Project description
Virtual brains for research
The complexity of the human brain poses a significant challenge to the investigation and hence understanding of the mechanisms governing its function and dysfunction. Digital twins are virtual models designed to reflect physical objects and offer an attractive approach for neuroscience research. The EU-funded eBRAIN-Health project will generate such virtual models of patients and healthy controls to study dementia, an important societal and medical issue. Researchers will process and combine molecular, cellular, physiology and behavioural data into a clinical research infrastructure. Simulating the human brain will assist the prediction of dementia risk as well as the development of health innovations.
Objective
The Project eBrain-Health will deliver a distributed research platform for modeling and simulating complex neurobiological phenomena of human brain function and dysfunction in a data protection compliant environment. It will provide thousands of multilevel virtual brains from patients and healthy human controls for research and innovation. Brain data from multiple sources will be pre-processed. Solving the societal grand challenge of dementia is a big task. Yet it appears feasible in a collective approach. Therefore, we will build an interdisciplinary digital twin for dementia for modeling and simulating complex phenomena at the service of research infrastructure communities. EBRAINS-Health-Cloud will offer end-to-end services for personalized complex brain modeling and simulations in distributed e-infrastructures with data protection by design and by default and simulation-ready human multiscale brain data that range from molecular (genomics, proteomics, metabolomics) and cellular to electrophysiology and imaging to behavioural, clinical, life-style and environmental data as well as data from wearables. Brain data are pre-processed and annotated such that they all relate to a common reference 3D brain space. EBRAINS-Health-Cloud constitutes a blend of three large-scale research programs: the FET Flagship Human Brain Project with its EBRAINS Research Infrastructure, the EOSC project Virtual Brain Cloud with its Virtual Research Environment for sensitive data and the H2020 project AI-MIND with intelligent tools for dementia risk estimation. The project will have synergies to topics of the Digital Europe Program, such as artificial intelligence, cybersecurity and supercomputing and the Health Data Space. EBRAINS-Health-Cloud offers a next generation clinical research infrastructure and creates an open yet protected space for groundbreaking digital health innovation by the research infrastructure communities comprising academia and the private sector.
Fields of science
- natural sciencescomputer and information sciencesartificial intelligence
- natural sciencesbiological sciencesgenetics
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- natural sciencescomputer and information sciencescomputer securitydata protection
- medical and health sciencesbasic medicineneurologydementia
Programme(s)
Funding Scheme
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinator
10117 Berlin
Germany
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Participants (17)
1170 Bruxelles / Brussel
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52428 Julich
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6525 XZ Nijmegen
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08002 Barcelona
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0450 Oslo
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10117 BERLIN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
80686 Munchen
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55128 Mainz
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1010 Wien
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28040 Madrid
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08019 Barcelona
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
151 25 Maroussi
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0313 Oslo
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1081 HV Amsterdam
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00185 Roma
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1736 SENNINGERBERG
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
78153 Le Chesnay Cedex
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Partners (2)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
1011 Lausanne
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
EH8 9YL Edinburgh
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