Project description
Personalised approaches for better healthcare
Aiming to increase overall patient safety, the EU-funded SafePolyMed research project seeks to develop innovative tools to help physicians and pharmacists better define, assess and manage drug-drug-gene interactions. Machine learning on large real-world data sets will identify patients at risk, model-based precision dosing tools will optimise treatments for patients, and patient-reported outcome measures will evaluate treatment success. Medication management centres will serve as a hub for patients and healthcare providers to explore underlying causes of poor treatment outcomes and define more personalised treatment plans. By educating citizens and empowering them to participate in self-documenting their therapy, the project seeks to improve the communication between patients and physicians and provide equal access to innovative, sustainable, high-quality healthcare across Europe.
Objective
Polypharmacy, multimorbidity and genetic heterogeneity can affect drug efficacy, raise the risk for adverse drug reactions (ADRs) and increase healthcare costs. ADRs are among the leading causes of death in developed countries and a major cause of hospitalization. Drug-drug interactions (DDIs) and drug-gene interactions (DGIs) are highly interconnected and require a holistic approach to improve safety of our citizens. However, investigations on real-life drug-drug-gene interactions (DDGIs) in clinical trials are unfeasible due to combinatorial explosion, high costs and ethical concerns. Hence, significant knowledge gaps exist. Furthermore, the lack of participation in managing their conditions might be excessively demanding for polymedicated and multimorbid citizens. SafePolyMed will develop a novel and innovative framework to define, assess and manage DDGIs for physicians and individual patients resulting in education and empowerment of citizens as well as in reduced healthcare costs by improving patient safety. The main objectives of SafePolyMed are (1) development of a novel, evidence-based risk scoring system using machine learning on large real-world datasets to identify patients at risk; (2) identification and validation of patient reported outcome measures for multifactorial patient safety in collaboration with European patient organizations;
(3) development of an electronic tool to empower patients by allowing them to properly manage their therapies, check for and educate about DD(G)Is and collect their patient reported outcomes; (4) mathematical modelling of clinically relevant compounds to derive individualized dose adaptations for safe and effective dose regimens in case of DDGIs, accessible via a web-based decision support system with tailored information for either citizens or physicians and (5) validation of the developed safety tools in a ?proof-of-principle? study including representative patient cohorts from different European clinical sites.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.2.1 - Health
MAIN PROGRAMME
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HORIZON.2.1.6 - Health Care Systems
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-RIA - HORIZON Research and Innovation Actions
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-HLTH-2021-CARE-05
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
66123 Saarbrucken
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.