Improving understanding of lung immunity in tuberculosis to establish a diverse, innovative TB vaccine pipeline targeting mucosal immunity

Informations projet

TBVAC-HORIZON

N° de convention de subvention: 101080309

DOI

10.3030/101080309

Date de signature de la CE 24 Avril 2023

Date de début 1 Avril 2023

Date de fin 31 Mars 2027

Financé au titre de

• Health

Coût total

€ 7 110 650,00

Contribution de l’UE

€ 6 183 822,00

Coordonné par

STICHTING TUBERCULOSIS VACCINE INITIATIVE
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Portfolio Advisory Committee established

Portfolio advisory committee composed of experts established

NHP biosample repository overview I

Periodic overview of banked NHP biomaterials available for investigation of host response profiles & biomarkers in WP3

Project Website Established

Project website and portal site online

Bioinformatics pipeline established

Bioinformatics pipeline and analysis methodology for spatial sequencing of vaccine-induced cellular responses in the M. tb-infected lung (King team)

Meeting 1 (Kickoff Meeting)

Kick-off meeting

Press release

Press release to announce the start of the project

Publications

Peer reviewed articles (31)

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis

Auteurs: Das M K, Savidge B, Pearl J E, Yates T, Miles G, Pareek M, Haldar P, Cooper A M
Publié dans: PLoS Pathogens, Numéro 20, 2024, ISSN 1553-7366
Éditeur: Public Library of Science
DOI: 10.1371/journal.ppat.1012565

Individual- and population-associated heterogeneity in vaccine-induced immune responses. The impact of inflammatory status and diabetic comorbidity

Auteurs: Simone A. Joosten
Publié dans: Seminars in Immunology, Numéro 78, 2025, ISSN 1044-5323
Éditeur: Elsevier BV
DOI: 10.1016/J.SMIM.2025.101964

Polycytotoxic T cells mediate antimicrobial activity against intracellular <i>Mycobacterium tuberculosis</i>

Auteurs: Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger
Publié dans: Infection and Immunity, Numéro 93, 2025, ISSN 0019-9567
Éditeur: American Society for Microbiology
DOI: 10.1128/IAI.00297-24

International Journal of Infectious Diseases

Auteurs: Goletti, D; Matteelli, A; Cliff, JM; Meintjes, G; Graham, S; Esmail, H; Shan Lee, S
Publié dans: International Journal of Infectious Diseases, 2025, ISSN 1201-9712
Éditeur: Elsevier Ltd
DOI: 10.1016/J.IJID.2025.107892

Therapy modulates the response to T cell epitopes over the spectrum of tuberculosis infection

Auteurs: Petrone L, Peruzzu D, Altera AMG, Salmi A, Vanini V, Cuzzi G, Coppola A, Mellini V, Gualano G, Palmieri F, Panda S, Peters B, Sette A, Lindestam Arlehamn C, Goletti D
Publié dans: Journal of Infection, 2024, ISSN 0163-4453
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/J.JINF.2024.106295

Polycytotoxic T cells mediate antimicrobial activity against intracellular <i>Mycobacterium tuberculosis</i>

Auteurs: Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger
Publié dans: Infection and Immunity, Numéro 93, 2025, ISSN 0019-9567
Éditeur: American Society for Microbiology
DOI: 10.1128/IAI.00297-24

Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury

Auteurs: Iain Stewart, Joseph Jacob, Joanna C. Porter, Bin Liu, Amanda L. Tatler, Nancy Gomez, Matthew R. Pugh, Alison E. John, Richard J. Allen, John F. Blaikley, Nazia Chaudhuri, Emma Denneny, Laura Fabbri, Peter M. George, Beatriz Guillen-Guio, Bibek Gooptu, Ian P. Hall, Ling Pei Ho, Ian Jarrold, Simon Johnson, Mark G. Jones, Fasihul Khan, Puja Mehta, Jane Mitchell, Philip L. Molyneaux, John E. Pearl, Karen Piper Hanley, Manuela Platé, Valerie Quinn, Pilar Rivera-Ortega, Laura C. Saunders, David J.F. Smith, Mark Spears, Lisa G. Spencer, Stefan C. Stanel, A.A. Roger Thompson, Simon Walsh, Jim M. Wild, Dan G. Wootton, Annemarie B. Docherty, Fergus Gleeson, William Greenhalf, Ewen M. Harrison, Nazir Lone, Jennifer Quint, Anastasia Maslova, Moritz Pohl, Adam Stephens, Simon Young, Amisha Singapuri, Aarti Shikotra, Marco Sereno, Ruth M. Saunders, Matthew Richardson, Betty Raman, Krisnah Poinasamy, Hamish J.C. McAuley, Michael Marks, Olivia C. Leavy, Linzy Houchen-Wolloff, Alex Horsley, Victoria C. Harris, Neil Greening, Rachael A. Evans, Omer Elneima, James D. Chalmers, Christopher E. Brightling, Rachel C. Chambers, Louise V. Wain, R. Gisli Jenkins, K. Abel, H. Adamali, D. Adeloye, O. Adeyemi, R. Adrego, L.A. Aguilar Jimenez, S. Ahmad, N. Ahmad Haider, R. Ahmed, N. Ahwireng, M. Ainsworth, B. Al-Sheklly, A. Alamoudi, M. Ali, M. Aljaroof, A.M. All, L. Allan, R.J. Allen, L. Allerton, L. Allsop, P. Almeida, D. Altmann, M. Alvarez Corral, S. Amoils, D. Anderson, C. Antoniades, G. Arbane, A. Arias, C. Armour, L. Armstrong, N. Armstrong, D. Arnold, H. Arnold, A. Ashish, A. Ashworth, M. Ashworth, S. Aslani, H. Assefa-Kebede, C. Atkin, P. Atkin, R. Aul, H. Aung, L. Austin, C. Avram, A. Ayoub, M. Babores, R. Baggott, J. Bagshaw, D. Baguley, L. Bailey, J.K. Baillie, S. Bain, M. Bakali, M. Bakau, E. Baldry, D. Baldwin, M. Baldwin, C. Ballard, A. Banerjee, B. Bang, R.E. Barker, L. Barman, S. Barratt, F. Barrett, D. Basire, N. Basu, M. Bates, A. Bates, R. Batterham, H. Baxendale, H. Bayes, M. Beadsworth, P. Beckett, M. Beggs, M. Begum, P. Beirne, D. Bell, R. Bell, K. Bennett, E. Beranova, A. Bermperi, A. Berridge, C. Berry, S. Betts, E. Bevan, K. Bhui, M. Bingham, K. Birchall, L. Bishop, K. Bisnauthsing, J. Blaikely, A. Bloss, A. Bolger, C.E. Bolton, J. Bonnington, A. Botkai, C. Bourne, M. Bourne, K. Bramham, L. Brear, G. Breen, J. Breeze, A. Briggs, E. Bright, C.E. Brightling, S. Brill, K. Brindle, L. Broad, A. Broadley, C. Brookes, M. Broome, A. Brown, A. Brown, J. Brown, J. Brown, J.S. Brown, M. Brown, M. Brown, V. Brown, T. Brugha, N. Brunskill, M. Buch, P. Buckley, A. Bularga, E. Bullmore, L. Burden, T. Burdett, D. Burn, G. Burns, A. Burns, J. Busby, R. Butcher, A. Butt, S. Byrne, P. Cairns, P.C. Calder, E. Calvelo, H. Carborn, B. Card, C. Carr, L. Carr, G. Carson, P. Carter, A. Casey, M. Cassar, J. Cavanagh, M. Chablani, T. Chalder, J.D. Chalmers, R.C. Chambers, F. Chan, K.M. Channon, K. Chapman, A. Charalambou, N. Chaudhuri, A. Checkley, J. Chen, Y. Cheng, L. Chetham, C. Childs, E.R. Chilvers, H. Chinoy, A. Chiribiri, K. Chong-James, G. Choudhury, N. Choudhury, P. Chowienczyk, C. Christie, M. Chrystal, D. Clark, C. Clark, J. Clarke, S. Clohisey, G. Coakley, Z. Coburn, S. Coetzee, J. Cole, C. Coleman, F. Conneh, D. Connell, B. Connolly, L. Connor, A. Cook, B. Cooper, J. Cooper, S. Cooper, D. Copeland, T. Cosier, M. Coulding, C. Coupland, E. Cox, T. Craig, P. Crisp, D. Cristiano, M.G. Crooks, A. Cross, I. Cruz, P. Cullinan, D. Cuthbertson, L. Daines, M. Dalton, P. Daly, A. Daniels, P. Dark, J. Dasgin, A. David, C. David, E. Davies, F. Davies, G. Davies, G.A. Davies, K. Davies, M.J. Davies, J. Dawson, E. Daynes, A. De Soyza, B. Deakin, A. Deans, C. Deas, J. Deery, S. Defres, A. Dell, K. Dempsey, E. Denneny, J. Dennis, A. Dewar, R. Dharmagunawardena, N. Diar-Bakerly, C. Dickens, A. Dipper, S. Diver, S.N. Diwanji, M. Dixon, R. Djukanovic, H. Dobson, S.L. Dobson, A.B. Docherty, A. Donaldson, T. Dong, N. Dormand, A. Dougherty, R. Dowling, S. Drain, K
Publié dans: eBioMedicine, Numéro 124, 2026, ISSN 2352-3964
Éditeur: Elsevier BV
DOI: 10.1016/J.EBIOM.2026.106134

Toward tuberculosis elimination: An update on tuberculosis vaccines in clinical trials

Auteurs: Carlos Martín, Jesús Gonzalo-Asensio, Nacho Aguiló, Ainhoa Arbués
Publié dans: International Journal of Infectious Diseases, Numéro 167, 2026, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2026.108513

First impressions count in TB

Auteurs: Andrea M. Cooper
Publié dans: Journal of Experimental Medicine, Numéro 222, 2025, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/JEM.20251753

World TB Day 2026: Scientific innovation across the tuberculosis continuum must now translate into global impact

Auteurs: Delia Goletti, Bruno Bezerril Andrade, Hanif Esmail, Jon S. Friedland, Carlos Martin, Deborah Hee Ling Ng, Giovanni Battista Migliori, Catherine WM Ong, Alimuddin Zumla, Eskild Petersen
Publié dans: International Journal of Infectious Diseases, Numéro 167, 2026, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2026.108571

Improved immune responses and tuberculosis protection by aerosol vaccination with recombinant BCG expressing ESX-1 from Mycobacterium marinum

Auteurs: Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, David Hardy, Roland Brosch
Publié dans: PLOS Pathogens, Numéro 22, 2026, ISSN 1553-7374
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PPAT.1013992

Immune dysregulation of diabetes in tuberculosis

Auteurs: Pei Min Thong, Yi Hao Wong, Hardy Kornfeld, Delia Goletti, Catherine W.M. Ong
Publié dans: Seminars in Immunology, Numéro 78, 2025, ISSN 1044-5323
Éditeur: Elsevier BV
DOI: 10.1016/J.SMIM.2025.101959

Characterization of QuantiFERON-TB-Plus Results in Patients with Tuberculosis Infection and Multiple Sclerosis

Auteurs: Elisa Petruccioli; Luca Prosperini; Serena Ruggieri; Valentina Vanini; Andrea Salmi; Gilda Cuzzi; Simonetta Galgani; Shalom Haggiag; Carla Tortorella; Gabriella Parisi; Alfio D’Agostino; Gina Gualan
Publié dans: Neurology International, 2025, ISSN 2035-8377
Éditeur: MDPI Basel
DOI: 10.3390/NEUROLINT17080119

Host-directed therapies: old and new approaches for the treatment of infections

Auteurs: Goletti D, Ong C W M, Friedland Jon S
Publié dans: International Journal of Infectious Diseases, Numéro 146, 2024, ISSN 1201-9712
Éditeur: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.107130

World TB Day 2025 Theme “Yes! We Can End TB: Commit, Invest, Deliver” can be made a reality through concerted global efforts to advance diagnosis, treatment and research of tuberculosis infection and disease

Auteurs: Delia Goletti, Alberto Matteelli, Jacqueline M. Cliff, Graeme Meintjes, Steve Graham, Hanif Esmail, Shui Shan Lee
Publié dans: International Journal of Infectious Diseases, Numéro 155, 2026, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2025.107892

Comparative Study of [18F]DPA714 and [18F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis

Auteurs: M. A. Stammes, M. P. M. Vierboom, C. C. Sombroek, J. Bakker, L. Meijer, R. A. W. Vervenne, S. O. Hofman, E. Nutma, I. Kondova, A. D. Windhorst, J. A. M. Langermans, F. A. W. Verreck
Publié dans: Molecular Imaging and Biology, Numéro 27, 2026, ISSN 1536-1632
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S11307-025-02057-6

Hypoxia restricts the generation of BCG-responsive polycytotoxic T cells

Auteurs: Jean de Dieu Harelimana, Max Bürger, Marc Zumwinkel, Jacky Mohnani, Maximilian Weper, Vincent Romahn, Markus Zähnle, Mark Grieshober, Steffen Stenger
Publié dans: Vaccine, Numéro 79, 2026, ISSN 0264-410X
Éditeur: Elsevier BV
DOI: 10.1016/J.VACCINE.2026.128456

Comparative Study of [18F]DPA714 and [18F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis

Auteurs: M. A. Stammes, M. P. M. Vierboom, C. C. Sombroek, J. Bakker, L. Meijer, R. A. W. Vervenne, S. O. Hofman, E. Nutma, I. Kondova, A. D. Windhorst, J. A. M. Langermans, F. A. W. Verreck
Publié dans: Molecular Imaging and Biology, 2025, ISSN 1536-1632
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S11307-025-02057-6

Impact of diabetes on TB infection diagnosis

Auteurs: Linda Petrone, Alessandra Aiello, Saeid Najafi-Fard, Delia Goletti
Publié dans: International Journal of Infectious Diseases, Numéro 167, 2026, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2026.108486

British Red Squirrels ( <i>S. vulgaris</i> ) With Leprosy Develop Skeletal Lesions

Auteurs: Elliot Elliott, Richard Thomas, Sarah A. Inskip, Andrea Cooper, Andrew C. Kitchener, Katie M. Beckmann, Anna Meredith
Publié dans: Interdisciplinary Perspectives on Infectious Diseases, Numéro 2026, 2026, ISSN 1687-708X
Éditeur: Wiley
DOI: 10.1155/IPID/5785505

Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design

Auteurs: Emma Lefrançais, Denis Hudrisier, Olivier Neyrolles, Samuel M. Behar, Joel D. Ernst
Publié dans: Nature Reviews Immunology, Numéro 25, 2025, ISSN 1474-1733
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41577-025-01192-Z

Diagnostic tests for tuberculosis infection and predictive indicators of disease progression: Utilizing host and pathogen biomarkers to enhance the tuberculosis elimination strategies

Auteurs: Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Publié dans: International Journal of Infectious Diseases, Numéro 155, 2026, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2025.107880

Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of adults with tuberculosis infection and disease

Auteurs: Repele F, Alonzi T, Navarra A, Farroni C, Salmi A, Cuzzi G, Delogu G, Gualano G, Puro V, De Carli G, Girardi E, Palmieri F, Martineau A R, Goletti D
Publié dans: International Journal of Infectious Diseases, Numéro 141, 2024, ISSN 1201-9712
Éditeur: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.106999

Addressing tuberculosis infection: an essential step in the fight against tuberculosis

Auteurs: Santin M, Trajman A, Goletti D, Anibarro L
Publié dans: Frontiers in Medicine, Numéro 11, 2024, ISSN 2296-858X
Éditeur: FRONTIERS MEDIA SA
DOI: 10.3389/FMED.2024.1428677

Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

Auteurs: Chiara Farroni; Anna Maria Gerarda Altera; Andrea Salmi; Valentina Vanini; Valentina Vanini; Gilda Cuzzi; Cecilia S. Lindestam Arlehamn; Alessandro Sette; Giovanni Delogu; Giovanni Delogu; Ivana Paluc
Publié dans: Frontiers in Immunology, 2025, ISSN 1664-3224
Éditeur: Lausanne Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1484143

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Auteurs: Grifoni A, Alonzi T, Alter G, McClain Noonan D, Landay A L, Albini A, Goletti D
Publié dans: Frontiers in Immunology, Numéro 14:1146704, 2023, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2023.1146704

Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

Auteurs: Chiara Farroni, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Gilda Cuzzi, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Giovanni Delogu, Ivana Palucci, Settimia Sbarra, Alessandra Aiello, Andrea Picchianti-Diamanti, Gina Gualano, Fabrizio Palmieri, Delia Goletti, Elisa Petruccioli
Publié dans: Frontiers in Immunology, Numéro 15, 2025, ISSN 1664-3224
Éditeur: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1484143

International Journal of Infectious Diseases

Auteurs: Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Publié dans: International Journal of Infectious Diseases, Numéro 155, 2025, ISSN 1201-9712
Éditeur: Elsevier BV
DOI: 10.1016/J.IJID.2025.107880

Seminars in Immunology

Auteurs: Pei Min Thong, Yi Hao Wong, Hardy Kornfeld, Delia Goletti, Catherine W.M. Ong
Publié dans: Seminars in Immunology, Numéro 78, 2025, ISSN 1044-5323
Éditeur: Academic Press
DOI: 10.1016/J.SMIM.2025.101959

Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine

Auteurs: Calcagno A, Coppola N, Sarmati L, Tadolini M, Parella R, Mateelli A, Riccardi N, Trezzi M, Di Biagio A, Pirriatore V, Russo A, Gualano G, Pontali E, Surace L, Falbo E, Mencarini J, Palmieri A, Gori A, Schiuma M, Lapadula G, Goletti D
Publié dans: Infection, Numéro 52, 2024, ISSN 0300-8126
Éditeur: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/S15010-024-02183-3

World Tuberculosis Day 2024 theme “Yes! We can end TB” can be made a reality through concerted global efforts that advance detection, diagnosis, and treatment of tuberculosis infection and disease

Auteurs: Goletti D, Al-Abri S, Migliori G B, Lindestam Arlehamn C, Haldar P, Sundling C, da Costa C, To K W, Martineau A R, Petersen E, Zumla A, Lee S S
Publié dans: International Journal of Infectious Diseases, Numéro 141, 2024, ISSN 1201-9712
Éditeur: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.106993

Other (1)

Seminars in Immunology

Auteurs: Simone A, Joosten
Publié dans: Individual- and population-associated heterogeneity in vaccine-induced immune responses. The impact of inflammatory status and diabetic comorbidity, 2025, ISSN 1044-5323
Éditeur: Elsevier
DOI: 10.1016/J.SMIM.2025.101964

Thesis and dissertations (1)

Exploring the efficacy of MTBVAC as a desensitizing treatment against asthma

Auteurs: Silvia Calvo García
Publié dans: N/A (Univ of Zaragoza internal), 2024
Éditeur: Universidad de Zaragoza

Book chapters (1)

Immunology of Tuberculosis

Auteurs: Andrea M Cooper
Publié dans: Encyclopedia of Immunobiology, 2026
Éditeur: Elsevier
DOI: 10.1016/B978-0-12-824465-4.00200-3