CENTRE FOR DATA ENRICHED MEDICINE (TEAMPERMED)

Informazioni relative al progetto

TeamPerMed

ID dell’accordo di sovvenzione: 101060011

DOI

10.3030/101060011

Data della firma CE 28 Aprile 2023

Data di avvio 1 Settembre 2023

Data di completamento 31 Agosto 2029

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 15 000 000,00

Contributo UE

€ 15 000 000,00

Coordinato da

TARTU ULIKOOL
Estonia

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (1)

Plan for dissemination, exploitation and communication

A detailed Plan for dissemination, exploitation and communication will be in place by M6. It will describe our target groups, messaging and tailored dissemination channels. We will create a project logo, flyers, templates for presentations, reports and deliverables.

Data Management Plan (1)

Data Management Plan

Data Management Plan (DMP) of TeamPerMed is to identify the project’s research data and to describe how to make them findable, accessible, interoperable and reusable (FAIR)

Pubblicazioni

Peer reviewed articles (16)

Analysis of follow-up data in large biobank cohorts: a review of methodology

Autori: Anastassia Kolde, Merli Koitmäe, Meelis Käärik, Märt Möls, Krista Fischer
Pubblicato in: Frontiers in Genetics, Numero 16, 2025, ISSN 1664-8021
Editore: Frontiers Media SA
DOI: 10.3389/FGENE.2025.1534726

Development and validation of a risk prediction algorithm for high-risk populations combining genetic and conventional risk factors of cardiovascular disease

Autori: Tuuli Puusepp; Ave Põld; Lili Milani; Aet Elken; Mikk Jürisson; Krista Fischer
Pubblicato in: European Heart Journal, 2025, ISSN 1522-9645
Editore: Oxford University Press
DOI: 10.1101/2025.04.02.25324383

Systematic evaluation of medication adherence determinants across 137 active substances on population-level real-world health data

Autori: Kerli Mooses, Marek Oja, Maria Malk, Helene Loorents, Maarja Pajusalu, Nikita Umov, Sirli Tamm, Johannes Holm, Hanna Keidong, Taavi Tillmann, Sulev Reisberg, Jaak Vilo, Raivo Kolde
Pubblicato in: Communications Medicine, Numero 6, 2026, ISSN 2730-664X
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S43856-026-01515-8

Characterization of prevalent genetic variants in the Estonian Biobank body-mass index GWAS

Autori: Erik Abner, Kanwal Batool, Nele Taba, Tiit Nikopensius, Kristi Läll, Anastasiia Alekseienko, Anders Eriksson, Joel Rämö, Hele Haapaniemi, Hanna Maria Kariis, Liis Haljasmägi, Urmo Võsa, Taavi Tillmann, Uku Vainik, Kelli Lehto, Hanna M. Ollila, Kai Kisand, null null, Andres Metspalu, Mait Metspalu, Lili Milani, Reedik Mägi, Tõnu Esko, Mari Nelis, Georgi Hudjashov, Tõnu Esko
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64006-9

Polygenic risk scores reveal shared polygenic risk across five common cardiovascular diseases

Autori: Tigist D. Adane, Bahar Sedaghati–Khayat, Lianne Trap, Asrat B. Dagnaw, Maryam Kavousi, Fernando Rivadeneira, Joyce B.J. van Meurs, André G. Uitterlinden, Jeroen G.J. van Rooij
Pubblicato in: Atherosclerosis, Numero 417, 2026, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/J.ATHEROSCLEROSIS.2026.120763

Resolving out of Africa event for Papua New Guinean population using neural network

Autori: Mayukh Mondal, Mathilde André, Ajai K. Pathak, Nicolas Brucato, François-Xavier Ricaut, Mait Metspalu, Anders Eriksson
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-61661-W

Extracting and Classifying Drug Discontinuations From Estonian Electronic Health Records: Development and Validation Study

Autori: Hendrik Šuvalov, Nikita Umov, Maria Malk, Markus Haug, Sven Laur, Marek Oja, Sirli Tamm, Sulev Reisberg, Jaak Vilo, Raivo Kolde
Pubblicato in: Journal of Medical Internet Research, Numero 28, 2026, ISSN 1438-8871
Editore: JMIR Publications Inc.
DOI: 10.2196/86183

The Estonian Biobank’s journey from biobanking to personalized medicine

Autori: Lili Milani, Maris Alver, Sven Laur, Sulev Reisberg, Toomas Haller, Oliver Aasmets, Erik Abner, Helene Alavere, Annely Allik, Tarmo Annilo, Krista Fischer, Robin Hofmeister, Georgi Hudjashov, Maarja Jõeloo, Mart Kals, Liis Karo-Astover, Silva Kasela, Anastassia Kolde, Kristi Krebs, Kertu Liis Krigul, Jaanika Kronberg, Karoliina Kruusmaa, Viktorija Kukuškina, Kadri Kõiv, Kelli Lehto, Liis Leitsalu, Sirje Lind, Laura Birgit Luitva, Kristi Läll, Kreete Lüll, Kristjan Metsalu, Mait Metspalu, René Mõttus, Mari Nelis, Tiit Nikopensius, Miriam Nurm, Margit Nõukas, Marek Oja, Elin Org, Marili Palover, Priit Palta, Vasili Pankratov, Kateryna Pantiukh, Natalia Pervjakova, Natàlia Pujol-Gualdo, Anu Reigo, Ene Reimann, Steven Smit, Diana Rogozina, Dage Särg, Nele Taba, Harry-Anton Talvik, Maris Teder-Laving, Neeme Tõnisson, Mariliis Vaht, Uku Vainik, Urmo Võsa, Burak Yelmen, Tõnu Esko, Raivo Kolde, Reedik Mägi, Jaak Vilo, Triin Laisk, Andres Metspalu
Pubblicato in: Nature Communications, Numero 16, 2025, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-58465-3

Scientific Reports

Autori: Liis Hiie; Anastassia Kolde; Natalia Pervjakova; Anu Reigo; Mait Metspalu; Andres Metspalu; Lili Milani; Tõnu Esko; Erik Abner; Urmo Võsa; Tõnu Esko; Krista Fischer; Priit Palta; Jaanika Kronberg
Pubblicato in: Scientific Reports, 2025, ISSN 2045-2322
Editore: Springer Nature
DOI: 10.1038/S41598-025-92840-W

Diverse landscape of genomic research within the Estonian Biobank

Autori: Reedik Mägi
Pubblicato in: Human Molecular Genetics, 2025, ISSN 0964-6906
Editore: Oxford University Press (OUP)
DOI: 10.1093/HMG/DDAF026

Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank

Autori: Liis Hiie, Anastassia Kolde, Natalia Pervjakova, Anu Reigo, null null, Mait Metspalu, Andres Metspalu, Lili Milani, Tõnu Esko, Erik Abner, Urmo Võsa, Tõnu Esko, Krista Fischer, Priit Palta, Jaanika Kronberg
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-92840-W

Pharmacokinetic recall study of Estonian Biobank participants with novel genetic variants in CYP2C19 and CYP2D6

Autori: Krebs, Kristi; Luitva, Laura Birgit; Kõre, Anette Caroline; Kokasaar, Raul; Jõeloo, Maarja; Hudjashov, Georgi; Maal, Kadri; Størset, Elisabet; Wollmann, Birgit Malene; Karo-Astover, Liis; Fischer, Krista; Team, Estonian Biobank Research; Lauschke, Volker M.; Ingelman-Sundberg, Magnus; Molden, Espen; Irs, Alar; Oselin, Kersti; Lass, Jana; Milani, Lili
Pubblicato in: npj Genomic Medicine, 2026, ISSN 2056-7944
Editore: Springer Nature
DOI: 10.1038/S41525-025-00549-6

A Comprehensive Approach to Days’ Supply Estimation in a Real-World Prescription Database: Algorithm Development and Validation Study

Autori: Maria Malk, Kerli Mooses, Marek Oja, Johannes Holm, Hanna Keidong, Nikita Umov, Sirli Tamm, Sulev Reisberg, Jaak Vilo, Raivo Kolde
Pubblicato in: Online Journal of Public Health Informatics, Numero 18, 2026, ISSN 1947-2579
Editore: JMIR Publications Inc.
DOI: 10.2196/83465

Genetic effects on migration behavior contribute to increasing spatial differentiation at trait-associated loci in Estonia

Autori: Ivan A. Kuznetsov, Andres Metspalu, Lili Milani, Tõnu Esko, Reedik Mägi, Mari Nelis, Georgi Hudjashov, Mait Metspalu, Uku Vainik, Luca Pagani, Francesco Montinaro, Vasili Pankratov
Pubblicato in: iScience, Numero 28, 2026, ISSN 2589-0042
Editore: Elsevier BV
DOI: 10.1016/J.ISCI.2025.114013

Pragmatic trial assessing polygenic risk driven statin therapy for cardiovascular disease prevention: study protocol for the EE-PRS trial

Autori: Ave Voit, Aet Elken, Margus Viigimaa, Ruth Kalda, Krista Fischer, Karolin Toompere, Alar Irs, Lili Milani, Helene Alavere, Sander Pajusalu, Elin Org, Janika Alloja, Katrin Kaarna, Mikk Jürisson
Pubblicato in: BMJ Open, Numero 16, 2026, ISSN 2044-6055
Editore: BMJ
DOI: 10.1136/BMJOPEN-2026-120048

Genetic analysis of circulating metabolic traits in 619,372 individuals

Autori: Ralf Tambets, Mihkel Jesse, Jaanika Kronberg, Adriaan van der Graaf, Erik Abner, Urmo Võsa, Ida Rahu, Nele Taba, Anastassia Kolde, Dzvenymyra Yarish, Sariyya Abdullayeva, Anastasiia Alekseienko, Andres Veidenberg, null null, Mari Nelis, Georgi Hudjasov, Mait Metspalu, Reedik Mägi, Andres Metspalu, Lili Milani, Krista Fischer, Zoltán Kutalik, Tõnu Esko, Kaur Alasoo, Priit Palta
Pubblicato in: Nature, 2026, ISSN 0028-0836
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41586-026-10532-5

Other (4)

From Biobanking to Personalized Medicine: the journey of the Estonian Biobank

Autori: Lili Milani, Maris Alver, Sven Laur, Sulev Reisberg, Toomas Haller, Oliver Aasmets, Erik Abner, Helene Alavere, Annely Allik, Tarmo Annilo, Krista Fischer, Georgi Hudjashov, Maarja Jeloo, Mart Kals, Liis Karo-Astover, Silva Kasela, Anastassia Kolde, Kristi Krebs, Kertu Liis Krigul, Jaanika Kronberg, Karoliina Kruusmaa, Viktorija Kukukina, Kadri Kiv, Kelli Lehto, Liis Leitsalu, Sirje Lind, Laura Birgit Luitva, Kristi Lll, Kreete Lll, Kristjan Metsalu, Mait Metspalu, Ren Mttus, Mari Nelis, Tiit Nikopensius, Miriam Nurm, Margit Nukas, Marek Oja, Elin Org, Marili Palover, Priit Palta, Vasili Pankratov, Kateryna Pantiukh, Natalia Pervjakova, Natlia Pujol-Gualdo, Anu Reigo, Ene Reimann, Steven Smit, Diana Sokurova, Nele Taba, Harry-Anton Talvik, Maris Teder-Laving, Neeme Tnisson, Mariliis Vaht, Uku Vainik, Urmo Vsa, Tnu Esko, Raivo Kolde, Reedik Mgi, Jaak Vilo, Triin Laisk, Andres Metspalu
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.09.22.24313964

Exploiting uniqueness: seed-chain-extend alignment on elastic founder graphs

Autori: Nicola Rizzo, Manuel Cceres, Veli Mkinen
Pubblicato in: 2024
Editore: Cold Spring Harbor Laboratory
DOI: 10.1101/2024.11.24.625039

StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data

Autori: James M. Holt; John Harting; Xiao Chen; Daniel Baker; Christopher T. Saunders; Zev Kronenberg; Nina Gonzaludo; Byunggil Yoo; Georgi Hudjashov; Maarja Joeloo; James M.J. Lawlor; Weng Khong Lim; Saumya S. Jamuar; Gregory M. Cooper; Lili Milani; Tomi Pastinen; Michael A. Eberle
Pubblicato in: bioRxiv, 2024
DOI: 10.1101/2024.12.10.627527

Efficient terabyte-scale text compression via stable local consistency and parallel grammar processing

Autori: Diego Diaz
Pubblicato in: 2024
Editore: ArXiv
DOI: 10.48550/arXiv.2411.12439

Conference proceedings (1)

Algorithms for Computing Very Large BWTs: a Short Survey.

Autori: Diaz-Dominguez D.; Egidi L.; Guerrini V.; Louza F. A.; Rosone G.
Pubblicato in: 2025
Editore: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
DOI: 10.4230/OASICS.MANZINI.7

Book chapters (1)

Practical Colinear Chaining on Sequences Revisited

Autori: Nicola Rizzo, Manuel Cáceres, Veli Mäkinen
Pubblicato in: Lecture Notes in Computer Science, Bioinformatics Research and Applications, 2025
Editore: Springer Nature Singapore
DOI: 10.1007/978-981-95-0695-8_17