, Tanwar DK, Arzate-Meija RG, Steg LC, Feudijo OU, Crespo M, Germain PL, Mansuy IM
Publié dans: Genetics and Genomics, 2023, ISSN 2050-084X
Éditeur: eLife
DOI: 10.7554/eLife.91528.1

A father’s legacy: the sperm epigenome, preimplantation development, and paternal environment

Auteurs: Leonard C. Steg, Isabelle M. Mansuy
Publié dans: Epigenomics, 2025, ISSN 1750-1911
Éditeur: Informa UK Limited
DOI: 10.1080/17501911.2025.2569301

Mapping prenatal predictors and neurobehavioral outcomes of an epigenetic marker of neonatal inflammation – A longitudinal population-based study

Auteurs: Anna Suleri, Nicole Creasey, Esther Walton, Ryan Muetzel, Janine F. Felix, Liesbeth Duijts, Veerle Bergink, Charlotte A.M. Cecil
Publié dans: Brain, Behavior, and Immunity, Numéro 122, 2025, ISSN 0889-1591
Éditeur: Elsevier BV
DOI: 10.1016/J.BBI.2024.08.053

Developmental trajectories of gyrification and sulcal morphometrics in children and adolescents at high familial risk for bipolar disorder or schizophrenia

Auteurs: Simon R. Poortman, Jakub Jamarík, Louise ten Harmsen van der Beek, Nikita Setiaman, Manon H.J. Hillegers, Marjolein E.A. Barendse, Neeltje E.M. van Haren
Publié dans: Developmental Cognitive Neuroscience, Numéro 72, 2025, ISSN 1878-9293
Éditeur: Elsevier BV
DOI: 10.1016/J.DCN.2025.101536

Long-term physical health conditions and youth anxiety and depression: Is there a causal link?

Auteurs: Amy Shakeshaft, Jessica R. Mundy, Emil M. Pedersen, Charlotte A. Dennison, Lucy Riglin, Daniela Bragantini, Elizabeth C. Corfield, Ajay K. Thapar, Ole A. Andreassen, Evie Stergiakouli, George Davey Smith, Laurie Hannigan, Katherine L. Musliner, Alexandra Havdahl, Anita Thapar
Publié dans: Psychological Medicine, Numéro 55, 2025, ISSN 0033-2917
Éditeur: Cambridge University Press (CUP)
DOI: 10.1017/S0033291724003271

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Auteurs: Kaupper CS, Blaauwendraad SM, Cecil CAM, Mulder RH, Gaillard R, Goncalves R, Borggraefe I, Koletzko B, Jaddoe VWV.
Publié dans: Metabolites, 2023, ISSN 2218-1989
Éditeur: Metabolites
DOI: 10.3390/metabo13111140

Comparing cognition in parents with schizophrenia or bipolar disorder and their 7-year-old offspring

Auteurs: Aja Neergaard Greve, Nicoline Hemager, Erik Lykke Mortensen, Ditte Lou Gantriis, Birgitte Klee Burton, Ditte Ellersgaard, Kerstin J. Plessen, Anne A.E. Thorup, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Ole Mors, Arndis Simonsen
Publié dans: Psychiatry Research, Numéro 340, 2024, ISSN 0165-1781
Éditeur: Elsevier BV
DOI: 10.1016/J.PSYCHRES.2024.116112

Debate: Child and adolescent mental health services: time to take the lead in prevention of psychosis in youth

Auteurs: Inmaculada Baeza, Gisela Sugranyes
Publié dans: Child and Adolescent Mental Health, Numéro 28, 2025, ISSN 1475-357X
Éditeur: Wiley
DOI: 10.1111/CAMH.12679

Effects of parental characteristics on the risk of psychopathology in offspring: a 4-year follow-up study

Auteurs: E. De la Serna, D. Moreno, G. Sugranyes, P. Camprodon-Boadas, D. Ilzarbe, A. Bigorra, B. Mora-Maltas, I. Baeza, I. Flamarique, S. Parrilla, C. M. Díaz-Caneja, C. Moreno, R. Borras, C. Torrent, C. Garcia-Rizo, J. Castro-Fornieles
Publié dans: European Child & Adolescent Psychiatry, Numéro 34, 2025, ISSN 1018-8827
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00787-025-02719-4

Fetal Head Growth and Head Circumference at Birth in Children of Women with Psychotic Disorders and Population-Based Controls

Auteurs: Lisanne A E M van Houtum, Dogukan Koc, Sterna A Grundeman, Hans J Duvekot, Hanan El Marroun, Neeltje E M van Haren, Hilmar H Bijma
Publié dans: Schizophrenia Bulletin, 2025, ISSN 0586-7614
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/SCHBUL/SBAF171

The Genetic Architecture of Differentiating Behavioral and Emotional Problems in Early Life

Auteurs: Adrian Dahl Askelund, Laura Hegemann, Andrea G. Allegrini, Elizabeth C. Corfield, Helga Ask, Neil M. Davies, Ole A. Andreassen, Alexandra Havdahl, Laurie J. Hannigan
Publié dans: Biological Psychiatry, Numéro 97, 2025, ISSN 0006-3223
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOPSYCH.2024.12.021

Age Trajectories of the Structural Connectome in Child and Adolescent Offspring of Individuals With Bipolar Disorder or Schizophrenia

Auteurs: Simon R. Poortman, Marjolein E.A. Barendse, Nikita Setiaman, Martijn P. van den Heuvel, Siemon C. de Lange, Manon H.J. Hillegers, Neeltje E.M. van Haren
Publié dans: Biological Psychiatry Global Open Science, Numéro 4, 2024, ISSN 2667-1743
Éditeur: Elsevier BV
DOI: 10.1016/J.BPSGOS.2024.100336

Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study

Auteurs: Kristina Salontaji, Kristine L. Haftorn, Faye Sanders, Christian M. Page, Esther Walton, Janine F. Felix, Mona Bekkhus, Jon Bohlin, Henning Tiemeier, Charlotte A. M. Cecil
Publié dans: Molecular Psychiatry, Numéro 29, 2024, ISSN 1359-4184
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41380-024-02544-2

Transgenerational effects of early life stress on the fecal microbiota in mice

Auteurs: Nize Otaru, Lola Kourouma, Benoit Pugin, Florentin Constancias, Christian Braegger, Isabelle M. Mansuy, Christophe Lacroix
Publié dans: Communications Biology, Numéro 7, 2024, ISSN 2399-3642
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S42003-024-06279-2

Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood

Auteurs: A. G. Allegrini, L. J. Hannigan, L. Frach, W. Barkhuizen, J. R. Baldwin, O. A. Andreassen, D. Bragantini, L. Hegemann, A. Havdahl, J-B. Pingault
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-57694-W

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain. 

Auteurs: Arzate-Mejia RG, Carullo NVN, Mansuy IM.
Publié dans: Current Opinion in Neurobiology, 2023, ISSN 0959-4388
Éditeur: Current Opinion in Neurobiology
DOI: 10.1016/J.CONB.2023.102832

Neurobiology and systems biology of stress resilience

Auteurs: Raffael Kalisch, Scott J. Russo, Marianne B. Müller
Publié dans: Physiological Reviews, Numéro 104, 2024, ISSN 0031-9333
Éditeur: American Physiological Society
DOI: 10.1152/PHYSREV.00042.2023

Early detection and intervention through the lens of the neurodevelopmental framework: the salience of developmental years and related services

Auteurs: Andrea Raballo, Michele Poletti, Antonio Preti
Publié dans: The British Journal of Psychiatry, Numéro 225, 2024, ISSN 0007-1250
Éditeur: Royal College of Psychiatrists
DOI: 10.1192/BJP.2024.146

Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior

Auteurs: Marta Schiavon, Birgitte K. Burton, Nicoline Hemager, Aja N. Greve, Katrine S. Spang, Ditte Ellersgaard, Kerstin Jessica Plessen, Jens Richardt M. Jepsen, Anne A. E. Thorup, Thomas Werge, Merete Nordentoft, Ron Nudel
Publié dans: European Journal of Neuroscience, Numéro 61, 2025, ISSN 0953-816X
Éditeur: Wiley
DOI: 10.1111/EJN.70163

Evocative effects of children's education‐associated genetics on maternal parenting: results from the Norwegian mother, father and child cohort study

Auteurs: Chloe Austerberry, Tetyana Zayats, Angelica Ronald, Elizabeth Corfield, Dinka Smajlagic, Alexandra Havdahl, Ole A. Andreassen, Per Magnus, Pål R. Njølstad, Mona Bekkhus, Pasco Fearon
Publié dans: Journal of Child Psychology and Psychiatry, 2025, ISSN 0021-9630
Éditeur: Wiley
DOI: 10.1111/JCPP.70025

The effect of age and sex on brain metabolites: from childhood to adulthood

Auteurs: María Ortuño, Adriana Fortea, Isabel Valli, Emma Muñoz-Moreno, Roger Borràs, Irene Martínez-Serrano, Mireia Masias Bruns, Patricia Camprodon-Boadas, Enric Vilajosana, Lydia Fortea, Joaquim Raduà, Elena de la Serna, Inmaculada Baeza, Josefina Castro-Fornieles, Gisela Sugranyes
Publié dans: NeuroImage, Numéro 317, 2025, ISSN 1053-8119
Éditeur: Elsevier BV
DOI: 10.1016/J.NEUROIMAGE.2025.121353

Assessing risk for bipolar disorder. Comments on ``Young people at risk for developing bipolar disorder: Two-year findings from the multicenter prospective, naturalistic Early-BipoLife study'' (Martini et al., 2023)

Auteurs: Mireia Solerdelcoll, Inmaculada Baeza, Gisela Sugranyes
Publié dans: European Neuropsychopharmacology, Numéro 81, 2025, ISSN 0924-977X
Éditeur: Elsevier BV
DOI: 10.1016/J.EURONEURO.2024.01.001

The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank

Auteurs: Rodriguez-Ayllon M, Neumann A, Hofman A, Vernooij MW, Neitzel J.
Publié dans: Neurobiology of Aging, 2024, ISSN 0197-4580
Éditeur: Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2024.03.001

Testing maternal effects of vitamin-D and omega-3 levels on offspring neurodevelopmental traits in the Norwegian Mother, Father and Child Cohort Study

Auteurs: Robyn E. Wootton, Kyle Dack, Hannah J. Jones, Lucy Riglin, Paul Madley-Dowd, Carolina Borges, Panagiota Pagoni, Christine Roth, Anne Lise Brantsæter, Elizabeth C. Corfield, Camilla Stoltenberg, Anne-Siri Øyen, George Davey Smith, Helga Ask, Anita Thapar, Evie Stergiakouli, Alexandra Havdahl
Publié dans: Psychological Medicine, Numéro 54, 2025, ISSN 0033-2917
Éditeur: Cambridge University Press (CUP)
DOI: 10.1017/S0033291724001466

Prenatal exposure to adverse life events and autism and autistic‐like traits in children in the Norwegian Mother, Father and Child Cohort Study (MoBa)

Auteurs: Aleksandra Kanina, Arvid Sjölander, Miriam I. Martini, Agnieszka Butwicka, Henrik Larsson, Amanda M. Hughes, Márta K. Radó, Mark J. Taylor, Alexandra Havdahl, Helga Ask, Mina A. Rosenqvist
Publié dans: JCPP Advances, 2025, ISSN 2692-9384
Éditeur: Wiley
DOI: 10.1002/JCV2.70002

Biological pathways underlying the relationship between childhood maltreatment and Multimorbidity: A two-step, multivariable Mendelian randomisation study

Auteurs: Vilte Baltramonaityte, Ville Karhunen, Janine F. Felix, Brenda W.J.H. Penninx, Charlotte A.M. Cecil, Graeme Fairchild, Yuri Milaneschi, Esther Walton
Publié dans: Brain, Behavior, and Immunity, Numéro 126, 2025, ISSN 0889-1591
Éditeur: Elsevier BV
DOI: 10.1016/J.BBI.2025.01.024

Neurobiology and systems biology of stress resilience. 

Auteurs: Kalisch R, Russo SJ, Müller MB.
Publié dans: Physiological Reviews, 2023, ISSN 0031-9333
Éditeur: Physiological Reviews
DOI: 10.1152/PHYSREV.00042.2023

Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.

Auteurs: Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, Blin O, Richardson JC, Bordet R, Lleó A, Alcolea D, Popp J, Marsh TW, Gorijala
Publié dans: Genome Medicine volume, 2023, ISSN 1756-994X
Éditeur: Genome Medicine volume
DOI: 10.1186/s13073-023-01233-z

Are different types of childhood adversities correlated within and across time? A comparison of data on adversity co-occurrence from three longitudinal birth cohort studies

Auteurs: Madison E. Bigler, Isabel K. Schuurmans, Yiwen Zhu, Nitasha Siddique, Nadia Hoffman, Nastassja Koen, Heather J. Zar, Dan J. Stein, Charlotte A.M. Cecil, Erin C. Dunn
Publié dans: Child Abuse & Neglect, Numéro 168, 2025, ISSN 0145-2134
Éditeur: Elsevier BV
DOI: 10.1016/J.CHIABU.2025.107315

Youth psychotic experiences: psychometric evaluation and diagnostic associations of the <scp>CAPE</scp> ‐16 in adolescents from the Norwegian Mother, Father and Child Cohort

Auteurs: Viktoria Birkenæs, Pravesh Parekh, Laura Hegemann, Nora R. Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B. Smeland, Ezra Susser, Katrina M. Rodriguez, Markos Tesfaye, Ole A. Andreassen, Alexandra Havdahl, Ida E. Sønderby
Publié dans: Journal of Child Psychology and Psychiatry, 2025, ISSN 0021-9630
Éditeur: Wiley
DOI: 10.1111/JCPP.70007

Parental education and children’s depression, anxiety, and ADHD traits, a within-family study in MoBa

Auteurs: Amanda M. Hughes, Fartein Ask Torvik, Elsje van Bergen, Laurie J. Hannigan, Elizabeth C. Corfield, Ole A. Andreassen, Eivind Ystrom, Helga Ask, George Davey Smith, Neil M. Davies, Alexandra Havdahl
Publié dans: npj Science of Learning, Numéro 9, 2024, ISSN 2056-7936
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41539-024-00260-8

Characterising developmental dynamics of adult epigenetic clock sites

Auteurs: Rosa H. Mulder, Alexander Neumann, Janine F. Felix, Matthew Suderman, Charlotte A.M. Cecil
Publié dans: eBioMedicine, Numéro 109, 2024, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/J.EBIOM.2024.105425

Remembering through the genome: the role of chromatin states in brain functions and diseases

Auteurs: Arzate-Mejia RG, Mansuy IM.
Publié dans: Translational Psychiatry, Numéro 122, 2023, ISSN 2158-3188
Éditeur: Translational Psychiatry
DOI: 10.1038/s41398-023-02415-4

Dynastic social processes and the transgenerational transmission of risk and resilience to mental illness: implications for prevention

Auteurs: Andrea Raballo, Michele Poletti, Antonio Preti
Publié dans: European Child &amp; Adolescent Psychiatry, Numéro 34, 2025, ISSN 1018-8827
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00787-024-02551-2

Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults

Auteurs: Yingjie Shi, Nina Roth Mota, Barbara Franke, Emma Sprooten
Publié dans: Translational Psychiatry, Numéro 15, 2025, ISSN 2158-3188
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41398-025-03443-Y

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Auteurs: Serena Defina, Tom Woofenden, Vilte Baltramonaityte, Henning Tiemeier, Graeme Fairchild, Janine F. Felix, Charlotte A.M. Cecil, Esther Walton
Publié dans: Preventive Medicine, Numéro 182, 2025, ISSN 0091-7435
Éditeur: Elsevier BV
DOI: 10.1016/J.YPMED.2024.107926