Descripción del proyecto
Nanorrecubrimientos superficiales para prevenir la transferencia de patógenos
En el proyecto STOP, financiado con fondos europeos, se crearán nanorrecubrimientos antimicrobianos y antivíricos para superficies que se tocan mucho. Los nanorrecubrimientos se elaborarán empleando combinaciones de nanopartículas inorgánicas, péptidos antimicrobianos y modificaciones superficiales nanométricas realizadas con láser. La eficacia de las formulaciones se determinará empleando las normas internacionales en vigor y nuevos métodos de ensayo. Los componentes de las formulaciones deben permitir obtener unos recubrimientos flexibles, pulverizables y duraderos, con un amplio espectro de actividad antivírica y antimicrobiana, además de presentar un riesgo reducido de desarrollo de resistencia. Los nanorrecubrimientos del proyecto reducirán considerablemente las infecciones que se transmiten a través de superficies que se tocan mucho, los costes sanitarios y la contaminación ambiental de los actuales desinfectantes, y mejorar la preparación general ante futuras pandemias.
Objetivo
The STOP project will develop antimicrobial and antiviral nanocoatings that can be flexibly or permanently applied to high-touch surfaces. These nanocoatings will be derived from a combination of inorganic nanoparticles, antimicrobial peptides and nanoscale laser surface patterning. The nanocoatings will be thoroughly characterised for their efficacy, using both existing international standards and improved testing methods developed within the project (the new testing methods will be proposed to standards agencies for adoption). Several different active substances will be explored (i) to allow formulation in highly flexible, sprayable, and long-lasting coatings, (ii) provide broad spectrum antimicrobial antiviral activity, and iii) reduce the chances of the development of resistance. To this end, the mode-of-action, and the risk of selection for antimicrobial resistance in bacteria and viruses will be assessed.
The flexible nanocoatings will provide a long-lasting (30 days) reduction in bioburden that resembles standards set for microbial colonization of surfaces in hospitals, which can only be reached after intense surface disinfection or permanent introduction of known antimicrobial material such as copper. This effect will be studied in a real-life intervention trail and with epidemiological models. The developed nanocoatings are expected to lead to significant reductions in infectious diseases transmitted from high-touch surfaces, healthcare cost savings, reduction in environmental pollution by disinfectants, and increased preparedness of the EU public health system to future pandemics. The safety of the nanomaterials will be backed up by human and environmental toxicity studies and life cycle analyses. From the beginning, attention will be paid to end-user acceptance, manufacturing scalability, and short-term exploitation by SMEs
Ámbito científico
- medical and health scienceshealth sciencesinfectious diseases
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- engineering and technologynanotechnologynano-materials
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Palabras clave
Programa(s)
Tema(s)
Convocatoria de propuestas
HORIZON-CL4-2021-RESILIENCE-01
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinador
12205 Berlin
Alemania