Projektbeschreibung
Antisense-Oligonukleotid-Technologie für die Behandlung von Lungenadenokarzinomen
Ein Lungenadenokarzinom ist eine aggressive Form von Lungenkrebs mit schlechter Prognose, die sich für 1/3 aller Lungenkrebsfälle verantwortlich zeichnet, und für die es derzeit keine zielgerichteten Behandlungstherapien gibt. Die überwiegende Mehrzahl der Lungenadenokarzinomtumore ist mit einer Numb-Isoform infolge alternativen Spleißens verbunden, welche die Proliferation der Krebszellen unterstützt und mit einer schlechteren Krankheitsprognose korreliert. Bereits entwickelte proprietäre Antisense-Oligonukleotide (AONs) konnten das pathologische Spleißen korrigieren und die Proliferation von Krebszellen und das Tumorwachstum bei mehreren Mausmodellen hemmen. Das EU-finanzierte Projekt TAONas-LUAD erstellt eine AONs-Technologie für die Validierung im Rahmen klinischer Studien und entwickelt einen Geschäftsplan für die Kommerzialisierung.
Ziel
Lung cancer is the leading cause of cancer-related deaths, with 1.8 million deaths expected globally in 2021. Lung adenocarcinomas (LUAD) represent 1/3 of all lung cancer cases. Despite notable advances, current treatments remain ineffective, resulting in <25% survival beyond 5 years. Due to the high heterogeneity of molecular abnormalities driving lung cancers, targeted therapies are applicable to only a small subset of patients. There is therefore an urgent unmet need for developing novel therapeutic approaches generally applicable to LUAD patients.
Alternative pre-mRNA splicing (AS) allows the synthesis of different protein variants from a single gene by differential selection of exonic sequences. Increased inclusion of exon 9 of the gene NUMB encodes a protein isoform that promotes cancer cell proliferation. This occurs in the vast majority of LUAD tumours, correlating with worse disease prognosis. Supported by the ERC PoC VALSL, we developed an innovative therapeutic approach based on the use of Antisense Oligonucleotides (AONs) that regulate NUMB AS. Our proprietary AONs correct NUMB pathological splicing, inhibit cancer cell proliferation and reduce tumour growth in four different mouse models of LUAD, including 2 Patient-Derived Xenograft models.
With support from the EIC Transition, we will bring this technology to a stage where it is ready to be validated in clinical trials. We will optimise our lead AONs by improving their chemistry, formulation and administration and will carry out regulatory pre-clinical studies. These will pave the way to the first application of AON-based splicing modulation in clinical oncology. To commercialise this technology, we also aim to develop the business plan for a spin-off company, AON Therapeutics. In the long term, our project has the potential to generate compounds, presentations and delivery methods that can be applicable to other target AS events and/or cancer types, as well as to other AS-related diseases.
Wissenschaftliches Gebiet
Schlüsselbegriffe
Programm/Programme
- HORIZON.3.1 - The European Innovation Council (EIC) Main Programme
Aufforderung zur Vorschlagseinreichung
HORIZON-EIC-2021-TRANSITIONOPEN-01
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-EIC - HORIZON EIC GrantsKoordinator
08003 Barcelona
Spanien