Projektbeschreibung
Ferngesteuerte Wirkstoffabgabe
Exosomen sind von Zellen abgegebene extrazelluläre Vesikel, die Nukleinsäuren, Proteine, Metaboliten und Lipide transportieren. Sie sind außerdem an der zellulären Kommunikation beteiligt. Neue Erkenntnisse unterstreichen ihre Rolle in der Pathophysiologie vieler Krankheiten. Das Projekt TheranoXome zielt darauf ab, Exosomen für die bildgestützte Wirkstoffabgabe zu nutzen. Das im Rahmen der Marie-Skłodowska-Curie-Maßnahmen finanzierte Projekt wird Nanopartikel zur Verabreichung von Chemotherapeutika mittels Exosomen einsetzen sowie deren Eigenschaften und Wirksamkeit anhand eines Mausmodells für Brustkrebs erproben. Wichtig ist, dass die spezifische Abgabe und der Verbleib dieser Exosomen durch Magnetresonanztomografie vermittelt wird.
Ziel
The primary objective of this project is to engineer a non-immunogenic cell-membrane mimicking drug delivery vehicle for remote-controlled precision drug delivery. This will be achieved by encapsulating stimuli-responsive & contrast enhancing nanoparticles and drug cargo into endogenous exosomes to develop a therapeutic-cum-diagnostic exosomal system viz; TheranoXome for image-guided stimuli-responsive drug delivery. Such bio-mimetic TheranoXomes if realized will have wide applicability as a universal drug-delivery agent. The project entails three steps: (1) Synthesizing TheranoXomes by template assisted loading of chemotherapeutic drugs, light responsive thermoplasmonic gold nanorods and magnetic nanoparticles as magnetic resonance imaging agents into exosomes; (2) (Bio-)Physicochemical characterization of TheranoXomes including colloidal properties, biomimetics, immuno-compatibility, light-triggered drug release, magnetism (imaging and magnetic guided enrichment) and in vitro studies (2D and 3D cell cultures); (3) Application of TheranoXomes in vivo in a breast tumor bearing mice model. I (the ER) will prepare, characterize and test the materials and application proposed, with the support of a multidisciplinary hub of specialists. The prime training aim of TheranoXome is to provide me with a solid foundation in biomaterials, which will support my future career endeavours, both in the academia or industry, to be an independent researcher, a founder of a start-up company or to become key player in the biomaterials sector. I will be hosted by the Centre for Research in Biological Chemistry and Molecular Materials (CiQUS) of the University of Santiago de Compostela, a cutting-edge multidisciplinary research centre at the interface of chemistry, biomedicine and molecular materials. The training will be further strengthened by one secondment (6 months) focused on in vivo (drug delivery and imaging) studies (Health Research Institute of Santiago de Compostela - IDIS).
Wissenschaftliches Gebiet
- natural sciencesbiological sciencescell biology
- medical and health sciencesclinical medicineoncology
- engineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging
- engineering and technologynanotechnologynano-materials
- engineering and technologyindustrial biotechnologybiomaterials
Schlüsselbegriffe
Programm/Programme
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsKoordinator
15782 Santiago De Compostela
Spanien