Project description
Training network for specialists in innovative natural products research
Funded by the Marie Skłodowska-Curie Actions programme, the MAGic-MOLFUN project will train the next generation of scientists in innovative natural products (NPs) research. The training will include wet-lab and computational skills, integrating genomics and metabolomics with pathway discovery and bioengineering approaches. The research of the project will focus on the complex biosynthesis and production of microbial NPs for applications in medicine, food, agriculture and biotechnology. The trainees will develop and use novel computational tools to improve the identification and prediction of biosynthetic gene clusters. Moreover, they will use cheminformatics to link the metabolomics data of NPs to the genomic data of the producers. These approaches will result in the discovery of NPs with novel bioactivities.
Objective
The MAGIC-MOLFUN doctorial network (DN) will train the next generation of specialists for transforming natural products research. They will be educated in a combination of wet-lab and computational skills to integrate genome mining and metabolomics with cutting-edge pathway discovery- and engineering approaches. There is a fast-growing demand for these combination of skills, but these are rarely taught in current integrated training programs.
These multidisciplinary skills and qualifications will be acquired while achieving the scientific goals of the program, namely understanding and developing the complex biosynthesis and production of microbial NPs for cross-sector applications such as medicine, food, agriculture, or biotechnology. Specifically, the Doctoral Candidates (DCs) will work in three areas: (i) develop novel computational tools and algorithms to improve the identification and prediction quality of biosynthetic gene clusters encoding NP biosynthesis in genomic data. This genome-centred approach is complemented by (ii) the use cheminformatics approaches to link metabolomics data of NPs with the genomic data of the producers, which will greatly improve the compound discovery and dereplication process. These two data-centric approaches will finally (iii) converge into experimental applications that discover and characterize novel NPs with promising bioactivities (e.g. antibiotics, pre-/probiotics, agrichemicals, bio-pigments).
The scientific training program is complemented by a comprehensive transferable skill training that will equip the DCs for todays’ demands of a successful career in industry and academia. The skills obtained in the DN will enable the DCs to work not only in natural product research but also many other data-intensive areas of biotechnology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- agricultural sciences agriculture, forestry, and fisheries agriculture
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2800 Kongens Lyngby
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.