COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Informations projet

METASTRA

N° de convention de subvention: 101080135

DOI

10.3030/101080135

Date de signature de la CE 14 Mars 2023

Date de début 1 Juillet 2023

Date de fin 30 Juin 2028

Financé au titre de

• Health

Coût total

€ 5 087 742,50

Contribution de l’UE

€ 5 087 742,50

Coordonné par

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

Midterm recruitment report for Train-METASTRA

It will be generated when 50% of the EHRs will be replicated through the transient loading zone from the primary hospital systems to the AlmaHealthDB servers. It will include an overview of the number of EHRs collected in each clinical site, indicating any problems in the process and measures eventually adopted to compensate for any delays.

METASTRA Communication Toolkit

Communication material tailored to target-group, including material for policymakers, and material in layman's language

Report on the status of posting results at the end of the retrospective study Train-METASTRA

Report detailing the status of posting results at the end of the retrospective study (Train-METASTRA)

Software documentation templates

The report will contain the templates for software documentation

Other (2)

Study initiation package for Validate-METASTRA study

Submission package, prior to enrolment of first subject, containing the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities

Approval of ex vivo study by Ethics Committees of UNIBO and USFD

Ethics documentation for the ex vivo study (anatomical specimens from human donors) by Ethics Committees of UNIBO and USFD

Websites, patent fillings, videos etc. (1)

Public project website

Public website of the METASTRA project

Publications

Peer reviewed articles (7)

Microstructure of the human metastatic vertebral body

Auteurs: Giulia Cavazzoni, Enrico Dall’Ara, Marco Palanca
Publié dans: Frontiers in Endocrinology, Numéro 15, 2025, ISSN 1664-2392
Éditeur: Frontiers Media SA
DOI: 10.3389/fendo.2024.1508504

Variability of intervertebral joint stiffness between specimens and spine levels

Auteurs: Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1372088

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Auteurs: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Publié dans: Jornada de Jóvenes Investigadores del I3A, Numéro 12, 2024, ISSN 2341-4790
Éditeur: Universidad de Zaragoza
DOI: 10.26754/jjii3a.202410652

Identification of a lumped-parameter model of the intervertebral joint from experimental data

Auteurs: Samuele L. Gould, Giorgio Davico, Marco Palanca, Marco Viceconti, Luca Cristofolini
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 12, 2024, ISSN 2296-4185
Éditeur: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1304334

Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies

Auteurs: Giulia Cavazzoni, Margherita Pasini, Christine L. Le Maitre, Enrico Dall'Ara, Marco Palanca
Publié dans: Acta Biomaterialia, 2025, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.018

METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Auteurs: L. Cristofolini, B. B. bròdano, E. Dall’Ara, R. Ferenc, S. J Ferguson, J. M. García-Aznar, A. Lazary, P. Vajkoczy, Jorrit-Jan Verlaan, L. Vidacs
Publié dans: Orthopaedic Proceedings, Numéro 106-B, 2024, ISSN 1358-992X
Éditeur: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2024.18.059

Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine

Auteurs: Sara Montanari, Giovanni Barbanti Bròdano, Elena Serchi, Rita Stagni, Alessandro Gasbarrini, Alfredo Conti, Luca Cristofolini
Publié dans: Scientific Reports, Numéro 14, 2024, ISSN 2045-2322
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-80741-3