Unlocking the scientific excellence and innovation capacity of the University of Aveiro in supramolecular multicomponent biomaterials for enabling advanced biomaterials for healthcare

Project Information

SUPRALIFE

Grant agreement ID: 101079482

DOI

10.3030/101079482

EC signature date 4 August 2022

Start date 1 January 2023

End date 31 December 2025

Funded under

• Widening participation and spreading excellence

Total cost

€ 1 499 887,50

EU contribution

€ 1 499 887,50

Coordinated by

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website, logo, and collaborative network establishment

Project website, logo, and collaborative network establishment.

Data Management Plan (1)

DMP

DMP.

Publications

Peer reviewed articles (23)

Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth (SUPRALIFE project publication, RP1)

Author(s): Maria Lopes; Marília Torrado; Daryl Barth; Sofia D. Santos; Melike Sever-Bahcekapili; Ayse B. Tekinay; Mustafa O. Guler; Franck Cleymand; Ana P. Pêgo; João Borges; João F. Mano
Published in: Biomaterials Science, 2023, ISSN 2047-4830
Publisher: Royal Society of Chemistry
DOI: 10.1039/D3BM00438D

Single‐Cell Liquid‐Core Microcapsules for Biomedical Applications

Author(s): Manuel Pires‐Santos, Mariana Carreira, Bruno P. Morais, Francisca G. Perfeito, Mariana B. Oliveira, Cátia F. Monteiro, Sara Nadine, João F. Mano
Published in: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Publisher: Wiley
DOI: 10.1002/ADHM.202403808

Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier (SUPRALIFE project related publication, RP2)

Author(s): C. G. Palivan, L. Heuberger, J. Gaitzsch, B. Voit, D. Appelhans, B. B. Fernandes, G. Battaglia, J. Du, L. Abdelmohsen, J. C. M. van Hest, J. Hu, S. Liu, Z. Zhong, H. Sun, A. Mutschler, S. Lecommandoux
Published in: Biomacromolecules, 2024, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.4C00769

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Author(s): Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Published in: Biomaterials, Issue 320, 2025, ISSN 0142-9612
Publisher: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123270

Self-Supporting Hyaluronic Acid-Functionalized G-Quadruplex-Based Perfusable Multicomponent Hydrogels Embedded in Photo-Cross-Linkable Matrices for Bioapplications (SUPRALIFE project publication, RP1)

Author(s): Vera Sousa; Adérito J. R. Amaral; Edgar J. Castanheira; Igor Marques; João M. M. Rodrigues; Vítor Félix; João Borges; João F. Mano
Published in: Biomacromolecules, 2023, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.3C00433

Unveiling the Potential of Single‐Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Author(s): Manuel Pires‐Santos, Sara Nadine, João F. Mano
Published in: Small Science, Issue 4, 2024, ISSN 2688-4046
Publisher: Wiley
DOI: 10.1002/smsc.202300332

Pierceable, Storable, and Manipulable Liquid Capsules for Precise Monitoring and Efficient Cargo Transport in Biotechnological Advances

Author(s): Ana Rita Pinho, Chunming Wang, Maria Clara Gomes, Joo Filipe Mano
Published in: Advanced Functional Materials, 2025, ISSN 1616-301X
Publisher: Wiley
DOI: 10.1002/adfm.202425715

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications (SUPRALIFE project publication, RP1)

Author(s): João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Published in: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Publisher: World Scientific
DOI: 10.1002/ADHM.202302713

Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment (SUPRALIFE project related publication, RP1)

Author(s): Margarida M. A. Sacramento; Mariana B. Oliveira; José R.B. Gomes; João Borges; Benjamin R. Freedman; David J. Mooney; João M. M. Rodrigues; João F. Mano
Published in: Advanced Healthcare Materials, 2024, ISSN 2192-2659
Publisher: Wiley
DOI: 10.1002/ADHM.202304587

Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers

Author(s): Laura Rijns, Martin G. T. A. Rutten, Riccardo Bellan, Hongbo Yuan, Mauro L. Mugnai, Susana Rocha, Emanuela del Gado, Paul H. J. Kouwer, Patricia Y. W. Dankers
Published in: Science Advances, Issue 10, 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR3209

Employing the SpyTag-SpyCatcher Reaction for the Modification of Supramolecular Polymers with Functional Proteins

Author(s): Fenna W.B. Craenmehr, Alexander Gräwe, Victor A. Veenbrink, Riccardo Bellan, Maarten Merkx, Patricia Y.W. Dankers
Published in: Bioconjugate Chemistry, Issue 36, 2025, ISSN 1043-1802
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOCONJCHEM.5C00046

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation (SUPRALIFE project related publication, RP2)

Author(s): Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, João F. Mano
Published in: ACS Nano, 2024, ISSN 1936-086X
Publisher: American Chemical Society
DOI: 10.1021/ACSNANO.4C02790

Co‐Assembled Supramolecular Hydrogelators Enhance Glomerulogenesis in Kidney Organoids Through Cell‐Adhesive Motifs

Author(s): Johnick F. van Sprang, Jasper G.M. Aarts, Martin G.T.A. Rutten, Laura Rijns, Bart M. Tiemeijer, Maaike J.G. Schotman, Patricia Y.W. Dankers
Published in: Advanced Functional Materials, Issue 34, 2025, ISSN 1616-301X
Publisher: Wiley
DOI: 10.1002/ADFM.202404786

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials (SUPRALIFE project related publication, RP1)

Author(s): Moniek G. J. Schmitz, Jasper G. M. Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J. M. Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A. J. Zaat, Jan de Boer, Morgan R. Alexander, Patricia Y. W. Dankers
Published in: Macromolecular Rapid Communications, 2024, ISSN 1022-1336
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/MARC.202300638

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials

Author(s): Moniek G. J. Schmitz, Jasper G. M. Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J. M. Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A. J. Zaat, Jan de Boer, Morgan R. Alexander, Patricia Y. W. Dankers
Published in: Macromolecular Rapid Communications, Issue 46, 2025, ISSN 1022-1336
Publisher: Wiley
DOI: 10.1002/MARC.202300638

Collagen type I mimicking peptide additives to functionalize synthetic supramolecular hydrogels (SUPRALIFE project related publication, RP1)

Author(s): Annika F. Vrehen, Johnick F. van Sprang, Maaike J.G. Schotman, Patricia Y.W. Dankers
Published in: Materials Today Bio, 2024, ISSN 2590-0064
Publisher: Elsevier
DOI: 10.1016/J.MTBIO.2024.101021

Advanced Materials

Author(s): Maritza M. Rovers; Theodora Rogkoti; Bram K. Bakker; Kalpit J. Bakal; Marcel H.P. van Genderen; Manuel Salmeron‐Sanchez; Patricia Y.W. Dankers
Published in: Advanced Materials, 2024, ISSN 0935-9648
Publisher: Wiley
DOI: 10.1002/ADMA.202405868

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery (SUPRALIFE project related publication, RP1)

Author(s): Cristiana F. V. Sousa; Luís P. G. Monteiro; João M. M. Rodrigues; João Borges; João F. Mano
Published in: Journal of Materials Chemistry B, 2023, ISSN 2050-7518
Publisher: Royal Society of Chemistry
DOI: 10.1039/D3TB00796K

Cell Surface Engineering Tools for Programming Living Assemblies (SUPRALIFE project related publication, RP1)

Author(s): José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Published in: Advanced Science, 2023, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/ADVS.202304040

Protocells Featuring Membrane-Bound and Dynamic Membraneless Organelles

Author(s): Clémence Schvartzman, Emmanuel Ibarboure, Anouk Martin, Elisabeth Garanger, Angela Mutschler, Sébastien Lecommandoux
Published in: Biomacromolecules, 2024, ISSN 1525-7797
Publisher: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.4C00200

Acidochromic Free-Standing Multilayered Chitosan-Pyranoflavylium/Alginate Membranes toward Food Smart Packaging Applications (SUPRALIFE project related publication, RP2)

Author(s): Mariana Cunha, Victor de Freitas, João Borges, João F. Mano, João M. M. Rodrigues, Luís Cruz
Published in: ACS Applied Polymer Materials, 2024, ISSN 2637-6105
Publisher: American Chemical Society
DOI: 10.1021/ACSAPM.4C01085

Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Author(s): Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron‐Sanchez, Patricia Y.W. Dankers
Published in: Advanced Materials, Issue 36, 2025, ISSN 0935-9648
Publisher: Wiley
DOI: 10.1002/ADMA.202405868

From natural to synthetic hydrogels: how much biochemical complexity is required for mechanotransduction?

Author(s): Johnick F. van Sprang, Imke P. M. Smits, Jasper C. H. Nooten, Peter-Paul K. H. Fransen, Serge H. M. Söntjens, Michel H. C. J. van Houtem, Henk M. Janssen, Martin G. T. A. Rutten, Maaike J. G. Schotman, P. Y. W. Dankers
Published in: Journal of Materials Chemistry B, Issue 13, 2025, ISSN 2050-750X
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4TB01774A