Descripción del proyecto
La relación entre el ejercicio durante la lactancia y la obesidad infantil
La creciente prevalencia de la obesidad infantil destaca la necesidad de estrategias preventivas innovadoras. Uno de los métodos consiste en controlar el aumento de peso del bebé durante los tres primeros meses de vida. Además, la composición de la leche materna puede influir en el riesgo de obesidad, lo que pone de manifiesto la importancia de que las madres sigan un modo de vida saludable. Sin embargo, existe un vacío importante en los conocimientos sobre el efecto del ejercicio durante la lactancia. El proyecto ExMilk, financiado por el Consejo Europeo de Investigación, tiene por objeto estudiar los efectos del ejercicio durante la lactancia, sobre todo en mujeres obesas o con sobrepeso, en la composición de la leche materna. Los resultados preliminares indican que el ejercicio influye en factores básicos del metabolismo energético. Además, en el proyecto se pretende determinar si esta alteración tiene alguna implicación en el riesgo de obesidad infantil.
Objetivo
Innovative preventive strategies are urgently required to halt the rising prevalence of childhood obesity given the inefficacy of current interventions. Mother-to-child transmission of obesity accounts for a large proportion of childhood obesity, more than what can be explained by genes. Nutrition during the first 3 months of life is crucial, with rapid weight gain in this period associated with subsequent obesity. Breastmilk is considered optimal for infant nutrition, but its composition depends on the mother’s metabolic health: the concentrations of some breastmilk compounds linked to infant obesity are associated with maternal body mass index. Maternal lifestyle factors, such as diet, can alter breastmilk composition. Little is, however, known about the effect of exercise during lactation. Exercise is a major regulator of systemic metabolism affecting multiple tissues and organs. In this ambitious, inter-disciplinary project, I will determine how exercise during lactation influences breastmilk composition in women with overweight/obesity and whether exercise-induced changes in breastmilk will influence infant obesity risk. My preliminary data show acute effects of exercise on breastmilk concentrations of adiponectin and lipid metabolites relevant for energy metabolism. In ExMilk, I will determine both acute effects and adaptations after regular exercise on a complex matrix of breastmilk compounds. By linking breastmilk data to comprehensive data for the infants, I will investigate the potential mechanisms underlying the effects of maternal exercise on infant obesity risk, mediated by changes in breastmilk composition. To reach my goals, I will perform gold-standard randomised trials and analyse biological samples from mothers and infants on multi-omics platforms. My experience in metabolomics and exercise intervention trials in reproductive-aged women will enable me to break new ground in understanding how exercise during lactation modifies infant obesity risk.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régimen de financiación
HORIZON-ERC - HORIZON ERC GrantsInstitución de acogida
7491 Trondheim
Noruega