DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

Informazioni relative al progetto

PAS GRAS

ID dell’accordo di sovvenzione: 101080329

DOI

10.3030/101080329

Data della firma CE 28 Aprile 2023

Data di avvio 1 Maggio 2023

Data di completamento 30 Aprile 2028

Finanziato da

• Health

Costo totale

€ 9 377 421,25

Contributo UE

€ 9 377 421,25

Coordinato da

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (5)

First PDEC version

First version of all actions for DC&E

First version of the Education and Training plan

A document stating all training and education activities across the consortium will be prepared.

Study initiation package

Report detailing the pre-registration (clinicaltrial.gov) of the clinical trial (WP5), final protocol and ethical issues

Pre-registration of animal studies

Report with the pre-registration of in vivo assays (including previous in vitro data)

Report from Kick-Off meeting

A report will be produced, including the compositionof the different boards

Data Management Plan (1)

Data management plan

A data management plan will be prepared by allpartners. Updated whenever necessary

Websites, patent fillings, videos etc. (2)

Project Website

Public website

Project social media

Report on PAS GRAS social media

Pubblicazioni

Peer reviewed articles (38)

Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Autori: Patrycja Jakubek, Barbara Pakula, Martin Rossmeisl, Paolo Pinton, Alessandro Rimessi, Mariusz Roman Wieckowski
Pubblicato in: Internal and Emergency Medicine, Numero 19, 2024, ISSN 1828-0447
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11739-024-03700-w

The role of <scp>CD20</scp>⁺ T cells: Insights in human peripheral blood

Autori: Aryane Cruz Oliveira Pinho, Pedro Barbosa, Maria Joo Pereira, Artur Paiva, Eugenia Carvalho, Paula Laranjeira
Pubblicato in: Cytometry Part B: Clinical Cytometry, Numero 106, 2024, ISSN 1552-4949
Editore: Wiley
DOI: 10.1002/cyto.b.22178

Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

Autori: Piero Portincasa, Gyorgy Baffy
Pubblicato in: European Journal of Internal Medicine, Numero 124, 2024, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2024.04.013

Short-term effects of obesity surgery versus low-energydiet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated 18F-FDG-PET/MRI

Autori: Jan W. Eriksson, Maria J. Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundstrm, Giovanni Fanni, Martin H. Lundqvist, Bjrn C. L. Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risrus, Hkan Ahlstrm
Pubblicato in: Diabetologia, Numero 67, 2024, ISSN 0012-186X
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s00125-024-06150-3

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Autori: Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Pubblicato in: International Journal of Molecular Sciences, Numero 24, 2023, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/ijms242015192

Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance

Autori: Argyri Mathioudaki, Giovanni Fanni, Jan W. Eriksson, Maria J. Pereira
Pubblicato in: Metabolites, Numero 14, 2024, ISSN 2218-1989
Editore: MDPI AG
DOI: 10.3390/metabo14080411

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Autori: Adriana Fontes, Adrian T. Jauch, Judith Sailer, Jonas Engler, Anabela Marisa Azul, Hans Zischka
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/ijms25147880

What are we missing to gain the battle against cardiovascular diseases?

Autori: Harshitha Shanmugam, Piero Portincasa, Agostino Di Ciaula
Pubblicato in: European Heart Journal, Numero 45, 2024, ISSN 0195-668X
Editore: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae279

Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery

Autori: Aryane Cruz Oliveira Pinho, Pedro Barbosa, Andr Lazaro, Jos G. Tralho, Maria Joo Pereira, Artur Paiva, Paula Laranjeira, Eugenia Carvalho
Pubblicato in: Immunology Letters, Numero 269, 2024, ISSN 0165-2478
Editore: Elsevier BV
DOI: 10.1016/j.imlet.2024.106911

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Autori: Mohamad Khalil, Francesca Piccapane, Mirco Vacca, Giuseppe Celano, Laura Mahdi, Valeria Perniola, Carmen Aurora Apa, Alessandro Annunziato, Ilaria Iacobellis, Giuseppe Procino, Maria Calasso, Maria De Angelis, Rosa Caroppo, Piero Portincasa
Pubblicato in: Nutrients, Numero 16, 2024, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/nu16050588

The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease

Autori: Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Piero Portincasa
Pubblicato in: Internal and Emergency Medicine, Numero 18, 2023, ISSN 1828-0447
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03343-3

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Autori: Mariana S. Diniz, Carina C. Magalhes, Carolina Tocantins, Lus F. Grilo, Jos Teixeira, Susana P. Pereira
Pubblicato in: Nutrients, Numero 15, 2023, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/nu15214623

Converging Pathways between Metabolic DysfunctionAssociated Steatotic Liver Disease (MASLD) and Diabetes in Children

Autori: Maria Felicia Faienza, Ilaria Farella, Mohamad Khalil, Piero Portincasa
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/ijms25189924

Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

Autori: Mariana S. Diniz, Ursula Hiden, Ins Falco-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 1869, 2024, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166834

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Autori: Mariana S. Diniz, Luís F. Grilo, Carolina Tocantins, Inês Falcão-Pires, Susana P. Pereira
Pubblicato in: Metabolites, Numero 13, 2025, ISSN 2218-1989
Editore: MDPI AG
DOI: 10.3390/metabo13070845

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Autori: Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S. Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T. Madreiter-Sokolowski, Susana P. Pereira, Ursula Hiden
Pubblicato in: Biology, Numero 13, 2024, ISSN 2079-7737
Editore: MDPI AG
DOI: 10.3390/biology13020070

Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

Autori: Agostino Di Ciaula, Mohamad Khalil, Gyorgy Baffy, Piero Portincasa
Pubblicato in: European Journal of Internal Medicine, Numero 128, 2024, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2024.07.008

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction

Autori: Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, Andr Nogueira da Costa, Philipp E. Scherer, Flvio Reis, Francisco Pereira, Raquel Seia, Paulo Matafome
Pubblicato in: Metabolism, Numero 153, 2024, ISSN 0026-0495
Editore: Elsevier BV
DOI: 10.1016/j.metabol.2024.155788

Hepatic glucose metabolism in the steatotic liver

Autori: Egeria Scoditti, Silvia Sabatini, Fabrizia Carli, Amalia Gastaldelli
Pubblicato in: Nature Reviews Gastroenterology &amp; Hepatology, Numero 21, 2024, ISSN 1759-5045
Editore: Springer Science and Business Media LLC
DOI: 10.1038/s41575-023-00888-8

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Autori: LusF. Grilo, JooD. Martins, MarianaS. Diniz, Carolina Tocantins, ChiaraH. Cavallaro, Ins Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, PeterW. Nathanielsz, PauloJ. Oliveira, SusanaP. Pereira
Pubblicato in: Clinical Science, Numero 137, 2023, ISSN 0143-5221
Editore: Portland Press Ltd.
DOI: 10.1042/CS20230048

Mitochondrial DNA – novel mechanisms of kidney damage and potential biomarker

Autori: Afshan N. Malik
Pubblicato in: Current Opinion in Nephrology &amp; Hypertension, Numero 32, 2024, ISSN 1062-4821
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/mnh.0000000000000922

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Autori: Diana Sousa, CarinaC. Magalhes, Paulo Matafome, SusanaP. Pereira
Pubblicato in: Bioscience Reports, Numero 44, 2024, ISSN 0144-8463
Editore: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Autori: Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik
Pubblicato in: Molecular Medicine, Numero 30, 2024, ISSN 1528-3658
Editore: Springer Science and Business Media LLC
DOI: 10.1186/s10020-024-00930-8

Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations

Autori: Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate, Alessandro Stella, Gabriella Garruti, John Thomas Lamont
Pubblicato in: Internal and Emergency Medicine, Numero 18, 2023, ISSN 1828-0447
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03355-z

Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options

Autori: Piero Portincasa, Mohamad Khalil, Laura Mahdi, Valeria Perniola, Valeria Idone, Annarita Graziani, Gyorgy Baffy, Agostino Di Ciaula
Pubblicato in: International Journal of Molecular Sciences, Numero 25, 2024, ISSN 1422-0067
Editore: MDPI AG
DOI: 10.3390/ijms25115640

Renal sinus adipose tissue: exploratory study of metabolic features and transcriptome compared with omental and subcutaneous adipose tissue

Autori: Maria J. Pereira, Argyri Mathioudaki, Alicia G. Otero, Padma Priya Duvvuri, Milica Vranic, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson
Pubblicato in: Obesity, Numero 32, 2024, ISSN 1930-7381
Editore: Wiley
DOI: 10.1002/oby.24114

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Autori: Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Pubblicato in: Advanced Science, Numero 11, 2024, ISSN 2198-3844
Editore: Wiley
DOI: 10.1002/advs.202309211

Corrigendum to “The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity” [Mol. Cell. Endocrinol. 594 (2024), 112367]

Autori: Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Inês Falcão-Pires, Hans Eickhoff, Sofia Viana, Flávio Reis, Ana Salomé Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seiça, Paulo Matafome
Pubblicato in: Molecular and Cellular Endocrinology, Numero 595, 2024, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/j.mce.2024.112410

Distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on markers of body fat storage. A real-life study

Autori: Mohamad Khalil, Hala Abdallah, Nour Jaber, Gabriella Garruti, Agostino Di Ciaula, Piero Portincasa
Pubblicato in: European Journal of Internal Medicine, Numero 129, 2024, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2024.08.014

Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy

Autori: Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, David Rizo-Roca, Estela Santos-Alves, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numero 1871, 2024, ISSN 0925-4439
Editore: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167539

The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity

Autori: Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Ins Falco-Pires, Hans Eickhoff, Sofia Viana, Flvio Reis, Ana Salom Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seia, Paulo Matafome
Pubblicato in: Molecular and Cellular Endocrinology, Numero 594, 2024, ISSN 0303-7207
Editore: Elsevier BV
DOI: 10.1016/j.mce.2024.112367

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Autori: Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Pubblicato in: JHEP Reports, Numero 6, 2024, ISSN 2589-5559
Editore: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101185

Oxidative stress in metabolic dysfunctionassociated steatotic liver disease (<scp>MASLD</scp>): How does the animal model resemble human disease?

Autori: Patrycja Jakubek, Piotr Kalinowski, Agnieszka KarkucinskaWieckowska, Aakruti Kaikini, Ins C. M. Simes, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Micha Grt, Maciej Pronicki, Magdalena LebiedzinskaArciszewska, Marcin Krawczyk, Mariusz R. Wieckowski
Pubblicato in: The FASEB Journal, Numero 38, 2024, ISSN 0892-6638
Editore: Wiley
DOI: 10.1096/fj.202302447R

Multidimensional Assessment of Sarcopenia and Sarcopenic Obesity in Geriatric Patients: Creatinine/Cystatin C Ratio Performs Better than Sarcopenia Index

Autori: Mohamad Khalil, Agostino Di Ciaula, Nour Jaber, Roberta Grandolfo, Flavia Fiermonte, Piero Portincasa
Pubblicato in: Metabolites, Numero 14, 2024, ISSN 2218-1989
Editore: MDPI AG
DOI: 10.3390/metabo14060306

Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women

Autori: Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J Pereira, Jan W Eriksson
Pubblicato in: Endocrinology, Numero 165, 2023, ISSN 1945-7170
Editore: The Endocrine Society
DOI: 10.1210/endocr/bqad172

Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

Autori: Piero Portincasa, Mohamad Khalil, Annarita Graziani, Gema Frhbeck, Gyorgy Baffy, Gabriella Garruti, Agostino Di Ciaula, Leonilde Bonfrate
Pubblicato in: European Journal of Internal Medicine, Numero 119, 2024, ISSN 0953-6205
Editore: Elsevier BV
DOI: 10.1016/j.ejim.2023.10.002

Metabolic mitochondrial alterations prevail in the female rat heart 8weeks after exercise cessation

Autori: Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena StevanovicSilva, Jorge Beleza, Pedro Coxito, David RizoRoca, Estela SantosAlves, Manoel Rios, Lina Carvalho, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Pubblicato in: European Journal of Clinical Investigation, Numero 53, 2023, ISSN 0014-2972
Editore: Wiley
DOI: 10.1111/eci.14069

Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity

Autori: Pedro Baptista Pereira, Estefania Torrejón, Inês Ferreira, Ana Sofia Carvalho, Akiko Teshima, Inês Sousa-Lima, Hans Christian Beck, Bruno Costa-Silva, Rune Matthiesen, Maria Paula Macedo, Rita Machado de Oliveira
Pubblicato in: Nutrients, Numero 16, 2024, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/nu16050736

Book chapters (1)

Absolute Quantification of Cellular and Cell-Free Mitochondrial DNA Copy Number from Human Blood and Urinary Samples Using Real Time Quantitative PCR

Autori: Eliane Caseiro Soares de Menezes, Afshan Navid Malik
Pubblicato in: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2024
Editore: Springer US
DOI: 10.1007/978-1-0716-4264-1_13