Descripción del proyecto
Avanzar en la medicina de precisión en Portugal
La prevalencia de las enfermedades crónicas está aumentando, lo que ejerce presión sobre la sostenibilidad de los sistemas sanitarios de todo el mundo. Para hacer frente a estos problemas, cada vez se presta más atención a la prevención de las enfermedades, la concienciación y la medicina de precisión. En el proyecto NIMSB, financiado por el programa Horizonte Europa, se respaldará la creación de un centro de excelencia, el Instituto NOVA de Biología de Sistemas Médicos (NIMSB, por sus siglas en inglés) de Lisboa. El objetivo del nuevo centro es integrar análisis celulares avanzados, métodos informático y datos multiómicos para comprender las enfermedades crónicas y desarrollar nuevos tratamientos. Investigadores y médicos colaborarán en él para desarrollar modelos cuantitativos y aplicar soluciones de medicina de precisión.
Objetivo
The rise of chronic diseases is shaping health policy priorities worldwide. As the population ages, these conditions affect increasing portions of society and are more difficult to manage, causing suffering in patients and their families for many years. Such increasing prevalence is a threat to the sustainability of healthcare systems. Thus, an increasing focus has been put on disease prevention and awareness, as well as on precision medicine. This project will create a new Centre of Excellence, NOVA Institute for Medical Systems Biology (NIMSB), which will use the most advanced cell analytics and experimental in vitro systems, combined with computational approaches to understand and fight chronic diseases. The core of the project will be the integration of multi-omics data from single cells from patient biopsies and derived organoids, bioinformatics and artificial intelligence, cell and molecular biology, and relevant animal model studies, to develop quantitative models that can inform on mechanisms of disease progression. Researchers and clinicians will collaborate to use this knowledge to implement novel precision medicine solutions, aiming to intercept diseases before symptoms develop, and also by improving diagnosis, disease course prediction and response to treatment. NIMSB will contribute to clinical practice improvement not only with technology but also by training the next generation of researchers and medical doctors in precision interceptive medicine and digital-transformation technologies. NOVA Medical School of NOVA University is in a unique position to coordinate the project due to its current drive for restructuring, established reputation as a top Medical School in Portugal, and research focus on chronic diseases. The Max Delbrück Center for Molecular Medicine is the best possible advanced partner, as it is a world leader in this research topic and has recently created the Berlin Institute for Medical Systems Biology, which is a model for NIMSB.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
HORIZON-WIDERA-2022-ACCESS-01-two-stage
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-CSA - HORIZON Coordination and Support ActionsCoordinador
1099 085 Lisboa
Portugal