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Understanding individual heterogeneity in ageing from stochastic dynamics of sigma factor regulatory network in bacteria

Project description

Gaining insight into ageing from bacterial transcriptional regulation

Sigma factors are the main constituents of transcription regulation in bacteria, playing a key role in gene expression regulation in response to environmental changes. They could provide insight into heterogeneity in ageing among individuals, going beyond bacteria and observed in diverse populations including humans. Scientific understanding of the molecular control of ageing via genetic and metabolic pathways does not fully explain this heterogeneity demonstrated by different ageing rates and patterns and even observed with fixed genetics and environment. With the support of the Marie Skłodowska-Curie Actions programme, the ASNet project will combine high-tech experimental techniques with mathematical modelling to elucidate the roles and mechanisms of four sigma factors in ageing processes of individual bacterial cells.

Coordinator

FREIE UNIVERSITAET BERLIN
Net EU contribution
€ 189 687,36
Address
Kaiserswerther Strasse 16-18
14195 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Other funding
No data