COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALISED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Informazioni relative al progetto

METASTRA

ID dell’accordo di sovvenzione: 101080135

DOI

10.3030/101080135

Data della firma CE 14 Marzo 2023

Data di avvio 1 Luglio 2023

Data di completamento 30 Giugno 2028

Finanziato da

• Health

Costo totale

€ 5 087 742,50

Contributo UE

€ 5 087 742,50

Coordinato da

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (4)

Report on the status of posting results at the end of the retrospective study Train-METASTRA

Report detailing the status of posting results at the end of the retrospective study (Train-METASTRA)

METASTRA Communication Toolkit

Communication material tailored to target-group, including material for policymakers, and material in layman's language

Midterm recruitment report for Train-METASTRA

It will be generated when 50% of the EHRs will be replicated through the transient loading zone from the primary hospital systems to the AlmaHealthDB servers. It will include an overview of the number of EHRs collected in each clinical site, indicating any problems in the process and measures eventually adopted to compensate for any delays.

Software documentation templates

The report will contain the templates for software documentation

Websites, patent fillings, videos etc. (1)

Public project website

Public website of the METASTRA project

Other (2)

Approval of ex vivo study by Ethics Committees of UNIBO and USFD

Ethics documentation for the ex vivo study (anatomical specimens from human donors) by Ethics Committees of UNIBO and USFD

Study initiation package for Validate-METASTRA study

Submission package, prior to enrolment of first subject, containing the final version of the study protocol as submitted to regulators, a registration number of the CT in a WHO or ICMJE-approved registry and approvals from ethics committees and national competent authorities

Pubblicazioni

Peer reviewed articles (7)

Microstructure of the human metastatic vertebral body

Autori: Giulia Cavazzoni, Enrico Dall’Ara, Marco Palanca
Pubblicato in: Frontiers in Endocrinology, Numero 15, 2025, ISSN 1664-2392
Editore: Frontiers Media SA
DOI: 10.3389/fendo.2024.1508504

Variability of intervertebral joint stiffness between specimens and spine levels

Autori: Samuele L. Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 12, 2024, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1372088

Modelo paramétrico en 3D de elementos finitos para la simulación mecánica de vértebras con lesiones metastásicas

Autori: Jaime Muñoz Allué, José Manuel García Aznar, Mª Ángeles Pérez Ansón
Pubblicato in: Jornada de Jóvenes Investigadores del I3A, Numero 12, 2024, ISSN 2341-4790
Editore: Universidad de Zaragoza
DOI: 10.26754/jjii3a.202410652

Identification of a lumped-parameter model of the intervertebral joint from experimental data

Autori: Samuele L. Gould, Giorgio Davico, Marco Palanca, Marco Viceconti, Luca Cristofolini
Pubblicato in: Frontiers in Bioengineering and Biotechnology, Numero 12, 2024, ISSN 2296-4185
Editore: Frontiers Media SA
DOI: 10.3389/fbioe.2024.1304334

Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies

Autori: Giulia Cavazzoni, Margherita Pasini, Christine L. Le Maitre, Enrico Dall'Ara, Marco Palanca
Pubblicato in: Acta Biomaterialia, 2025, ISSN 1742-7061
Editore: Elsevier BV
DOI: 10.1016/j.actbio.2025.01.018

METASTRA: COMPUTER-AIDED EFFECTIVE FRACTURE RISK STRATIFICATION OF PATIENTS WITH VERTEBRAL METASTASES FOR PERSONALIZED TREATMENT THROUGH ROBUST COMPUTATIONAL MODELS VALIDATED IN CLINICAL SETTINGS

Autori: L. Cristofolini, B. B. bròdano, E. Dall’Ara, R. Ferenc, S. J Ferguson, J. M. García-Aznar, A. Lazary, P. Vajkoczy, Jorrit-Jan Verlaan, L. Vidacs
Pubblicato in: Orthopaedic Proceedings, Numero 106-B, 2024, ISSN 1358-992X
Editore: British Editorial Society of Bone & Joint Surgery
DOI: 10.1302/1358-992X.2024.18.059

Experimental ex vivo characterization of the biomechanical effects of laminectomy and posterior fixation of the lumbo-sacral spine

Autori: Sara Montanari, Giovanni Barbanti Bròdano, Elena Serchi, Rita Stagni, Alessandro Gasbarrini, Alfredo Conti, Luca Cristofolini
Pubblicato in: Scientific Reports, Numero 14, 2024, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41598-024-80741-3