COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Project Information

METASTRA

Grant agreement ID: 101080135

DOI

10.3030/101080135

EC signature date 14 March 2023

Start date 1 July 2023

End date 30 June 2028

Funded under

• Health

Total cost

€ 5 087 742,50

EU contribution

€ 5 087 742,50

Coordinated by

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (4)

Report on the status of posting results at the end of the retrospective study Train-METASTRA

Report detailing the status of posting results at the end of the retrospective study (Train-METASTRA)

METASTRA Communication Toolkit

Communication material tailored to target-group, including material for policymakers, and material in layman's language

Midterm recruitment report for Train-METASTRA

It will be generated when 50% of the EHRs will be replicated through the transient loading zone from the primary hospital systems to the AlmaHealthDB servers. It will include an overview of the number of EHRs collected in each clinical site, indicating any problems in the process and measures eventually adopted to compensate for any delays.

Software documentation templates

The report will contain the templates for software documentation

Websites, patent fillings, videos etc. (1)

Public project website

Public website of the METASTRA project

Other (2)

Approval of ex vivo study by Ethics Committees of UNIBO and USFD

Ethics documentation for the ex vivo study (anatomical specimens from human donors) by Ethics Committees of UNIBO and USFD

Study initiation package for Validate-METASTRA study

Submission package, prior to enrolment of first subject, containing the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities

Publications

Peer reviewed articles (20)

Generation of severely scoliotic subject-specific musculoskeletal models

Author(s): Samuele Luca Gould, Giorgio Davico, Monica Cosentino, Luca Cristofolini, Marco Viceconti
Published in: PLOS One, Issue 20, 2025, ISSN 1932-6203
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0336211

Microstructure of the human metastatic vertebral body

Author(s): Giulia Cavazzoni, Enrico Dall’Ara, Marco Palanca
Published in: Frontiers in Endocrinology, Issue 15, 2025, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2024.1508504

THE METASTRA PROJECT: DEVELOPMENT AND VALIDATION OF COMPUTATIONAL TOOLS TO STRATIFY PATIENTS WITH VERTEBRAL METASTASES AT RISK OF FRACTURE

Author(s): Luca Cristofolini, Giovanni Barbanti-Bròdano, Enrico Dall'Ara, Rudolf Ferenc, Stephen J Ferguson, José Manuel García-Aznar, Aron Lazary, Peter Vajkoczy, Jorrit-Jan Verlaan, László Vidács
Published in: Orthopaedic Proceedings, Issue 107-B, 2025, ISSN 1358-992X
Publisher: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.091

Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion

Author(s): Margherita Pasini, Giulia Cavazzoni, Enrico Dall’Ara, Samuele Luca Gould, Christine Le Maitre, Luca Cristofolini, Marco Palanca
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 170, 2026, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.107109

Variability of intervertebral joint stiffness between specimens and spine levels

Author(s): Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Published in: Frontiers in Bioengineering and Biotechnology, Issue 12, 2024, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1372088

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Author(s): Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Published in: Jornada de Jóvenes Investigadores del I3A, Issue 12, 2024, ISSN 2341-4790
Publisher: Universidad de Zaragoza
DOI: 10.26754/jjii3a.202410652

Identification of a lumped-parameter model of the intervertebral joint from experimental data

Author(s): Samuele L. Gould, Giorgio Davico, Marco Palanca, Marco Viceconti, Luca Cristofolini
Published in: Frontiers in Bioengineering and Biotechnology, Issue 12, 2024, ISSN 2296-4185
Publisher: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1304334

Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies

Author(s): Giulia Cavazzoni, Margherita Pasini, Christine L. Le Maitre, Enrico Dall'Ara, Marco Palanca
Published in: Acta Biomaterialia, 2025, ISSN 1742-7061
Publisher: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.018

Development and Mechanical Testing of Synthetic 3D-Printed Models of Healthy and Metastatic Vertebrae

Author(s): Daniela Bruno, Riccardo Forni, Marco Palanca, Luca Cristofolini, Paolo Gargiulo
Published in: Journal of Manufacturing and Materials Processing, Issue 9, 2025, ISSN 2504-4494
Publisher: MDPI AG
DOI: 10.3390/JMMP9110373

Diagnostic accuracy of dual-layer spectral CT for osteolytic vertebral metastases

Author(s): Simone van der Star, Netanja I. Harlianto, Stéphanie V. de Lange, Jorrit-Jan Verlaan, Arnold M. R. Schilham, Madeleine Kok, Pim A. de Jong, Wouter Foppen
Published in: Skeletal Radiology, Issue 55, 2025, ISSN 0364-2348
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00256-025-05023-Z

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Author(s): Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Published in: Jornada de Jóvenes Investigadores del I3A, Issue 12, 2024, ISSN 2341-4790
Publisher: Universidad de Zaragoza
DOI: 10.26754/JJII3A.202410652

Prediction of compressive strength of vertebral body with metastatic lesions based on quantitative computed tomography-based subject-specific finite element models

Author(s): Rajdeep Ghosh, Eddie Shearman, Robert Roger, Marco Palanca, Enrico Dall'Ara, Damien Lacroix
Published in: Bone, Issue 211, 2026, ISSN 8756-3282
Publisher: Elsevier BV
DOI: 10.1016/J.BONE.2026.117961

WHY TECHNICAL INNOVATIONS ARE NEEDED TO FACILITATE BETTER CHARACTERIZATION OF PATHOLOGICAL FRACTURES IN METASTATIC SPINAL DISEASE

Author(s): Jorrit-Jan Verlaan, Peter Vajkoczy, Gastone Castellani, Giovanni Barbanti Bròdano, Floris van Tol, Anne Versteeg, Aron Lazary
Published in: Orthopaedic Proceedings, Issue 107-B, 2025, ISSN 1358-992X
Publisher: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.095

CLINICALLY RELEVANT PARAMETERS TO STRATIFY THE RISK OF FRACTURE IN VERTEBRAE WITH METASTASES: INSIGHT FROM BIOMECHANICAL EXPERIMENTS

Author(s): Marco Palanca, Giulia Cavazzoni, Margherita Pasini, Enrico Dall'Ara, Luca Cristofolini
Published in: Orthopaedic Proceedings, Issue 107-B, 2025, ISSN 1358-992X
Publisher: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.092

METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Author(s): L. Cristofolini, B. B. bròdano, E. Dall’Ara, R. Ferenc, S. J Ferguson, J. M. García-Aznar, A. Lazary, P. Vajkoczy, Jorrit-Jan Verlaan, L. Vidacs
Published in: Orthopaedic Proceedings, Issue 106-B, 2024, ISSN 1358-992X
Publisher: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2024.18.059

Assessing the reproducibility of a subject-specific finite element modelling pipeline for the human metastatic vertebrae

Author(s): Robert Roger, Rajdeep Ghosh, Yuanrui Cai, Fiona Gibson, Áron Lazáry, Lingzhong Guo, Damien Lacroix, Enrico Dall’Ara
Published in: Scientific Reports, Issue 16, 2026, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-46900-4

Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements

Author(s): Chiara Garavelli, Alessandra Aldieri, Marco Palanca, Enrico Dall’Ara, Marco Viceconti
Published in: Biomechanics and Modeling in Mechanobiology, Issue 24, 2025, ISSN 1617-7959
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S10237-025-01950-X

WE NEED TO BETTER ASSESS THE RISK OF FRACTURE IN SPINE METASTATIC PATIENTS

Author(s): Giovanni Barbanti Brodano, Aron Lazary, Sabato Mellone, Jorrit-Jan Verlaan, Cristiana Griffoni, Peter Vajkoczy
Published in: Orthopaedic Proceedings, Issue 107-B, 2025, ISSN 1358-992X
Publisher: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.096

COMPARISON OF SPINAL LOAD PREDICTIONS FROM MUSCULOSKELETAL AND STATISTICAL SHAPE MODELLING

Author(s): Florian Rieger, Guillem Fernandez, Enrico Dall'Ara, Dominique A. Rothenfluh, Stephen J. Ferguson, Dominika Ignasiak
Published in: Orthopaedic Proceedings, Issue 107-B, 2025, ISSN 1358-992X
Publisher: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.094

Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine

Author(s): Sara Montanari, Giovanni Barbanti Bròdano, Elena Serchi, Rita Stagni, Alessandro Gasbarrini, Alfredo Conti, Luca Cristofolini
Published in: Scientific Reports, Issue 14, 2024, ISSN 2045-2322
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-80741-3

Book chapters (2)

A GDPR-Aligned Infrastructure Enabling Secure Multicenter Research Studies

Author(s): Serena Moscato, Cleiston Rodrigues Da Silva, Antonino Amedeo La Mattina, Valerio Antonio Arcobelli, Sabato Mellone
Published in: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Publisher: IOS Press
DOI: 10.3233/SHTI260474

Toward Interoperable Variable Definitions: A FHIR-Based Standardization Strategy for the METASTRA Project

Author(s): Serena Moscato, Alberto Marfoglia, Valerio Antonio Arcobelli, Maria Rita Intagliata, Cristiana Griffoni, Giovanni Barbanti-Bròdano, Alessandro Gasbarrini, Antonella Carbonaro, Sabato Mellone
Published in: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Publisher: IOS Press
DOI: 10.3233/SHTI260393