Bioinspired Oxidation of Hydrocarbons in Confined Spaces

Informazioni relative al progetto

ConfiMet

ID dell’accordo di sovvenzione: 101061493

DOI

10.3030/101061493

Progetto concluso il 27 Settembre 2023

Data della firma CE 29 Agosto 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2024

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 181 152,96

Coordinato da

UNIVERSITAT DE GIRONA
Spain

Periodic Reporting for period 1 - ConfiMet (Bioinspired Oxidation of Hydrocarbons in Confined Spaces)

Periodo di rendicontazione: 2023-01-01 al 2024-12-31

Sintesi del contesto e degli obiettivi generali del progetto

In the general context of developing sustainable methods for chemical synthesis, the selective functionalization of C-H bonds is an area of enormous potential given the ubiquity of C-H bonds in organic molecules. The main challenge associated with this transformation is discriminating among the multiple C-H bonds present in a molecule -typically of similar strength. The ConfiMet project aims at addressing this problem by mimicking enzymatic C-H oxidation reactions, which are highly selective transformations governed by molecular recognition phenomena. The objective of ConfiMet is to develop synthetic molecular receptors functionalized with early transition metal complexes (metallocavitands) able to perform C-H oxidations of substrates bound within the binding site of the receptor, delivering unprecedented selectivity profiles. This newfound selectivity will be dictated by the orientation of the substrate within the active site, which will be pre-organized by means of carefully designed non-covalent interactions.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

1. Two new metallocavitand receptors based on Mn and Fe have been synthesized. These hosts are based on a supporting scaffold that incorporates hydrogen bond donor fragments that should help pre-organize the resulting metallocavitands.
2. The Fe-based metallocavitand receptor has been tested in the C-H oxidation reaction of adamantane, producing interesting preliminary results in terms of selectivity.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

Although a preliminary C-H oxidation reaction test was carried out with a promising outcome, the early termination of the action did not permit to gather sufficient reactivity data to extract meaningful conclusions. Likewise, a realistic assessment of the potential impact of the results is not possible.