Twinning for excellence in biophysics of protein interactions and self-assembly

Informacje na temat projektu

TWIN2PIPSA

Identyfikator umowy o grant: 101079147

DOI

10.3030/101079147

Projekt został zamknięty

Data podpisania przez KE 4 Lipca 2022

Data rozpoczęcia 1 Października 2022

Data zakończenia 31 Marca 2026

Finansowanie w ramach

• Widening participation and spreading excellence

Koszt całkowity

€ 1 228 957,00

Wkład UE

€ 1 228 957,00

Koordynowany przez

FCIENCIAS.ID - ASSOCIACAO PARA A INVESTIGACAO E DESENVOLVIMENTO DE CIENCIAS
Portugal

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Data Management Plan (1)

Data management plan

Websites, patent fillings, videos etc. (1)

Project website and digital platform structure

Publikacje

Peer reviewed articles (44)

Constant-pH MD simulations of the protonation-triggered conformational switching in diphtheria toxin translocation domain

Autorzy: Nuno F.B. Oliveira, Alexey S. Ladokhin, Miguel Machuqueiro
Opublikowane w: Biophysical Journal, Numer 123, 2024, ISSN 0006-3495
Wydawca: Elsevier BV
DOI: 10.1016/J.BPJ.2024.08.023

The Dimensionality of Hydrogen Bond Networks Induces Diverse Physical Properties of Peptide Crystals

Autorzy: Hui Yuan, Pierre-Andre Cazade, Chengqian Yuan, Bin Xue, Vijay Bhooshan Kumar, Rusen Yang, Gal Finkelstein-Zuta, Lihi Gershon, Maoz Lahav, Sigal Rencus-Lazar, Yi Cao, Davide Levy, Damien Thompson, Ehud Gazit
Opublikowane w: ACS Materials Letters, Numer 6, 2024, ISSN 2639-4979
Wydawca: American Chemical Society (ACS)
DOI: 10.34961/RESEARCHREPOSITORY-UL.26561434

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

Autorzy: Pedro M. P. Fernandes; Romina A. Guedes; Bruno L. Victor; Jorge A. R. Salvador; Rita C. Guedes
Opublikowane w: Frontiers in Chemistry, Numer 11-2023, 2024, ISSN 2296-2646
Wydawca: Frontiers Media
DOI: 10.3389/fchem.2023.1322628

Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease

Autorzy: Vasco Neto; Bruno Lourenço Victor; Nuno Galamba
Opublikowane w: Journal of Medicinal Chemistry, 2023, ISSN 0022-2623
Wydawca: American Chemical Society
DOI: 10.26434/chemrxiv-2023-qrzl0

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Autorzy: António J. Figueira; Joana Saavedra; Isabel Cardoso; Cláudio M. Gomes
Opublikowane w: Frontiers in Neuroscience, 2023, ISSN 1662-453X
Wydawca: Frontiers
DOI: 10.3389/fnins.2023.1162741

Biophysical Studies of Amyloid-Binding Fluorophores to Tau AD Core Fibrils Formed without Cofactors

Autorzy: Daniela P. Freitas, Joana Saavedra, Isabel Cardoso, Cláudio M. Gomes
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2024, ISSN 1422-0067
Wydawca: MDPI AG
DOI: 10.3390/IJMS25189946

Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail

Autorzy: André M.M. Gomes, Paulo J. Costa, Miguel Machuqueiro
Opublikowane w: BBA Advances, Numer 4, 2023, ISSN 2667-1603
Wydawca: Elsevier BV
DOI: 10.1016/J.BBADVA.2023.100099

A human microglial cell model of autosomal recessive spastic ataxia of Charlevoix-Saguenay

Autorzy: Fernanda Murtinheira, Elisa Farsetti, Luana Macedo, Ana Sofia Boasinha, Mario S. Rodrigues, Adelaide Fernandes, Federico Herrera
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 1870, 2024, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/J.BBADIS.2024.167452

S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

Autorzy: António J. Figueira, Joana Saavedra, Isabel Cardoso, Cláudio M. Gomes
Opublikowane w: Frontiers in Neuroscience, Numer 17, 2023, ISSN 1662-453X
Wydawca: Frontiers Media SA
DOI: 10.3389/FNINS.2023.1162741

Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology

Autorzy: Romina Coelho; Chiara A. De Benedictis; Ann Katrin Sauer; António J. Figueira; Hélio Faustino; Andreas M. Grabrucker; Cláudio M. Gomes
Opublikowane w: International Journal of Molecular Sciences, 2024, ISSN 1422-0067
Wydawca: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms25031787

Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12

Autorzy: Tiina J. Ahonen, Choa P. Ng, Beatriz Farinha, Bárbara Almeida, Bruno L. Victor, Christopher Reynolds, Eija Kalso, Jari Yli-Kauhaluoma, Jennifer Greaves, Vânia M. Moreira
Opublikowane w: ACS Medicinal Chemistry Letters, Numer 14, 2023, ISSN 1948-5875
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACSMEDCHEMLETT.3C00313

Functional modulation of RAGE activation by multimeric S100B using single-domain antibodies

Autorzy: Margarida C. Simões, Joana S. Cristóvão, Els Pardon, Jan Steyaert, Günter Fritz, Cláudio M. Gomes
Opublikowane w: Journal of Biological Chemistry, Numer 300, 2024, ISSN 0021-9258
Wydawca: Elsevier BV
DOI: 10.1016/J.JBC.2024.107983

Molecular Engineering of Ordered Piezoelectric Sulfonic Acid‐Containing Assemblies

Autorzy: Hui Yuan, Pierre‐Andre Cazade, Shuaikang Zhou, Linda J. W. Shimon, Chengqian Yuan, Dan Tan, Cunshun Liu, Wei Fan, Vijayakanth Thangavel, Yi Cao, Damien Thompson, Xuehai Yan, Rusen Yang, Bin Xue, Ehud Gazit
Opublikowane w: Small, Numer 20, 2023, ISSN 1613-6810
Wydawca: Wiley
DOI: 10.1002/SMLL.202309493

Neuronal expression of S100B triggered by oligomeric Aβ peptide contributes to protection against cytoskeletal damage and synaptic loss

Autorzy: Joana Saavedra, Mariana Nascimento, António J. Figueira, Marina I. Oliveira da Silva, Tiago Gião, João Oliveira, Márcia A. Liz, Cláudio M. Gomes, Isabel Cardoso
Opublikowane w: Frontiers in Molecular Neuroscience, Numer 18, 2025, ISSN 1662-5099
Wydawca: Frontiers Media SA
DOI: 10.3389/FNMOL.2025.1636365

Intrinsic bond strength index as a halogen bond interaction energy predictor

Autorzy: Ona Šivickytė, Paulo J. Costa
Opublikowane w: Physical Chemistry Chemical Physics, Numer 25, 2023, ISSN 1463-9076
Wydawca: Royal Society of Chemistry (RSC)
DOI: 10.26434/CHEMRXIV-2022-C6NPJ-V3

Is There a Functional Role for the Knotted Topology in Protein UCH-L1?

Autorzy: Sara G. F. Ferreira, Manoj K. Sriramoju, Shang-Te Danny Hsu, Patrícia F. N. Faísca, Miguel Machuqueiro
Opublikowane w: Journal of Chemical Information and Modeling, Numer 64, 2024, ISSN 1549-9596
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACS.JCIM.4C00880

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein

Autorzy: Justine Mortelecque, Orgeta Zejneli, Séverine Bégard, Margarida C. Simões, Lea ElHajjar, Marine Nguyen, François-Xavier Cantrelle, Xavier Hanoulle, Jean-Christophe Rain, Morvane Colin, Cláudio M. Gomes, Luc Buée, Isabelle Landrieu, Clément Danis, Elian Dupré
Opublikowane w: Journal of Biological Chemistry, Numer 300, 2024, ISSN 0021-9258
Wydawca: Elsevier BV
DOI: 10.1016/J.JBC.2024.107163EXTERNALLINK

Morphological and Biophysical Study of S100A9 Protein Fibrils by Atomic Force Microscopy Imaging and Nanomechanical Analysis

Autorzy: Ana P. Carapeto, Carlos Marcuello, Patrícia F. N. Faísca, Mário S. Rodrigues
Opublikowane w: Biomolecules, Numer 14, 2024, ISSN 2218-273X
Wydawca: MDPI AG
DOI: 10.3390/BIOM14091091

Role of topology in protein thermal stability

Autorzy: João N. C. Especial, Beatriz P. Teixeira, Ana Nunes, Miguel Machuqueiro, Patrícia F. N. Faísca
Opublikowane w: Physical Review Research, Numer 8, 2026, ISSN 2643-1564
Wydawca: American Physical Society (APS)
DOI: 10.1103/9KZY-W2TZ

Sacsin deletion decreases cell viscoelasticity and motility in a glial cell model of autosomal recessive spastic ataxia of Charlevoix Saguenay

Autorzy: Fernanda Murtinheira, João Belo, Ana Sofia Boasinha, Tiago T. Robalo, Vukosava M. Torres, Francisco R. Pinto, Constança Pimenta, Patricia Nascimento, Mario S. Rodrigues, Federico Herrera
Opublikowane w: Archives of Biochemistry and Biophysics, Numer 772, 2025, ISSN 0003-9861
Wydawca: Elsevier BV
DOI: 10.1016/J.ABB.2025.110569

Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches

Autorzy: Inês Paccetti-Alves; Marta S. P. Batista; Catarina Pimpão; Bruno L. Victor; Graça Soveral
Opublikowane w: International Journal of Molecular Sciences; Volume 24; Numer 6; Pages: 6004, 2023, ISSN 1422-0067
Wydawca: MDPI
DOI: 10.3390/ijms24066004

Probing the Interactions of Thiazole Abietane Inhibitors with the Human Serine Hydrolases ABHD16A and ABHD12

Autorzy: Tiina J. Ahonen; Choa P. N; Beatriz Farinha; Bárbara Almeida; Bruno L. Victor; Christopher Reynolds; Eija Kalso; Jari Yli-Kauhaluoma; Jennifer Greaves; Vânia M. Moreira
Opublikowane w: ACS Medicinal Chemistry Letters, 2023, ISSN 1948-5875
Wydawca: American Chemical Society
DOI: 10.1021/acsmedchemlett.3c00313

Synthesis, Activity, Toxicity, and In Silico Studies of New Antimycobacterial N-Alkyl Nitrobenzamides

Autorzy: João P. Pais, Olha Antoniuk, David Pires, Tiago Delgado, Andreia Fortuna, Paulo J. Costa, Elsa Anes, Luis Constantino
Opublikowane w: Pharmaceuticals, Numer 17, 2024, ISSN 1424-8247
Wydawca: MDPI AG
DOI: 10.3390/PH17050608

Conformation-Driven Phase Separation in the Linker Domain of Focal Adhesion Kinases

Autorzy: Lucy Martin, Daniela P. Freitas, Emmanuelle Boll, Alain Brans, Justine Mortelecque, François-Xavier Cantrelle, Pierre Dourlen, Cláudio M. Gomes, Clément Danis, Isabelle Landrieu
Opublikowane w: Biochemistry, Numer 64, 2025, ISSN 0006-2960
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOCHEM.4C00677

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor

Autorzy: Mickael Diallo; Constança Pimenta; Fernanda Murtinheira; Daniela Martins-Alves; Francisco R. Pinto; André Abrantes da Costa; Ricardo Letra-Vilela; Vanesa Martin; Carmen Rodriguez; Mário S. Rodrigues; Federico Herrera
Opublikowane w: Cellular Oncology, 2023, ISSN 2211-3436
Wydawca: Springer Nature
DOI: 10.21203/rs.3.rs-3188959/v1

Assessment of Halogen Off-Center Point-Charge Models Using Explicit Solvent Simulations

Autorzy: Andreia Fortuna; Paulo J. Costa
Opublikowane w: Journal of Chemical Information and Modeling, 2023, ISSN 1549-9596
Wydawca: ACS Publications
DOI: 10.26434/chemrxiv-2023-sgbfb

Cyclic Peptides as Aggregation Inhibitors for Sickle Cell Disease

Autorzy: Vasco Neto, Bruno Lourenço Victor, Nuno Galamba
Opublikowane w: Journal of Medicinal Chemistry, Numer 66, 2023, ISSN 0022-2623
Wydawca: American Chemical Society (ACS)
DOI: 10.26434/CHEMRXIV-2023-QRZL0

Assessment of Halogen Off-Center Point-Charge Models Using Explicit Solvent Simulations

Autorzy: Andreia Fortuna, Paulo J. Costa
Opublikowane w: Journal of Chemical Information and Modeling, Numer 63, 2023, ISSN 1549-9596
Wydawca: American Chemical Society (ACS)
DOI: 10.26434/CHEMRXIV-2023-SGBFB

Amyloid-like Structures in Marine Adhesive Proteins

Autorzy: Mariana Rodrigues Santos, Bárbara Joana Henriques, Romana Santos
Opublikowane w: Marine Drugs, Numer 23, 2025, ISSN 1660-3397
Wydawca: MDPI AG
DOI: 10.3390/MD23090363

Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer’s Disease Pathology

Autorzy: Romina Coelho, Chiara A. De Benedictis, Ann Katrin Sauer, António J. Figueira, Hélio Faustino, Andreas M. Grabrucker, Cláudio M. Gomes
Opublikowane w: International Journal of Molecular Sciences, Numer 25, 2024, ISSN 1422-0067
Wydawca: MDPI AG
DOI: 10.3390/IJMS25031787

Is spastic ataxia 8 a protein misfolding disorder?

Autorzy: Pedro Ferreira-Peralta; Brenda França; Fernanda Murtinheira; Mario S. Rodrigues; Federico Herrera
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, ISSN 0925-4439
Wydawca: Elsevier B.V.
DOI: 10.1016/j.bbadis.2023.166882

Recent advances on molecular dynamics-based techniques to address drug membrane permeability with atomistic detail

Autorzy: André M.M. Gomes; Paulo J. Costa; Miguel Machuqueiro
Opublikowane w: BBA Advances, 2023, ISSN 2667-1603
Wydawca: Elsevier B.V.
DOI: 10.1016/j.bbadva.2023.100099

Influence of Iodine Merz–Singh–Kollman Radius on the Calculated Charges and Hydration Free Energies of Iodinated Molecules

Autorzy: Andreia Fortuna; Pedro M. S. Suzano; Miguel Machuqueiro; Paulo J. Costa
Opublikowane w: Journal of Computational Biophysics and Chemistry, Numer 04, 2024, ISSN 2737-4165
Wydawca: World Scientific Publishing
DOI: 10.1142/S2737416523500722

Journal of Biological Chemistry

Autorzy: Justine Mortelecque; Orgeta Zejneli; Séverine Bégard; Margarida C. Simões; Lea ElHajjar; Marine Nguyen; François-Xavier Cantrelle; Xavier Hanoulle; Jean-Christophe Rain; Morvane Colin; Cláudio M. Gomes; Luc Buée; Isabelle Landrieu; ClémenDanis C, Dupré E.
Opublikowane w: Journal of Biological Chemistry, Numer 4, 2024, ISSN 0021-9258
Wydawca: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2024.107163

S100B Mitigates Cytoskeletal and Mitochondrial Alterations in a Glial Cell Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay

Autorzy: Ana Sofia Boasinha, Fernanda Murtinheira, Susana Solá, Cláudio M. Gomes, Federico Herrera
Opublikowane w: Molecular Neurobiology, Numer 62, 2025, ISSN 0893-7648
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S12035-025-05057-3

Cross-Interactions of Aβ Peptides Implicated in Alzheimer’s Disease Shape Amyloid Oligomer Structures and Aggregation

Autorzy: Tanja Habeck, Silvana Smilla Zurmühl, António J. Figueira, Edvaldo Vasconcelos Soares Maciel, Cláudio M. Gomes, Frederik Lermyte
Opublikowane w: ACS Chemical Neuroscience, Numer 15, 2024, ISSN 1948-7193
Wydawca: American Chemical Society (ACS)
DOI: 10.1021/ACSCHEMNEURO.4C00492

Intrinsic Bond Strength Index as a halogen bond interaction energy predictor

Autorzy: Ona Šivickytė; Paulo J. Costa
Opublikowane w: Physical Chemistry Chemical Physics, 2023, ISSN 1463-9084
Wydawca: Royal Society of Chemistry
DOI: 10.26434/chemrxiv-2022-c6npj

Adding the AMBER 14SB Force Field to the Stochastic Titration CpHMD Method

Autorzy: João G. N. Sequeira, Adrian E. Roitberg, Miguel Machuqueiro
Opublikowane w: Journal of Chemical Theory and Computation, Numer 21, 2025, ISSN 1549-9618
Wydawca: American Chemical Society (ACS)
DOI: 10.26434/CHEMRXIV-2025-38NFP

Folding and knotting of biotic and prebiotic amino acid sequences through reverse evolution

Autorzy: João N.C. Especial, Patrícia F.N. Faísca
Opublikowane w: Biophysical Journal, Numer 124, 2025, ISSN 0006-3495
Wydawca: Elsevier BV
DOI: 10.1101/2025.06.04.657801

Discrete Actuation of Water‐Responsive Crystalline Metal–Peptide Frameworks

Autorzy: Hui Yuan, Yiming Tang, Elma Naranjo, Pierre‐Andre Cazade, Yifei Yao, Vijayakanth Thangavel, Rusen Yang, Sigal Rencus‐Lazar, Damien Thompson, Linda J. W. Shimon, Guanghong Wei, Xi Chen, Ehud Gazit
Opublikowane w: Angewandte Chemie International Edition, Numer 64, 2025, ISSN 1433-7851
Wydawca: Wiley
DOI: 10.1002/ANIE.202513629

Decoding the secrets: how conformational and structural regulators inhibit the human 20S proteasome

Autorzy: Pedro M. P. Fernandes, Romina A. Guedes, Bruno L. Victor, Jorge A. R. Salvador, Rita C. Guedes
Opublikowane w: Frontiers in Chemistry, Numer 11, 2024, ISSN 2296-2646
Wydawca: Frontiers Media SA
DOI: 10.3389/FCHEM.2023.1322628

Is spastic ataxia 8 a protein misfolding disorder?

Autorzy: Pedro Ferreira-Peralta, Brenda França, Fernanda Murtinheira, Mario S. Rodrigues, Federico Herrera
Opublikowane w: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numer 1870, 2024, ISSN 0925-4439
Wydawca: Elsevier BV
DOI: 10.1016/J.BBADIS.2023.166882

Asymmetric post-translational modifications regulate the nuclear translocation of STAT3 homodimers in response to leukemia inhibitory factor

Autorzy: Mickael Diallo, Constança Pimenta, Fernanda Murtinheira, Daniela Martins-Alves, Francisco R. Pinto, André Abrantes da Costa, Ricardo Letra-Vilela, Vanesa Martin, Carmen Rodriguez, Mário S. Rodrigues, Federico Herrera
Opublikowane w: Cellular Oncology, Numer 47, 2023, ISSN 2211-3428
Wydawca: Springer Science and Business Media LLC
DOI: 10.21203/RS.3.RS-3188959/V1

Unraveling the Aquaporin-3 Inhibitory Effect of Rottlerin by Experimental and Computational Approaches

Autorzy: Inês Paccetti-Alves, Marta S. P. Batista, Catarina Pimpão, Bruno L. Victor, Graça Soveral
Opublikowane w: International Journal of Molecular Sciences, Numer 24, 2023, ISSN 1422-0067
Wydawca: MDPI AG
DOI: 10.3390/IJMS24066004

Other (7)

Identifying functional sites at scale

Autorzy: Cagiada, Matteo
Opublikowane w: 2023
DOI: 10.5281/zenodo.10409579

Proximity Labelling Assays to Detect Protein Interactions in Cells

Autorzy: Bar, Daniel
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/ZENODO.14046998

Shifting KRAS hotspot mutations inhibition paradigm in colorectal cancer

Autorzy: Ana Rita Brás; Ana Lopes; Nuno Mendes; Paulo J. Costa; Anabela Ferreira; Sara Granja; Ana Paula Silva; Francisco Tortosa; Fátima Baltazar; Fátima Gärtner; Maria João Sousa; Andreia Valente; Ana Preto
Opublikowane w: bioRxiv, 2023
Wydawca: bioRxiv
DOI: 10.1101/2023.08.09.552513

Computational tools to analyse protein stability and abundance

Autorzy: Schulze, Thea Klarsø
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/ZENODO.10783195

Understanding intrinsically disordered proteins: from integrative modelling to design

Autorzy: Pesce, Francesco
Opublikowane w: 2023
DOI: 10.5281/zenodo.10379566

Computational tools to analyse protein variant effects

Autorzy: Jonsson, Nicolas
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/ZENODO.10783189

Advanced Microscopy and Live Cell Imaging

Autorzy: Lisby, Michael
Opublikowane w: 2024
Wydawca: Zenodo
DOI: 10.5281/ZENODO.14046016

Thesis and dissertations (3)

Investigation of S100 proteins and their role in huntingtin aggregation

Autorzy: Marta Sofia Silva da Cruz Botelho
Opublikowane w: ULisboa Repository, 2023
Wydawca: Author Edition

The role of post-translational modifications on NKX6-2 behavior and function

Autorzy: Brenda Gabriella França
Opublikowane w: NOVA University Repository, 2023
Wydawca: Author Edition

Sea urchin inspired adhesive proteins - expression and purification of Nectin structural domains

Autorzy: Mariana Rodrigues dos Santos
Opublikowane w: ULisboa Repository, 2023
Wydawca: Author Edition