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MAtching Genes with MOLecules for FUNctional Analysis

Objective

The MAGIC-MOLFUN doctorial network (DN) will train the next generation of specialists for transforming natural products research. They will be educated in a combination of wet-lab and computational skills to integrate genome mining and metabolomics with cutting-edge pathway discovery- and engineering approaches. There is a fast-growing demand for these combination of skills, but these are rarely taught in current integrated training programs.
These multidisciplinary skills and qualifications will be acquired while achieving the scientific goals of the program, namely understanding and developing the complex biosynthesis and production of microbial NPs for cross-sector applications such as medicine, food, agriculture, or biotechnology. Specifically, the Doctoral Candidates (DCs) will work in three areas: (i) develop novel computational tools and algorithms to improve the identification and prediction quality of biosynthetic gene clusters encoding NP biosynthesis in genomic data. This genome-centred approach is complemented by (ii) the use cheminformatics approaches to link metabolomics data of NPs with the genomic data of the producers, which will greatly improve the compound discovery and dereplication process. These two data-centric approaches will finally (iii) converge into experimental applications that discover and characterize novel NPs with promising bioactivities (e.g. antibiotics, pre-/probiotics, agrichemicals, bio-pigments).
The scientific training program is complemented by a comprehensive transferable skill training that will equip the DCs for todays’ demands of a successful career in industry and academia. The skills obtained in the DN will enable the DCs to work not only in natural product research but also many other data-intensive areas of biotechnology.

Coordinator

DANMARKS TEKNISKE UNIVERSITET
Net EU contribution
€ 905 364,00
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Denmark

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Region
Danmark Hovedstaden Københavns omegn
Activity type
Higher or Secondary Education Establishments
Other funding
No data

Participants (5)

WAGENINGEN UNIVERSITY
Netherlands
Net EU contribution
€ 548 740,80
Address
Droevendaalsesteeg 4
6708 PB Wageningen

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Region
Oost-Nederland Gelderland Veluwe
Activity type
Higher or Secondary Education Establishments
Other funding
No data
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 521 078,40
Address
Geschwister-scholl-platz
72074 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Other funding
No data
NAICONS SRL
Italy
Net EU contribution
€ 259 437,60
Address
Via Guaragna 3
20147 Saronno Va

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Ovest Lombardia Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
C-LECTA GMBH
Germany
Net EU contribution
€ 260 539,20
Address
Perlickstrasse 5
04103 Leipzig

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Sachsen Leipzig Leipzig
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
FUNDACION CENTRO DE EXCELENCIA EN INVESTIGACION DE MEDICAMENTOS INNOVADORES EN ANDALUCIA
Spain
Net EU contribution
€ 251 971,20
Address
Avda Del Conocimiento 3
18100 Armilla Granada

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Region
Andalucía Granada
Activity type
Research Organisations
Other funding
No data

Partners (6)

Hexagon Bio, Inc.
United States
Net EU contribution
€ 0,00
Address
1505 Adams Drive, Suite A
94025 Menlo Park

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
CHROMOLOGICS APS
Denmark
Net EU contribution
€ 0,00
Address
Maskinvej 5
2860 Soborg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Danmark Hovedstaden Københavns omegn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
UNIVERSIDAD DE GRANADA
Spain
Net EU contribution
€ 0,00
Address
Cuesta Del Hospicio Sn
18071 Granada

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Region
Andalucía Granada
Activity type
Higher or Secondary Education Establishments
Other funding
No data
UNIVERSITA DEGLI STUDI DI MILANO
Italy
Net EU contribution
€ 0,00
Address
Via Festa Del Perdono 7
20122 Milano

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Other funding
No data
Corteva Agriscience LLC, USA
United States
Net EU contribution
€ 0,00
Address
9330 Zionsville Road
46268 Indianapolis

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
No data
UNIVERSITY OF STRATHCLYDE
United Kingdom
Net EU contribution
€ 0,00
Address
Richmond Street 16
G1 1XQ Glasgow

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Region
West Central Scotland Glasgow City
Activity type
Higher or Secondary Education Establishments
Other funding
No data