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Mechanisms of cell plasticity in the liver

Project description

Mechanisms of liver cells regeneration

Liver epithelial cells possess unique plasticity by which terminally differentiated cells change identity to regenerate injured or maldeveloped tissue. In Alagille syndrome, some patients can recover underdeveloped liver bile ducts, important for draining bile. Various animal models of Alagille syndrome have demonstrated that different cell types can contribute to bile duct regeneration that vary in quality depending on the region in the liver. The PlasticLiver project will employ a novel high-resolution barcode lineage tracing and gene expression profiling approach to resolve region-specific cell sources and mechanisms in liver regeneration in a mouse model for Alagille syndrome, contributing to deeper understanding of endogenous regenerative programs. The project will furthermore explore possibilities of enhancing the quality of bile duct regeneration.


Net EU contribution
€ 222 727,68
Nobels Vag 5
17177 Stockholm

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Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
No data