Descrizione del progetto
Esercizio fisico durante l’allattamento e obesità infantile
La crescente prevalenza dell’obesità infantile sottolinea la necessità di strategie preventive innovative. Un approccio consiste nel monitorare l’aumento di peso del bambino nei primi tre mesi di vita. Inoltre, è importante notare che la composizione del latte materno può influenzare il rischio di obesità, il che sottolinea l’importanza che le madri mantengano uno stile di vita sano. Tuttavia, esiste una lacuna significativa nelle nostre conoscenze riguardo all’impatto dell’esercizio fisico sulla lattazione. Il progetto ExMilk, finanziato dal CER, è dedicato allo studio degli effetti dell’esercizio fisico durante l’allattamento, in particolare nelle donne sovrappeso o obese, sulla composizione del latte materno. I risultati preliminari suggeriscono che l’esercizio fisico influisce su fattori critici del metabolismo energetico. Inoltre, lo studio intende determinare se questa alterazione abbia implicazioni per il rischio di obesità infantile.
Obiettivo
Innovative preventive strategies are urgently required to halt the rising prevalence of childhood obesity given the inefficacy of current interventions. Mother-to-child transmission of obesity accounts for a large proportion of childhood obesity, more than what can be explained by genes. Nutrition during the first 3 months of life is crucial, with rapid weight gain in this period associated with subsequent obesity. Breastmilk is considered optimal for infant nutrition, but its composition depends on the mother’s metabolic health: the concentrations of some breastmilk compounds linked to infant obesity are associated with maternal body mass index. Maternal lifestyle factors, such as diet, can alter breastmilk composition. Little is, however, known about the effect of exercise during lactation. Exercise is a major regulator of systemic metabolism affecting multiple tissues and organs. In this ambitious, inter-disciplinary project, I will determine how exercise during lactation influences breastmilk composition in women with overweight/obesity and whether exercise-induced changes in breastmilk will influence infant obesity risk. My preliminary data show acute effects of exercise on breastmilk concentrations of adiponectin and lipid metabolites relevant for energy metabolism. In ExMilk, I will determine both acute effects and adaptations after regular exercise on a complex matrix of breastmilk compounds. By linking breastmilk data to comprehensive data for the infants, I will investigate the potential mechanisms underlying the effects of maternal exercise on infant obesity risk, mediated by changes in breastmilk composition. To reach my goals, I will perform gold-standard randomised trials and analyse biological samples from mothers and infants on multi-omics platforms. My experience in metabolomics and exercise intervention trials in reproductive-aged women will enable me to break new ground in understanding how exercise during lactation modifies infant obesity risk.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Argomento(i)
Meccanismo di finanziamento
HORIZON-ERC - HORIZON ERC GrantsIstituzione ospitante
7491 Trondheim
Norvegia