Improving understanding of lung immunity in tuberculosis to establish a diverse, innovative TB vaccine pipeline targeting mucosal immunity

Informazioni relative al progetto

TBVAC-HORIZON

ID dell’accordo di sovvenzione: 101080309

DOI

10.3030/101080309

Data della firma CE 24 Aprile 2023

Data di avvio 1 Aprile 2023

Data di completamento 31 Marzo 2027

Finanziato da

• Health

Costo totale

€ 7 110 650,00

Contributo UE

€ 6 183 822,00

Coordinato da

STICHTING TUBERCULOSIS VACCINE INITIATIVE
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (6)

Portfolio Advisory Committee established

Portfolio advisory committee composed of experts established

NHP biosample repository overview I

Periodic overview of banked NHP biomaterials available for investigation of host response profiles & biomarkers in WP3

Project Website Established

Project website and portal site online

Bioinformatics pipeline established

Bioinformatics pipeline and analysis methodology for spatial sequencing of vaccine-induced cellular responses in the M. tb-infected lung (King team)

Meeting 1 (Kickoff Meeting)

Kick-off meeting

Press release

Press release to announce the start of the project

Pubblicazioni

Peer reviewed articles (31)

Altered hepatic metabolic landscape and insulin sensitivity in response to pulmonary tuberculosis

Autori: Das M K, Savidge B, Pearl J E, Yates T, Miles G, Pareek M, Haldar P, Cooper A M
Pubblicato in: PLoS Pathogens, Numero 20, 2024, ISSN 1553-7366
Editore: Public Library of Science
DOI: 10.1371/journal.ppat.1012565

Individual- and population-associated heterogeneity in vaccine-induced immune responses. The impact of inflammatory status and diabetic comorbidity

Autori: Simone A. Joosten
Pubblicato in: Seminars in Immunology, Numero 78, 2025, ISSN 1044-5323
Editore: Elsevier BV
DOI: 10.1016/J.SMIM.2025.101964

Polycytotoxic T cells mediate antimicrobial activity against intracellular <i>Mycobacterium tuberculosis</i>

Autori: Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger
Pubblicato in: Infection and Immunity, Numero 93, 2025, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/IAI.00297-24

International Journal of Infectious Diseases

Autori: Goletti, D; Matteelli, A; Cliff, JM; Meintjes, G; Graham, S; Esmail, H; Shan Lee, S
Pubblicato in: International Journal of Infectious Diseases, 2025, ISSN 1201-9712
Editore: Elsevier Ltd
DOI: 10.1016/J.IJID.2025.107892

Therapy modulates the response to T cell epitopes over the spectrum of tuberculosis infection

Autori: Petrone L, Peruzzu D, Altera AMG, Salmi A, Vanini V, Cuzzi G, Coppola A, Mellini V, Gualano G, Palmieri F, Panda S, Peters B, Sette A, Lindestam Arlehamn C, Goletti D
Pubblicato in: Journal of Infection, 2024, ISSN 0163-4453
Editore: W. B. Saunders Co., Ltd.
DOI: 10.1016/J.JINF.2024.106295

Polycytotoxic T cells mediate antimicrobial activity against intracellular <i>Mycobacterium tuberculosis</i>

Autori: Marc Zumwinkel, Aaron Chirambo, Markus Zähnle, Max Bürger, Mark Grieshober, Vincent Romahn, Henry Mwandumba, Steffen Stenger
Pubblicato in: Infection and Immunity, Numero 93, 2025, ISSN 0019-9567
Editore: American Society for Microbiology
DOI: 10.1128/IAI.00297-24

Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury

Autori: Iain Stewart, Joseph Jacob, Joanna C. Porter, Bin Liu, Amanda L. Tatler, Nancy Gomez, Matthew R. Pugh, Alison E. John, Richard J. Allen, John F. Blaikley, Nazia Chaudhuri, Emma Denneny, Laura Fabbri, Peter M. George, Beatriz Guillen-Guio, Bibek Gooptu, Ian P. Hall, Ling Pei Ho, Ian Jarrold, Simon Johnson, Mark G. Jones, Fasihul Khan, Puja Mehta, Jane Mitchell, Philip L. Molyneaux, John E. Pearl, Karen Piper Hanley, Manuela Platé, Valerie Quinn, Pilar Rivera-Ortega, Laura C. Saunders, David J.F. Smith, Mark Spears, Lisa G. Spencer, Stefan C. Stanel, A.A. Roger Thompson, Simon Walsh, Jim M. Wild, Dan G. Wootton, Annemarie B. Docherty, Fergus Gleeson, William Greenhalf, Ewen M. Harrison, Nazir Lone, Jennifer Quint, Anastasia Maslova, Moritz Pohl, Adam Stephens, Simon Young, Amisha Singapuri, Aarti Shikotra, Marco Sereno, Ruth M. Saunders, Matthew Richardson, Betty Raman, Krisnah Poinasamy, Hamish J.C. McAuley, Michael Marks, Olivia C. Leavy, Linzy Houchen-Wolloff, Alex Horsley, Victoria C. Harris, Neil Greening, Rachael A. Evans, Omer Elneima, James D. Chalmers, Christopher E. Brightling, Rachel C. Chambers, Louise V. Wain, R. Gisli Jenkins, K. Abel, H. Adamali, D. Adeloye, O. Adeyemi, R. Adrego, L.A. Aguilar Jimenez, S. Ahmad, N. Ahmad Haider, R. Ahmed, N. Ahwireng, M. Ainsworth, B. Al-Sheklly, A. Alamoudi, M. Ali, M. Aljaroof, A.M. All, L. Allan, R.J. Allen, L. Allerton, L. Allsop, P. Almeida, D. Altmann, M. Alvarez Corral, S. Amoils, D. Anderson, C. Antoniades, G. Arbane, A. Arias, C. Armour, L. Armstrong, N. Armstrong, D. Arnold, H. Arnold, A. Ashish, A. Ashworth, M. Ashworth, S. Aslani, H. Assefa-Kebede, C. Atkin, P. Atkin, R. Aul, H. Aung, L. Austin, C. Avram, A. Ayoub, M. Babores, R. Baggott, J. Bagshaw, D. Baguley, L. Bailey, J.K. Baillie, S. Bain, M. Bakali, M. Bakau, E. Baldry, D. Baldwin, M. Baldwin, C. Ballard, A. Banerjee, B. Bang, R.E. Barker, L. Barman, S. Barratt, F. Barrett, D. Basire, N. Basu, M. Bates, A. Bates, R. Batterham, H. Baxendale, H. Bayes, M. Beadsworth, P. Beckett, M. Beggs, M. Begum, P. Beirne, D. Bell, R. Bell, K. Bennett, E. Beranova, A. Bermperi, A. Berridge, C. Berry, S. Betts, E. Bevan, K. Bhui, M. Bingham, K. Birchall, L. Bishop, K. Bisnauthsing, J. Blaikely, A. Bloss, A. Bolger, C.E. Bolton, J. Bonnington, A. Botkai, C. Bourne, M. Bourne, K. Bramham, L. Brear, G. Breen, J. Breeze, A. Briggs, E. Bright, C.E. Brightling, S. Brill, K. Brindle, L. Broad, A. Broadley, C. Brookes, M. Broome, A. Brown, A. Brown, J. Brown, J. Brown, J.S. Brown, M. Brown, M. Brown, V. Brown, T. Brugha, N. Brunskill, M. Buch, P. Buckley, A. Bularga, E. Bullmore, L. Burden, T. Burdett, D. Burn, G. Burns, A. Burns, J. Busby, R. Butcher, A. Butt, S. Byrne, P. Cairns, P.C. Calder, E. Calvelo, H. Carborn, B. Card, C. Carr, L. Carr, G. Carson, P. Carter, A. Casey, M. Cassar, J. Cavanagh, M. Chablani, T. Chalder, J.D. Chalmers, R.C. Chambers, F. Chan, K.M. Channon, K. Chapman, A. Charalambou, N. Chaudhuri, A. Checkley, J. Chen, Y. Cheng, L. Chetham, C. Childs, E.R. Chilvers, H. Chinoy, A. Chiribiri, K. Chong-James, G. Choudhury, N. Choudhury, P. Chowienczyk, C. Christie, M. Chrystal, D. Clark, C. Clark, J. Clarke, S. Clohisey, G. Coakley, Z. Coburn, S. Coetzee, J. Cole, C. Coleman, F. Conneh, D. Connell, B. Connolly, L. Connor, A. Cook, B. Cooper, J. Cooper, S. Cooper, D. Copeland, T. Cosier, M. Coulding, C. Coupland, E. Cox, T. Craig, P. Crisp, D. Cristiano, M.G. Crooks, A. Cross, I. Cruz, P. Cullinan, D. Cuthbertson, L. Daines, M. Dalton, P. Daly, A. Daniels, P. Dark, J. Dasgin, A. David, C. David, E. Davies, F. Davies, G. Davies, G.A. Davies, K. Davies, M.J. Davies, J. Dawson, E. Daynes, A. De Soyza, B. Deakin, A. Deans, C. Deas, J. Deery, S. Defres, A. Dell, K. Dempsey, E. Denneny, J. Dennis, A. Dewar, R. Dharmagunawardena, N. Diar-Bakerly, C. Dickens, A. Dipper, S. Diver, S.N. Diwanji, M. Dixon, R. Djukanovic, H. Dobson, S.L. Dobson, A.B. Docherty, A. Donaldson, T. Dong, N. Dormand, A. Dougherty, R. Dowling, S. Drain, K
Pubblicato in: eBioMedicine, Numero 124, 2026, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/J.EBIOM.2026.106134

Toward tuberculosis elimination: An update on tuberculosis vaccines in clinical trials

Autori: Carlos Martín, Jesús Gonzalo-Asensio, Nacho Aguiló, Ainhoa Arbués
Pubblicato in: International Journal of Infectious Diseases, Numero 167, 2026, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2026.108513

First impressions count in TB

Autori: Andrea M. Cooper
Pubblicato in: Journal of Experimental Medicine, Numero 222, 2025, ISSN 0022-1007
Editore: Rockefeller University Press
DOI: 10.1084/JEM.20251753

World TB Day 2026: Scientific innovation across the tuberculosis continuum must now translate into global impact

Autori: Delia Goletti, Bruno Bezerril Andrade, Hanif Esmail, Jon S. Friedland, Carlos Martin, Deborah Hee Ling Ng, Giovanni Battista Migliori, Catherine WM Ong, Alimuddin Zumla, Eskild Petersen
Pubblicato in: International Journal of Infectious Diseases, Numero 167, 2026, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2026.108571

Improved immune responses and tuberculosis protection by aerosol vaccination with recombinant BCG expressing ESX-1 from Mycobacterium marinum

Autori: Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, David Hardy, Roland Brosch
Pubblicato in: PLOS Pathogens, Numero 22, 2026, ISSN 1553-7374
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PPAT.1013992

Immune dysregulation of diabetes in tuberculosis

Autori: Pei Min Thong, Yi Hao Wong, Hardy Kornfeld, Delia Goletti, Catherine W.M. Ong
Pubblicato in: Seminars in Immunology, Numero 78, 2025, ISSN 1044-5323
Editore: Elsevier BV
DOI: 10.1016/J.SMIM.2025.101959

Characterization of QuantiFERON-TB-Plus Results in Patients with Tuberculosis Infection and Multiple Sclerosis

Autori: Elisa Petruccioli; Luca Prosperini; Serena Ruggieri; Valentina Vanini; Andrea Salmi; Gilda Cuzzi; Simonetta Galgani; Shalom Haggiag; Carla Tortorella; Gabriella Parisi; Alfio D’Agostino; Gina Gualan
Pubblicato in: Neurology International, 2025, ISSN 2035-8377
Editore: MDPI Basel
DOI: 10.3390/NEUROLINT17080119

Host-directed therapies: old and new approaches for the treatment of infections

Autori: Goletti D, Ong C W M, Friedland Jon S
Pubblicato in: International Journal of Infectious Diseases, Numero 146, 2024, ISSN 1201-9712
Editore: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.107130

World TB Day 2025 Theme “Yes! We Can End TB: Commit, Invest, Deliver” can be made a reality through concerted global efforts to advance diagnosis, treatment and research of tuberculosis infection and disease

Autori: Delia Goletti, Alberto Matteelli, Jacqueline M. Cliff, Graeme Meintjes, Steve Graham, Hanif Esmail, Shui Shan Lee
Pubblicato in: International Journal of Infectious Diseases, Numero 155, 2026, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2025.107892

Comparative Study of [18F]DPA714 and [18F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis

Autori: M. A. Stammes, M. P. M. Vierboom, C. C. Sombroek, J. Bakker, L. Meijer, R. A. W. Vervenne, S. O. Hofman, E. Nutma, I. Kondova, A. D. Windhorst, J. A. M. Langermans, F. A. W. Verreck
Pubblicato in: Molecular Imaging and Biology, Numero 27, 2026, ISSN 1536-1632
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S11307-025-02057-6

Hypoxia restricts the generation of BCG-responsive polycytotoxic T cells

Autori: Jean de Dieu Harelimana, Max Bürger, Marc Zumwinkel, Jacky Mohnani, Maximilian Weper, Vincent Romahn, Markus Zähnle, Mark Grieshober, Steffen Stenger
Pubblicato in: Vaccine, Numero 79, 2026, ISSN 0264-410X
Editore: Elsevier BV
DOI: 10.1016/J.VACCINE.2026.128456

Comparative Study of [18F]DPA714 and [18F]FDG PET Tracers in an Experimental Model of Pulmonary Tuberculosis

Autori: M. A. Stammes, M. P. M. Vierboom, C. C. Sombroek, J. Bakker, L. Meijer, R. A. W. Vervenne, S. O. Hofman, E. Nutma, I. Kondova, A. D. Windhorst, J. A. M. Langermans, F. A. W. Verreck
Pubblicato in: Molecular Imaging and Biology, 2025, ISSN 1536-1632
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S11307-025-02057-6

Impact of diabetes on TB infection diagnosis

Autori: Linda Petrone, Alessandra Aiello, Saeid Najafi-Fard, Delia Goletti
Pubblicato in: International Journal of Infectious Diseases, Numero 167, 2026, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2026.108486

British Red Squirrels ( <i>S. vulgaris</i> ) With Leprosy Develop Skeletal Lesions

Autori: Elliot Elliott, Richard Thomas, Sarah A. Inskip, Andrea Cooper, Andrew C. Kitchener, Katie M. Beckmann, Anna Meredith
Pubblicato in: Interdisciplinary Perspectives on Infectious Diseases, Numero 2026, 2026, ISSN 1687-708X
Editore: Wiley
DOI: 10.1155/IPID/5785505

Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design

Autori: Emma Lefrançais, Denis Hudrisier, Olivier Neyrolles, Samuel M. Behar, Joel D. Ernst
Pubblicato in: Nature Reviews Immunology, Numero 25, 2025, ISSN 1474-1733
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41577-025-01192-Z

Diagnostic tests for tuberculosis infection and predictive indicators of disease progression: Utilizing host and pathogen biomarkers to enhance the tuberculosis elimination strategies

Autori: Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Pubblicato in: International Journal of Infectious Diseases, Numero 155, 2026, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2025.107880

Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of adults with tuberculosis infection and disease

Autori: Repele F, Alonzi T, Navarra A, Farroni C, Salmi A, Cuzzi G, Delogu G, Gualano G, Puro V, De Carli G, Girardi E, Palmieri F, Martineau A R, Goletti D
Pubblicato in: International Journal of Infectious Diseases, Numero 141, 2024, ISSN 1201-9712
Editore: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.106999

Addressing tuberculosis infection: an essential step in the fight against tuberculosis

Autori: Santin M, Trajman A, Goletti D, Anibarro L
Pubblicato in: Frontiers in Medicine, Numero 11, 2024, ISSN 2296-858X
Editore: FRONTIERS MEDIA SA
DOI: 10.3389/FMED.2024.1428677

Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

Autori: Chiara Farroni; Anna Maria Gerarda Altera; Andrea Salmi; Valentina Vanini; Valentina Vanini; Gilda Cuzzi; Cecilia S. Lindestam Arlehamn; Alessandro Sette; Giovanni Delogu; Giovanni Delogu; Ivana Paluc
Pubblicato in: Frontiers in Immunology, 2025, ISSN 1664-3224
Editore: Lausanne Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1484143

Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

Autori: Grifoni A, Alonzi T, Alter G, McClain Noonan D, Landay A L, Albini A, Goletti D
Pubblicato in: Frontiers in Immunology, Numero 14:1146704, 2023, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2023.1146704

Specific immune response to M. tuberculosis and ability to in vitro control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection

Autori: Chiara Farroni, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Gilda Cuzzi, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Giovanni Delogu, Ivana Palucci, Settimia Sbarra, Alessandra Aiello, Andrea Picchianti-Diamanti, Gina Gualano, Fabrizio Palmieri, Delia Goletti, Elisa Petruccioli
Pubblicato in: Frontiers in Immunology, Numero 15, 2025, ISSN 1664-3224
Editore: Frontiers Media SA
DOI: 10.3389/FIMMU.2024.1484143

International Journal of Infectious Diseases

Autori: Tonino Alonzi, Elisa Petruccioli, Alessandra Aiello, Federica Repele, Delia Goletti
Pubblicato in: International Journal of Infectious Diseases, Numero 155, 2025, ISSN 1201-9712
Editore: Elsevier BV
DOI: 10.1016/J.IJID.2025.107880

Seminars in Immunology

Autori: Pei Min Thong, Yi Hao Wong, Hardy Kornfeld, Delia Goletti, Catherine W.M. Ong
Pubblicato in: Seminars in Immunology, Numero 78, 2025, ISSN 1044-5323
Editore: Academic Press
DOI: 10.1016/J.SMIM.2025.101959

Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine

Autori: Calcagno A, Coppola N, Sarmati L, Tadolini M, Parella R, Mateelli A, Riccardi N, Trezzi M, Di Biagio A, Pirriatore V, Russo A, Gualano G, Pontali E, Surace L, Falbo E, Mencarini J, Palmieri A, Gori A, Schiuma M, Lapadula G, Goletti D
Pubblicato in: Infection, Numero 52, 2024, ISSN 0300-8126
Editore: Urban und Vogel Medien und Medizin Verlagsgesellschaft mbH
DOI: 10.1007/S15010-024-02183-3

World Tuberculosis Day 2024 theme “Yes! We can end TB” can be made a reality through concerted global efforts that advance detection, diagnosis, and treatment of tuberculosis infection and disease

Autori: Goletti D, Al-Abri S, Migliori G B, Lindestam Arlehamn C, Haldar P, Sundling C, da Costa C, To K W, Martineau A R, Petersen E, Zumla A, Lee S S
Pubblicato in: International Journal of Infectious Diseases, Numero 141, 2024, ISSN 1201-9712
Editore: Elsevier Sci Ltd
DOI: 10.1016/J.IJID.2024.106993

Other (1)

Seminars in Immunology

Autori: Simone A, Joosten
Pubblicato in: Individual- and population-associated heterogeneity in vaccine-induced immune responses. The impact of inflammatory status and diabetic comorbidity, 2025, ISSN 1044-5323
Editore: Elsevier
DOI: 10.1016/J.SMIM.2025.101964

Thesis and dissertations (1)

Exploring the efficacy of MTBVAC as a desensitizing treatment against asthma

Autori: Silvia Calvo García
Pubblicato in: N/A (Univ of Zaragoza internal), 2024
Editore: Universidad de Zaragoza

Book chapters (1)

Immunology of Tuberculosis

Autori: Andrea M Cooper
Pubblicato in: Encyclopedia of Immunobiology, 2026
Editore: Elsevier
DOI: 10.1016/B978-0-12-824465-4.00200-3