COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Risultati finali

Report on the status of posting results at the end of the retrospective study Train-METASTRA

Report detailing the status of posting results at the end of the retrospective study (Train-METASTRA)

Communication material tailored to target-group, including material for policymakers, and material in layman's language

Midterm recruitment report for Train-METASTRA

It will be generated when 50% of the EHRs will be replicated through the transient loading zone from the primary hospital systems to the AlmaHealthDB servers. It will include an overview of the number of EHRs collected in each clinical site, indicating any problems in the process and measures eventually adopted to compensate for any delays.

Software documentation templates

The report will contain the templates for software documentation

Approval of ex vivo study by Ethics Committees of UNIBO and USFD

Ethics documentation for the ex vivo study (anatomical specimens from human donors) by Ethics Committees of UNIBO and USFD

Study initiation package for Validate-METASTRA study

Submission package, prior to enrolment of first subject, containing the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities

Pubblicazioni

Generation of severely scoliotic subject-specific musculoskeletal models

Autori: Samuele Luca Gould, Giorgio Davico, Monica Cosentino, Luca Cristofolini, Marco Viceconti
Pubblicato in: PLOS One, Numero 20, 2025, ISSN 1932-6203
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PONE.0336211

Microstructure of the human metastatic vertebral body

Autori: Giulia Cavazzoni, Enrico Dall’Ara, Marco Palanca
Pubblicato in: Frontiers in Endocrinology, Numero 15, 2025, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2024.1508504

THE METASTRA PROJECT: DEVELOPMENT AND VALIDATION OF COMPUTATIONAL TOOLS TO STRATIFY PATIENTS WITH VERTEBRAL METASTASES AT RISK OF FRACTURE

Autori: Luca Cristofolini, Giovanni Barbanti-Bròdano, Enrico Dall'Ara, Rudolf Ferenc, Stephen J Ferguson, José Manuel García-Aznar, Aron Lazary, Peter Vajkoczy, Jorrit-Jan Verlaan, László Vidács
Pubblicato in: Orthopaedic Proceedings, Numero 107-B, 2025, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.091

Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion

Autori: Margherita Pasini, Giulia Cavazzoni, Enrico Dall’Ara, Samuele Luca Gould, Christine Le Maitre, Luca Cristofolini, Marco Palanca
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, Numero 170, 2026, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.107109

Variability of intervertebral joint stiffness between specimens and spine levels

Autori: Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 12, 2024, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1372088

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Autori: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Pubblicato in: Jornada de Jóvenes Investigadores del I3A, Numero 12, 2024, ISSN 2341-4790
Editore: Universidad de Zaragoza
DOI: 10.26754/jjii3a.202410652

Identification of a lumped-parameter model of the intervertebral joint from experimental data

Autori: Samuele L. Gould, Giorgio Davico, Marco Palanca, Marco Viceconti, Luca Cristofolini
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 12, 2024, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1304334

Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies

Autori: Giulia Cavazzoni, Margherita Pasini, Christine L. Le Maitre, Enrico Dall'Ara, Marco Palanca
Pubblicato in: Acta Biomaterialia, 2025, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.018

Development and Mechanical Testing of Synthetic 3D-Printed Models of Healthy and Metastatic Vertebrae

Autori: Daniela Bruno, Riccardo Forni, Marco Palanca, Luca Cristofolini, Paolo Gargiulo
Pubblicato in: Journal of Manufacturing and Materials Processing, Numero 9, 2025, ISSN 2504-4494
Editore: MDPI AG
DOI: 10.3390/JMMP9110373

Diagnostic accuracy of dual-layer spectral CT for osteolytic vertebral metastases

Autori: Simone van der Star, Netanja I. Harlianto, Stéphanie V. de Lange, Jorrit-Jan Verlaan, Arnold M. R. Schilham, Madeleine Kok, Pim A. de Jong, Wouter Foppen
Pubblicato in: Skeletal Radiology, Numero 55, 2025, ISSN 0364-2348
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S00256-025-05023-Z

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Autori: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Pubblicato in: Jornada de Jóvenes Investigadores del I3A, Numero 12, 2024, ISSN 2341-4790
Editore: Universidad de Zaragoza
DOI: 10.26754/JJII3A.202410652

Prediction of compressive strength of vertebral body with metastatic lesions based on quantitative computed tomography-based subject-specific finite element models

Autori: Rajdeep Ghosh, Eddie Shearman, Robert Roger, Marco Palanca, Enrico Dall'Ara, Damien Lacroix
Pubblicato in: Bone, Numero 211, 2026, ISSN 8756-3282
Editore: Elsevier BV
DOI: 10.1016/J.BONE.2026.117961

WHY TECHNICAL INNOVATIONS ARE NEEDED TO FACILITATE BETTER CHARACTERIZATION OF PATHOLOGICAL FRACTURES IN METASTATIC SPINAL DISEASE

Autori: Jorrit-Jan Verlaan, Peter Vajkoczy, Gastone Castellani, Giovanni Barbanti Bròdano, Floris van Tol, Anne Versteeg, Aron Lazary
Pubblicato in: Orthopaedic Proceedings, Numero 107-B, 2025, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.095

CLINICALLY RELEVANT PARAMETERS TO STRATIFY THE RISK OF FRACTURE IN VERTEBRAE WITH METASTASES: INSIGHT FROM BIOMECHANICAL EXPERIMENTS

Autori: Marco Palanca, Giulia Cavazzoni, Margherita Pasini, Enrico Dall'Ara, Luca Cristofolini
Pubblicato in: Orthopaedic Proceedings, Numero 107-B, 2025, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.092

METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Autori: L. Cristofolini, B. B. bròdano, E. Dall’Ara, R. Ferenc, S. J Ferguson, J. M. García-Aznar, A. Lazary, P. Vajkoczy, Jorrit-Jan Verlaan, L. Vidacs
Pubblicato in: Orthopaedic Proceedings, Numero 106-B, 2024, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2024.18.059

Assessing the reproducibility of a subject-specific finite element modelling pipeline for the human metastatic vertebrae

Autori: Robert Roger, Rajdeep Ghosh, Yuanrui Cai, Fiona Gibson, Áron Lazáry, Lingzhong Guo, Damien Lacroix, Enrico Dall’Ara
Pubblicato in: Scientific Reports, Numero 16, 2026, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-026-46900-4

Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements

Autori: Chiara Garavelli, Alessandra Aldieri, Marco Palanca, Enrico Dall’Ara, Marco Viceconti
Pubblicato in: Biomechanics and Modeling in Mechanobiology, Numero 24, 2025, ISSN 1617-7959
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10237-025-01950-X

WE NEED TO BETTER ASSESS THE RISK OF FRACTURE IN SPINE METASTATIC PATIENTS

Autori: Giovanni Barbanti Brodano, Aron Lazary, Sabato Mellone, Jorrit-Jan Verlaan, Cristiana Griffoni, Peter Vajkoczy
Pubblicato in: Orthopaedic Proceedings, Numero 107-B, 2025, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.096

COMPARISON OF SPINAL LOAD PREDICTIONS FROM MUSCULOSKELETAL AND STATISTICAL SHAPE MODELLING

Autori: Florian Rieger, Guillem Fernandez, Enrico Dall'Ara, Dominique A. Rothenfluh, Stephen J. Ferguson, Dominika Ignasiak
Pubblicato in: Orthopaedic Proceedings, Numero 107-B, 2025, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2025.9.094

Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine

Autori: Sara Montanari, Giovanni Barbanti Bròdano, Elena Serchi, Rita Stagni, Alessandro Gasbarrini, Alfredo Conti, Luca Cristofolini
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-80741-3

A GDPR-Aligned Infrastructure Enabling Secure Multicenter Research Studies

Autori: Serena Moscato, Cleiston Rodrigues Da Silva, Antonino Amedeo La Mattina, Valerio Antonio Arcobelli, Sabato Mellone
Pubblicato in: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Editore: IOS Press
DOI: 10.3233/SHTI260474

Toward Interoperable Variable Definitions: A FHIR-Based Standardization Strategy for the METASTRA Project

Autori: Serena Moscato, Alberto Marfoglia, Valerio Antonio Arcobelli, Maria Rita Intagliata, Cristiana Griffoni, Giovanni Barbanti-Bròdano, Alessandro Gasbarrini, Antonella Carbonaro, Sabato Mellone
Pubblicato in: Studies in Health Technology and Informatics, Opening the Personal Gate between Technology and Health Care, 2026
Editore: IOS Press
DOI: 10.3233/SHTI260393

Risultati dei progetti

Risultati finali

Pubblicazioni

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