COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Livrables

Report on the status of posting results at the end of the retrospective study Train-METASTRA

Report detailing the status of posting results at the end of the retrospective study (Train-METASTRA)

Communication material tailored to target-group, including material for policymakers, and material in layman's language

Midterm recruitment report for Train-METASTRA

It will be generated when 50% of the EHRs will be replicated through the transient loading zone from the primary hospital systems to the AlmaHealthDB servers. It will include an overview of the number of EHRs collected in each clinical site, indicating any problems in the process and measures eventually adopted to compensate for any delays.

Software documentation templates

The report will contain the templates for software documentation

Approval of ex vivo study by Ethics Committees of UNIBO and USFD

Ethics documentation for the ex vivo study (anatomical specimens from human donors) by Ethics Committees of UNIBO and USFD

Study initiation package for Validate-METASTRA study

Submission package, prior to enrolment of first subject, containing the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities

Publications

Generation of severely scoliotic subject-specific musculoskeletal models

Auteurs: Samuele Luca Gould, Giorgio Davico, Monica Cosentino, Luca Cristofolini, Marco Viceconti
Publié dans: PLOS One, Numéro 20, 2025, ISSN 1932-6203
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0336211

Microstructure of the human metastatic vertebral body

Auteurs: Giulia Cavazzoni, Enrico Dall’Ara, Marco Palanca
Publié dans: Frontiers in Endocrinology, Numéro 15, 2025, ISSN 1664-2392
Éditeur: Frontiers Media SA
DOI: 10.3389/fendo.2024.1508504

THE METASTRA PROJECT: DEVELOPMENT AND VALIDATION OF COMPUTATIONAL TOOLS TO STRATIFY PATIENTS WITH VERTEBRAL METASTASES AT RISK OF FRACTURE

Auteurs: Luca Cristofolini, Giovanni Barbanti-Bròdano, Enrico Dall'Ara, Rudolf Ferenc, Stephen J Ferguson, José Manuel García-Aznar, Aron Lazary, Peter Vajkoczy, Jorrit-Jan Verlaan, László Vidács
Publié dans: Orthopaedic Proceedings, Numéro 107-B, 2025, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.091

Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion

Auteurs: Margherita Pasini, Giulia Cavazzoni, Enrico Dall’Ara, Samuele Luca Gould, Christine Le Maitre, Luca Cristofolini, Marco Palanca
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, Numéro 170, 2026, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.107109

Variability of intervertebral joint stiffness between specimens and spine levels

Auteurs: Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1372088

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Auteurs: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Publié dans: Jornada de Jóvenes Investigadores del I3A, Numéro 12, 2024, ISSN 2341-4790
Éditeur: Universidad de Zaragoza
DOI: 10.26754/jjii3a.202410652

Identification of a lumped-parameter model of the intervertebral joint from experimental data

Auteurs: Samuele L. Gould, Giorgio Davico, Marco Palanca, Marco Viceconti, Luca Cristofolini
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1304334

Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies

Auteurs: Giulia Cavazzoni, Margherita Pasini, Christine L. Le Maitre, Enrico Dall'Ara, Marco Palanca
Publié dans: Acta Biomaterialia, 2025, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.018

Development and Mechanical Testing of Synthetic 3D-Printed Models of Healthy and Metastatic Vertebrae

Auteurs: Daniela Bruno, Riccardo Forni, Marco Palanca, Luca Cristofolini, Paolo Gargiulo
Publié dans: Journal of Manufacturing and Materials Processing, Numéro 9, 2025, ISSN 2504-4494
Éditeur: MDPI AG
DOI: 10.3390/JMMP9110373

Diagnostic accuracy of dual-layer spectral CT for osteolytic vertebral metastases

Auteurs: Simone van der Star, Netanja I. Harlianto, Stéphanie V. de Lange, Jorrit-Jan Verlaan, Arnold M. R. Schilham, Madeleine Kok, Pim A. de Jong, Wouter Foppen
Publié dans: Skeletal Radiology, Numéro 55, 2025, ISSN 0364-2348
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S00256-025-05023-Z

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Auteurs: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Publié dans: Jornada de Jóvenes Investigadores del I3A, Numéro 12, 2024, ISSN 2341-4790
Éditeur: Universidad de Zaragoza
DOI: 10.26754/JJII3A.202410652

Prediction of compressive strength of vertebral body with metastatic lesions based on quantitative computed tomography-based subject-specific finite element models

Auteurs: Rajdeep Ghosh, Eddie Shearman, Robert Roger, Marco Palanca, Enrico Dall'Ara, Damien Lacroix
Publié dans: Bone, Numéro 211, 2026, ISSN 8756-3282
Éditeur: Elsevier BV
DOI: 10.1016/J.BONE.2026.117961

WHY TECHNICAL INNOVATIONS ARE NEEDED TO FACILITATE BETTER CHARACTERIZATION OF PATHOLOGICAL FRACTURES IN METASTATIC SPINAL DISEASE

Auteurs: Jorrit-Jan Verlaan, Peter Vajkoczy, Gastone Castellani, Giovanni Barbanti Bròdano, Floris van Tol, Anne Versteeg, Aron Lazary
Publié dans: Orthopaedic Proceedings, Numéro 107-B, 2025, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.095

CLINICALLY RELEVANT PARAMETERS TO STRATIFY THE RISK OF FRACTURE IN VERTEBRAE WITH METASTASES: INSIGHT FROM BIOMECHANICAL EXPERIMENTS

Auteurs: Marco Palanca, Giulia Cavazzoni, Margherita Pasini, Enrico Dall'Ara, Luca Cristofolini
Publié dans: Orthopaedic Proceedings, Numéro 107-B, 2025, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.092

METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Auteurs: L. Cristofolini, B. B. bròdano, E. Dall’Ara, R. Ferenc, S. J Ferguson, J. M. García-Aznar, A. Lazary, P. Vajkoczy, Jorrit-Jan Verlaan, L. Vidacs
Publié dans: Orthopaedic Proceedings, Numéro 106-B, 2024, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2024.18.059

Assessing the reproducibility of a subject-specific finite element modelling pipeline for the human metastatic vertebrae

Auteurs: Robert Roger, Rajdeep Ghosh, Yuanrui Cai, Fiona Gibson, Áron Lazáry, Lingzhong Guo, Damien Lacroix, Enrico Dall’Ara
Publié dans: Scientific Reports, Numéro 16, 2026, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-46900-4

Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements

Auteurs: Chiara Garavelli, Alessandra Aldieri, Marco Palanca, Enrico Dall’Ara, Marco Viceconti
Publié dans: Biomechanics and Modeling in Mechanobiology, Numéro 24, 2025, ISSN 1617-7959
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S10237-025-01950-X

WE NEED TO BETTER ASSESS THE RISK OF FRACTURE IN SPINE METASTATIC PATIENTS

Auteurs: Giovanni Barbanti Brodano, Aron Lazary, Sabato Mellone, Jorrit-Jan Verlaan, Cristiana Griffoni, Peter Vajkoczy
Publié dans: Orthopaedic Proceedings, Numéro 107-B, 2025, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.096

COMPARISON OF SPINAL LOAD PREDICTIONS FROM MUSCULOSKELETAL AND STATISTICAL SHAPE MODELLING

Auteurs: Florian Rieger, Guillem Fernandez, Enrico Dall'Ara, Dominique A. Rothenfluh, Stephen J. Ferguson, Dominika Ignasiak
Publié dans: Orthopaedic Proceedings, Numéro 107-B, 2025, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.094

Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine

Auteurs: Sara Montanari, Giovanni Barbanti Bròdano, Elena Serchi, Rita Stagni, Alessandro Gasbarrini, Alfredo Conti, Luca Cristofolini
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-80741-3

A GDPR-Aligned Infrastructure Enabling Secure Multicenter Research Studies

Auteurs: Serena Moscato, Cleiston Rodrigues Da Silva, Antonino Amedeo La Mattina, Valerio Antonio Arcobelli, Sabato Mellone
Publié dans: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Éditeur: IOS Press
DOI: 10.3233/SHTI260474

Toward Interoperable Variable Definitions: A FHIR-Based Standardization Strategy for the METASTRA Project

Auteurs: Serena Moscato, Alberto Marfoglia, Valerio Antonio Arcobelli, Maria Rita Intagliata, Cristiana Griffoni, Giovanni Barbanti-Bròdano, Alessandro Gasbarrini, Antonella Carbonaro, Sabato Mellone
Publié dans: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Éditeur: IOS Press
DOI: 10.3233/SHTI260393

Resultats de projets

Livrables

Publications

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