Description du projet
Nanorevêtements de surface pour prévenir le transfert d’agents pathogènes
Le projet STOP, financé par l’UE, vise à développer des nanorevêtements antimicrobiens et antiviraux destinés à être appliqués sur des surfaces souvent touchées. Les nanorevêtements seront développés en combinant des nanoparticules inorganiques, des peptides antimicrobiens et des modifications de surface par laser à l’échelle nanométrique. L’efficacité des formulations sera évaluée à l’aide de normes internationales existantes et de nouvelles méthodes d’essai. Les composants des formulations doivent permettre des revêtements flexibles, pulvérisables et durables, avec un large spectre d’activité antimicrobienne et antivirale et un risque réduit de développement de résistance. Les nanorevêtements du projet permettront de réduire considérablement les infections transmises par les surfaces à fort contact, les coûts des soins de santé et la pollution de l’environnement par les désinfectants actuels, et d’améliorer la préparation générale aux futures pandémies.
Objectif
The STOP project will develop antimicrobial and antiviral nanocoatings that can be flexibly or permanently applied to high-touch surfaces. These nanocoatings will be derived from a combination of inorganic nanoparticles, antimicrobial peptides and nanoscale laser surface patterning. The nanocoatings will be thoroughly characterised for their efficacy, using both existing international standards and improved testing methods developed within the project (the new testing methods will be proposed to standards agencies for adoption). Several different active substances will be explored (i) to allow formulation in highly flexible, sprayable, and long-lasting coatings, (ii) provide broad spectrum antimicrobial antiviral activity, and iii) reduce the chances of the development of resistance. To this end, the mode-of-action, and the risk of selection for antimicrobial resistance in bacteria and viruses will be assessed.
The flexible nanocoatings will provide a long-lasting (30 days) reduction in bioburden that resembles standards set for microbial colonization of surfaces in hospitals, which can only be reached after intense surface disinfection or permanent introduction of known antimicrobial material such as copper. This effect will be studied in a real-life intervention trail and with epidemiological models. The developed nanocoatings are expected to lead to significant reductions in infectious diseases transmitted from high-touch surfaces, healthcare cost savings, reduction in environmental pollution by disinfectants, and increased preparedness of the EU public health system to future pandemics. The safety of the nanomaterials will be backed up by human and environmental toxicity studies and life cycle analyses. From the beginning, attention will be paid to end-user acceptance, manufacturing scalability, and short-term exploitation by SMEs
Champ scientifique
- medical and health scienceshealth sciencesinfectious diseases
- medical and health scienceshealth sciencespublic healthepidemiologypandemics
- engineering and technologynanotechnologynano-materials
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantivirals
Programme(s)
Thème(s)
Régime de financement
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinateur
12205 Berlin
Allemagne