Unlocking the scientific excellence and innovation capacity of the University of Aveiro in supramolecular multicomponent biomaterials for enabling advanced biomaterials for healthcare

Información del proyecto

SUPRALIFE

Identificador del acuerdo de subvención: 101079482

DOI

10.3030/101079482

Proyecto cerrado

Fecha de la firma de la CE 4 Agosto 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2025

Financiado con arreglo a

• Widening participation and spreading excellence

Coste total

€ 1 499 887,50

Aportación de la UE

€ 1 499 887,50

Coordinado por

UNIVERSIDADE DE AVEIRO
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Websites, patent fillings, videos etc. (1)

Project website, logo, and collaborative network establishment

Project website, logo, and collaborative network establishment.

Data Management Plan (1)

DMP

DMP.

Publicaciones

Peer reviewed articles (30)

Biohybrid corneal stromal tissue formation using keratocytes encapsulated in supramolecular microgels

Autores: Maritza M. Rovers, Annika F. Vrehen, Patricia Y.W. Dankers
Publicado en: Materials Today Bio, Edición 34, 2026, ISSN 2590-0064
Editor: Elsevier BV
DOI: 10.1016/J.MTBIO.2025.102214

Supramolecular presentation of bioinstructive peptides on soft multilayered nanobiomaterials stimulates neurite outgrowth (SUPRALIFE project publication, RP1)

Autores: Maria Lopes; Marília Torrado; Daryl Barth; Sofia D. Santos; Melike Sever-Bahcekapili; Ayse B. Tekinay; Mustafa O. Guler; Franck Cleymand; Ana P. Pêgo; João Borges; João F. Mano
Publicado en: Biomaterials Science, 2023, ISSN 2047-4830
Editor: Royal Society of Chemistry
DOI: 10.1039/D3BM00438D

Supramolecular assembly of multi-purpose tissue engineering platforms from human extracellular matrix

Autores: Bruno Ladeira, Maria Gomes, Kongchang Wei, Catarina Custódio, João Mano
Publicado en: Biomaterials, Edición 320, 2025, ISSN 0142-9612
Editor: Elsevier BV
DOI: 10.1016/J.BIOMATERIALS.2025.123270

Injectable and self-healable supramolecular hydrogels assembled by quaternised chitosan/alginate polyelectrolyte complexation for sustained drug delivery and cell encapsulation

Autores: Cristiana F. V. Sousa, João Borges, João F. Mano
Publicado en: Biomaterials Science, Edición 13, 2025, ISSN 2047-4830
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5BM00072F

Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel–Cell Interactions

Autores: Laura Rijns, Matthew B. Baker, Patricia Y. W. Dankers
Publicado en: Journal of the American Chemical Society, Edición 146, 2024, ISSN 0002-7863
Editor: American Chemical Society (ACS)
DOI: 10.1021/JACS.4C02980

Self-Supporting Hyaluronic Acid-Functionalized G-Quadruplex-Based Perfusable Multicomponent Hydrogels Embedded in Photo-Cross-Linkable Matrices for Bioapplications (SUPRALIFE project publication, RP1)

Autores: Vera Sousa; Adérito J. R. Amaral; Edgar J. Castanheira; Igor Marques; João M. M. Rodrigues; Vítor Félix; João Borges; João F. Mano
Publicado en: Biomacromolecules, 2023, ISSN 1525-7797
Editor: American Chemical Society
DOI: 10.1021/ACS.BIOMAC.3C00433

Unveiling the Potential of Single‐Cell Encapsulation in Biomedical Applications: Current Advances and Future Perspectives

Autores: Manuel Pires‐Santos, Sara Nadine, João F. Mano
Publicado en: Small Science, Edición 4, 2024, ISSN 2688-4046
Editor: Wiley
DOI: 10.1002/smsc.202300332

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Autores: Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers
Publicado en: Advanced Biology, Edición 9, 2025, ISSN 2701-0198
Editor: Wiley
DOI: 10.1002/ADBI.202400690

Recent Developments in Layer-by-Layer Assembly for Drug Delivery and Tissue Engineering Applications (SUPRALIFE project publication, RP1)

Autores: João Borges, Jinfeng Zeng, Xi Qiu Liu, Hao Chang, Claire Monge, Charlotte Garot, Ke-feng Ren, Paul Machillot, Nihal E. Vrana, Philippe Lavalle, Takami Akagi, Michiya Matsusaki, Jian Ji, Mitsuru Akashi, João F. Mano, Varvara Gribova, Catherine Picart
Publicado en: Advanced Healthcare Materials, 2023, ISSN 2192-2659
Editor: World Scientific
DOI: 10.1002/ADHM.202302713

Natural Polymer-Polyphenol Bioadhesive Coacervate with Stable Wet Adhesion, Antibacterial Activity, and On-Demand Detachment (SUPRALIFE project related publication, RP1)

Autores: Margarida M. A. Sacramento; Mariana B. Oliveira; José R.B. Gomes; João Borges; Benjamin R. Freedman; David J. Mooney; João M. M. Rodrigues; João F. Mano
Publicado en: Advanced Healthcare Materials, 2024, ISSN 2192-2659
Editor: Wiley
DOI: 10.1002/ADHM.202304587

Controlling Intestinal Organoid Polarity using Synthetic Dynamic Hydrogels Decorated with Laminin‐Derived IKVAV Peptides

Autores: Laura Rijns, Joost A. P. M. Wijnakker, Victor A. Veenbrink, Riccardo Bellan, Fenna W. B. Craenmehr, Simone I. S. Hendrikse, Johnick F. van Sprang, Wim de Lau, E. W. Meijer, Hans Clevers, Patricia Y. W. Dankers
Publicado en: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Editor: Wiley
DOI: 10.1002/ADHM.202502079

Supramolecular Additive Screening to Engineer Microfibrous Rafts for Expansion of Pluripotent Stem Cells in Dynamic Suspension

Autores: Johnick F. van Sprang, Jasper G. M. Aarts, Boris Arts, Joyce E. P. Brouns, Muhabbat I. Komil, Paul A. A. Bartels, Patricia Y. W. Dankers
Publicado en: Advanced Healthcare Materials, Edición 14, 2025, ISSN 2192-2640
Editor: Wiley
DOI: 10.1002/ADHM.202404186

Production of recombinant methionine‐containing elastin‐like polypeptides in a fermenter using <scp>ECPM1</scp> medium

Autores: Alice Delhaes, Laure Bataille, Myriam Médéric, Sébastien Lecommandoux, Elisabeth Garanger
Publicado en: Biotechnology Progress, Edición 41, 2025, ISSN 8756-7938
Editor: Wiley
DOI: 10.1002/BTPR.70057

Synthetic, multi-dynamic hydrogels by uniting stress-stiffening and supramolecular polymers

Autores: Laura Rijns, Martin G. T. A. Rutten, Riccardo Bellan, Hongbo Yuan, Mauro L. Mugnai, Susana Rocha, Emanuela del Gado, Paul H. J. Kouwer, Patricia Y. W. Dankers
Publicado en: Science Advances, Edición 10, 2024, ISSN 2375-2548
Editor: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.ADR3209

Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity

Autores: Vera Sousa, Bruno Ladeira, Elisabeth Garanger, Sébastien Lecommandoux, E. W. Meijer, Patricia Y. W. Dankers, João F. Mano, João Borges
Publicado en: ACS Nano, Edición 19, 2025, ISSN 1936-0851
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACSNANO.5C10088

Employing the SpyTag-SpyCatcher Reaction for the Modification of Supramolecular Polymers with Functional Proteins

Autores: Fenna W.B. Craenmehr, Alexander Gräwe, Victor A. Veenbrink, Riccardo Bellan, Maarten Merkx, Patricia Y.W. Dankers
Publicado en: Bioconjugate Chemistry, Edición 36, 2025, ISSN 1043-1802
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOCONJCHEM.5C00046

Thiol-ene click chemistry: Enabling 3D printing of natural-based inks for biomedical applications

Autores: Andreia P. Malafaia, Rita Sobreiro-Almeida, João M.M. Rodrigues, João F. Mano
Publicado en: Biomaterials Advances, Edición 167, 2024, ISSN 2772-9508
Editor: Elsevier BV
DOI: 10.1016/J.BIOADV.2024.214105

Marine-Origin Polysaccharides and Their Chemically Modified Derivatives as Sources of Advanced Biofunctional Materials for Biomedical Applications

Autores: Vera Sousa, Luís P. G. Monteiro, Djenisa H. A. Rocha, João M. M. Rodrigues, João Borges, João F. Mano
Publicado en: Biomacromolecules, Edición 26, 2025, ISSN 1525-7797
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOMAC.4C01682

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

Autores: Cátia F. Monteiro, Maria C. Gomes, Pankaj Bharmoria, Mara G. Freire, João A. P. Coutinho, Catarina A. Custódio, João F. Mano
Publicado en: ACS Nano, 2024, ISSN 1936-086X
Editor: American Chemical Society
DOI: 10.1021/ACSNANO.4C02790

Co‐Assembled Supramolecular Hydrogelators Enhance Glomerulogenesis in Kidney Organoids Through Cell‐Adhesive Motifs

Autores: Johnick F. van Sprang, Jasper G.M. Aarts, Martin G.T.A. Rutten, Laura Rijns, Bart M. Tiemeijer, Maaike J.G. Schotman, Patricia Y.W. Dankers
Publicado en: Advanced Functional Materials, Edición 34, 2025, ISSN 1616-301X
Editor: Wiley
DOI: 10.1002/ADFM.202404786

Monomer exchange dynamics in ureido–pyrimidinone supramolecular polymers <i>via</i> molecular simulations

Autores: Annalisa Cardellini, Cristina Caruso, Laura Rijns, Patricia Y. W. Dankers, Giovanni M. Pavan, Claudio Perego
Publicado en: Journal of Materials Chemistry B, Edición 13, 2025, ISSN 2050-750X
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5TB01272D

Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular Biomaterials (SUPRALIFE project related publication, RP1)

Autores: Moniek G. J. Schmitz, Jasper G. M. Aarts, Laurence Burroughs, Phanikrishna Sudarsanam, Tim J. M. Kuijpers, Martijn Riool, Leonie de Boer, Xuan Xue, Dragan Bosnacki, Sebastian A. J. Zaat, Jan de Boer, Morgan R. Alexander, Patricia Y. W. Dankers
Publicado en: Macromolecular Rapid Communications, 2024, ISSN 1022-1336
Editor: John Wiley & Sons Ltd.
DOI: 10.1002/MARC.202300638

Collagen type I mimicking peptide additives to functionalize synthetic supramolecular hydrogels (SUPRALIFE project related publication, RP1)

Autores: Annika F. Vrehen, Johnick F. van Sprang, Maaike J.G. Schotman, Patricia Y.W. Dankers
Publicado en: Materials Today Bio, 2024, ISSN 2590-0064
Editor: Elsevier
DOI: 10.1016/J.MTBIO.2024.101021

Mimicking the extracellular world: from natural to fully synthetic matrices utilizing supramolecular biomaterials

Autores: Laura Rijns, Martin G. T. A. Rutten, Annika F. Vrehen, Ana A. Aldana, Matthew B. Baker, Patricia Y. W. Dankers
Publicado en: Nanoscale, Edición 16, 2024, ISSN 2040-3364
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4NR02088J

Marine-origin polysaccharides-based free-standing multilayered membranes as sustainable nanoreservoirs for controlled drug delivery (SUPRALIFE project related publication, RP1)

Autores: Cristiana F. V. Sousa; Luís P. G. Monteiro; João M. M. Rodrigues; João Borges; João F. Mano
Publicado en: Journal of Materials Chemistry B, 2023, ISSN 2050-7518
Editor: Royal Society of Chemistry
DOI: 10.1039/D3TB00796K

Using a Supramolecular Monomer Formulation Approach to Engineer Modular, Dynamic Microgels, and Composite Macrogels

Autores: Maritza M. Rovers, Theodora Rogkoti, Bram K. Bakker, Kalpit J. Bakal, Marcel H.P. van Genderen, Manuel Salmeron‐Sanchez, Patricia Y.W. Dankers
Publicado en: Advanced Materials, Edición 36, 2024, ISSN 0935-9648
Editor: Wiley
DOI: 10.1002/ADMA.202405868

Cell Surface Engineering Tools for Programming Living Assemblies (SUPRALIFE project related publication, RP1)

Autores: José Almeida-Pinto, Matilde R. Lagarto, Pedro Lavrador, João F. Mano, Vítor M. Gaspar
Publicado en: Advanced Science, 2023, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/ADVS.202304040

Acidochromic Free-Standing Multilayered Chitosan-Pyranoflavylium/Alginate Membranes toward Food Smart Packaging Applications

Autores: Mariana Cunha, Victor de Freitas, João Borges, João F. Mano, João M. M. Rodrigues, Luís Cruz
Publicado en: ACS Applied Polymer Materials, 2024, ISSN 2637-6105
Editor: American Chemical Society
DOI: 10.1021/ACSAPM.4C01085

From natural to synthetic hydrogels: how much biochemical complexity is required for mechanotransduction?

Autores: Johnick F. van Sprang, Imke P. M. Smits, Jasper C. H. Nooten, Peter-Paul K. H. Fransen, Serge H. M. Söntjens, Michel H. C. J. van Houtem, Henk M. Janssen, Martin G. T. A. Rutten, Maaike J. G. Schotman, P. Y. W. Dankers
Publicado en: Journal of Materials Chemistry B, Edición 13, 2025, ISSN 2050-750X
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4TB01774A

Molecularly Engineered Supramolecular Thermoresponsive Hydrogels with Tunable Mechanical and Dynamic Properties

Autores: Laura Rijns, Heleen Duijs, René P. M. Lafleur, Ruth Cardinaels, Anja R. A. Palmans, Patricia Y. W. Dankers, Lu Su
Publicado en: Biomacromolecules, Edición 25, 2024, ISSN 1525-7797
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.BIOMAC.3C01357