Unlocking the scientific excellence and innovation capacity of the University of Aveiro in supramolecular multicomponent biomaterials for enabling advanced biomaterials for healthcare

Informations projet

SUPRALIFE

N° de convention de subvention: 101079482

DOI

10.3030/101079482

Projet clôturé

Date de signature de la CE 4 Août 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2025

Financé au titre de

• Widening participation and spreading excellence

Coût total

€ 1 499 887,50

Contribution de l’UE

€ 1 499 887,50

Coordonné par

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Websites, patent fillings, videos etc. (1)

Project website, logo, and collaborative network establishment

Project website, logo, and collaborative network establishment.

Data Management Plan (1)

DMP

DMP.

Publications

Peer reviewed articles (30)

Biohybrid corneal stromal tissue formation using keratocytes encapsulated in supramolecular microgels

Auteurs: Maritza M. Rovers, Annika F. Vrehen, Patricia Y.W. Dankers
Publié dans: Materials Today Bio, Numéro 34, 2026, ISSN 2590-0064
Éditeur: Elsevier BV
DOI: 10.1016/J.MTBIO.2025.102214

Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth (SUPRALIFE project publication, RP1)

Auteurs: Maria Lopes; Marília Torrado; Daryl Barth; Sofia D. Santos; Melike Sever-Bahcekapili; Ayse B. Tekinay; Mustafa O. Guler; Franck Cleymand; Ana P. Pêgo; João Borges; João F. Mano
Publié dans: Biomaterials Science, 2023, ISSN 2047-4830
Éditeur: Royal Society of Chemistry
DOI: 10.1039/D3BM00438D

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Auteurs: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Publié dans: Biomaterials, Numéro 320, 2025, ISSN 0142-9612
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123270

Injectable and self-healable supramolecular hydrogels assembled by quaternised chitosan/alginate polyelectrolyte complexation for sustained drug delivery and cell encapsulation

Auteurs: Cristiana F. V. Sousa, João Borges, João F. Mano
Publié dans: Biomaterials Science, Numéro 13, 2025, ISSN 2047-4830
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5BM00072F

Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel–Cell Interactions

Auteurs: Laura Rijns, Matthew B. Baker, Patricia Y. W. Dankers
Publié dans: Journal of the American Chemical Society, Numéro 146, 2024, ISSN 0002-7863
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/JACS.4C02980

Self-Supporting Hyaluronic Acid-Functionalized G-Quadruplex-Based Perfusable Multicomponent Hydrogels Embedded in Photo-Cross-Linkable Matrices for Bioapplications (SUPRALIFE project publication, RP1)

Auteurs: Vera Sousa; Adérito J. R. Amaral; Edgar J. Castanheira; Igor Marques; João M. M. Rodrigues; Vítor Félix; João Borges; João F. Mano
Publié dans: Biomacromolecules, 2023, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.3C00433

Unveiling the Potential of Single‐Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Auteurs: Manuel Pires‐Santos, Sara Nadine, João F. Mano
Publié dans: Small Science, Numéro 4, 2024, ISSN 2688-4046
Éditeur: Wiley
DOI: 10.1002/smsc.202300332

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Auteurs: Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers
Publié dans: Advanced Biology, Numéro 9, 2025, ISSN 2701-0198
Éditeur: Wiley
DOI: 10.1002/ADBI.202400690

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications (SUPRALIFE project publication, RP1)

Auteurs: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Publié dans: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/ADHM.202302713

Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment (SUPRALIFE project related publication, RP1)

Auteurs: Margarida M. A. Sacramento; Mariana B. Oliveira; José R.B. Gomes; João Borges; Benjamin R. Freedman; David J. Mooney; João M. M. Rodrigues; João F. Mano
Publié dans: Advanced Healthcare Materials, 2024, ISSN 2192-2659
Éditeur: Wiley
DOI: 10.1002/ADHM.202304587

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Auteurs: Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers
Publié dans: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Éditeur: Wiley
DOI: 10.1002/ADHM.202502079

Supramolecular Additive Screening to Engineer Microfibrous Rafts for Expansion of Pluripotent Stem Cells in Dynamic Suspension

Auteurs: Johnick F. van Sprang, Jasper G. M. Aarts, Boris Arts, Joyce E. P. Brouns, Muhabbat I. Komil, Paul A. A. Bartels, Patricia Y. W. Dankers
Publié dans: Advanced Healthcare Materials, Numéro 14, 2025, ISSN 2192-2640
Éditeur: Wiley
DOI: 10.1002/ADHM.202404186

Production of recombinant methionine‐containing elastin‐like polypeptides in a fermenter using <scp>ECPM1</scp> medium

Auteurs: Alice Delhaes, Laure Bataille, Myriam Médéric, Sébastien Lecommandoux, Elisabeth Garanger
Publié dans: Biotechnology Progress, Numéro 41, 2025, ISSN 8756-7938
Éditeur: Wiley
DOI: 10.1002/BTPR.70057

Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers

Auteurs: Laura Rijns, Martin G. T. A. Rutten, Riccardo Bellan, Hongbo Yuan, Mauro L. Mugnai, Susana Rocha, Emanuela del Gado, Paul H. J. Kouwer, Patricia Y. W. Dankers
Publié dans: Science Advances, Numéro 10, 2024, ISSN 2375-2548
Éditeur: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR3209

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Auteurs: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Publié dans: ACS Nano, Numéro 19, 2025, ISSN 1936-0851
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.5C10088

Employing the SpyTag-SpyCatcher Reaction for the Modification of Supramolecular Polymers with Functional Proteins

Auteurs: Fenna W.B. Craenmehr, Alexander Gräwe, Victor A. Veenbrink, Riccardo Bellan, Maarten Merkx, Patricia Y.W. Dankers
Publié dans: Bioconjugate Chemistry, Numéro 36, 2025, ISSN 1043-1802
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOCONJCHEM.5C00046

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Auteurs: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Publié dans: Biomaterials Advances, Numéro 167, 2024, ISSN 2772-9508
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOADV.2024.214105

Marine-Origin Polysaccharides and Their Chemically Modified Derivatives as Sources of Advanced Biofunctional Materials for Biomedical Applications

Auteurs: Vera Sousa, Luís P. G. Monteiro, Djenisa H. A. Rocha, João M. M. Rodrigues, João Borges, João F. Mano
Publié dans: Biomacromolecules, Numéro 26, 2025, ISSN 1525-7797
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOMAC.4C01682

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Auteurs: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, João F. Mano
Publié dans: ACS Nano, 2024, ISSN 1936-086X
Éditeur: American Chemical Society
DOI: 10.1021/ACSNANO.4C02790

Co‐Assembled Supramolecular Hydrogelators Enhance Glomerulogenesis in Kidney Organoids Through Cell‐Adhesive Motifs

Auteurs: Johnick F. van Sprang, Jasper G.M. Aarts, Martin G.T.A. Rutten, Laura Rijns, Bart M. Tiemeijer, Maaike J.G. Schotman, Patricia Y.W. Dankers
Publié dans: Advanced Functional Materials, Numéro 34, 2025, ISSN 1616-301X
Éditeur: Wiley
DOI: 10.1002/ADFM.202404786

Monomer exchange dynamics in ureido–pyrimidinone supramolecular polymers <i>via</i> molecular simulations

Auteurs: Annalisa Cardellini, Cristina Caruso, Laura Rijns, Patricia Y. W. Dankers, Giovanni M. Pavan, Claudio Perego
Publié dans: Journal of Materials Chemistry B, Numéro 13, 2025, ISSN 2050-750X
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5TB01272D

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials (SUPRALIFE project related publication, RP1)

Auteurs: Moniek G. J. Schmitz, Jasper G. M. Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J. M. Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A. J. Zaat, Jan de Boer, Morgan R. Alexander, Patricia Y. W. Dankers
Publié dans: Macromolecular Rapid Communications, 2024, ISSN 1022-1336
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/MARC.202300638

Collagen type I mimicking peptide additives to functionalize synthetic supramolecular hydrogels (SUPRALIFE project related publication, RP1)

Auteurs: Annika F. Vrehen, Johnick F. van Sprang, Maaike J.G. Schotman, Patricia Y.W. Dankers
Publié dans: Materials Today Bio, 2024, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/J.MTBIO.2024.101021

Mimicking the extracellular world: from natural to fully synthetic matrices utilizing supramolecular biomaterials

Auteurs: Laura Rijns, Martin G. T. A. Rutten, Annika F. Vrehen, Ana A. Aldana, Matthew B. Baker, Patricia Y. W. Dankers
Publié dans: Nanoscale, Numéro 16, 2024, ISSN 2040-3364
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4NR02088J

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery (SUPRALIFE project related publication, RP1)

Auteurs: Cristiana F. V. Sousa; Luís P. G. Monteiro; João M. M. Rodrigues; João Borges; João F. Mano
Publié dans: Journal of Materials Chemistry B, 2023, ISSN 2050-7518
Éditeur: Royal Society of Chemistry
DOI: 10.1039/D3TB00796K

Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Auteurs: Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron‐Sanchez, Patricia Y.W. Dankers
Publié dans: Advanced Materials, Numéro 36, 2024, ISSN 0935-9648
Éditeur: Wiley
DOI: 10.1002/ADMA.202405868

Cell Surface Engineering Tools for Programming Living Assemblies (SUPRALIFE project related publication, RP1)

Auteurs: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Publié dans: Advanced Science, 2023, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/ADVS.202304040

Acidochromic Free-Standing Multilayered Chitosan-Pyranoflavylium/Alginate Membranes toward Food Smart Packaging Applications

Auteurs: Mariana Cunha, Victor de Freitas, João Borges, João F. Mano, João M. M. Rodrigues, Luís Cruz
Publié dans: ACS Applied Polymer Materials, 2024, ISSN 2637-6105
Éditeur: American Chemical Society
DOI: 10.1021/ACSAPM.4C01085

From natural to synthetic hydrogels: how much biochemical complexity is required for mechanotransduction?

Auteurs: Johnick F. van Sprang, Imke P. M. Smits, Jasper C. H. Nooten, Peter-Paul K. H. Fransen, Serge H. M. Söntjens, Michel H. C. J. van Houtem, Henk M. Janssen, Martin G. T. A. Rutten, Maaike J. G. Schotman, P. Y. W. Dankers
Publié dans: Journal of Materials Chemistry B, Numéro 13, 2025, ISSN 2050-750X
Éditeur: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4TB01774A

Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties

Auteurs: Laura Rijns, Heleen Duijs, René P. M. Lafleur, Ruth Cardinaels, Anja R. A. Palmans, Patricia Y. W. Dankers, Lu Su
Publié dans: Biomacromolecules, Numéro 25, 2024, ISSN 1525-7797
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOMAC.3C01357