Running in the FAMILY - Understanding and predicting the intergenerational transmission of mental illness

Informations projet

FAMILY

N° de convention de subvention: 101057529

DOI

10.3030/101057529

Date de signature de la CE 24 Mai 2022

Date de début 1 Octobre 2022

Date de fin 30 Septembre 2027

Financé au titre de

• Health

Coût total

€ 10 906 409,75

Contribution de l’UE

€ 10 906 409,75

Coordonné par

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (7)

1st version of data management, harmonisation, and open science plan
Report on the software pipelines based on simulation studies
Training plan
Marketing materials
1st report and plan for gender balance
Dissemination and Communication plan
Report on relevant outside initiatives and activities in the field and plan for collaboration

Other (2)

Registration numbers of the clinical studies (WHO Registry criteria)
Ethics institutional approvals

Websites, patent fillings, videos etc. (1)

Go-online of the public project website

Publications

Peer reviewed articles (17)

Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities

Auteurs: Charlotte A. M. Cecil, Alexander Neumann, Esther Walto
Publié dans: JCPP Advances, Numéro 3, 1, 2023, ISSN 2692-9384
Éditeur: CPP Advances Volume 3, Issue 1
DOI: 10.1186/s13073-023-01233-z

Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development

Auteurs: Hughes DE, Kunitoki K, Elyounssi S, Luo M, Bazer OM, Hopkinson CE, Dowling KF, Doyle AE, Dunn EC, Eryilmaz H, Gilman JM, Holt DJ, Valera EM, Smoller JW, Cecil CAM, Tiemeier H, Lee PH, Roffman JL.
Publié dans: Nature Neuroscience, Numéro 26, 2023, ISSN 1546-1726
Éditeur: Nature Neuroscience
DOI: 10.1038/s41593-023-01321-8

Early-life stress and the gut microbiome: A comprehensive population-based investigation

Auteurs: Mulder RH, Kraaij R, Schuurmans IK, Frances-Cuesta C, Sanz Y, Medina-Gomez C, Duijts L, Rivadeneira F, Tiemeier H, Jaddoe VWV, Felix JF, Cecil CAM.
Publié dans: Brain, Behavior, and Immunity, 2024, ISSN 0889-1591
Éditeur: Brain, Behavior, and Immunity
DOI: 10.1016/j.bbi.2024.02.024

A systematic review of neuroimaging epigenetic research: calling for an increased focus on development

Auteurs: Walton E, Baltramonaityte V, Calhoun V, Heijmans BT, Thompson PM, Cecil CAM.
Publié dans: Molecular Psychiatry, Numéro 28, 2023, ISSN 1476-5578
Éditeur: Molecular Psychiatry
DOI: 10.1038/s41380-023-02067-2

Exposure to prenatal infection and the developmentof internalizing and externalizing problems inchildren: a longitudinal population-based study

Auteurs: Suleri A, Rommel AS, Neumann A, Luo M, Hillegers M, de Witte L, Bergink V, Cecil CAM.
Publié dans: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Éditeur: Journal of Child Psychology and Psychiatry
DOI: 10.1111/jcpp.13923

Principal and independent genomic components of brain structure and function

Auteurs: Oblong LM,Soheili-Nezhad S, Trevisan N, Shi Y, Beckmann CF, Sprooten E
Publié dans: Genes, Brain and Behavior, 2024, ISSN 1601-183X
Éditeur: Genes, Brain and Behavior
DOI: 10.1111/gbb.12876

Risk factors for mood disorders among offspring of parents with bipolar disorder: Findings from a discordant-sibling study

Auteurs: Giacomo FD, Strippoli MF, Castelao E, Amoussou JR, Gholam M, Ranjbar S, Glaus J, Marquet P, Preisig M, Plessen KJ, Vandeleur CL.
Publié dans: Psychiatry Research, 2023, ISSN 0165-1781
Éditeur: Psychiatry Research
DOI: 10.1016/j.psychres.2023.115615

On Navigating Analytical Choices in Research on Early Life Adversity: A Commentary on Sisitsky et al. (2023).

Auteurs: Cecil CAM, Schuurmans IK. 
Publié dans: Research on Child and Adolescent Psychopathology, 2023, ISSN 2730-7174
Éditeur: Research on Child and Adolescent Psychopathology
DOI: 10.1007/S10802-023-01103-7

DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.

Auteurs: Luo M, Walton E, Neumann A, Thio CHL, Felix JF, van IJzendoorn MH, Pappa I, Cecil CAM. 
Publié dans: Journal of Child Psychology and Psychiatry, 2024, ISSN 0021-9630
Éditeur: Journal of Child Psychology and Psychiatry
DOI: 10.1111/JCPP.13866

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Auteurs: Defina S, Woofenden T, Baltramonaityte V, Tiemeier H, Fairchild G, Felix JF, Cecil CAM, Walton E.
Publié dans: Preventive Medicine, 2024, ISSN 0091-7435
Éditeur: Preventive Medicine
DOI: 10.1016/j.ypmed.2024.107926

Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life

Auteurs: Lazar-Contes I, Tanwar DK, Arzate-Meija RG, Steg LC, Feudijo OU, Crespo M, Germain PL, Mansuy IM
Publié dans: Genetics and Genomics, 2023, ISSN 2050-084X
Éditeur: eLife
DOI: 10.7554/eLife.91528.1

Cord Blood Metabolite Profiles and Their Association with Autistic Traits in Childhood

Auteurs: Kaupper CS, Blaauwendraad SM, Cecil CAM, Mulder RH, Gaillard R, Goncalves R, Borggraefe I, Koletzko B, Jaddoe VWV.
Publié dans: Metabolites, 2023, ISSN 2218-1989
Éditeur: Metabolites
DOI: 10.3390/metabo13111140

The epigenome under pressure: On regulatory adaptation to chronic stress in the brain. 

Auteurs: Arzate-Mejia RG, Carullo NVN, Mansuy IM.
Publié dans: Current Opinion in Neurobiology, 2023, ISSN 0959-4388
Éditeur: Current Opinion in Neurobiology
DOI: 10.1016/J.CONB.2023.102832

The bidirectional relationship between brain structure and physical activity: A longitudinal analysis in the UK Biobank

Auteurs: Rodriguez-Ayllon M, Neumann A, Hofman A, Vernooij MW, Neitzel J.
Publié dans: Neurobiology of Aging, 2024, ISSN 0197-4580
Éditeur: Neurobiology of Aging
DOI: 10.1016/j.neurobiolaging.2024.03.001

Neurobiology and systems biology of stress resilience. 

Auteurs: Kalisch R, Russo SJ, Müller MB.
Publié dans: Physiological Reviews, 2023, ISSN 0031-9333
Éditeur: Physiological Reviews
DOI: 10.1152/PHYSREV.00042.2023

Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning.

Auteurs: Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, Blin O, Richardson JC, Bordet R, Lleó A, Alcolea D, Popp J, Marsh TW, Gorijala
Publié dans: Genome Medicine volume, 2023, ISSN 1756-994X
Éditeur: Genome Medicine volume
DOI: 10.1186/s13073-023-01233-z

Remembering through the genome: the role of chromatin states in brain functions and diseases

Auteurs: Arzate-Mejia RG, Mansuy IM.
Publié dans: Translational Psychiatry, Numéro 122, 2023, ISSN 2158-3188
Éditeur: Translational Psychiatry
DOI: 10.1038/s41398-023-02415-4