Descripción del proyecto
Una administración de fármacos controlada de forma remota
Los exosomas son vesículas extracelulares derivadas de células que transportan ácidos nucleicos, proteínas, metabolitos y lípidos. Participan en la comunicación intercelular y cada vez hay más pruebas de que desempeñan una función en la fisiopatología de numerosas enfermedades. El proyecto TheranoXome se propone aprovechar los exosomas para la administración de fármacos guiada por imágenes. El equipo de este proyecto, financiado por las Acciones Marie Skłodowska-Curie, utilizará nanopartículas para administrar fármacos quimioterapéuticos en el interior de los exosomas y comprobar tanto sus propiedades como su eficacia en un modelo murino del cáncer de mama. Cabe destacar que la administración específica y el destino de estos exosomas se realizará utilizando imágenes por resonancia magnética nuclear.
Objetivo
The primary objective of this project is to engineer a non-immunogenic cell-membrane mimicking drug delivery vehicle for remote-controlled precision drug delivery. This will be achieved by encapsulating stimuli-responsive & contrast enhancing nanoparticles and drug cargo into endogenous exosomes to develop a therapeutic-cum-diagnostic exosomal system viz; TheranoXome for image-guided stimuli-responsive drug delivery. Such bio-mimetic TheranoXomes if realized will have wide applicability as a universal drug-delivery agent. The project entails three steps: (1) Synthesizing TheranoXomes by template assisted loading of chemotherapeutic drugs, light responsive thermoplasmonic gold nanorods and magnetic nanoparticles as magnetic resonance imaging agents into exosomes; (2) (Bio-)Physicochemical characterization of TheranoXomes including colloidal properties, biomimetics, immuno-compatibility, light-triggered drug release, magnetism (imaging and magnetic guided enrichment) and in vitro studies (2D and 3D cell cultures); (3) Application of TheranoXomes in vivo in a breast tumor bearing mice model. I (the ER) will prepare, characterize and test the materials and application proposed, with the support of a multidisciplinary hub of specialists. The prime training aim of TheranoXome is to provide me with a solid foundation in biomaterials, which will support my future career endeavours, both in the academia or industry, to be an independent researcher, a founder of a start-up company or to become key player in the biomaterials sector. I will be hosted by the Centre for Research in Biological Chemistry and Molecular Materials (CiQUS) of the University of Santiago de Compostela, a cutting-edge multidisciplinary research centre at the interface of chemistry, biomedicine and molecular materials. The training will be further strengthened by one secondment (6 months) focused on in vivo (drug delivery and imaging) studies (Health Research Institute of Santiago de Compostela - IDIS).
Ámbito científico
- natural sciencesbiological sciencescell biology
- medical and health sciencesclinical medicineoncology
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- engineering and technologynanotechnologynano-materials
- engineering and technologyindustrial biotechnologybiomaterials
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinador
15782 Santiago De Compostela
España