Improving understanding of lung immunity in tuberculosis to establish a diverse, innovative TB vaccine pipeline targeting mucosal immunity

Información del proyecto

TBVAC-HORIZON

Identificador del acuerdo de subvención: 101080309

DOI

10.3030/101080309

Fecha de la firma de la CE 24 Abril 2023

Fecha de inicio 1 Abril 2023

Fecha de finalización 31 Marzo 2027

Financiado con arreglo a

• Health

Coste total

€ 7 110 650,00

Aportación de la UE

€ 6 183 822,00

Coordinado por

STICHTING TUBERCULOSIS VACCINE INITIATIVE
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (6)

Portfolio Advisory Committee established

Portfolio advisory committee composed of experts established

NHP biosample repository overview I

Periodic overview of banked NHP biomaterials available for investigation of host response profiles & biomarkers in WP3

Project Website Established

Project website and portal site online

Bioinformatics pipeline established

Bioinformatics pipeline and analysis methodology for spatial sequencing of vaccine-induced cellular responses in the M. tb-infected lung (King team)

Meeting 1 (Kickoff Meeting)

Kick-off meeting

Press release

Press release to announce the start of the project

Publicaciones

Peer reviewed articles (15)

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis

Autores: Das M K, Savidge B, Pearl J E, Yates T, Miles G, Pareek M, Haldar P, Cooper A M
Publicado en: PLoS Pathogens, Edición 20, 2024, ISSN 1553-7366
Editor: Public Library of Science
DOI: 10.1371/journal.ppat.1012565

International Journal of Infectious Diseases

Autores: Goletti, D; Matteelli, A; Cliff, JM; Meintjes, G; Graham, S; Esmail, H; Shan Lee, S
Publicado en: International Journal of Infectious Diseases, 2025, ISSN 1201-9712
Editor: Elsevier Ltd
DOI: 10.1016/J.IJID.2025.107892

Therapy modulates the response to T cell epitopes over the spectrum of tuberculosis infection

Autores: Petrone L, Peruzzu D, Altera AMG, Salmi A, Vanini V, Cuzzi G, Coppola A, Mellini V, Gualano G, Palmieri F, Panda S, Peters B, Sette A, Lindestam Arlehamn C, Goletti D
Publicado en: Journal of Infection, 2024, ISSN 0163-4453
Editor: W. B. Saunders Co., Ltd.
DOI: 10.1016/J.JINF.2024.106295

Polycytotoxic T cells mediate antimicrobial activity against intracellular <i>Mycobacterium tuberculosis</i>

Autores: Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger
Publicado en: Infection and Immunity, Edición 93, 2025, ISSN 0019-9567
Editor: American Society for Microbiology
DOI: 10.1128/IAI.00297-24

Characterization of QuantiFERON-TB-Plus Results in Patients with Tuberculosis Infection and Multiple Sclerosis

Autores: Elisa Petruccioli; Luca Prosperini; Serena Ruggieri; Valentina Vanini; Andrea Salmi; Gilda Cuzzi; Simonetta Galgani; Shalom Haggiag; Carla Tortorella; Gabriella Parisi; Alfio D’Agostino; Gina Gualan
Publicado en: Neurology International, 2025, ISSN 2035-8377
Editor: MDPI Basel
DOI: 10.3390/NEUROLINT17080119

Host-directed therapies: old and new approaches for the treatment of infections

Autores: Goletti D, Ong C W M, Friedland Jon S
Publicado en: International Journal of Infectious Diseases, Edición 146, 2024, ISSN 1201-9712
Editor: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.107130

Comparative Study of [18F]DPA714 and [18F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis

Autores: M. A. Stammes, M. P. M. Vierboom, C. C. Sombroek, J. Bakker, L. Meijer, R. A. W. Vervenne, S. O. Hofman, E. Nutma, I. Kondova, A. D. Windhorst, J. A. M. Langermans, F. A. W. Verreck
Publicado en: Molecular Imaging and Biology, 2025, ISSN 1536-1632
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S11307-025-02057-6

Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of adults with tuberculosis infection and disease

Autores: Repele F, Alonzi T, Navarra A, Farroni C, Salmi A, Cuzzi G, Delogu G, Gualano G, Puro V, De Carli G, Girardi E, Palmieri F, Martineau A R, Goletti D
Publicado en: International Journal of Infectious Diseases, Edición 141, 2024, ISSN 1201-9712
Editor: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.106999

Addressing tuberculosis infection: an essential step in the fight against tuberculosis

Autores: Santin M, Trajman A, Goletti D, Anibarro L
Publicado en: Frontiers in Medicine, Edición 11, 2024, ISSN 2296-858X
Editor: FRONTIERS MEDIA SA
DOI: 10.3389/FMED.2024.1428677

Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

Autores: Chiara Farroni; Anna Maria Gerarda Altera; Andrea Salmi; Valentina Vanini; Valentina Vanini; Gilda Cuzzi; Cecilia S. Lindestam Arlehamn; Alessandro Sette; Giovanni Delogu; Giovanni Delogu; Ivana Paluc
Publicado en: Frontiers in Immunology, 2025, ISSN 1664-3224
Editor: Lausanne Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1484143

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Autores: Grifoni A, Alonzi T, Alter G, McClain Noonan D, Landay A L, Albini A, Goletti D
Publicado en: Frontiers in Immunology, Edición 14:1146704, 2023, ISSN 1664-3224
Editor: Frontiers Media SA
DOI: 10.3389/FIMMU.2023.1146704

International Journal of Infectious Diseases

Autores: Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Publicado en: International Journal of Infectious Diseases, Edición 155, 2025, ISSN 1201-9712
Editor: Elsevier BV
DOI: 10.1016/J.IJID.2025.107880

Seminars in Immunology

Autores: Pei Min Thong, Yi Hao Wong, Hardy Kornfeld, Delia Goletti, Catherine W.M. Ong
Publicado en: Seminars in Immunology, Edición 78, 2025, ISSN 1044-5323
Editor: Academic Press
DOI: 10.1016/J.SMIM.2025.101959

Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine

Autores: Calcagno A, Coppola N, Sarmati L, Tadolini M, Parella R, Mateelli A, Riccardi N, Trezzi M, Di Biagio A, Pirriatore V, Russo A, Gualano G, Pontali E, Surace L, Falbo E, Mencarini J, Palmieri A, Gori A, Schiuma M, Lapadula G, Goletti D
Publicado en: Infection, Edición 52, 2024, ISSN 0300-8126
Editor: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/S15010-024-02183-3

World Tuberculosis Day 2024 theme “Yes! We can end TB” can be made a reality through concerted global efforts that advance detection, diagnosis, and treatment of tuberculosis infection and disease

Autores: Goletti D, Al-Abri S, Migliori G B, Lindestam Arlehamn C, Haldar P, Sundling C, da Costa C, To K W, Martineau A R, Petersen E, Zumla A, Lee S S
Publicado en: International Journal of Infectious Diseases, Edición 141, 2024, ISSN 1201-9712
Editor: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.106993

Thesis and dissertations (1)

Exploring the efficacy of MTBVAC as a desensitizing treatment against asthma

Autores: Silvia Calvo García
Publicado en: N/A (Univ of Zaragoza internal), 2024
Editor: Universidad de Zaragoza