Unlocking the scientific excellence and innovation capacity of the University of Aveiro in supramolecular multicomponent biomaterials for enabling advanced biomaterials for healthcare

Informazioni relative al progetto

SUPRALIFE

ID dell’accordo di sovvenzione: 101079482

DOI

10.3030/101079482

Progetto chiuso

Data della firma CE 4 Agosto 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2025

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 1 499 887,50

Contributo UE

€ 1 499 887,50

Coordinato da

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Websites, patent fillings, videos etc. (1)

Project website, logo, and collaborative network establishment

Project website, logo, and collaborative network establishment.

Data Management Plan (1)

DMP

DMP.

Pubblicazioni

Peer reviewed articles (38)

Biohybrid corneal stromal tissue formation using keratocytes encapsulated in supramolecular microgels

Autori: Maritza M. Rovers, Annika F. Vrehen, Patricia Y.W. Dankers
Pubblicato in: Materials Today Bio, Numero 34, 2026, ISSN 2590-0064
Editore: Elsevier BV
DOI: 10.1016/J.MTBIO.2025.102214

Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth (SUPRALIFE project publication, RP1)

Autori: Maria Lopes; Marília Torrado; Daryl Barth; Sofia D. Santos; Melike Sever-Bahcekapili; Ayse B. Tekinay; Mustafa O. Guler; Franck Cleymand; Ana P. Pêgo; João Borges; João F. Mano
Pubblicato in: Biomaterials Science, 2023, ISSN 2047-4830
Editore: Royal Society of Chemistry
DOI: 10.1039/D3BM00438D

Single‐Cell Liquid‐Core Microcapsules for Biomedical Applications

Autori: Manuel Pires‐Santos, Mariana Carreira, Bruno P. Morais, Francisca G. Perfeito, Mariana B. Oliveira, Cátia F. Monteiro, Sara Nadine, João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Editore: Wiley
DOI: 10.1002/ADHM.202403808

Advancing Artificial Cells with Functional Compartmentalized Polymeric Systems - In Honor of Wolfgang Meier (SUPRALIFE project related publication, RP2)

Autori: C. G. Palivan, L. Heuberger, J. Gaitzsch, B. Voit, D. Appelhans, B. B. Fernandes, G. Battaglia, J. Du, L. Abdelmohsen, J. C. M. van Hest, J. Hu, S. Liu, Z. Zhong, H. Sun, A. Mutschler, S. Lecommandoux
Pubblicato in: Biomacromolecules, 2024, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.4C00769

Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Autori: Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron‐Sanchez, Patricia Y.W. Dankers
Pubblicato in: Advanced Materials, Numero 36, 2025, ISSN 0935-9648
Editore: Wiley
DOI: 10.1002/ADMA.202405868

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Autori: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Pubblicato in: Biomaterials, Numero 320, 2025, ISSN 0142-9612
Editore: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123270

Injectable and self-healable supramolecular hydrogels assembled by quaternised chitosan/alginate polyelectrolyte complexation for sustained drug delivery and cell encapsulation

Autori: Cristiana F. V. Sousa, João Borges, João F. Mano
Pubblicato in: Biomaterials Science, Numero 13, 2025, ISSN 2047-4830
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5BM00072F

Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel–Cell Interactions

Autori: Laura Rijns, Matthew B. Baker, Patricia Y. W. Dankers
Pubblicato in: Journal of the American Chemical Society, Numero 146, 2024, ISSN 0002-7863
Editore: American Chemical Society (ACS)
DOI: 10.1021/JACS.4C02980

Self-Supporting Hyaluronic Acid-Functionalized G-Quadruplex-Based Perfusable Multicomponent Hydrogels Embedded in Photo-Cross-Linkable Matrices for Bioapplications (SUPRALIFE project publication, RP1)

Autori: Vera Sousa; Adérito J. R. Amaral; Edgar J. Castanheira; Igor Marques; João M. M. Rodrigues; Vítor Félix; João Borges; João F. Mano
Pubblicato in: Biomacromolecules, 2023, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.3C00433

Unveiling the Potential of Single‐Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Autori: Manuel Pires‐Santos, Sara Nadine, João F. Mano
Pubblicato in: Small Science, Numero 4, 2024, ISSN 2688-4046
Editore: Wiley
DOI: 10.1002/smsc.202300332

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Autori: Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers
Pubblicato in: Advanced Biology, Numero 9, 2025, ISSN 2701-0198
Editore: Wiley
DOI: 10.1002/ADBI.202400690

Pierceable, Storable, and Manipulable Liquid Capsules for Precise Monitoring and Efficient Cargo Transport in Biotechnological Advances

Autori: Ana Rita Pinho, Chunming Wang, Maria Clara Gomes, Joo Filipe Mano
Pubblicato in: Advanced Functional Materials, 2025, ISSN 1616-301X
Editore: Wiley
DOI: 10.1002/adfm.202425715

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications (SUPRALIFE project publication, RP1)

Autori: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Pubblicato in: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Editore: World Scientific
DOI: 10.1002/ADHM.202302713

Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment (SUPRALIFE project related publication, RP1)

Autori: Margarida M. A. Sacramento; Mariana B. Oliveira; José R.B. Gomes; João Borges; Benjamin R. Freedman; David J. Mooney; João M. M. Rodrigues; João F. Mano
Pubblicato in: Advanced Healthcare Materials, 2024, ISSN 2192-2659
Editore: Wiley
DOI: 10.1002/ADHM.202304587

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Autori: Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers
Pubblicato in: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Editore: Wiley
DOI: 10.1002/ADHM.202502079

Supramolecular Additive Screening to Engineer Microfibrous Rafts for Expansion of Pluripotent Stem Cells in Dynamic Suspension

Autori: Johnick F. van Sprang, Jasper G. M. Aarts, Boris Arts, Joyce E. P. Brouns, Muhabbat I. Komil, Paul A. A. Bartels, Patricia Y. W. Dankers
Pubblicato in: Advanced Healthcare Materials, Numero 14, 2025, ISSN 2192-2640
Editore: Wiley
DOI: 10.1002/ADHM.202404186

Production of recombinant methionine‐containing elastin‐like polypeptides in a fermenter using <scp>ECPM1</scp> medium

Autori: Alice Delhaes, Laure Bataille, Myriam Médéric, Sébastien Lecommandoux, Elisabeth Garanger
Pubblicato in: Biotechnology Progress, Numero 41, 2025, ISSN 8756-7938
Editore: Wiley
DOI: 10.1002/BTPR.70057

Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers

Autori: Laura Rijns, Martin G. T. A. Rutten, Riccardo Bellan, Hongbo Yuan, Mauro L. Mugnai, Susana Rocha, Emanuela del Gado, Paul H. J. Kouwer, Patricia Y. W. Dankers
Pubblicato in: Science Advances, Numero 10, 2024, ISSN 2375-2548
Editore: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR3209

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Autori: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Pubblicato in: ACS Nano, Numero 19, 2025, ISSN 1936-0851
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.5C10088

Employing the SpyTag-SpyCatcher Reaction for the Modification of Supramolecular Polymers with Functional Proteins

Autori: Fenna W.B. Craenmehr, Alexander Gräwe, Victor A. Veenbrink, Riccardo Bellan, Maarten Merkx, Patricia Y.W. Dankers
Pubblicato in: Bioconjugate Chemistry, Numero 36, 2025, ISSN 1043-1802
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOCONJCHEM.5C00046

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Autori: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Pubblicato in: Biomaterials Advances, Numero 167, 2024, ISSN 2772-9508
Editore: Elsevier BV
DOI: 10.1016/J.BIOADV.2024.214105

Marine-Origin Polysaccharides and Their Chemically Modified Derivatives as Sources of Advanced Biofunctional Materials for Biomedical Applications

Autori: Vera Sousa, Luís P. G. Monteiro, Djenisa H. A. Rocha, João M. M. Rodrigues, João Borges, João F. Mano
Pubblicato in: Biomacromolecules, Numero 26, 2025, ISSN 1525-7797
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOMAC.4C01682

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Autori: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, João F. Mano
Pubblicato in: ACS Nano, 2024, ISSN 1936-086X
Editore: American Chemical Society
DOI: 10.1021/ACSNANO.4C02790

Co‐Assembled Supramolecular Hydrogelators Enhance Glomerulogenesis in Kidney Organoids Through Cell‐Adhesive Motifs

Autori: Johnick F. van Sprang, Jasper G.M. Aarts, Martin G.T.A. Rutten, Laura Rijns, Bart M. Tiemeijer, Maaike J.G. Schotman, Patricia Y.W. Dankers
Pubblicato in: Advanced Functional Materials, Numero 34, 2025, ISSN 1616-301X
Editore: Wiley
DOI: 10.1002/ADFM.202404786

Monomer exchange dynamics in ureido–pyrimidinone supramolecular polymers <i>via</i> molecular simulations

Autori: Annalisa Cardellini, Cristina Caruso, Laura Rijns, Patricia Y. W. Dankers, Giovanni M. Pavan, Claudio Perego
Pubblicato in: Journal of Materials Chemistry B, Numero 13, 2025, ISSN 2050-750X
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5TB01272D

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials (SUPRALIFE project related publication, RP1)

Autori: Moniek G. J. Schmitz, Jasper G. M. Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J. M. Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A. J. Zaat, Jan de Boer, Morgan R. Alexander, Patricia Y. W. Dankers
Pubblicato in: Macromolecular Rapid Communications, 2024, ISSN 1022-1336
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/MARC.202300638

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials

Autori: Moniek G. J. Schmitz, Jasper G. M. Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J. M. Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A. J. Zaat, Jan de Boer, Morgan R. Alexander, Patricia Y. W. Dankers
Pubblicato in: Macromolecular Rapid Communications, Numero 46, 2025, ISSN 1022-1336
Editore: Wiley
DOI: 10.1002/MARC.202300638

Collagen type I mimicking peptide additives to functionalize synthetic supramolecular hydrogels (SUPRALIFE project related publication, RP1)

Autori: Annika F. Vrehen, Johnick F. van Sprang, Maaike J.G. Schotman, Patricia Y.W. Dankers
Pubblicato in: Materials Today Bio, 2024, ISSN 2590-0064
Editore: Elsevier
DOI: 10.1016/J.MTBIO.2024.101021

Mimicking the extracellular world: from natural to fully synthetic matrices utilizing supramolecular biomaterials

Autori: Laura Rijns, Martin G. T. A. Rutten, Annika F. Vrehen, Ana A. Aldana, Matthew B. Baker, Patricia Y. W. Dankers
Pubblicato in: Nanoscale, Numero 16, 2024, ISSN 2040-3364
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4NR02088J

Advanced Materials

Autori: Maritza M. Rovers; Theodora Rogkoti; Bram K. Bakker; Kalpit J. Bakal; Marcel H.P. van Genderen; Manuel Salmeron‐Sanchez; Patricia Y.W. Dankers
Pubblicato in: Advanced Materials, 2024, ISSN 0935-9648
Editore: Wiley
DOI: 10.1002/ADMA.202405868

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery (SUPRALIFE project related publication, RP1)

Autori: Cristiana F. V. Sousa; Luís P. G. Monteiro; João M. M. Rodrigues; João Borges; João F. Mano
Pubblicato in: Journal of Materials Chemistry B, 2023, ISSN 2050-7518
Editore: Royal Society of Chemistry
DOI: 10.1039/D3TB00796K

Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Autori: Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron‐Sanchez, Patricia Y.W. Dankers
Pubblicato in: Advanced Materials, Numero 36, 2024, ISSN 0935-9648
Editore: Wiley
DOI: 10.1002/ADMA.202405868

Cell Surface Engineering Tools for Programming Living Assemblies (SUPRALIFE project related publication, RP1)

Autori: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Pubblicato in: Advanced Science, 2023, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/ADVS.202304040

Protocells Featuring Membrane-Bound and Dynamic Membraneless Organelles

Autori: Clémence Schvartzman, Emmanuel Ibarboure, Anouk Martin, Elisabeth Garanger, Angela Mutschler, Sébastien Lecommandoux
Pubblicato in: Biomacromolecules, 2024, ISSN 1525-7797
Editore: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.4C00200

Acidochromic Free-Standing Multilayered Chitosan-Pyranoflavylium/Alginate Membranes toward Food Smart Packaging Applications

Autori: Mariana Cunha, Victor de Freitas, João Borges, João F. Mano, João M. M. Rodrigues, Luís Cruz
Pubblicato in: ACS Applied Polymer Materials, 2024, ISSN 2637-6105
Editore: American Chemical Society
DOI: 10.1021/ACSAPM.4C01085

Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Autori: Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron‐Sanchez, Patricia Y.W. Dankers
Pubblicato in: Advanced Materials, Numero 36, 2025, ISSN 0935-9648
Editore: Wiley
DOI: 10.1002/ADMA.202405868

From natural to synthetic hydrogels: how much biochemical complexity is required for mechanotransduction?

Autori: Johnick F. van Sprang, Imke P. M. Smits, Jasper C. H. Nooten, Peter-Paul K. H. Fransen, Serge H. M. Söntjens, Michel H. C. J. van Houtem, Henk M. Janssen, Martin G. T. A. Rutten, Maaike J. G. Schotman, P. Y. W. Dankers
Pubblicato in: Journal of Materials Chemistry B, Numero 13, 2025, ISSN 2050-750X
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4TB01774A

Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties

Autori: Laura Rijns, Heleen Duijs, René P. M. Lafleur, Ruth Cardinaels, Anja R. A. Palmans, Patricia Y. W. Dankers, Lu Su
Pubblicato in: Biomacromolecules, Numero 25, 2024, ISSN 1525-7797
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOMAC.3C01357