A Modular Framework for Designing and Producing Biohybrid Machines

Leistungen

Plan for Dissemination, Exploitation and Communication

Plan will be periodically updated and presented at periodic review meetings.

Performance simulations and analysis of results

Report on performed simulations, their correlation with experiments and analysis of predictive power. Updated at month 36.

Data management plan

Data management plan done in accordance to EC template

The Framework specifications

Periodic reports on the initial framework specifications (M06) and further developments, standards implemented, how it is integrated with the BIMC development. Deliverable updates will be done at Months 18 and 36

Experimental performance

Report on performed tests and obtained results. Updated at month 36

Catheter muscle integration

Report on integrating muscle contraction-based motion into a catheter, the production methods chosen and parameters used for that choice.

Report of the kick-off meeting

Report of the decisions from the kick-off meeting.

Additional simulation modules

Report on developed modules for simulating electric stimulus-response and rotation&bending dynamics, how they are implemented, and performance results.

Early career development

Periodic reports on performed activities described in T5.2. Updated at Month 36.

IP, regulation and dissemination report

Periodic reports on performed activities in T5.5-6. Updated at month 36.

System observables

Report on the estimated main observable parameters for modelling biohybrid catheter.

Culture and actuator chamber with integrated sensors

Progress report (M18) and the final report (M28) on the chamber design and fabrication.

Test plan & cases

Report on developed documentation templates, test plan, test cases and updates (on months 18 and 30).

Uncertainty analysis

Reports on uncertainty & sensitivity analyses, and acceptability ranges. Updated at month 36.

3D evolvable simulator

Report on the implemented voxel-based simulator, how it is integrated with evolvable algorithms and performance results.

Machine learning optimization

Report on DNN methodology applied, tests performed, parameter and metaparameter optimizations, performances. The updated version will be uploaded in month 36.

Feedback system control software

Progress report (M18) and the final report (M32) on the control software development, testing and calibration results.

Bill of materials

Report on the first version (M06) and the final, updated BOM will be updated at M24

BHM Catheter skeleton design and fabrication

Report on catheter design, structure, materials used, test results.

Web and public presence

Launched website, social media, flyers

Veröffentlichungen

Bio-intelligent manufacturing cell for bio-hybrid machines fabrication

Autoren: Teti, Roberto; Caggiano, Alessandra; Balaz, Igor
Veröffentlicht in: Procedia CIRP, 2024, ISSN 2212-8271
Herausgeber: Elsevier
DOI: 10.1016/J.PROCIR.2024.08.275

Mechanical Deformation Effects on Flexible Thin Film Transistors: A Comparison Between 6,13‐Bis(Triisopropylsilylethynyl)Pentacene and N,N′‐Bis‐(2‐Ethylhexyl)‐1,7‐Dicyanoperylene‐3,4:9,10‐bis(Dicarboximide) Derivatives

Autoren: A. Mascia, M. Concas, E. Podda, G. Casula, S. Lai, P. Cosseddu
Veröffentlicht in: Advanced Materials Interfaces, Ausgabe 12, 2025, ISSN 2196-7350
Herausgeber: Wiley
DOI: 10.1002/ADMI.202400783

Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter

Autoren: Michail-Antisthenis Tsompanas; Michail-Antisthenis Tsompanas; Igor Balaz
Veröffentlicht in: Frontiers in Robotics and AI, 2024, ISSN 2296-9144
Herausgeber: Frontiers Media SA
DOI: 10.3389/FROBT.2024.1337722

Engineered Plasmonic and Fluorescent Nanomaterials for Biosensing, Motion, Imaging, and Therapeutic Applications

Autoren: David Esporrín‐Ubieto, Juan C. Fraire, Daniel Sánchez‐deAlcázar, Samuel Sánchez
Veröffentlicht in: Advanced Materials, Ausgabe 37, 2025, ISSN 0935-9648
Herausgeber: Wiley
DOI: 10.1002/ADMA.202502171

Bio-Hybrid Steerable Catheter Fabrication and Assembly within the EC ‘BioMeld’ Project - Part 1: Manufacturing Process Steps

Autoren: Roberto Teti, Alessandra Caggiano
Veröffentlicht in: Procedia CIRP, Ausgabe 138, 2026, ISSN 2212-8271
Herausgeber: Elsevier BV
DOI: 10.1016/J.PROCIR.2026.01.204

Development of an electrical current stimulator for controlling biohybrid machines

Autoren: Riccardo Collu, Judith Fuentes, Florencia Lezcano, Maria Crespo-Cuadraro, Andrea Bartolucci, Leonardo Ricotti, Lorenzo Vannozzi, Samuel Sánchez, Stefano Lai, Massimo Barbaro
Veröffentlicht in: Scientific Reports, Ausgabe 15, 2025, ISSN 2045-2322
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-06465-0

Real‐Time Force Monitoring of Electrically Stimulated 3D‐Bioengineered Muscle Bioactuators Using Organic Sensors with Tunable Sensitivity

Autoren: Stefano Lai; Judith Fuentes; Maria Guix; Giulia Casula; Piero Cosseddu; Samuel Sánchez
Veröffentlicht in: Advanced Intelligent Systems, 2024, ISSN 2640-4567
Herausgeber: Wiley Online Library
DOI: 10.1002/AISY.202400407

Ferrofluid‐Based Bioink for 3D Printed Skeletal Muscle Tissues with Enhanced Force and Magnetic Response

Autoren: Judith Fuentes; Maria Guix; Zoran M. Cenev; Anna C. Bakenecker; Noelia Ruiz‐González; Grégory Beaune; Jaakko V.I. Timonen; Samuel Sanchez; Veronika Magdanz
Veröffentlicht in: Advanced Materials Interfaces, 2025, ISSN 2196-7350
Herausgeber: Willey
DOI: 10.1002/ADMI.202400824

Merging BioActuation and BioCapacitive properties: A 3D bioprinted devices to self-stimulate using self-stored energy

Autoren: Brenda G. Molina, Judith Fuentes, Carlos Alemán, Samuel Sánchez
Veröffentlicht in: Biosensors and Bioelectronics, Ausgabe Volume 251, 1 May 2024, 116117, 2024, ISSN 0956-5663
Herausgeber: Elsevier
DOI: 10.1016/j.bios.2024.116117

Bioengineering fascicle-like skeletal muscle bioactuators via pluronic-assisted co-axial 3D bioprinting (PACA-3D)

Autoren: Judith Fuentes, Rafael Mestre, Maria Guix, David Esporrín-Ubieto, Ibtissam Ghailan Tribak, Noelia Ruiz-González, Tania Patiño, Samuel Sánchez
Veröffentlicht in: Biofabrication, Ausgabe 17, 2025, ISSN 1758-5082
Herausgeber: IOP Publishing
DOI: 10.1088/1758-5090/ADDC9B

Outline of an evolutionary morphology generator towards the modular design of a biohybrid catheter

Autoren: Michail-Antisthenis Tsompanas, Igor Balaz
Veröffentlicht in: Frontiers in Robotics and AI, 2024, ISSN 2296-9144
Herausgeber: Frontiers Media SA
DOI: 10.3389/frobt.2024.1337722

Multicellular muscle-tendon bioprinting of mechanically optimized musculoskeletal bioactuators with enhanced force transmission

Autoren: Miriam Filippi; Diana Mock; Judith Fuentes; Mike Y. Michelis; Aiste Balciunaite; Pablo Paniagua; Raoul Hopf; Adina Barteld; Selina Eng; Asia Badolato; Jess Snedeker; Maria Guix; Samuel Sanchez; Robert K. Katzschmann
Veröffentlicht in: Science Advances, 2025, ISSN 2375-2548
Herausgeber: American Association for the Advancement of Science (AAAS)
DOI: 10.3929/ETHZ-B-000745894

Fabrication of Flexible Double‐Gate Organic Thin Film Transistor For Tactile Applications

Autoren: Mattia Concas; Antonello Mascia; Stefano Lai; Annalisa Bonfiglio; Piero Cosseddu
Veröffentlicht in: Advanced Materials Technologies, 2024, ISSN 2365-709X
Herausgeber: Wiley
DOI: 10.1002/ADMT.202400534

Soft robotics: what’s next in bioinspired design and applications of soft robots?

Autoren: Cecilia Laschi; Li Wen; Fumiya Iida; Arsen Abdulali; Helmut Hauser; Yifan Wang; Ke Liu; Leonardo Ricotti; Matteo Cianchetti; Kaspar Althoefer; Pham Huy Nguyen; Mirko Kovač; Marcello Calisti
Veröffentlicht in: Bioinspiration & Biomimetics, 2025, ISSN 1748-3190
Herausgeber: IOP Publishing Ltd
DOI: 10.1088/1748-3190/AE066D

Wearable Stimulator for Upper and Lower Limb Somatotopic Sensory Feedback Restoration

Autoren: Roberto Paolini, Riccardo Collu, Laura Tullio, Andrea Demofonti, Alessia Scarpelli, Francesca Cordella, Massimo Barbaro, Loredana Zollo
Veröffentlicht in: IEEE Transactions on Biomedical Circuits and Systems, Ausgabe 20, 2026, ISSN 1932-4545
Herausgeber: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/TBCAS.2025.3607203

Optimizing the Substrate for Hypercube‐Based Neuroevolution of Augmented Topologies to Design Soft Actuators

Autoren: Hugo Alcaraz‐Herrera, Michail‐Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Veröffentlicht in: Concurrency and Computation: Practice and Experience, Ausgabe 37, 2026, ISSN 1532-0626
Herausgeber: Wiley
DOI: 10.1002/CPE.70204

Monolithic Biohybrid Flexure Mechanism Actuated by Bioengineered Skeletal Muscle Tissue

Autoren: Andrea Bartolucci; Judith Fuentes; Daniele Guarnera; Florencia Lezcano; Maria Crespo‐Cuadrado; Lorena Guachi‐Guachi; Francesco Iacoponi; Carlotta Salvatori; Riccardo Collu; Massimo Barbaro; Stefano Lai; Leonardo Ricotti; Samuel Sánchez; Lorenzo Vannozzi
Veröffentlicht in: Advanced Intelligent Systems, 2025, ISSN 2640-4567
Herausgeber: Wiley Online Library
DOI: 10.1002/AISY.202400989

Biologicalisation in manufacturing – Current state and future trends

Autoren: Konrad Wegener, Oliver Damm, Simon Harst, Steffen Ihlenfeldt, Laszlo Monostori, Roberto Teti, Rafi Wertheim, Gerry Byrne
Veröffentlicht in: CIRP Annals, Ausgabe 72, 2025, ISSN 0007-8506
Herausgeber: Elsevier BV
DOI: 10.1016/J.CIRP.2023.05.005

Using neuroevolution for designing soft medical devices

Autoren: Hugo Alcaraz-Herrera; Michail-Antisthenis Tsompanas; Igor Balaz; Andrew Adamatzky
Veröffentlicht in: Biomimetic Intelligence and Robotics, 2025, ISSN 2667-3797
Herausgeber: Elsevier
DOI: 10.48550/ARXIV.2408.09107

Bio-Hybrid Steerable Catheter Fabrication and Assembly within the EC ‘BioMeld’ Project - Part 2: Production Plan Achievement

Autoren: Alessandra Caggiano, Roberto Teti
Veröffentlicht in: Procedia CIRP, Ausgabe 138, 2026, ISSN 2212-8271
Herausgeber: Elsevier BV
DOI: 10.1016/J.PROCIR.2026.01.205

A novel concept of steerable catheters actuated by muscle cells: the BioMeld project

Autoren: Salvatori C, Ricotti L, Vannozzi L
Veröffentlicht in: 2023, ISSN 2724-2129
Herausgeber: Gruppo Nazionale di Bioingegneria

NeuroEvolution algorithms applied in the designing process of biohybrid actuators

Autoren: Alcaraz-Herrera, H., Tsompanas, MA., Balaz, I., Adamatzky, A.
Veröffentlicht in: Intelligent Distributed Computing XVII (IDC 2024), ISSN 1860-9503
Herausgeber: Springer

Incremental Growth on Compositional Pattern Producing Networks Based Optimization of Biohybrid Actuators

Autoren: Tsompanas, MA
Veröffentlicht in: 2024, ISSN 1611-3349
Herausgeber: Springer Nature Switzerland AG
DOI: 10.1007/978-3-031-56855-8_17

A Modular Portable Current Stimulator for Electrical Stimulation of Excitable Tissues

Autoren: Riccardo Collu, Stefano Lai, Antonello Mascia, Roberto Paolini, Elena Ferrazzano, Loredana Zollo, Piero Cosseddu, Massimo Barbaro
Veröffentlicht in: Lecture Notes in Electrical Engineering, Proceedings of SIE 2024, 2025
Herausgeber: Springer Nature Switzerland
DOI: 10.1007/978-3-031-71518-1_54

Incremental Growth on Compositional Pattern Producing Networks Based Optimization of Biohybrid Actuators

Autoren: Michail-Antisthenis I. Tsompanas
Veröffentlicht in: Lecture Notes in Computer Science - Applications of Evolutionary Computation, 2024
Herausgeber: Springer
DOI: 10.1007/978-3-031-56855-8_17

Control of Biohybrid Actuators Using Neuroevolution

Autoren: Hugo Alcaraz-Herrera; Michail-Antisthenis I. Tsompanas; Igor Balaz; Andrew Adamatzky
Veröffentlicht in: Proceedings of the 16th International Joint Conference on Computational Intelligence, 2024, ISSN 2184-3236
Herausgeber: ScitePress Digital Library
DOI: 10.48550/ARXIV.2411.08261

A Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study

Autoren: Salvatori, C., Trucco, D., Niosi, I., Ricotti, L., Vannozzi, L.
Veröffentlicht in: 2023, ISSN 1611-3349
Herausgeber: Springer, Cham
DOI: 10.1007/978-3-031-39504-8_26

Development of an electrical current stimulator for controlling biohybrid machines

Autoren: Collu, Riccardo; Fuentes, Judith; Lezcano, Florencia; Crespo-Cuadraro, Maria; Bartolucci, Andrea; Ricotti, Leonardo; Vannozzi, Lorenzo; Sánchez, Samuel; Lai, Stefano; Barbaro, Massimo
Veröffentlicht in: Scientific Reports, 2025
Herausgeber: IEEE
DOI: 10.1038/S41598-025-06465-0

A Novel Steerable Catheter Controlled with a Biohybrid Actuator: A Feasibility Study

Autoren: Carlotta Salvatori; Diego Trucco; Ignazio Niosi; Leonardo Ricotti; Lorenzo Vannozzi
Veröffentlicht in: Lecture Notes in Computer Science - Biomimetic and Biohybrid Systems, 2023
Herausgeber: Springer Nature
DOI: 10.1007/978-3-031-39504-8_26

Designing morphologies of soft medical devices using cooperative neuro coevolution

Autoren: Hugo Alcaraz-Herrera, Michail-Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Veröffentlicht in: Proceedings of the Genetic and Evolutionary Computation Conference Companion, 2025
Herausgeber: ACM
DOI: 10.1145/3712255.3726671

NEAT and HyperNEAT based Design for Soft Actuator Controllers

Autoren: Alcaraz-Herrera, H., Tsompanas, M. A., Balaz, I., & Adamatzky, A.
Veröffentlicht in: Studies in Computational Intelligence
Herausgeber: Springer

A novel concept of steerable catheters actuated by muscle cells: the BioMeld project

Autoren: Salvatori, C., Ricotti, L., & Vannozzi, L.
Veröffentlicht in: NATIONAL CONGRESS OF BIOENGINEERING. PROCEEDINGS.. Patron Editore Srl.
Herausgeber: GNB Proceedings

NeuroEvolution Algorithms Applied in the Designing Process of Biohybrid Actuators

Autoren: Hugo Alcaraz-Herrera; Michail-Antisthenis Tsompanas; Igor Balaz; Andrew Adamatzky
Veröffentlicht in: Studies in Computational Intelligence ISBN: 9783031876387, 2025
Herausgeber: Springer
DOI: 10.48550/ARXIV.2408.07671

Evaluating Fitness Averaging Strategies in Cooperative NeuroCoEvolution for Automated Soft Actuator Design

Autoren: Hugo Alcaraz-Herrera, Michail-Antisthenis Tsompanas, Igor Balaz, Andrew Adamatzky
Veröffentlicht in: Communications in Computer and Information Science, Computational Intelligence, 2026
Herausgeber: Springer Nature Switzerland
DOI: 10.1007/978-3-032-15635-8_8

Leistungen

Veröffentlichungen

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