Twinning for excellence in biophysics of protein interactions and self-assembly

Información del proyecto

TWIN2PIPSA

Identificador del acuerdo de subvención: 101079147

DOI

10.3030/101079147

Proyecto cerrado

Fecha de la firma de la CE 4 Julio 2022

Fecha de inicio 1 Octubre 2022

Fecha de finalización 30 Septiembre 2025

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 228 957,00

Aportación de la UE

€ 1 228 957,00

Coordinado por

FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Data management plan

Websites, patent fillings, videos etc. (1)

Project website and digital platform structure

Publicaciones

Other (3)

Identifying functional sites at scale

Autores: Cagiada, Matteo
Publicado en: 2023
DOI: 10.5281/zenodo.10409579

Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer

Autores: Ana Rita Brás; Ana Lopes; Nuno Mendes; Paulo J. Costa; Anabela Ferreira; Sara Granja; Ana Paula Silva; Francisco Tortosa; Fátima Baltazar; Fátima Gärtner; Maria João Sousa; Andreia Valente; Ana Preto
Publicado en: bioRxiv, 2023
Editor: bioRxiv
DOI: 10.1101/2023.08.09.552513

Understanding intrinsically disordered proteins: from integrative modelling to design

Autores: Pesce, Francesco
Publicado en: 2023
DOI: 10.5281/zenodo.10379566

Peer reviewed articles (13)

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

Autores: Pedro M. P. Fernandes; Romina A. Guedes; Bruno L. Victor; Jorge A. R. Salvador; Rita C. Guedes
Publicado en: Frontiers in Chemistry, Edición 11-2023, 2024, ISSN 2296-2646
Editor: Frontiers Media
DOI: 10.3389/fchem.2023.1322628

Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease

Autores: Vasco Neto; Bruno Lourenço Victor; Nuno Galamba
Publicado en: Journal of Medicinal Chemistry, 2023, ISSN 0022-2623
Editor: American Chemical Society
DOI: 10.26434/chemrxiv-2023-qrzl0

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Autores: António J. Figueira; Joana Saavedra; Isabel Cardoso; Cláudio M. Gomes
Publicado en: Frontiers in Neuroscience, 2023, ISSN 1662-453X
Editor: Frontiers
DOI: 10.3389/fnins.2023.1162741

Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology

Autores: Romina Coelho; Chiara A. De Benedictis; Ann Katrin Sauer; António J. Figueira; Hélio Faustino; Andreas M. Grabrucker; Cláudio M. Gomes
Publicado en: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031787

Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches

Autores: Inês Paccetti-Alves; Marta S. P. Batista; Catarina Pimpão; Bruno L. Victor; Graça Soveral
Publicado en: International Journal of Molecular Sciences; Volume 24; Edición 6; Pages: 6004, 2023, ISSN 1422-0067
Editor: MDPI
DOI: 10.3390/ijms24066004

Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12

Autores: Tiina J. Ahonen; Choa P. N; Beatriz Farinha; Bárbara Almeida; Bruno L. Victor; Christopher Reynolds; Eija Kalso; Jari Yli-Kauhaluoma; Jennifer Greaves; Vânia M. Moreira
Publicado en: ACS Medicinal Chemistry Letters, 2023, ISSN 1948-5875
Editor: American Chemical Society
DOI: 10.1021/acsmedchemlett.3c00313

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor

Autores: Mickael Diallo; Constança Pimenta; Fernanda Murtinheira; Daniela Martins-Alves; Francisco R. Pinto; André Abrantes da Costa; Ricardo Letra-Vilela; Vanesa Martin; Carmen Rodriguez; Mário S. Rodrigues; Federico Herrera
Publicado en: Cellular Oncology, 2023, ISSN 2211-3436
Editor: Springer Nature
DOI: 10.21203/rs.3.rs-3188959/v1

Assessment of Halogen Off-Center Point-Charge Models Using Explicit Solvent Simulations

Autores: Andreia Fortuna; Paulo J. Costa
Publicado en: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Editor: ACS Publications
DOI: 10.26434/chemrxiv-2023-sgbfb

Is spastic ataxia 8 a protein misfolding disorder?

Autores: Pedro Ferreira-Peralta; Brenda França; Fernanda Murtinheira; Mario S. Rodrigues; Federico Herrera
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, ISSN 0925-4439
Editor: Elsevier B.V.
DOI: 10.1016/j.bbadis.2023.166882

Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail

Autores: André M.M. Gomes; Paulo J. Costa; Miguel Machuqueiro
Publicado en: BBA Advances, 2023, ISSN 2667-1603
Editor: Elsevier B.V.
DOI: 10.1016/j.bbadva.2023.100099

Influence of Iodine Merz–Singh–Kollman Radius on the Calculated Charges and Hydration Free Energies of Iodinated Molecules

Autores: Andreia Fortuna; Pedro M. S. Suzano; Miguel Machuqueiro; Paulo J. Costa
Publicado en: Journal of Computational Biophysics and Chemistry, Edición 04, 2024, ISSN 2737-4165
Editor: World Scientific Publishing
DOI: 10.1142/S2737416523500722

Journal of Biological Chemistry

Autores: Justine Mortelecque; Orgeta Zejneli; Séverine Bégard; Margarida C. Simões; Lea ElHajjar; Marine Nguyen; François-Xavier Cantrelle; Xavier Hanoulle; Jean-Christophe Rain; Morvane Colin; Cláudio M. Gomes; Luc Buée; Isabelle Landrieu; ClémenDanis C, Dupré E.
Publicado en: Journal of Biological Chemistry, Edición 4, 2024, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.107163

Intrinsic Bond Strength Index as a halogen bond interaction energy predictor

Autores: Ona Šivickytė; Paulo J. Costa
Publicado en: Physical Chemistry Chemical Physics, 2023, ISSN 1463-9084
Editor: Royal Society of Chemistry
DOI: 10.26434/chemrxiv-2022-c6npj

Thesis and dissertations (3)

Investigation of S100 proteins and their role in huntingtin aggregation

Autores: Marta Sofia Silva da Cruz Botelho
Publicado en: ULisboa Repository, 2023
Editor: Author Edition

The role of post-translational modifications on NKX6-2 behavior and function

Autores: Brenda Gabriella França
Publicado en: NOVA University Repository, 2023
Editor: Author Edition

Sea urchin inspired adhesive proteins - expression and purification of Nectin structural domains

Autores: Mariana Rodrigues dos Santos
Publicado en: ULisboa Repository, 2023
Editor: Author Edition