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CORDIS

Development of artificial phosphoinositides aiming at HIV eradication

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (opens in new window)

The research data of this project will generally be obtained from computer-based devices. Experimental and computational data of this project will be machine-retrievable and stored in these specialized devices and will be reusable when it is needed. The security of my project data will be ensured with codes and these computer-based devices will be maintained by the IT department of IKCU. When the findings of this project are published, digital object identifiers (DOIs) will be assigned to them. Publications will be accessible through the most important databases and trusted repositories.

Communication, Dissemination and Exploitation Plan (opens in new window)

This project depends on creating strong synergy within various research disciplines. This means that significant advancements will also take place in the fields of drug synthesis, nanoparticle technology and biology. It is expected that the project will generate high quality publications, technological know‐how and IP (patents). It will thus have a scientific as well as industrial impact in the bio‐medical and pharmaceutical sectors, particularly in drug discovery and development. Therefore, the main direct result of my project will be the development of a drug candidate for HIV/AIDS that can be taken into the animal test, preclinical studies and then clinical trial phase.

Publications

Design, Synthesis, and Mechanistic Anticancer Evaluation of New Pyrimidine-Tethered Compounds (opens in new window)

Author(s): Farida Reymova, Belgin Sever, Edanur Topalan, Canan Sevimli-Gur, Mustafa Can, Amaç Fatih Tuyun, Faika Başoğlu, Abdulilah Ece, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Published in: Pharmaceuticals, Issue 18, 2025, ISSN 1424-8247
Publisher: MDPI AG
DOI: 10.3390/PH18020270

Assessment of the anticancer function of <i>Coronilla orientalis</i> MILLER through comprehensive <i>in vitro</i> and computational studies (opens in new window)

Author(s): Halilibrahim Ciftci; Ayhan Oral; Yalcin Coskun; Gülin Renda; Masami Otsuka; Mikako Fujita; Belgin Sever
Published in: Turkish Journal of Biochemistry, 2025, ISSN 0250-4685
Publisher: De Gruyter Brill
DOI: 10.1515/TJB-2024-0251

A Structural Insight Into Two Important ErbB Receptors (EGFR and HER2) and Their Relevance to Non‐Small Cell Lung Cancer (opens in new window)

Author(s): Edanur Topalan, Ahmet Büyükgüngör, Melih Çiğdem, Sinan Güra, Belgin Sever, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Published in: Archiv der Pharmazie, Issue 358, 2025, ISSN 0365-6233
Publisher: Wiley
DOI: 10.1002/ARDP.202400992

Structure and Dynamics of the ABL1 Tyrosine Kinase and Its Important Role in Chronic Myeloid Leukemia (opens in new window)

Author(s): Ayca Irgit, Reyhan Kamıs, Belgin Sever, Amaç Fatih Tuyun, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Published in: Archiv der Pharmazie, Issue 358, 2025, ISSN 0365-6233
Publisher: Wiley
DOI: 10.1002/ARDP.70005

A Review of FDA-Approved Anti-HIV-1 Drugs, Anti-Gag Compounds, and Potential Strategies for HIV-1 Eradication (opens in new window)

Author(s): Belgin Sever, Masami Otsuka, Mikako Fujita and Halilibrahim Ciftci
Published in: International Journal of Molecular Sciences, Issue 3659, 2024, ISSN 1422-0067
Publisher: MDPI
DOI: 10.3390/ijms25073659

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions (opens in new window)

Author(s): Ilkin Yapici, Arda Gorkem Tokur, Belgin Sever, Halilibrahim Ciftci, Ayse Nazli Basak, Hasan DeMirci
Published in: International Journal of Molecular Sciences, Issue 26, 2025, ISSN 1422-0067
Publisher: MDPI AG
DOI: 10.3390/IJMS26094228

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