Development of artificial phosphoinositides aiming at HIV eradication

Informations projet

Super-HIPPO

N° de convention de subvention: 101061939

DOI

10.3030/101061939

Projet clôturé

Date de signature de la CE 5 Août 2022

Date de début 1 Septembre 2023

Date de fin 31 Octobre 2025

Financé au titre de

• Marie Skłodowska-Curie Actions (MSCA)

Coût total

Aucune donnée

Contribution de l’UE

€ 148 478,40

Coordonné par

IZMIR KATIP CELEBI UNIVERSITESI
Türkiye

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Livrables

Data Management Plan (1)

Data Management Plan

The research data of this project will generally be obtained from computer-based devices. Experimental and computational data of this project will be machine-retrievable and stored in these specialized devices and will be reusable when it is needed. The security of my project data will be ensured with codes and these computer-based devices will be maintained by the IT department of IKCU. When the findings of this project are published, digital object identifiers (DOIs) will be assigned to them. Publications will be accessible through the most important databases and trusted repositories.

Documents, reports (1)

Communication, Dissemination and Exploitation Plan

This project depends on creating strong synergy within various research disciplines. This means that significant advancements will also take place in the fields of drug synthesis, nanoparticle technology and biology. It is expected that the project will generate high quality publications, technological know‐how and IP (patents). It will thus have a scientific as well as industrial impact in the bio‐medical and pharmaceutical sectors, particularly in drug discovery and development. Therefore, the main direct result of my project will be the development of a drug candidate for HIV/AIDS that can be taken into the animal test, preclinical studies and then clinical trial phase.

Publications

Peer reviewed articles (6)

Design, Synthesis, and Mechanistic Anticancer Evaluation of New Pyrimidine-Tethered Compounds

Auteurs: Farida Reymova, Belgin Sever, Edanur Topalan, Canan Sevimli-Gur, Mustafa Can, Amaç Fatih Tuyun, Faika Başoğlu, Abdulilah Ece, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Publié dans: Pharmaceuticals, Numéro 18, 2025, ISSN 1424-8247
Éditeur: MDPI AG
DOI: 10.3390/PH18020270

Assessment of the anticancer function of <i>Coronilla orientalis</i> MILLER through comprehensive <i>in vitro</i> and computational studies

Auteurs: Halilibrahim Ciftci; Ayhan Oral; Yalcin Coskun; Gülin Renda; Masami Otsuka; Mikako Fujita; Belgin Sever
Publié dans: Turkish Journal of Biochemistry, 2025, ISSN 0250-4685
Éditeur: De Gruyter Brill
DOI: 10.1515/TJB-2024-0251

A Structural Insight Into Two Important ErbB Receptors (EGFR and HER2) and Their Relevance to Non‐Small Cell Lung Cancer

Auteurs: Edanur Topalan, Ahmet Büyükgüngör, Melih Çiğdem, Sinan Güra, Belgin Sever, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Publié dans: Archiv der Pharmazie, Numéro 358, 2025, ISSN 0365-6233
Éditeur: Wiley
DOI: 10.1002/ARDP.202400992

Structure and Dynamics of the ABL1 Tyrosine Kinase and Its Important Role in Chronic Myeloid Leukemia

Auteurs: Ayca Irgit, Reyhan Kamıs, Belgin Sever, Amaç Fatih Tuyun, Masami Otsuka, Mikako Fujita, Hasan Demirci, Halilibrahim Ciftci
Publié dans: Archiv der Pharmazie, Numéro 358, 2025, ISSN 0365-6233
Éditeur: Wiley
DOI: 10.1002/ARDP.70005

A Review of FDA-Approved Anti-HIV-1 Drugs, Anti-Gag Compounds, and Potential Strategies for HIV-1 Eradication

Auteurs: Belgin Sever, Masami Otsuka, Mikako Fujita and Halilibrahim Ciftci
Publié dans: International Journal of Molecular Sciences, Numéro 3659, 2024, ISSN 1422-0067
Éditeur: MDPI
DOI: 10.3390/ijms25073659

Structural Insights into the Dynamics of Water in SOD1 Catalysis and Drug Interactions

Auteurs: Ilkin Yapici, Arda Gorkem Tokur, Belgin Sever, Halilibrahim Ciftci, Ayse Nazli Basak, Hasan DeMirci
Publié dans: International Journal of Molecular Sciences, Numéro 26, 2025, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/IJMS26094228