Projektbeschreibung
Die nächste Generation Knochenaufbauprozesse vorbereiten
Das Gesundheitswesen im Allgemeinen und die Orthopädie und Knochenbehandlung im Besonderen zählen zu den wichtigsten Bereichen, die der 3D-Druck revolutioniert hat. Als Antwort auf die Nachfrage nach erschwinglicheren und personalisierten Behandlungen für Patientinnen und Patienten der Osteopathie zielt das EU-finanzierte Projekt AffordBoneS darauf ab, den Bereich der Knochenregeneration zu erforschen und maßgeschneiderte und kostengünstige Lösungen für den Knochenaufbau anzubieten. Das Projekt bringt eine Reihe verschiedener Sachverständiger aus den Bereichen Materialtechnik, Biologie, Medizin und Pharmazie zusammen, um Gerüste zu entwickeln, die mithilfe von 3D-druckbarem, mehrfach mit Ionen substituiertem Kalziumphosphat hergestellt werden.
Ziel
Less than half of the global population is covered by essential healthcare services and the aim of the postdoctoral fellowship project AffordBoneS is to obtain personalized and affordable scaffolds for bone augmentation procedures. Dr. Antonia Ressler (applicant) will study scaffolds obtained by using 3D-printable calcium phosphate multi-substituted with ions (strontium, magnesium, and zinc) crucial for efficient bone regeneration. Stereolithography, as an additive manufacturing technique, is going to be used for printing precise, highly porous, scaffolds based on multi-substituted calcium phosphates for bone augmentation procedures in collaboration with the company Lithoz. After the detailed analysis of physicochemical properties of printed scaffolds, in vitro and in vivo biological properties will be obtained to determine the scaffold's osteogenic properties and the influence of substituted ions on bone regeneration by using stem cells from female and male donors and female and male rats, respectively. Further, company Planmeca will provide patient real cases and the needed technologies for obtaining a demonstration of a personalized scaffold, customized to the patient complex jaw bone defect. The project will be carried out at the Faculty of Engineering and Natural Sciences and the Faculty of Medicine and Health Technology of Tampere University, under the supervision of Prof. Erkki Levanen and co-supervision of Prof. Susanna Miettinen. AffordBoneS project requires a high level of interdisciplinary work and the project is planned bearing in the mind that the improvement in the field of bone regeneration relies on bringing together experts from different fields, who are nowadays distant from each other, such as material engineers, biologists, clinicians, surgeons, and related companies.
Wissenschaftliches Gebiet
- natural scienceschemical sciencesinorganic chemistrytransition metals
- natural scienceschemical sciencesinorganic chemistryalkaline earth metals
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- medical and health scienceshealth scienceshealth care services
- engineering and technologymechanical engineeringmanufacturing engineeringadditive manufacturing
Programm/Programme
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-AG-UN - HORIZON Unit GrantKoordinator
33100 Tampere
Finnland