Closed-loop Individualized image-guided Transcranial Ultrasonic Stimulation

Informazioni relative al progetto

CITRUS

ID dell’accordo di sovvenzione: 101071008

DOI

10.3030/101071008

Progetto chiuso

Data della firma CE 14 Settembre 2022

Data di avvio 1 Ottobre 2022

Data di completamento 30 Settembre 2026

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 3 799 402,50

Contributo UE

€ 3 799 402,50

Coordinato da

MEDIZINISCHE UNIVERSITAET WIEN
Austria

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (2)

Public project website

A project website will be established and serve as the main platform for displaying project activities and results Social media accounts will be set up and used to enhance the visibility of the project

Project awareness video

Short video demonstrating the ideas and partners of the CITRUS project to be used on the website and social media

Data Management Plan (2)

Data Management Plan

Document detailing the DMP of the CITRUS project

Update Data Management Plan - RP2

First update of the Data Management Plan.

Other (1)

Interdisciplinary training workshop

Interdisciplinary training workshop open to portfolio members

Documents, reports (4)

MR-ARFI phantom tests

Report on tests and validations of MRARFI results in agarose phantom

RP2 - Report on Portfolio activities

The report will present the collaboration activities that have been carried out in each reporting period and contain relevant material (e.g. power point presentations, minutes of the meetings etc.). It also explains how the Portfolio activities and the EIC proactive project management approach contribute to the achievement of the project objectives and help the transition to market.

Navigation accuracy assessment report

Report on the accuracy of navigating in the MR environment

RP1 – Report on portfolio activities

The report will present the collaboration activities that have been carried out in each reporting period and contain relevant material eg power point presentations minutes of the meetings etc It also explains how the Portfolio activities and the EIC proactive project management approach contribute to the achievement of the project objectives and help the transition to market

Pubblicazioni

Peer reviewed articles (8)

ITRUSST consensus on standardised reporting for transcranial ultrasound stimulation

Autori: Eleanor Martin, Jean-François Aubry, Mark Schafer, Lennart Verhagen, Bradley Treeby, Kim Butts Pauly
Pubblicato in: Brain Stimulation, Numero 17, 2024, ISSN 1935-861X
Editore: Elsevier BV
DOI: 10.1016/J.BRS.2024.04.013

ITRUSST consensus on biophysical safety for transcranial ultrasound stimulation

Autori: Jean-François Aubry, David Attali, Mark E. Schafer, Elsa Fouragnan, Charles F. Caskey, Robert Chen, Ghazaleh Darmani, Ellen J. Bubrick, Jérôme Sallet, Christopher R. Butler, Charlotte J. Stagg, Miriam C. Klein-Flügge, Seung-Schik Yoo, Christy K. Holland, Bradley Treeby, Eleanor Martin, Lennart Verhagen, Kim Butts Pauly
Pubblicato in: Brain Stimulation, Numero 18, 2025, ISSN 1935-861X
Editore: Elsevier BV
DOI: 10.1016/J.BRS.2025.10.007

Enhancing transcranial ultrasound stimulation planning with MRI-derived skull masks: a comparative analysis with CT-based processing

Autori: Ali K Zadeh, Oula Puonti, Björn Sigurðsson, Axel Thielscher, Oury Monchi, Samuel Pichardo
Pubblicato in: Journal of Neural Engineering, Numero 22, 2025, ISSN 1741-2560
Editore: IOP Publishing
DOI: 10.1088/1741-2552/ADAB22

Panoramic Magnetic Resonance Imaging of the Breast With a Wearable Coil Vest

Autori: Obermann, Michael; Nohava, Lena; Frass-Kriegl, Roberta; Soanca, Onisim; Ginefri, Jean-Christophe; Felblinger, Jacques; Clauser, Paola; Baltzer, Pascal A.T.; Laistler, Elmar
Pubblicato in: Investigative Radiology, Numero 58, 2023, ISSN 1536-0210
Editore: Wolters Kluwer Health
DOI: 10.1097/RLI.0000000000000991

Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation

Autori: Benjamin R. Kop, Linda de Jong, Butts Pauly Kim, Hanneke E.M. den Ouden, Lennart Verhagen
Pubblicato in: Brain Stimulation, Numero 18, 2026, ISSN 1935-861X
Editore: Elsevier BV
DOI: 10.1016/J.BRS.2025.06.009

Clinical Neurophysiology

Autori: Keith R. Murphy, Tulika Nandi, Benjamin Kop, Takahiro Osada, Maximilian Lueckel, W. Apoutou N’Djin, Kevin A. Caulfield, Anton Fomenko, Hartwig R. Siebner, Yoshikazu Ugawa, Lennart Verhagen, Sven Bestmann, Eleanor Martin, Kim Butts Pauly, Elsa Fouragnan, T
Pubblicato in: Clinical Neurophysiology, Numero 171, 2025, ISSN 1388-2457
Editore: Elsevier
DOI: 10.1016/J.CLINPH.2025.01.004

A modular system of flexible receive-only coil arrays for 3 T Magnetic Resonance Imaging

Autori: Lena Nohava, Michael Obermann, Roberta Frass-Kriegl, Onisim Soanca, Elmar Laistler
Pubblicato in: Zeitschrift für Medizinische Physik, Numero 35, 2025, ISSN 0939-3889
Editore: Elsevier BV
DOI: 10.1016/J.ZEMEDI.2023.05.002

The relationship between parameters and effects in transcranial ultrasonic stimulation

Autori: Tulika Nandi, Benjamin R. Kop, Kim Butts Pauly, Charlotte J. Stagg, Lennart Verhagen
Pubblicato in: Brain Stimulation, Numero 17, 2024, ISSN 1935-861X
Editore: Elsevier BV
DOI: 10.1016/J.BRS.2024.10.008

Conference proceedings (31)

Towards online assessment of Transcranial Ultrasound Stimulation foci: processing pipeline for MR-ARFI

Autori: Campilho B, Grosshagauer S, Hewener H, Arbabi A, Risser C, Marques J, Soanca O, Degel C, van den Heuvel D, Nohava L, Hodono S, Laistler E, Tretbar S, Norris D, Windischberger C
Pubblicato in: Proceedings of the ESMRMB 2024, 2024
Editore: ESMRMB
DOI: 10.5281/ZENODO.14051478

3D Displacement Vector Field Imaging for Transcranial focused Ultrasound Stimulation Cross-beam Localization

Autori: Shota Hodono, Martijn A Cloos, David Norris
Pubblicato in: Proceedings of the ISMRM Benelux chapter meeting, 2026
Editore: ISMRM Benelux Chapter

Fast Geometric Re-planning Compensates for Small Transducer Placement Offsets in Transcranial Ultrasound Stimulation

Autori: Jonas Kielmann, Suhas Vijayakumar, Arno Schmitgen, Jiri Jaros, Marta Jaros, Eleanor Martin
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

Investigating the stability of thermal and physiological noise in phase domain using NORDIC for low-intensity MR-Acoustic Radiation Force Imaging (ARFI) in humans

Autori: Hodono S, Marques J, Norris D
Pubblicato in: Proceedings of the ESMRMB 2024, 2024
Editore: ESMRMB
DOI: 10.5281/ZENODO.14179297

k-Dispatch: Enabling Cost-Optimized Biomedical Workflow Offloading

Autori: Marta Jaros, Jiri Jaros
Pubblicato in: Proceedings of the 33rd International Symposium on High-Performance Parallel and Distributed Computing, 2025
Editore: ACM
DOI: 10.1145/3625549.3658828

Design and evaluation of a 16-channel TUS/MR head coil

Autori: Lena Nohava, Onisim Soanca, Michael Obermann, Sarah Grosshagauer, Shota Hodono, Bernardo Campilho, Holger Hewener, Steffen Tretbar, Arno Schmitgen, Sven Arnold, Christian Windischberger, Elmar Laistler
Pubblicato in: ISMRM Annual Meeting, 2025 ISMRM & ISMRT Annual Meeting, 2025
Editore: ISMRM
DOI: 10.58530/2025/0673

A Roadmap for High-Performance k-Wave: Accelerated Acoustic, Elastic, and Thermal Solvers

Autori: Jiri Jaros
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

Protocol Optimization and Neural Target Engagement of the Human sgACC Using Online TUS-fMRI with the CITRUS System

Autori: Suhas Vijayakumar, King Yi Cho, Maximilian Lueckel, Carys Evans, Lennart Verhagen, Shota Hodono, David Norris, Holger Hewener, Steffen Tretbar, Eleanor Martin, Bradley Treeby, Jonas Kielman, Arno Schmitgen, Sven Arnold, Björn Sigurðsson, Axel Thielscher,
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

3D Displacement Vector Field Imaging for TUS cross-beam localization

Autori: Shota Hodono, Martijn A Cloos, David Norris
Pubblicato in: Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition, 2026
Editore: ISMRM

Techniques for Efficient Fourier Transform Computation in Ultrasound Simulations

Autori: Ondrej Olsak, Jiri Jaros
Pubblicato in: Proceedings of the 33rd International Symposium on High-Performance Parallel and Distributed Computing, 2024
Editore: HPDC
DOI: 10.1145/3625549.3658825

Prediction of Distributed Ultrasound Simulation Execution Time Using Machine Learning

Autori: Jiri Jaros, Marta Jaros, Martin Buchta
Pubblicato in: 2024 IEEE Congress on Evolutionary Computation (CEC), 2024
Editore: IEEE
DOI: 10.1109/CEC60901.2024.10611947

petra2density – an MRI processing pipeline to create a density map of the head

Autori: Björn Sigurðsson, Ikko Kimura, Oula Puonti, Axel Thielscher
Pubblicato in: Proceedings of the Focused Ultrasound Neuormodulation Conference, 2026
Editore: Focused Ultrasound Neuormodulation Conferenc

An Acquisition and Reconstruction Approach for Closed Loop Transcranial focused Ultrasound Stimulation Navigation

Autori: Shota Hodono, David Norris
Pubblicato in: Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition, 2026
Editore: ISMRM

Investigating Sustained sgACC Network Modulation Following Offline TUSUsing the CITRUS System

Autori: Suhas Vijayakumar, Thu Nguyen, Maximilian Lueckel, Carys Evans, Lennart Verhagen, Shota Hodono, David Norris, Holger Hewener, Steffen Tretbar, Eleanor Martin, Bradley Treeby, Jonas Kielman, Arno Schmitgen, Sven Arnold, Björn Sigurðsson, Axel Thielscher, M
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

CITRUS: Validated TUS neuromodulation via steerable transducers, MR-ARFI, and tailored MR-hardware

Autori: Christian Windischberger, Holger Hewener, Aidin Arbabi, Bernardo Campilho, Christoph Risser, José Marques, Sarah Grosshagauer, Christian Degel, Daan von den Heuvel, Lena Nohava, Onisim Soanca, Shota Hodono, Elmar Laistler, Steffen Tretbar, David Norris
Pubblicato in: Proceedings of the Annual Meeting of the OHBM, 2026
Editore: OBHM

Evaluation of Libraries for the One-Dimensional Sparse Fourier Transform

Autori: Olsak O, Jaros J
Pubblicato in: Proceedings of the 6th Users' Conference of IT4Innovations, 2023
Editore: IT4Innovations
DOI: 10.5281/ZENODO.14333714

Towards Online Closed-Loop Transcranial Focused Ultrasound Stimulation Neuronavigation

Autori: Shota Hodono, David Norris
Pubblicato in: Proceedings of the Annual Meeting of the OHBM, 2026
Editore: OHBM

Reducing MR-ARFI Scan Time Using a Physiological Noise-Free Reference Image and Polynomial Fitting for Noise Removal

Autori: Shota Hodono, David Norris
Pubblicato in: Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition, 2026
Editore: ISMRM

k-Plan: From the Hospital to the Cluster and Back

Autori: Marta Jaros
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

From Pascal to Blackwell: Benchmarking Multi-GPU k-Wave with a Global FFT Solver

Autori: Oliver Kunik, Jiri Jaros
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

Online Engagement of Subgenual Cingulate Circuitry Using Transcranial Ultrasound during fMRI

Autori: Suhas Vijayakumar, King Yi Cho, Maximilian Lueckel, Carys Evans, Shota Hodono, Lennart Verhagen, David Norris, Holger Hewener, Steffen Tretbar, Eleanor Martin, Jonas Kielman, Arno Schmitgen, Sven Arnold, Björn Sigurðsson, Axel Thielscher, Marta Jaroš, Ond
Pubblicato in: Proceedings of the Annual Meeting of the OHBM, 2026
Editore: OHBM

On the Usage of the Sparse Fourier Transform in Ultrasound Propagation Simulation

Autori: Ondrej Olsak, Jiri Jaros
Pubblicato in: Proceedings of the 2023 10th International Conference on Bioinformatics Research and Applications, 2023
Editore: ICBRA
DOI: 10.1145/3632047.3632064

Investigating the possibility of using pruned FFT in ultrasound wave propagation simulations

Autori: Olsak O, Jaros J
Pubblicato in: Proceedings of the 8th Users' Conference of IT4Innovations, 2024
Editore: IT4Innovations
DOI: 10.5281/ZENODO.16418529

The CITRUS approach: validated transcranial ultrasound stimulation through steerable transducers and MR acoustic radiation force imaging

Autori: Christian Windischberger, Holger Hewener, Aidin Arbabi, Bernardo Campilho, Christoph Risser, José Marques, Sarah Grosshagauer, Christian Degel, Daan van den Heuvel, Lena Nohava, Onisim Soanca, Shota Hodono, Elmar Laistler, Steffen Tretbar, David Norris
Pubblicato in: Brain Stimulation, Numero 18, 2025, ISSN 1935-861X
Editore: Elsevier BV
DOI: 10.1016/J.BRS.2024.12.711

Calculating Tissue Heating from Simultaneous Transcranial Ultrasound Stimulation and MRI

Autori: Kristen Zarcone, Shota Hodono, Giuseppe Carluccio, Ming Lu, Xinqiang Yan, Lennart Verhagen, Martijn A Cloos, David G Norris, Samuel Pichardo, Christopher M Collins, Kim B Pauly, William A Grissom
Pubblicato in: Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition, 2026
Editore: ISMRM

Steerable transcranial ultrasound stimulation (TUS) validated by acoustic radiation force imaging

Autori: Campilho B, Hewener H, Arbabi A, Grosshagauer S, Risser C, van den Heuvel D, Marques J, Degel C, Tretbar S, Norris D, Windischberger C
Pubblicato in: Proceedings of the OHBM 2024, 2024
Editore: OHBM
DOI: 10.5281/ZENODO.14197941

Acceleration of Ultrasound Neurostimulation Using Mixed-Precision Arithmetic

Autori: Jiri Jaros, Radek Duchon
Pubblicato in: Proceedings of the 33rd International Symposium on High-Performance Parallel and Distributed Computing, 2025
Editore: ACM
DOI: 10.1145/3625549.3658823

Design of a 16-channel TUS/MR headcoil for concurrent neuromodulation andimaging

Autori: Lena Nohava, Onisim Soanca, Sarah Grosshagauer, Michael Obermann, Shota Hodono, Bernardo Campilho, Holger Hewener, Steffen Tretbar, Arno Schmitgen, Sven Arnold, Christian Windischberger, Elmar Laistler
Pubblicato in: Proceedings of the OHBM 2025, 2025
Editore: OHBM

Bone density prediction from any head MRI

Autori: Sigurðsson B, Nielsen JD, Puonti O, Iglesias JE, Thielscher A
Pubblicato in: Proceedings of the 8th ISMRM Nordic Chapter Annual Meeting, 2024
Editore: ISMRM Nordic Chapter
DOI: 10.5281/ZENODO.14333423

Equivalent source modelling of multielement array transducers for ultrasound neuromodulation

Autori: Eleanor Martin, Wolfgang Bost, Holger Hewener, Steffen Tretbar
Pubblicato in: Proceedings of the Focused Ultrasound Neuromodulation Conference, 2026
Editore: Focused Ultrasound Neuromodulation Conference

Acceleration of Heat Diffusion Simulation on Single-Node Systems

Autori: Bayer D, Jaros J
Pubblicato in: Proceedings of the 6th Users' Conference of IT4Innovations, 2022
Editore: IT4Innovations
DOI: 10.5281/ZENODO.14417460