European Commission logo
français français
CORDIS - Résultats de la recherche de l’UE
CORDIS

A holistic approach to training a new generation of scientists in marine biodiscovery

Description du projet

Les produits naturels microbiens marins: du fond de la mer au chevet du malade

Les composés biologiquement actifs produits par les micro-organismes qui vivent dans les environnements marins ont le potentiel d’être développés en tant que nouveaux médicaments et traitements pour diverses maladies. Ces produits naturels microbiens marins se caractérisent souvent par des structures et des activités biologiques uniques. Avec le soutien du programme Actions Marie Skłodowska-Curie, le projet HOTBIO formera des scientifiques en début de carrière qui pourront faire passer ces produits du stade de la découverte à celui de la commercialisation. Cela implique toutes les étapes du processus de découverte de médicaments, y compris l’isolement microbien, la purification des composés, l’identification, la synthèse d’analogues et le développement de médicaments. L’objectif du projet est de créer une nouvelle génération de scientifiques capables d’amener ces composés prometteurs au chevet des patients, où ils peuvent avoir un impact positif sur la santé humaine.

Objectif

The HOTBIO consortium will train a new generation of early-stage scientists to take marine microbial natural products from the seabed to the bedside. They will be involved in every stage of the pipeline from microbial isolation through compound purification and identification to making analogues with desirable drug-like properties. They will gain associated skills in access and benefit sharing, intellectual property and entrepreneurship. Students graduating from HOTBIO will be in a unique position to enter a challenging labour market as they will have received multidisciplinary training at world leading research groups in academia as well as at industry partners. Mentorship will be provided by industrial scientists and recent graduates from the MSCA ITN MarPipe.

The HOTBIO consortium consists of eight beneficiaries from seven European countries, including two members from non-academic sectors, that will host ten PhD students. Three more PhD students hosted by two Swiss associated partners will be funded by the Swiss State Secretariat for Education, Research and Innovation. In addition to secondments at the partners in Europe, students will also get the opportunity to do secondments in low-to-middle income countries (LMICs) in Africa and Asia to get a deeper understanding of how modern research can be done in resource-limited setting.

HOTBIO expands a conventional marine biodiscovery pipeline by including computer aided drug design (CADD), chemical synthesis of optimized compounds (i.e. medicinal chemistry), target deconvolution and extensive ADMET profiling. This will advance the bioactive microbial secondary metabolites to the later stages of preclinical development, and it will also inform the decisions and priorities of what kind of compounds that should be targeted in the initial phase of the drug discovery process. The downstream development will include hit compounds from earlier projects.

Coordinateur

UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Contribution nette de l'UE
€ 595 497,60
Adresse
HANSINE HANSENS VEG 14
9019 Tromso
Norvège

Voir sur la carte

Région
Norge Nord-Norge Troms og Finnmark
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée

Participants (6)

Partenaires (11)