Development of artificial phosphoinositides aiming at HIV eradication

Información del proyecto

Super-HIPPO

Identificador del acuerdo de subvención: 101061939

DOI

10.3030/101061939

Proyecto cerrado

Fecha de la firma de la CE 5 Agosto 2022

Fecha de inicio 1 Septiembre 2023

Fecha de finalización 31 Octubre 2025

Financiado con arreglo a

• Marie Skłodowska-Curie Actions (MSCA)

Coste total

Sin datos

Aportación de la UE

€ 148 478,40

Coordinado por

IZMIR KATIP CELEBI UNIVERSITESI
Türkiye

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Data Management Plan

The research data of this project will generally be obtained from computer-based devices. Experimental and computational data of this project will be machine-retrievable and stored in these specialized devices and will be reusable when it is needed. The security of my project data will be ensured with codes and these computer-based devices will be maintained by the IT department of IKCU. When the findings of this project are published, digital object identifiers (DOIs) will be assigned to them. Publications will be accessible through the most important databases and trusted repositories.

Documents, reports (1)

Communication, Dissemination and Exploitation Plan

This project depends on creating strong synergy within various research disciplines. This means that significant advancements will also take place in the fields of drug synthesis, nanoparticle technology and biology. It is expected that the project will generate high quality publications, technological know‐how and IP (patents). It will thus have a scientific as well as industrial impact in the bio‐medical and pharmaceutical sectors, particularly in drug discovery and development. Therefore, the main direct result of my project will be the development of a drug candidate for HIV/AIDS that can be taken into the animal test, preclinical studies and then clinical trial phase.

Publicaciones

Peer reviewed articles (6)

Design, Synthesis, and Mechanistic Anticancer Evaluation of New Pyrimidine-Tethered Compounds

Autores: Farida Reymova, Belgin Sever, Edanur Topalan, Canan Sevimli-Gur, Mustafa Can, Amaç Fatih Tuyun, Faika Başoğlu, Abdulilah Ece, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Publicado en: Pharmaceuticals, Edición 18, 2025, ISSN 1424-8247
Editor: MDPI AG
DOI: 10.3390/PH18020270

Assessment of the anticancer function of <i>Coronilla orientalis</i> MILLER through comprehensive <i>in vitro</i> and computational studies

Autores: Halilibrahim Ciftci; Ayhan Oral; Yalcin Coskun; Gülin Renda; Masami Otsuka; Mikako Fujita; Belgin Sever
Publicado en: Turkish Journal of Biochemistry, 2025, ISSN 0250-4685
Editor: De Gruyter Brill
DOI: 10.1515/TJB-2024-0251

A Structural Insight Into Two Important ErbB Receptors (EGFR and HER2) and Their Relevance to Non‐Small Cell Lung Cancer

Autores: Edanur Topalan, Ahmet Büyükgüngör, Melih Çiğdem, Sinan Güra, Belgin Sever, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Publicado en: Archiv der Pharmazie, Edición 358, 2025, ISSN 0365-6233
Editor: Wiley
DOI: 10.1002/ARDP.202400992

Structure and Dynamics of the ABL1 Tyrosine Kinase and Its Important Role in Chronic Myeloid Leukemia

Autores: Ayca Irgit, Reyhan Kamıs, Belgin Sever, Amaç Fatih Tuyun, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Publicado en: Archiv der Pharmazie, Edición 358, 2025, ISSN 0365-6233
Editor: Wiley
DOI: 10.1002/ARDP.70005

A Review of FDA-Approved Anti-HIV-1 Drugs, Anti-Gag Compounds, and Potential Strategies for HIV-1 Eradication

Autores: Belgin Sever, Masami Otsuka, Mikako Fujita and Halilibrahim Ciftci
Publicado en: International Journal of Molecular Sciences, Edición 3659, 2024, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms25073659

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions

Autores: Ilkin Yapici, Arda Gorkem Tokur, Belgin Sever, Halilibrahim Ciftci, Ayse Nazli Basak, Hasan DeMirci
Publicado en: International Journal of Molecular Sciences, Edición 26, 2025, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/IJMS26094228