COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Informacje na temat projektu

METASTRA

Identyfikator umowy o grant: 101080135

DOI

10.3030/101080135

Data podpisania przez KE 14 Marca 2023

Data rozpoczęcia 1 Lipca 2023

Data zakończenia 30 Czerwca 2028

Finansowanie w ramach

Health

Koszt całkowity

€ 5 087 742,50

Wkład UE

€ 5 087 742,50

5 087 742,50

Koordynowany przez

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy

CORDIS oferuje możliwość skorzystania z odnośników do publicznie dostępnych publikacji i rezultatów projektów realizowanych w ramach programów ramowych HORYZONT.

Odnośniki do rezultatów i publikacji związanych z poszczególnymi projektami 7PR, a także odnośniki do niektórych konkretnych kategorii wyników, takich jak zbiory danych i oprogramowanie, są dynamicznie pobierane z systemu OpenAIRE .

Rezultaty

Report on the status of posting results at the end of the retrospective study Train-METASTRA

Report detailing the status of posting results at the end of the retrospective study (Train-METASTRA)

METASTRA Communication Toolkit

Communication material tailored to target-group, including material for policymakers, and material in layman's language

Midterm recruitment report for Train-METASTRA

It will be generated when 50% of the EHRs will be replicated through the transient loading zone from the primary hospital systems to the AlmaHealthDB servers. It will include an overview of the number of EHRs collected in each clinical site, indicating any problems in the process and measures eventually adopted to compensate for any delays.

Software documentation templates

The report will contain the templates for software documentation

Approval of ex vivo study by Ethics Committees of UNIBO and USFD

Ethics documentation for the ex vivo study (anatomical specimens from human donors) by Ethics Committees of UNIBO and USFD

Study initiation package for Validate-METASTRA study

Submission package, prior to enrolment of first subject, containing the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities

Publikacje

Generation of severely scoliotic subject-specific musculoskeletal models

Autorzy: Samuele Luca Gould, Giorgio Davico, Monica Cosentino, Luca Cristofolini, Marco Viceconti
Opublikowane w: PLOS One, Numer 20, 2025, ISSN 1932-6203
Wydawca: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0336211

Microstructure of the human metastatic vertebral body

Autorzy: Giulia Cavazzoni, Enrico Dall’Ara, Marco Palanca
Opublikowane w: Frontiers in Endocrinology, Numer 15, 2025, ISSN 1664-2392
Wydawca: Frontiers Media SA
DOI: 10.3389/fendo.2024.1508504

THE METASTRA PROJECT: DEVELOPMENT AND VALIDATION OF COMPUTATIONAL TOOLS TO STRATIFY PATIENTS WITH VERTEBRAL METASTASES AT RISK OF FRACTURE

Autorzy: Luca Cristofolini, Giovanni Barbanti-Bròdano, Enrico Dall'Ara, Rudolf Ferenc, Stephen J Ferguson, José Manuel García-Aznar, Aron Lazary, Peter Vajkoczy, Jorrit-Jan Verlaan, László Vidács
Opublikowane w: Orthopaedic Proceedings, Numer 107-B, 2025, ISSN 1358-992X
Wydawca: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.091

Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion

Autorzy: Margherita Pasini, Giulia Cavazzoni, Enrico Dall’Ara, Samuele Luca Gould, Christine Le Maitre, Luca Cristofolini, Marco Palanca
Opublikowane w: Journal of the Mechanical Behavior of Biomedical Materials, Numer 170, 2026, ISSN 1751-6161
Wydawca: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.107109

Variability of intervertebral joint stiffness between specimens and spine levels

Autorzy: Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 12, 2024, ISSN 2296-4185
Wydawca: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1372088

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Autorzy: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Opublikowane w: Jornada de Jóvenes Investigadores del I3A, Numer 12, 2024, ISSN 2341-4790
Wydawca: Universidad de Zaragoza
DOI: 10.26754/jjii3a.202410652

Identification of a lumped-parameter model of the intervertebral joint from experimental data

Autorzy: Samuele L. Gould, Giorgio Davico, Marco Palanca, Marco Viceconti, Luca Cristofolini
Opublikowane w: Frontiers in Bioengineering and Biotechnology, Numer 12, 2024, ISSN 2296-4185
Wydawca: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1304334

Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies

Autorzy: Giulia Cavazzoni, Margherita Pasini, Christine L. Le Maitre, Enrico Dall'Ara, Marco Palanca
Opublikowane w: Acta Biomaterialia, 2025, ISSN 1742-7061
Wydawca: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.018

Development and Mechanical Testing of Synthetic 3D-Printed Models of Healthy and Metastatic Vertebrae

Autorzy: Daniela Bruno, Riccardo Forni, Marco Palanca, Luca Cristofolini, Paolo Gargiulo
Opublikowane w: Journal of Manufacturing and Materials Processing, Numer 9, 2025, ISSN 2504-4494
Wydawca: MDPI AG
DOI: 10.3390/JMMP9110373

Diagnostic accuracy of dual-layer spectral CT for osteolytic vertebral metastases

Autorzy: Simone van der Star, Netanja I. Harlianto, Stéphanie V. de Lange, Jorrit-Jan Verlaan, Arnold M. R. Schilham, Madeleine Kok, Pim A. de Jong, Wouter Foppen
Opublikowane w: Skeletal Radiology, Numer 55, 2025, ISSN 0364-2348
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S00256-025-05023-Z

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Prediction of compressive strength of vertebral body with metastatic lesions based on quantitative computed tomography-based subject-specific finite element models

Autorzy: Rajdeep Ghosh, Eddie Shearman, Robert Roger, Marco Palanca, Enrico Dall'Ara, Damien Lacroix
Opublikowane w: Bone, Numer 211, 2026, ISSN 8756-3282
Wydawca: Elsevier BV
DOI: 10.1016/J.BONE.2026.117961

WHY TECHNICAL INNOVATIONS ARE NEEDED TO FACILITATE BETTER CHARACTERIZATION OF PATHOLOGICAL FRACTURES IN METASTATIC SPINAL DISEASE

Autorzy: Jorrit-Jan Verlaan, Peter Vajkoczy, Gastone Castellani, Giovanni Barbanti Bròdano, Floris van Tol, Anne Versteeg, Aron Lazary
Opublikowane w: Orthopaedic Proceedings, Numer 107-B, 2025, ISSN 1358-992X
Wydawca: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.095

CLINICALLY RELEVANT PARAMETERS TO STRATIFY THE RISK OF FRACTURE IN VERTEBRAE WITH METASTASES: INSIGHT FROM BIOMECHANICAL EXPERIMENTS

Autorzy: Marco Palanca, Giulia Cavazzoni, Margherita Pasini, Enrico Dall'Ara, Luca Cristofolini
Opublikowane w: Orthopaedic Proceedings, Numer 107-B, 2025, ISSN 1358-992X
Wydawca: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.092

METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Autorzy: L. Cristofolini, B. B. bròdano, E. Dall’Ara, R. Ferenc, S. J Ferguson, J. M. García-Aznar, A. Lazary, P. Vajkoczy, Jorrit-Jan Verlaan, L. Vidacs
Opublikowane w: Orthopaedic Proceedings, Numer 106-B, 2024, ISSN 1358-992X
Wydawca: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2024.18.059

Assessing the reproducibility of a subject-specific finite element modelling pipeline for the human metastatic vertebrae

Autorzy: Robert Roger, Rajdeep Ghosh, Yuanrui Cai, Fiona Gibson, Áron Lazáry, Lingzhong Guo, Damien Lacroix, Enrico Dall’Ara
Opublikowane w: Scientific Reports, Numer 16, 2026, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-46900-4

Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements

Autorzy: Chiara Garavelli, Alessandra Aldieri, Marco Palanca, Enrico Dall’Ara, Marco Viceconti
Opublikowane w: Biomechanics and Modeling in Mechanobiology, Numer 24, 2025, ISSN 1617-7959
Wydawca: Springer Science and Business Media LLC
DOI: 10.1007/S10237-025-01950-X

WE NEED TO BETTER ASSESS THE RISK OF FRACTURE IN SPINE METASTATIC PATIENTS

Autorzy: Giovanni Barbanti Brodano, Aron Lazary, Sabato Mellone, Jorrit-Jan Verlaan, Cristiana Griffoni, Peter Vajkoczy
Opublikowane w: Orthopaedic Proceedings, Numer 107-B, 2025, ISSN 1358-992X
Wydawca: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.096

COMPARISON OF SPINAL LOAD PREDICTIONS FROM MUSCULOSKELETAL AND STATISTICAL SHAPE MODELLING

Autorzy: Florian Rieger, Guillem Fernandez, Enrico Dall'Ara, Dominique A. Rothenfluh, Stephen J. Ferguson, Dominika Ignasiak
Opublikowane w: Orthopaedic Proceedings, Numer 107-B, 2025, ISSN 1358-992X
Wydawca: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.094

Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine

Autorzy: Sara Montanari, Giovanni Barbanti Bròdano, Elena Serchi, Rita Stagni, Alessandro Gasbarrini, Alfredo Conti, Luca Cristofolini
Opublikowane w: Scientific Reports, Numer 14, 2024, ISSN 2045-2322
Wydawca: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-80741-3

A GDPR-Aligned Infrastructure Enabling Secure Multicenter Research Studies

Autorzy: Serena Moscato, Cleiston Rodrigues Da Silva, Antonino Amedeo La Mattina, Valerio Antonio Arcobelli, Sabato Mellone
Opublikowane w: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Wydawca: IOS Press
DOI: 10.3233/SHTI260474

Toward Interoperable Variable Definitions: A FHIR-Based Standardization Strategy for the METASTRA Project

Autorzy: Serena Moscato, Alberto Marfoglia, Valerio Antonio Arcobelli, Maria Rita Intagliata, Cristiana Griffoni, Giovanni Barbanti-Bròdano, Alessandro Gasbarrini, Antonella Carbonaro, Sabato Mellone
Opublikowane w: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Wydawca: IOS Press
DOI: 10.3233/SHTI260393

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