DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

Información del proyecto

PAS GRAS

Identificador del acuerdo de subvención: 101080329

DOI

10.3030/101080329

Fecha de la firma de la CE 28 Abril 2023

Fecha de inicio 1 Mayo 2023

Fecha de finalización 30 Abril 2028

Financiado con arreglo a

• Health

Coste total

€ 9 377 421,25

Aportación de la UE

€ 9 377 421,25

Coordinado por

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

First PDEC version

First version of all actions for DC&E

First version of the Education and Training plan

A document stating all training and education activities across the consortium will be prepared.

Study initiation package

Report detailing the pre-registration (clinicaltrial.gov) of the clinical trial (WP5), final protocol and ethical issues

Pre-registration of animal studies

Report with the pre-registration of in vivo assays (including previous in vitro data)

Report from Kick-Off meeting

A report will be produced, including the compositionof the different boards

Data Management Plan (1)

Data management plan

A data management plan will be prepared by allpartners. Updated whenever necessary

Websites, patent fillings, videos etc. (2)

Project Website

Public website

Project social media

Report on PAS GRAS social media

Publicaciones

Peer reviewed articles (38)

Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Autores: Patrycja Jakubek, Barbara Pakula, Martin Rossmeisl, Paolo Pinton, Alessandro Rimessi, Mariusz Roman Wieckowski
Publicado en: Internal and Emergency Medicine, Edición 19, 2024, ISSN 1828-0447
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s11739-024-03700-w

The role of <scp>CD20</scp>⁺ T cells: Insights in human peripheral blood

Autores: Aryane Cruz Oliveira Pinho, Pedro Barbosa, Maria Joo Pereira, Artur Paiva, Eugenia Carvalho, Paula Laranjeira
Publicado en: Cytometry Part B: Clinical Cytometry, Edición 106, 2024, ISSN 1552-4949
Editor: Wiley
DOI: 10.1002/cyto.b.22178

Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

Autores: Piero Portincasa, Gyorgy Baffy
Publicado en: European Journal of Internal Medicine, Edición 124, 2024, ISSN 0953-6205
Editor: Elsevier BV
DOI: 10.1016/j.ejim.2024.04.013

Short-term effects of obesity surgery versus low-energydiet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated 18F-FDG-PET/MRI

Autores: Jan W. Eriksson, Maria J. Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundstrm, Giovanni Fanni, Martin H. Lundqvist, Bjrn C. L. Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risrus, Hkan Ahlstrm
Publicado en: Diabetologia, Edición 67, 2024, ISSN 0012-186X
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s00125-024-06150-3

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Autores: Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Publicado en: International Journal of Molecular Sciences, Edición 24, 2023, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/ijms242015192

Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance

Autores: Argyri Mathioudaki, Giovanni Fanni, Jan W. Eriksson, Maria J. Pereira
Publicado en: Metabolites, Edición 14, 2024, ISSN 2218-1989
Editor: MDPI AG
DOI: 10.3390/metabo14080411

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Autores: Adriana Fontes, Adrian T. Jauch, Judith Sailer, Jonas Engler, Anabela Marisa Azul, Hans Zischka
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/ijms25147880

What are we missing to gain the battle against cardiovascular diseases?

Autores: Harshitha Shanmugam, Piero Portincasa, Agostino Di Ciaula
Publicado en: European Heart Journal, Edición 45, 2024, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae279

Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery

Autores: Aryane Cruz Oliveira Pinho, Pedro Barbosa, Andr Lazaro, Jos G. Tralho, Maria Joo Pereira, Artur Paiva, Paula Laranjeira, Eugenia Carvalho
Publicado en: Immunology Letters, Edición 269, 2024, ISSN 0165-2478
Editor: Elsevier BV
DOI: 10.1016/j.imlet.2024.106911

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Autores: Mohamad Khalil, Francesca Piccapane, Mirco Vacca, Giuseppe Celano, Laura Mahdi, Valeria Perniola, Carmen Aurora Apa, Alessandro Annunziato, Ilaria Iacobellis, Giuseppe Procino, Maria Calasso, Maria De Angelis, Rosa Caroppo, Piero Portincasa
Publicado en: Nutrients, Edición 16, 2024, ISSN 2072-6643
Editor: MDPI AG
DOI: 10.3390/nu16050588

The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease

Autores: Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Piero Portincasa
Publicado en: Internal and Emergency Medicine, Edición 18, 2023, ISSN 1828-0447
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03343-3

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Autores: Mariana S. Diniz, Carina C. Magalhes, Carolina Tocantins, Lus F. Grilo, Jos Teixeira, Susana P. Pereira
Publicado en: Nutrients, Edición 15, 2023, ISSN 2072-6643
Editor: MDPI AG
DOI: 10.3390/nu15214623

Converging Pathways between Metabolic DysfunctionAssociated Steatotic Liver Disease (MASLD) and Diabetes in Children

Autores: Maria Felicia Faienza, Ilaria Farella, Mohamad Khalil, Piero Portincasa
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/ijms25189924

Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

Autores: Mariana S. Diniz, Ursula Hiden, Ins Falco-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Edición 1869, 2024, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166834

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Autores: Mariana S. Diniz, Luís F. Grilo, Carolina Tocantins, Inês Falcão-Pires, Susana P. Pereira
Publicado en: Metabolites, Edición 13, 2025, ISSN 2218-1989
Editor: MDPI AG
DOI: 10.3390/metabo13070845

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Autores: Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S. Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T. Madreiter-Sokolowski, Susana P. Pereira, Ursula Hiden
Publicado en: Biology, Edición 13, 2024, ISSN 2079-7737
Editor: MDPI AG
DOI: 10.3390/biology13020070

Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

Autores: Agostino Di Ciaula, Mohamad Khalil, Gyorgy Baffy, Piero Portincasa
Publicado en: European Journal of Internal Medicine, Edición 128, 2024, ISSN 0953-6205
Editor: Elsevier BV
DOI: 10.1016/j.ejim.2024.07.008

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction

Autores: Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, Andr Nogueira da Costa, Philipp E. Scherer, Flvio Reis, Francisco Pereira, Raquel Seia, Paulo Matafome
Publicado en: Metabolism, Edición 153, 2024, ISSN 0026-0495
Editor: Elsevier BV
DOI: 10.1016/j.metabol.2024.155788

Hepatic glucose metabolism in the steatotic liver

Autores: Egeria Scoditti, Silvia Sabatini, Fabrizia Carli, Amalia Gastaldelli
Publicado en: Nature Reviews Gastroenterology &amp; Hepatology, Edición 21, 2024, ISSN 1759-5045
Editor: Springer Science and Business Media LLC
DOI: 10.1038/s41575-023-00888-8

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Autores: LusF. Grilo, JooD. Martins, MarianaS. Diniz, Carolina Tocantins, ChiaraH. Cavallaro, Ins Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, PeterW. Nathanielsz, PauloJ. Oliveira, SusanaP. Pereira
Publicado en: Clinical Science, Edición 137, 2023, ISSN 0143-5221
Editor: Portland Press Ltd.
DOI: 10.1042/CS20230048

Mitochondrial DNA – novel mechanisms of kidney damage and potential biomarker

Autores: Afshan N. Malik
Publicado en: Current Opinion in Nephrology &amp; Hypertension, Edición 32, 2024, ISSN 1062-4821
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/mnh.0000000000000922

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Autores: Diana Sousa, CarinaC. Magalhes, Paulo Matafome, SusanaP. Pereira
Publicado en: Bioscience Reports, Edición 44, 2024, ISSN 0144-8463
Editor: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Autores: Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik
Publicado en: Molecular Medicine, Edición 30, 2024, ISSN 1528-3658
Editor: Springer Science and Business Media LLC
DOI: 10.1186/s10020-024-00930-8

Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations

Autores: Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate, Alessandro Stella, Gabriella Garruti, John Thomas Lamont
Publicado en: Internal and Emergency Medicine, Edición 18, 2023, ISSN 1828-0447
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03355-z

Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options

Autores: Piero Portincasa, Mohamad Khalil, Laura Mahdi, Valeria Perniola, Valeria Idone, Annarita Graziani, Gyorgy Baffy, Agostino Di Ciaula
Publicado en: International Journal of Molecular Sciences, Edición 25, 2024, ISSN 1422-0067
Editor: MDPI AG
DOI: 10.3390/ijms25115640

Renal sinus adipose tissue: exploratory study of metabolic features and transcriptome compared with omental and subcutaneous adipose tissue

Autores: Maria J. Pereira, Argyri Mathioudaki, Alicia G. Otero, Padma Priya Duvvuri, Milica Vranic, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson
Publicado en: Obesity, Edición 32, 2024, ISSN 1930-7381
Editor: Wiley
DOI: 10.1002/oby.24114

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Autores: Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Publicado en: Advanced Science, Edición 11, 2024, ISSN 2198-3844
Editor: Wiley
DOI: 10.1002/advs.202309211

Corrigendum to “The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity” [Mol. Cell. Endocrinol. 594 (2024), 112367]

Autores: Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Inês Falcão-Pires, Hans Eickhoff, Sofia Viana, Flávio Reis, Ana Salomé Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seiça, Paulo Matafome
Publicado en: Molecular and Cellular Endocrinology, Edición 595, 2024, ISSN 0303-7207
Editor: Elsevier BV
DOI: 10.1016/j.mce.2024.112410

Distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on markers of body fat storage. A real-life study

Autores: Mohamad Khalil, Hala Abdallah, Nour Jaber, Gabriella Garruti, Agostino Di Ciaula, Piero Portincasa
Publicado en: European Journal of Internal Medicine, Edición 129, 2024, ISSN 0953-6205
Editor: Elsevier BV
DOI: 10.1016/j.ejim.2024.08.014

Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy

Autores: Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, David Rizo-Roca, Estela Santos-Alves, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Edición 1871, 2024, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167539

The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity

Autores: Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Ins Falco-Pires, Hans Eickhoff, Sofia Viana, Flvio Reis, Ana Salom Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seia, Paulo Matafome
Publicado en: Molecular and Cellular Endocrinology, Edición 594, 2024, ISSN 0303-7207
Editor: Elsevier BV
DOI: 10.1016/j.mce.2024.112367

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Autores: Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Publicado en: JHEP Reports, Edición 6, 2024, ISSN 2589-5559
Editor: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101185

Oxidative stress in metabolic dysfunctionassociated steatotic liver disease (<scp>MASLD</scp>): How does the animal model resemble human disease?

Autores: Patrycja Jakubek, Piotr Kalinowski, Agnieszka KarkucinskaWieckowska, Aakruti Kaikini, Ins C. M. Simes, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Micha Grt, Maciej Pronicki, Magdalena LebiedzinskaArciszewska, Marcin Krawczyk, Mariusz R. Wieckowski
Publicado en: The FASEB Journal, Edición 38, 2024, ISSN 0892-6638
Editor: Wiley
DOI: 10.1096/fj.202302447R

Multidimensional Assessment of Sarcopenia and Sarcopenic Obesity in Geriatric Patients: Creatinine/Cystatin C Ratio Performs Better than Sarcopenia Index

Autores: Mohamad Khalil, Agostino Di Ciaula, Nour Jaber, Roberta Grandolfo, Flavia Fiermonte, Piero Portincasa
Publicado en: Metabolites, Edición 14, 2024, ISSN 2218-1989
Editor: MDPI AG
DOI: 10.3390/metabo14060306

Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women

Autores: Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J Pereira, Jan W Eriksson
Publicado en: Endocrinology, Edición 165, 2023, ISSN 1945-7170
Editor: The Endocrine Society
DOI: 10.1210/endocr/bqad172

Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

Autores: Piero Portincasa, Mohamad Khalil, Annarita Graziani, Gema Frhbeck, Gyorgy Baffy, Gabriella Garruti, Agostino Di Ciaula, Leonilde Bonfrate
Publicado en: European Journal of Internal Medicine, Edición 119, 2024, ISSN 0953-6205
Editor: Elsevier BV
DOI: 10.1016/j.ejim.2023.10.002

Metabolic mitochondrial alterations prevail in the female rat heart 8weeks after exercise cessation

Autores: Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena StevanovicSilva, Jorge Beleza, Pedro Coxito, David RizoRoca, Estela SantosAlves, Manoel Rios, Lina Carvalho, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Publicado en: European Journal of Clinical Investigation, Edición 53, 2023, ISSN 0014-2972
Editor: Wiley
DOI: 10.1111/eci.14069

Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity

Autores: Pedro Baptista Pereira, Estefania Torrejón, Inês Ferreira, Ana Sofia Carvalho, Akiko Teshima, Inês Sousa-Lima, Hans Christian Beck, Bruno Costa-Silva, Rune Matthiesen, Maria Paula Macedo, Rita Machado de Oliveira
Publicado en: Nutrients, Edición 16, 2024, ISSN 2072-6643
Editor: MDPI AG
DOI: 10.3390/nu16050736

Book chapters (1)

Absolute Quantification of Cellular and Cell-Free Mitochondrial DNA Copy Number from Human Blood and Urinary Samples Using Real Time Quantitative PCR

Autores: Eliane Caseiro Soares de Menezes, Afshan Navid Malik
Publicado en: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2024
Editor: Springer US
DOI: 10.1007/978-1-0716-4264-1_13