A Modular Framework for Designing and Producing Biohybrid Machines

Informations projet

BioMeld

N° de convention de subvention: 101070328

DOI

10.3030/101070328

Projet clôturé

Date de signature de la CE 24 Juin 2022

Date de début 1 Octobre 2022

Date de fin 31 Mars 2026

Financé au titre de

• Digital, Industry and Space

Coût total

€ 3 978 056,93

Contribution de l’UE

€ 3 978 056,93

Coordonné par

UNIVERZITET U NOVOM SADU, POLJOPRIVREDNI FAKULTET NOVI SAD
Serbia

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (19)

Plan for Dissemination, Exploitation and Communication

Plan will be periodically updated and presented at periodic review meetings.

Performance simulations and analysis of results

Report on performed simulations, their correlation with experiments and analysis of predictive power. Updated at month 36.

Data management plan

Data management plan done in accordance to EC template

The Framework specifications

Periodic reports on the initial framework specifications (M06) and further developments, standards implemented, how it is integrated with the BIMC development. Deliverable updates will be done at Months 18 and 36

Experimental performance

Report on performed tests and obtained results. Updated at month 36

Catheter muscle integration

Report on integrating muscle contraction-based motion into a catheter, the production methods chosen and parameters used for that choice.

Report of the kick-off meeting

Report of the decisions from the kick-off meeting.

Additional simulation modules

Report on developed modules for simulating electric stimulus-response and rotation&bending dynamics, how they are implemented, and performance results.

Early career development

Periodic reports on performed activities described in T5.2. Updated at Month 36.

IP, regulation and dissemination report

Periodic reports on performed activities in T5.5-6. Updated at month 36.

System observables

Report on the estimated main observable parameters for modelling biohybrid catheter.

Culture and actuator chamber with integrated sensors

Progress report (M18) and the final report (M28) on the chamber design and fabrication.

Test plan & cases

Report on developed documentation templates, test plan, test cases and updates (on months 18 and 30).

Uncertainty analysis

Reports on uncertainty & sensitivity analyses, and acceptability ranges. Updated at month 36.

3D evolvable simulator

Report on the implemented voxel-based simulator, how it is integrated with evolvable algorithms and performance results.

Machine learning optimization

Report on DNN methodology applied, tests performed, parameter and metaparameter optimizations, performances. The updated version will be uploaded in month 36.

Feedback system control software

Progress report (M18) and the final report (M32) on the control software development, testing and calibration results.

Bill of materials

Report on the first version (M06) and the final, updated BOM will be updated at M24

BHM Catheter skeleton design and fabrication

Report on catheter design, structure, materials used, test results.

Websites, patent fillings, videos etc. (1)

Web and public presence

Launched website, social media, flyers

Publications

Peer reviewed articles (20)

Bio-intelligent manufacturing cell for bio-hybrid machines fabrication

Auteurs: Teti, Roberto; Caggiano, Alessandra; Balaz, Igor
Publié dans: Procedia CIRP, 2024, ISSN 2212-8271
Éditeur: Elsevier
DOI: 10.1016/J.PROCIR.2024.08.275

Mechanical Deformation Effects on Flexible Thin Film Transistors: A Comparison Between 6,13‐Bis(Triisopropylsilylethynyl)Pentacene and N,N′‐Bis‐(2‐Ethylhexyl)‐1,7‐Dicyanoperylene‐3,4:9,10‐bis(Dicarboximide) Derivatives

Auteurs: A. Mascia, M. Concas, E. Podda, G. Casula, S. Lai, P. Cosseddu
Publié dans: Advanced Materials Interfaces, Numéro 12, 2025, ISSN 2196-7350
Éditeur: Wiley
DOI: 10.1002/ADMI.202400783

Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter

Auteurs: Michail-Antisthenis Tsompanas; Michail-Antisthenis Tsompanas; Igor Balaz
Publié dans: Frontiers in Robotics and AI, 2024, ISSN 2296-9144
Éditeur: Frontiers Media SA
DOI: 10.3389/FROBT.2024.1337722

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications

Auteurs: David Esporrín‐Ubieto, Juan C. Fraire, Daniel Sánchez‐deAlcázar, Samuel Sánchez
Publié dans: Advanced Materials, Numéro 37, 2025, ISSN 0935-9648
Éditeur: Wiley
DOI: 10.1002/ADMA.202502171

Bio-Hybrid Steerable Catheter Fabrication and Assembly within the EC ‘BioMeld’ Project - Part 1: Manufacturing Process Steps

Auteurs: Roberto Teti, Alessandra Caggiano
Publié dans: Procedia CIRP, Numéro 138, 2026, ISSN 2212-8271
Éditeur: Elsevier BV
DOI: 10.1016/J.PROCIR.2026.01.204

Development of an electrical current stimulator for controlling biohybrid machines

Auteurs: Riccardo Collu, Judith Fuentes, Florencia Lezcano, Maria Crespo-Cuadraro, Andrea Bartolucci, Leonardo Ricotti, Lorenzo Vannozzi, Samuel Sánchez, Stefano Lai, Massimo Barbaro
Publié dans: Scientific Reports, Numéro 15, 2025, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-06465-0

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

Auteurs: Stefano Lai; Judith Fuentes; Maria Guix; Giulia Casula; Piero Cosseddu; Samuel Sánchez
Publié dans: Advanced Intelligent Systems, 2024, ISSN 2640-4567
Éditeur: Wiley Online Library
DOI: 10.1002/AISY.202400407

Ferrofluid‐Based Bioink for 3D Printed Skeletal Muscle Tissues with Enhanced Force and Magnetic Response

Auteurs: Judith Fuentes; Maria Guix; Zoran M. Cenev; Anna C. Bakenecker; Noelia Ruiz‐González; Grégory Beaune; Jaakko V.I. Timonen; Samuel Sanchez; Veronika Magdanz
Publié dans: Advanced Materials Interfaces, 2025, ISSN 2196-7350
Éditeur: Willey
DOI: 10.1002/ADMI.202400824

Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy

Auteurs: Brenda G. Molina, Judith Fuentes, Carlos Alemán, Samuel Sánchez
Publié dans: Biosensors and Bioelectronics, Numéro Volume 251, 1 May 2024, 116117, 2024, ISSN 0956-5663
Éditeur: Elsevier
DOI: 10.1016/j.bios.2024.116117

Bioengineering fascicle-like skeletal muscle bioactuators via pluronic-assisted co-axial 3D bioprinting (PACA-3D)

Auteurs: Judith Fuentes, Rafael Mestre, Maria Guix, David Esporrín-Ubieto, Ibtissam Ghailan Tribak, Noelia Ruiz-González, Tania Patiño, Samuel Sánchez
Publié dans: Biofabrication, Numéro 17, 2025, ISSN 1758-5082
Éditeur: IOP Publishing
DOI: 10.1088/1758-5090/ADDC9B

Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter

Auteurs: Michail-Antisthenis Tsompanas, Igor Balaz
Publié dans: Frontiers in Robotics and AI, 2024, ISSN 2296-9144
Éditeur: Frontiers Media SA
DOI: 10.3389/frobt.2024.1337722

Multicellular muscle-tendon bioprinting of mechanically optimized musculoskeletal bioactuators with enhanced force transmission

Auteurs: Miriam Filippi; Diana Mock; Judith Fuentes; Mike Y. Michelis; Aiste Balciunaite; Pablo Paniagua; Raoul Hopf; Adina Barteld; Selina Eng; Asia Badolato; Jess Snedeker; Maria Guix; Samuel Sanchez; Robert K. Katzschmann
Publié dans: Science Advances, 2025, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.3929/ETHZ-B-000745894

Fabrication of Flexible Double‐Gate Organic Thin Film Transistor For Tactile Applications

Auteurs: Mattia Concas; Antonello Mascia; Stefano Lai; Annalisa Bonfiglio; Piero Cosseddu
Publié dans: Advanced Materials Technologies, 2024, ISSN 2365-709X
Éditeur: Wiley
DOI: 10.1002/ADMT.202400534

Soft robotics: what’s next in bioinspired design and applications of soft robots?

Auteurs: Cecilia Laschi; Li Wen; Fumiya Iida; Arsen Abdulali; Helmut Hauser; Yifan Wang; Ke Liu; Leonardo Ricotti; Matteo Cianchetti; Kaspar Althoefer; Pham Huy Nguyen; Mirko Kovač; Marcello Calisti
Publié dans: Bioinspiration & Biomimetics, 2025, ISSN 1748-3190
Éditeur: IOP Publishing Ltd
DOI: 10.1088/1748-3190/AE066D

Wearable Stimulator for Upper and Lower Limb Somatotopic Sensory Feedback Restoration

Auteurs: Roberto Paolini, Riccardo Collu, Laura Tullio, Andrea Demofonti, Alessia Scarpelli, Francesca Cordella, Massimo Barbaro, Loredana Zollo
Publié dans: IEEE Transactions on Biomedical Circuits and Systems, Numéro 20, 2026, ISSN 1932-4545
Éditeur: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBCAS.2025.3607203

Optimizing the Substrate for Hypercube‐Based Neuroevolution of Augmented Topologies to Design Soft Actuators

Auteurs: Hugo Alcaraz‐Herrera, Michail‐Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Publié dans: Concurrency and Computation: Practice and Experience, Numéro 37, 2026, ISSN 1532-0626
Éditeur: Wiley
DOI: 10.1002/CPE.70204

Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue

Auteurs: Andrea Bartolucci; Judith Fuentes; Daniele Guarnera; Florencia Lezcano; Maria Crespo‐Cuadrado; Lorena Guachi‐Guachi; Francesco Iacoponi; Carlotta Salvatori; Riccardo Collu; Massimo Barbaro; Stefano Lai; Leonardo Ricotti; Samuel Sánchez; Lorenzo Vannozzi
Publié dans: Advanced Intelligent Systems, 2025, ISSN 2640-4567
Éditeur: Wiley Online Library
DOI: 10.1002/AISY.202400989

Biologicalisation in manufacturing – Current state and future trends

Auteurs: Konrad Wegener, Oliver Damm, Simon Harst, Steffen Ihlenfeldt, Laszlo Monostori, Roberto Teti, Rafi Wertheim, Gerry Byrne
Publié dans: CIRP Annals, Numéro 72, 2025, ISSN 0007-8506
Éditeur: Elsevier BV
DOI: 10.1016/J.CIRP.2023.05.005

Using neuroevolution for designing soft medical devices

Auteurs: Hugo Alcaraz-Herrera; Michail-Antisthenis Tsompanas; Igor Balaz; Andrew Adamatzky
Publié dans: Biomimetic Intelligence and Robotics, 2025, ISSN 2667-3797
Éditeur: Elsevier
DOI: 10.48550/ARXIV.2408.09107

Bio-Hybrid Steerable Catheter Fabrication and Assembly within the EC ‘BioMeld’ Project - Part 2: Production Plan Achievement

Auteurs: Alessandra Caggiano, Roberto Teti
Publié dans: Procedia CIRP, Numéro 138, 2026, ISSN 2212-8271
Éditeur: Elsevier BV
DOI: 10.1016/J.PROCIR.2026.01.205

Conference proceedings (14)

A novel concept of steerable catheters actuated by muscle cells: the BioMeld project

Auteurs: Salvatori C, Ricotti L, Vannozzi L
Publié dans: 2023, ISSN 2724-2129
Éditeur: Gruppo Nazionale di Bioingegneria

NeuroEvolution algorithms applied in the designing process of biohybrid actuators

Auteurs: Alcaraz-Herrera, H., Tsompanas, MA., Balaz, I., Adamatzky, A.
Publié dans: Intelligent Distributed Computing XVII (IDC 2024), ISSN 1860-9503
Éditeur: Springer

Incremental Growth on Compositional Pattern Producing Networks Based Optimization of Biohybrid Actuators

Auteurs: Tsompanas, MA
Publié dans: 2024, ISSN 1611-3349
Éditeur: Springer Nature Switzerland AG
DOI: 10.1007/978-3-031-56855-8_17

A Modular Portable Current Stimulator for Electrical Stimulation of Excitable Tissues

Auteurs: Riccardo Collu, Stefano Lai, Antonello Mascia, Roberto Paolini, Elena Ferrazzano, Loredana Zollo, Piero Cosseddu, Massimo Barbaro
Publié dans: Lecture Notes in Electrical Engineering, Proceedings of SIE 2024, 2025
Éditeur: Springer Nature Switzerland
DOI: 10.1007/978-3-031-71518-1_54

Incremental Growth on Compositional Pattern Producing Networks Based Optimization of Biohybrid Actuators

Auteurs: Michail-Antisthenis I. Tsompanas
Publié dans: Lecture Notes in Computer Science - Applications of Evolutionary Computation, 2024
Éditeur: Springer
DOI: 10.1007/978-3-031-56855-8_17

Control of Biohybrid Actuators Using Neuroevolution

Auteurs: Hugo Alcaraz-Herrera; Michail-Antisthenis I. Tsompanas; Igor Balaz; Andrew Adamatzky
Publié dans: Proceedings of the 16th International Joint Conference on Computational Intelligence, 2024, ISSN 2184-3236
Éditeur: ScitePress Digital Library
DOI: 10.48550/ARXIV.2411.08261

A Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study

Auteurs: Salvatori, C., Trucco, D., Niosi, I., Ricotti, L., Vannozzi, L.
Publié dans: 2023, ISSN 1611-3349
Éditeur: Springer, Cham
DOI: 10.1007/978-3-031-39504-8_26

Development of an electrical current stimulator for controlling biohybrid machines

Auteurs: Collu, Riccardo; Fuentes, Judith; Lezcano, Florencia; Crespo-Cuadraro, Maria; Bartolucci, Andrea; Ricotti, Leonardo; Vannozzi, Lorenzo; Sánchez, Samuel; Lai, Stefano; Barbaro, Massimo
Publié dans: Scientific Reports, 2025
Éditeur: IEEE
DOI: 10.1038/S41598-025-06465-0

A Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study

Auteurs: Carlotta Salvatori; Diego Trucco; Ignazio Niosi; Leonardo Ricotti; Lorenzo Vannozzi
Publié dans: Lecture Notes in Computer Science - Biomimetic and Biohybrid Systems, 2023
Éditeur: Springer Nature
DOI: 10.1007/978-3-031-39504-8_26

Designing morphologies of soft medical devices using cooperative neuro coevolution

Auteurs: Hugo Alcaraz-Herrera, Michail-Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Publié dans: Proceedings of the Genetic and Evolutionary Computation Conference Companion, 2025
Éditeur: ACM
DOI: 10.1145/3712255.3726671

NEAT and HyperNEAT based Design for Soft Actuator Controllers

Auteurs: Alcaraz-Herrera, H., Tsompanas, M. A., Balaz, I., & Adamatzky, A.
Publié dans: Studies in Computational Intelligence
Éditeur: Springer

A novel concept of steerable catheters actuated by muscle cells: the BioMeld project

Auteurs: Salvatori, C., Ricotti, L., & Vannozzi, L.
Publié dans: NATIONAL CONGRESS OF BIOENGINEERING. PROCEEDINGS.. Patron Editore Srl.
Éditeur: GNB Proceedings

NeuroEvolution Algorithms Applied in the Designing Process of Biohybrid Actuators

Auteurs: Hugo Alcaraz-Herrera; Michail-Antisthenis Tsompanas; Igor Balaz; Andrew Adamatzky
Publié dans: Studies in Computational Intelligence ISBN: 9783031876387, 2025
Éditeur: Springer
DOI: 10.48550/ARXIV.2408.07671

Evaluating Fitness Averaging Strategies in Cooperative NeuroCoEvolution for Automated Soft Actuator Design

Auteurs: Hugo Alcaraz-Herrera, Michail-Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Publié dans: Communications in Computer and Information Science, Computational Intelligence, 2026
Éditeur: Springer Nature Switzerland
DOI: 10.1007/978-3-032-15635-8_8