Descripción del proyecto
Red de formación de especialistas en investigación innovadora sobre productos naturales
En el proyecto MAGic-MOLFUN, financiado por las Acciones Marie Skłodowska-Curie, se formará a la próxima generación de científicos en la investigación de productos naturales innovadores. La formación incluirá técnicas de laboratorio e informáticas, que integrarán la genómica y la metabolómica con el descubrimiento de rutas y métodos de bioingeniería. La investigación del proyecto se centrará en la compleja biosíntesis y producción de productos naturales microbianos para aplicaciones en medicina, alimentación, agricultura y biotecnología. Los científicos en formación desarrollarán y utilizarán nuevas herramientas informáticas para mejorar la identificación y predicción de grupos de genes biosintéticos. Además, utilizarán la quimioinformática para vincular los datos metabolómicos de los productos naturales con los datos genómicos de los productores. Estos métodos permitirán descubrir nanopartículas con nuevas bioactividades.
Objetivo
The MAGIC-MOLFUN doctorial network (DN) will train the next generation of specialists for transforming natural products research. They will be educated in a combination of wet-lab and computational skills to integrate genome mining and metabolomics with cutting-edge pathway discovery- and engineering approaches. There is a fast-growing demand for these combination of skills, but these are rarely taught in current integrated training programs.
These multidisciplinary skills and qualifications will be acquired while achieving the scientific goals of the program, namely understanding and developing the complex biosynthesis and production of microbial NPs for cross-sector applications such as medicine, food, agriculture, or biotechnology. Specifically, the Doctoral Candidates (DCs) will work in three areas: (i) develop novel computational tools and algorithms to improve the identification and prediction quality of biosynthetic gene clusters encoding NP biosynthesis in genomic data. This genome-centred approach is complemented by (ii) the use cheminformatics approaches to link metabolomics data of NPs with the genomic data of the producers, which will greatly improve the compound discovery and dereplication process. These two data-centric approaches will finally (iii) converge into experimental applications that discover and characterize novel NPs with promising bioactivities (e.g. antibiotics, pre-/probiotics, agrichemicals, bio-pigments).
The scientific training program is complemented by a comprehensive transferable skill training that will equip the DCs for todays’ demands of a successful career in industry and academia. The skills obtained in the DN will enable the DCs to work not only in natural product research but also many other data-intensive areas of biotechnology.
Ámbito científico
- agricultural sciencesagriculture, forestry, and fisheriesagricultureagronomyplant protection
- natural sciencescomputer and information sciencescomputational science
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- natural scienceschemical sciencesanalytical chemistrymass spectrometry
- natural sciencesbiological sciencesmicrobiology
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinador
2800 Kongens Lyngby
Dinamarca