Description du projet
L’impact de l’exercice physique pendant l’allaitement sur l’obésité infantile
La prévalence croissante de l’obésité infantile souligne la nécessité de stratégies préventives innovantes. L’une des approches consiste à surveiller la prise de poids du bébé au cours des trois premiers mois de sa vie. En outre, il faut savoir que la composition du lait maternel peut influencer le risque d’obésité, ce qui souligne l’importance pour les mères de maintenir un mode de vie sain. Nos connaissances relatives à l’impact de l’exercice physique sur la lactation demeurent toutefois fort lacunaires. Le projet ExMilk, financé par le CER, se consacre à l’étude des effets de l’exercice physique pendant l’allaitement, en particulier chez les femmes en surpoids ou obèses, sur la composition du lait maternel. Les résultats préliminaires suggèrent que l’exercice physique influence les facteurs critiques du métabolisme énergétique. L’étude entend également déterminer si cette altération a une incidence sur le risque d’obésité infantile.
Objectif
Innovative preventive strategies are urgently required to halt the rising prevalence of childhood obesity given the inefficacy of current interventions. Mother-to-child transmission of obesity accounts for a large proportion of childhood obesity, more than what can be explained by genes. Nutrition during the first 3 months of life is crucial, with rapid weight gain in this period associated with subsequent obesity. Breastmilk is considered optimal for infant nutrition, but its composition depends on the mother’s metabolic health: the concentrations of some breastmilk compounds linked to infant obesity are associated with maternal body mass index. Maternal lifestyle factors, such as diet, can alter breastmilk composition. Little is, however, known about the effect of exercise during lactation. Exercise is a major regulator of systemic metabolism affecting multiple tissues and organs. In this ambitious, inter-disciplinary project, I will determine how exercise during lactation influences breastmilk composition in women with overweight/obesity and whether exercise-induced changes in breastmilk will influence infant obesity risk. My preliminary data show acute effects of exercise on breastmilk concentrations of adiponectin and lipid metabolites relevant for energy metabolism. In ExMilk, I will determine both acute effects and adaptations after regular exercise on a complex matrix of breastmilk compounds. By linking breastmilk data to comprehensive data for the infants, I will investigate the potential mechanisms underlying the effects of maternal exercise on infant obesity risk, mediated by changes in breastmilk composition. To reach my goals, I will perform gold-standard randomised trials and analyse biological samples from mothers and infants on multi-omics platforms. My experience in metabolomics and exercise intervention trials in reproductive-aged women will enable me to break new ground in understanding how exercise during lactation modifies infant obesity risk.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Thème(s)
Régime de financement
HORIZON-ERC - HORIZON ERC GrantsInstitution d’accueil
7491 Trondheim
Norvège